JP6509811B2 - ジブチルヒドロキシトルエンの安定化方法 - Google Patents
ジブチルヒドロキシトルエンの安定化方法 Download PDFInfo
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- JP6509811B2 JP6509811B2 JP2016507754A JP2016507754A JP6509811B2 JP 6509811 B2 JP6509811 B2 JP 6509811B2 JP 2016507754 A JP2016507754 A JP 2016507754A JP 2016507754 A JP2016507754 A JP 2016507754A JP 6509811 B2 JP6509811 B2 JP 6509811B2
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- dibutylhydroxytoluene
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- 235000010354 butylated hydroxytoluene Nutrition 0.000 title claims description 125
- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical compound CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 title claims description 112
- 238000000034 method Methods 0.000 title claims description 28
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- 239000003795 chemical substances by application Substances 0.000 claims description 46
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 42
- TVQZAMVBTVNYLA-UHFFFAOYSA-N Pranoprofen Chemical compound C1=CC=C2CC3=CC(C(C(O)=O)C)=CC=C3OC2=N1 TVQZAMVBTVNYLA-UHFFFAOYSA-N 0.000 claims description 40
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- VLARUOGDXDTHEH-UHFFFAOYSA-L disodium cromoglycate Chemical compound [Na+].[Na+].O1C(C([O-])=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C([O-])=O)O2 VLARUOGDXDTHEH-UHFFFAOYSA-L 0.000 claims description 18
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- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 13
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- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A—HUMAN NECESSITIES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1412—Containers with closing means, e.g. caps
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Landscapes
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- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| JP2014046903 | 2014-03-10 | ||
| JP2014046903 | 2014-03-10 | ||
| PCT/JP2015/056985 WO2015137326A1 (ja) | 2014-03-10 | 2015-03-10 | ジブチルヒドロキシトルエンの安定化方法 |
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| JP6509811B2 true JP6509811B2 (ja) | 2019-05-08 |
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| JP (2) | JP6509811B2 (zh) |
| CN (1) | CN106068122B (zh) |
| RU (1) | RU2690490C2 (zh) |
| TW (1) | TWI644663B (zh) |
| WO (1) | WO2015137326A1 (zh) |
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| JP2017105752A (ja) * | 2015-08-31 | 2017-06-15 | ロート製薬株式会社 | 眼科組成物 |
| JPWO2017043488A1 (ja) * | 2015-09-08 | 2018-06-28 | ロート製薬株式会社 | 眼科組成物 |
| JPWO2019230971A1 (ja) * | 2018-05-31 | 2021-07-08 | 千寿製薬株式会社 | ジブチルヒドロキシトルエンの含量低下が抑制された眼科用液剤 |
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| DE69534258T2 (de) * | 1994-03-15 | 2006-05-04 | Mitsubishi Pharma Corp. | Verfahren zur Stabilisierung von Pranoprofen und stabile flüssige Zubereitung von Pranoprofen |
| JP4831944B2 (ja) * | 2004-04-28 | 2011-12-07 | ロート製薬株式会社 | プラノプロフェン含有組成物 |
| JP4989898B2 (ja) * | 2005-01-26 | 2012-08-01 | ロート製薬株式会社 | プラノプロフェン含有組成物 |
| JP2007099697A (ja) * | 2005-10-05 | 2007-04-19 | Rohto Pharmaceut Co Ltd | プラノプロフェン及びクロモグリク酸塩含有点眼剤 |
| JP6009141B2 (ja) * | 2009-10-09 | 2016-10-19 | ロート製薬株式会社 | 水性組成物 |
| CN102085395A (zh) * | 2009-12-02 | 2011-06-08 | 日本乐敦制药株式会社 | 硅酮水凝胶隐形眼镜用眼科组合物 |
| WO2013009961A1 (en) * | 2011-07-12 | 2013-01-17 | University Of Houston | Design of ultra-fast suspended graphene nano-sensors suitable for large scale production |
| WO2013099861A1 (ja) * | 2011-12-27 | 2013-07-04 | 千寿製薬株式会社 | ジブチルヒドロキシトルエン含有製剤及びジブチルヒドロキシトルエンの安定化方法 |
| TWI644663B (zh) * | 2014-03-10 | 2018-12-21 | 日商千壽製藥股份有限公司 | 二丁基羥基甲苯的穩定化方法，及含二丁基羥基甲苯之製品(一) |
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| JP2019147802A (ja) * | 2014-03-10 | 2019-09-05 | 千寿製薬株式会社 | ジブチルヒドロキシトルエンの安定化方法 |
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| Publication number | Publication date |
|---|---|
| WO2015137326A1 (ja) | 2015-09-17 |
| JP2019147802A (ja) | 2019-09-05 |
| RU2016139409A (ru) | 2018-04-10 |
| CN106068122A (zh) | 2016-11-02 |
| JPWO2015137326A1 (ja) | 2017-04-06 |
| CN106068122B (zh) | 2019-04-19 |
| JP6800264B2 (ja) | 2020-12-16 |
| RU2016139409A3 (zh) | 2018-09-26 |
| TWI644663B (zh) | 2018-12-21 |
| TW201617056A (zh) | 2016-05-16 |
| RU2690490C2 (ru) | 2019-06-04 |
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