JP6490669B2 - 単離腎細胞を含有するオルガノイド及びその使用 - Google Patents

単離腎細胞を含有するオルガノイド及びその使用 Download PDF

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JP6490669B2
JP6490669B2 JP2016513062A JP2016513062A JP6490669B2 JP 6490669 B2 JP6490669 B2 JP 6490669B2 JP 2016513062 A JP2016513062 A JP 2016513062A JP 2016513062 A JP2016513062 A JP 2016513062A JP 6490669 B2 JP6490669 B2 JP 6490669B2
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cells
cell
renal
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kidney
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JP2016519930A (ja
JP2016519930A5 (https=
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ジョイディープ バス，
ジョイディープ バス，
アンドリュー ブルース，
アンドリュー ブルース，
ラスティ ケリー，
ラスティ ケリー，
ケリー ガスリー，
ケリー ガスリー，
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インリージェン
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C12N5/0686—Kidney cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/25—Urinary tract cells, renal cells
    • C12N2502/256—Renal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/28—Vascular endothelial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Materials For Medical Uses (AREA)
JP2016513062A 2013-05-08 2014-05-08 単離腎細胞を含有するオルガノイド及びその使用 Active JP6490669B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361855146P 2013-05-08 2013-05-08
US61/855,146 2013-05-08
US201361855152P 2013-05-09 2013-05-09
US61/855,152 2013-05-09
PCT/US2014/037275 WO2014182885A2 (en) 2013-05-08 2014-05-08 Organoids comprising isolated renal cells and uses thereof

Related Child Applications (1)

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JP2019034989A Division JP7062605B2 (ja) 2013-05-08 2019-02-27 単離腎細胞を含有するオルガノイド及びその使用

Publications (3)

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JP2016519930A JP2016519930A (ja) 2016-07-11
JP2016519930A5 JP2016519930A5 (https=) 2017-10-05
JP6490669B2 true JP6490669B2 (ja) 2019-03-27

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JP2016513062A Active JP6490669B2 (ja) 2013-05-08 2014-05-08 単離腎細胞を含有するオルガノイド及びその使用
JP2019034989A Active JP7062605B2 (ja) 2013-05-08 2019-02-27 単離腎細胞を含有するオルガノイド及びその使用
JP2022030862A Active JP7493252B2 (ja) 2013-05-08 2022-03-01 単離腎細胞を含有するオルガノイド及びその使用
JP2024078330A Pending JP2024105523A (ja) 2013-05-08 2024-05-14 単離腎細胞を含有するオルガノイド及びその使用

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JP2022030862A Active JP7493252B2 (ja) 2013-05-08 2022-03-01 単離腎細胞を含有するオルガノイド及びその使用
JP2024078330A Pending JP2024105523A (ja) 2013-05-08 2024-05-14 単離腎細胞を含有するオルガノイド及びその使用

Country Status (17)

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US (2) US20160101133A1 (https=)
EP (2) EP4299721A3 (https=)
JP (4) JP6490669B2 (https=)
KR (8) KR102710014B1 (https=)
CN (1) CN105378062A (https=)
AU (3) AU2014262670B2 (https=)
CA (1) CA2911291A1 (https=)
DK (1) DK2994528T3 (https=)
ES (1) ES2970230T3 (https=)
FI (1) FI2994528T3 (https=)
HR (1) HRP20240170T1 (https=)
HU (1) HUE065125T2 (https=)
PL (1) PL2994528T3 (https=)
PT (1) PT2994528T (https=)
RU (1) RU2722361C2 (https=)
SI (1) SI2994528T1 (https=)
WO (1) WO2014182885A2 (https=)

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AU2023206151B2 (en) 2026-01-29
EP4299721A3 (en) 2024-04-24
DK2994528T3 (da) 2024-02-05
BR112015027996A8 (pt) 2017-10-10
KR102618557B1 (ko) 2023-12-28
HUE065125T2 (hu) 2024-05-28
EP2994528A2 (en) 2016-03-16
KR20160005037A (ko) 2016-01-13
KR102710014B1 (ko) 2024-09-26
KR102225312B1 (ko) 2021-03-10
WO2014182885A2 (en) 2014-11-13
KR20240144472A (ko) 2024-10-02
JP2019122381A (ja) 2019-07-25
KR20220005636A (ko) 2022-01-13
AU2020203860B2 (en) 2023-04-27
JP7493252B2 (ja) 2024-05-31
AU2014262670A1 (en) 2015-11-26
BR112015027996A2 (pt) 2017-09-12
WO2014182885A3 (en) 2015-04-16
RU2015152257A (ru) 2017-06-09
AU2023206151A1 (en) 2023-08-10
FI2994528T3 (fi) 2024-02-07
JP2022071069A (ja) 2022-05-13
RU2722361C2 (ru) 2020-05-29
KR102668827B1 (ko) 2024-05-27
CA2911291A1 (en) 2014-11-13
NZ752702A (en) 2021-11-26
CN105378062A (zh) 2016-03-02
PT2994528T (pt) 2024-02-13
HRP20240170T1 (hr) 2024-04-12
PL2994528T3 (pl) 2024-04-22
JP7062605B2 (ja) 2022-05-06
KR20240001290A (ko) 2024-01-03
EP2994528B1 (en) 2023-11-08
KR20230110834A (ko) 2023-07-25
US20220249569A1 (en) 2022-08-11
NZ713875A (en) 2021-11-26
AU2014262670B2 (en) 2020-07-09
KR20210029285A (ko) 2021-03-15
KR20240090622A (ko) 2024-06-21
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