JP6515182B2 - Ｗｔ１抗原ペプチドおよび免疫調節剤の併用 - Google Patents

Ｗｔ１抗原ペプチドおよび免疫調節剤の併用 Download PDF

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Publication number
JP6515182B2
JP6515182B2 JP2017519401A JP2017519401A JP6515182B2 JP 6515182 B2 JP6515182 B2 JP 6515182B2 JP 2017519401 A JP2017519401 A JP 2017519401A JP 2017519401 A JP2017519401 A JP 2017519401A JP 6515182 B2 JP6515182 B2 JP 6515182B2
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peptide
seq
cancer
antibody
cells
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Japanese (ja)
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JPWO2016186177A1 (ja
Inventor
秀夫 高須
秀夫 高須
恵弥 中村
恵弥 中村
後藤　正志
正志 後藤
奈津子 杉辺
奈津子 杉辺
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International Institute of Cancer Immunology Inc
Sumitomo Pharma Co Ltd
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Sumitomo Dainippon Pharma Co Ltd
International Institute of Cancer Immunology Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001152—Transcription factors, e.g. SOX or c-MYC
    • A61K39/001153—Wilms tumor 1 [WT1]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP2017519401A 2015-05-20 2016-05-19 Ｗｔ１抗原ペプチドおよび免疫調節剤の併用 Active JP6515182B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2015103145 2015-05-20
JP2015103145 2015-05-20
PCT/JP2016/064923 WO2016186177A1 (ja) 2015-05-20 2016-05-19 Ｗｔ１抗原ペプチドおよび免疫調節剤の併用

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JPWO2016186177A1 JPWO2016186177A1 (ja) 2018-04-12
JP6515182B2 true JP6515182B2 (ja) 2019-05-15

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JP2017519401A Active JP6515182B2 (ja) 2015-05-20 2016-05-19 Ｗｔ１抗原ペプチドおよび免疫調節剤の併用
JP2019076826A Active JP6713160B2 (ja) 2015-05-20 2019-04-15 Ｗｔ１抗原ペプチドおよび免疫調節剤の併用
JP2020012396A Active JP6956967B2 (ja) 2015-05-20 2020-01-29 Ｗｔ１抗原ペプチドおよび免疫調節剤の併用
JP2021154508A Active JP7253210B2 (ja) 2015-05-20 2021-09-22 Ｗｔ１抗原ペプチドおよび免疫調節剤の併用

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JP2019076826A Active JP6713160B2 (ja) 2015-05-20 2019-04-15 Ｗｔ１抗原ペプチドおよび免疫調節剤の併用
JP2020012396A Active JP6956967B2 (ja) 2015-05-20 2020-01-29 Ｗｔ１抗原ペプチドおよび免疫調節剤の併用
JP2021154508A Active JP7253210B2 (ja) 2015-05-20 2021-09-22 Ｗｔ１抗原ペプチドおよび免疫調節剤の併用

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US (2) US20180140691A1 (enExample)
EP (1) EP3299028B1 (enExample)
JP (4) JP6515182B2 (enExample)
CN (1) CN107921106B (enExample)
CA (1) CA2986367A1 (enExample)
ES (1) ES2993462T3 (enExample)
WO (1) WO2016186177A1 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014157692A1 (ja) 2013-03-29 2014-10-02 大日本住友製薬株式会社 Ｗｔ１抗原ペプチドコンジュゲートワクチン
CN116327902A (zh) * 2015-11-20 2023-06-27 纪念斯隆凯特林癌症中心 用于治疗癌症的方法和组合物
WO2018039629A2 (en) 2016-08-25 2018-03-01 Northwestern University Micellar spherical nucleic acids from thermoresponsive, traceless templates
EP3549957A4 (en) 2016-11-30 2020-08-05 Sumitomo Dainippon Pharma Co., Ltd. AUXILIARY PEPTIDE WT1, AND COMBINATION OF DUDIT PEPTIDE AND CONJUGATE PEPTIDE ANTIGENIC FOR CANCER
AU2017379900B2 (en) 2016-12-22 2024-12-05 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
MY192920A (en) * 2017-03-15 2022-09-15 Cancer Res Malaysia Immunogenic peptide composition
US11696954B2 (en) 2017-04-28 2023-07-11 Exicure Operating Company Synthesis of spherical nucleic acids using lipophilic moieties
KR20250139417A (ko) 2017-05-31 2025-09-23 주식회사 에스티큐브앤컴퍼니 Btn1a1에 면역특이적으로 결합하는 항체 및 분자를 사용하여 암을 치료하는 방법
WO2019046321A1 (en) * 2017-08-28 2019-03-07 Bristol-Myers Squibb Company TIM-3 ANTAGONISTS FOR THE TREATMENT AND DIAGNOSIS OF CANCERS
PT3691620T (pt) * 2017-10-05 2022-10-06 Fulcrum Therapeutics Inc Os inibidores da quinase p38 reduzem a expressão de dux4 e genes a jusante para o tratamento de fshd
KR102184377B1 (ko) * 2018-02-19 2020-11-30 고려대학교 산학협력단 열충격단백질의 에피토프를 포함하는 백신 및 이의 용도
WO2020067453A1 (ja) 2018-09-28 2020-04-02 大日本住友製薬株式会社 注射用組成物
MX2021003938A (es) * 2018-10-05 2021-08-11 Int Inst Cancer Immunology Inc Composicion para prevenir o tratar un tumor benigno.
IL287064B2 (en) * 2019-04-10 2025-07-01 Slsg Ltd Llc Multi-valent immunotherapy composition and methods of use for treating wt1-positive cancers
US20210030868A1 (en) * 2019-07-29 2021-02-04 Cai Gu Huang Formulation of antibody based drugs for treating lung cancer by inhalation
WO2021117771A1 (ja) 2019-12-10 2021-06-17 大日本住友製薬株式会社 ペプチドエマルション製剤の調製方法
US20230331858A1 (en) * 2019-12-24 2023-10-19 Neoleukin Therapeutics, Inc. Combination therapy using an il-2 receptor agonist and an immune checkpoint inhibitor
CN115697374A (zh) * 2020-05-12 2023-02-03 得克萨斯州大学系统董事会 用于治疗胶质母细胞瘤的方法
JP2023525822A (ja) * 2020-05-12 2023-06-19 エルジー・ケム・リミテッド 多量体ｔ細胞調節性ポリペプチド及びその使用方法
TW202200188A (zh) * 2020-05-12 2022-01-01 日商大日本住友製藥股份有限公司 用以處置癌症之醫藥組合物
EP4149534A4 (en) * 2020-05-12 2024-09-04 Cue Biopharma, Inc. MULTIMERIC POLYPEPTIDES MODULATING T CELLS AND METHODS OF USE THEREOF
CN111647066B (zh) * 2020-07-01 2020-12-18 维肽瀛(上海)生物技术有限公司 Wt1多肽肿瘤抑制剂
JPWO2022030631A1 (enExample) * 2020-08-07 2022-02-10
EP4313046A1 (en) * 2021-03-31 2024-02-07 Celleron Therapeutics Limited Vaccine adjuvant
CN117838860B (zh) * 2023-11-27 2025-03-14 四川大学 一种抑制周围神经侵袭的药物、药物组合物、联合用药物
CN119161494B (zh) * 2024-11-18 2025-10-21 北京宝易生物技术有限公司 疫苗稀释液制备方法和应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2572715A1 (en) * 2002-12-30 2013-03-27 3M Innovative Properties Company Immunostimulatory Combinations
ES2332590T3 (es) * 2003-01-15 2010-02-09 International Institute Of Cancer Immunology, Inc. Dimero peptidico.
CA2520586C (en) * 2003-03-27 2011-06-14 Lankenau Institute For Medical Research Novel ido inhibitors and methods of use
US20040197312A1 (en) * 2003-04-02 2004-10-07 Marina Moskalenko Cytokine-expressing cellular vaccine combinations
CA2527102A1 (en) * 2003-07-10 2005-01-20 Cytos Biotechnology Ag Packaged virus-like particles
EP1670513B1 (en) * 2003-10-06 2013-01-23 Cedars-Sinai Medical Center Cox-2 inhibitors and dendritic cells for use in the treatment of cancer.
JP5427027B2 (ja) * 2006-05-03 2014-02-26 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・コロラド，ア・ボディー・コーポレイト Ｃｄ４０アゴニスト抗体／ｉ型インターフェロン相乗性アジュバントの結合体、それを含む複合体、および細胞性免疫を強化する治療としてのその使用
CA2652599C (en) * 2006-05-03 2019-09-24 Ross Kedl Cd40 agonist antibody/type1 interferon synergistic adjuvant combination, conjugates containing and use thereof as a therapeutic to enhance cellular immunity
GB0620894D0 (en) * 2006-10-20 2006-11-29 Univ Southampton Human immune therapies using a CD27 agonist alone or in combination with other immune modulators
CN102282265B (zh) * 2008-11-28 2020-07-24 埃默里大学 用于治疗传染病和肿瘤的方法
KR101208587B1 (ko) * 2009-06-24 2012-12-06 여오영 하이드록시클로로퀸을 포함하는 항암 치료를 위한 국소 투여용 주사제 조성물
KR101958753B1 (ko) * 2010-04-13 2019-03-15 셀덱스 쎄라퓨틱스, 인크. 인간 ｃｄ27에 결합하는 항체 및 이의 용도
CN103157108B (zh) * 2011-12-13 2016-01-20 宁云山 免疫调节剂组合物及其药物组合物和应用
EP2790730B1 (en) * 2011-12-15 2019-01-23 The University of Chicago Methods and compositions for cancer therapy using mutant light molecules with increased affinity to receptors
AR090263A1 (es) * 2012-03-08 2014-10-29 Hoffmann La Roche Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
CN103830211A (zh) * 2012-11-27 2014-06-04 上海曼克尔瑞生物医药技术有限公司 一种β-catenin蛋白抑制剂-姜黄素在肝癌治疗方面的应用
JP6497691B2 (ja) * 2013-02-05 2019-04-10 日東電工株式会社 粘膜投与用ｗｔ１ペプチド癌ワクチン組成物
KR20210108497A (ko) * 2013-02-26 2021-09-02 메모리얼 슬로안 케터링 캔서 센터 면역치료용 조성물 및 방법
WO2014157692A1 (ja) * 2013-03-29 2014-10-02 大日本住友製薬株式会社 Ｗｔ１抗原ペプチドコンジュゲートワクチン
CA2920377A1 (en) * 2013-08-05 2015-02-12 Cambridge Enterprise Limited Inhibition of cxcr4 signaling in cancer immunotherapy

Also Published As

Publication number Publication date
EP3299028A1 (en) 2018-03-28
US20180140691A1 (en) 2018-05-24
JPWO2016186177A1 (ja) 2018-04-12
JP7253210B2 (ja) 2023-04-06
JP2022000454A (ja) 2022-01-04
HK1250213A1 (en) 2018-12-07
CA2986367A1 (en) 2016-11-24
JP6956967B2 (ja) 2021-11-02
CN107921106B (zh) 2023-09-08
CN107921106A (zh) 2018-04-17
WO2016186177A1 (ja) 2016-11-24
EP3299028A4 (en) 2019-02-27
EP3299028B1 (en) 2024-10-30
ES2993462T3 (en) 2024-12-30
US20240293521A1 (en) 2024-09-05
HK1248546A1 (zh) 2018-10-19
JP2020075934A (ja) 2020-05-21
JP2019135251A (ja) 2019-08-15
JP6713160B2 (ja) 2020-06-24

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