JP2016519930A5 - - Google Patents
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- JP2016519930A5 JP2016519930A5 JP2016513062A JP2016513062A JP2016519930A5 JP 2016519930 A5 JP2016519930 A5 JP 2016519930A5 JP 2016513062 A JP2016513062 A JP 2016513062A JP 2016513062 A JP2016513062 A JP 2016513062A JP 2016519930 A5 JP2016519930 A5 JP 2016519930A5
- Authority
- JP
- Japan
- Prior art keywords
- cell group
- organoid
- cells
- cell
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 45
- 210000002220 organoid Anatomy 0.000 claims 19
- 238000000034 method Methods 0.000 claims 11
- 210000002889 endothelial cell Anatomy 0.000 claims 7
- 238000009472 formulation Methods 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- 239000007972 injectable composition Substances 0.000 claims 6
- 239000007788 liquid Substances 0.000 claims 5
- 102000003951 Erythropoietin Human genes 0.000 claims 4
- 108090000394 Erythropoietin Proteins 0.000 claims 4
- 239000012620 biological material Substances 0.000 claims 4
- 229940105423 erythropoietin Drugs 0.000 claims 4
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 4
- 230000000975 bioactive effect Effects 0.000 claims 3
- 239000000499 gel Substances 0.000 claims 3
- 208000017169 kidney disease Diseases 0.000 claims 3
- 239000002609 medium Substances 0.000 claims 3
- 239000012591 Dulbecco’s Phosphate Buffered Saline Substances 0.000 claims 2
- 108010010803 Gelatin Proteins 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 230000003511 endothelial effect Effects 0.000 claims 2
- 239000008273 gelatin Substances 0.000 claims 2
- 229920000159 gelatin Polymers 0.000 claims 2
- 235000019322 gelatine Nutrition 0.000 claims 2
- 235000011852 gelatine desserts Nutrition 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- 239000000017 hydrogel Substances 0.000 claims 2
- 108010082117 matrigel Proteins 0.000 claims 2
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 102000012422 Collagen Type I Human genes 0.000 claims 1
- 108010022452 Collagen Type I Proteins 0.000 claims 1
- 102000004266 Collagen Type IV Human genes 0.000 claims 1
- 108010042086 Collagen Type IV Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 208000007502 anemia Diseases 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 229940096422 collagen type i Drugs 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 210000003606 umbilical vein Anatomy 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361855146P | 2013-05-08 | 2013-05-08 | |
| US61/855,146 | 2013-05-08 | ||
| US201361855152P | 2013-05-09 | 2013-05-09 | |
| US61/855,152 | 2013-05-09 | ||
| PCT/US2014/037275 WO2014182885A2 (en) | 2013-05-08 | 2014-05-08 | Organoids comprising isolated renal cells and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019034989A Division JP7062605B2 (ja) | 2013-05-08 | 2019-02-27 | 単離腎細胞を含有するオルガノイド及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016519930A JP2016519930A (ja) | 2016-07-11 |
| JP2016519930A5 true JP2016519930A5 (https=) | 2017-10-05 |
| JP6490669B2 JP6490669B2 (ja) | 2019-03-27 |
Family
ID=50942860
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016513062A Active JP6490669B2 (ja) | 2013-05-08 | 2014-05-08 | 単離腎細胞を含有するオルガノイド及びその使用 |
| JP2019034989A Active JP7062605B2 (ja) | 2013-05-08 | 2019-02-27 | 単離腎細胞を含有するオルガノイド及びその使用 |
| JP2022030862A Active JP7493252B2 (ja) | 2013-05-08 | 2022-03-01 | 単離腎細胞を含有するオルガノイド及びその使用 |
| JP2024078330A Pending JP2024105523A (ja) | 2013-05-08 | 2024-05-14 | 単離腎細胞を含有するオルガノイド及びその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019034989A Active JP7062605B2 (ja) | 2013-05-08 | 2019-02-27 | 単離腎細胞を含有するオルガノイド及びその使用 |
| JP2022030862A Active JP7493252B2 (ja) | 2013-05-08 | 2022-03-01 | 単離腎細胞を含有するオルガノイド及びその使用 |
| JP2024078330A Pending JP2024105523A (ja) | 2013-05-08 | 2024-05-14 | 単離腎細胞を含有するオルガノイド及びその使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20160101133A1 (https=) |
| EP (2) | EP4299721A3 (https=) |
| JP (4) | JP6490669B2 (https=) |
| KR (8) | KR102710014B1 (https=) |
| CN (1) | CN105378062A (https=) |
| AU (3) | AU2014262670B2 (https=) |
| CA (1) | CA2911291A1 (https=) |
| DK (1) | DK2994528T3 (https=) |
| ES (1) | ES2970230T3 (https=) |
| FI (1) | FI2994528T3 (https=) |
| HR (1) | HRP20240170T1 (https=) |
| HU (1) | HUE065125T2 (https=) |
| PL (1) | PL2994528T3 (https=) |
| PT (1) | PT2994528T (https=) |
| RU (1) | RU2722361C2 (https=) |
| SI (1) | SI2994528T1 (https=) |
| WO (1) | WO2014182885A2 (https=) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| RU2702721C2 (ru) | 2012-10-24 | 2019-10-09 | инРиджен | Популяции клеток почек и их применение |
| MX2015017235A (es) | 2013-06-13 | 2017-05-04 | Orgenesis Ltd | Poblaciones celulares, metodos de transdiferenciacion y metodos de uso de los mismos. |
| CN106661548B (zh) | 2014-05-28 | 2020-12-11 | 儿童医院医疗中心 | 用于经由定向分化将前体细胞转化为胃组织的方法和系统 |
| JP6804438B2 (ja) | 2014-10-17 | 2020-12-23 | チルドレンズ ホスピタル メディカル センター | 多能性幹細胞を使用するヒト小腸のｉｎ ｖｉｖｏモデル、並びにそれを作製、及び使用する方法 |
| US11192292B2 (en) | 2014-12-05 | 2021-12-07 | University Of Florida Research Foundation, Inc. | 3D printing using phase changing matertials as support |
| MA41296A (fr) | 2014-12-30 | 2017-11-07 | Orgenesis Ltd | Procédés de transdifférenciation et procédés d'utilisation de ceux-ci |
| WO2016130953A1 (en) | 2015-02-13 | 2016-08-18 | University Of Florida Research Foundation, Inc. | High speed 3d printing system for wound and tissue replacement |
| JP6998215B2 (ja) | 2015-05-08 | 2022-02-10 | ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド | ３次元細胞培養のための成長培地 |
| US11027483B2 (en) | 2015-09-03 | 2021-06-08 | University Of Florida Research Foundation, Inc. | Valve incorporating temporary phase change material |
| WO2017041041A1 (en) * | 2015-09-03 | 2017-03-09 | The Brigham And Women's Hospital, Inc. | Three-dimensional differentiation of epiblast spheroids to kidney organoids models stage-specific epithelial physiology, morphogenesis, and disease |
| WO2017049066A1 (en) * | 2015-09-18 | 2017-03-23 | University Of Florida Research Foundation, Incorporated | Apparatus for culturing and interacting with a three-dimensional cell culture |
| WO2017096263A1 (en) | 2015-12-04 | 2017-06-08 | University Of Florida Research Foundation, Incorporated | Crosslinkable or functionalizable polymers for 3d printing of soft materials |
| ES2929758T3 (es) | 2016-05-05 | 2022-12-01 | Childrens Hospital Med Ct | Métodos para la fabricación in vitro de tejido del fondo gástrico y composiciones relacionadas con el mismo |
| CN111334463B (zh) * | 2016-05-18 | 2024-02-20 | 学校法人庆应义塾 | 类器官培养用细胞培养基、培养方法及类器官 |
| US11124644B2 (en) | 2016-09-01 | 2021-09-21 | University Of Florida Research Foundation, Inc. | Organic microgel system for 3D printing of silicone structures |
| KR102729404B1 (ko) | 2016-11-04 | 2024-11-14 | 칠드런즈 호스피탈 메디칼 센터 | 간 유사 장기 조성물 및 이를 제조 및 사용하는 방법 |
| JP7068305B2 (ja) | 2016-12-05 | 2022-05-16 | チルドレンズ ホスピタル メディカル センター | 結腸オルガノイドならびにその作製方法および使用方法 |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| US12281334B2 (en) | 2017-04-14 | 2025-04-22 | Children's Hospital Medical Center | Multi donor stem cell compositions and methods of making same |
| EP3635106A4 (en) | 2017-05-08 | 2021-01-06 | Orgenesis Ltd. | POPULATIONS OF TRANSDIFFERENTIATED CELLS AND THEIR METHODS OF USE |
| WO2018220622A2 (en) * | 2017-05-29 | 2018-12-06 | Orgenesis Ltd. | Compositions and methods for providing cell replacement therapy |
| WO2019006127A1 (en) * | 2017-06-28 | 2019-01-03 | Rutgers, The State University Of New Jersey | ORGANOIDS DERIVED FROM A SINGLE RENAL CELL |
| EP3694603B1 (en) | 2017-10-10 | 2026-04-08 | Children's Hospital Medical Center | Esophageal tissue and/or organoid compositions and methods of making same |
| US12379372B2 (en) | 2017-12-21 | 2025-08-05 | Children's Hospital Medical Center | Digitalized human organoids and methods of using same |
| JP2019196342A (ja) * | 2018-05-10 | 2019-11-14 | 学校法人大阪医科薬科大学 | スタチン封入ナノ粒子製剤、それを含有する歯髄由来幹細胞及びそれを含む細胞製剤。 |
| US12320800B2 (en) | 2018-05-16 | 2025-06-03 | University Of Washington | High-throughput automation of organoids for identifying therapeutic strategies |
| KR102094929B1 (ko) * | 2018-07-06 | 2020-03-30 | 한국생명공학연구원 | 신장 스페로이드 및 그의 제조 방법 |
| KR102887406B1 (ko) | 2018-07-26 | 2025-11-19 | 칠드런즈 호스피탈 메디칼 센터 | 간-담도-췌장 조직 및 이를 제조하는 방법 |
| EP3843760A4 (en) * | 2018-08-31 | 2022-11-09 | Timothy Bertram | COMPOSITIONS WITH CELL-DERIVED VESICLES AND THEIR USES |
| AU2019339410A1 (en) | 2018-09-12 | 2021-04-15 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| KR102118807B1 (ko) | 2018-11-26 | 2020-06-03 | 숭실대학교산학협력단 | 3차원 오가노이드 제조용 형상변화형 하이드로젤 몰드 조성물 및 이를 통해 제조된 몰드 |
| KR20200065892A (ko) * | 2018-11-30 | 2020-06-09 | 오가노이드사이언스 주식회사 | 오가노이드의 생체 이식용 조성물 |
| WO2020160371A1 (en) | 2019-02-01 | 2020-08-06 | The University Of Hong Kong | Innervated organoid compositions and methods of making same |
| ES2983230T3 (es) | 2019-04-11 | 2024-10-22 | Univ Of Pittsburgh Of The Commonwealthsystem Of Higher Education | Procedimiento de trasplante de células mínimamente invasivo para inducir el desarrollo de organogénesis in vivo |
| WO2020243613A1 (en) | 2019-05-31 | 2020-12-03 | Children's Hospital Medical Center | Methods of generating and expanding hematopoietic stem cells |
| WO2020243633A1 (en) | 2019-05-31 | 2020-12-03 | Children's Hospital Medical Center | Shaped organoid compositions and methods of making same |
| US20230029554A1 (en) * | 2019-12-12 | 2023-02-02 | The Walter And Eliza Hall Institute Of Medecal Research | Organoid cultures |
| US20230056414A1 (en) * | 2020-08-26 | 2023-02-23 | Gecoll Biomedical Co., Ltd. | 3d cell culture gel kit and 3d cell culture method using the same |
| CN115400147A (zh) * | 2021-05-26 | 2022-11-29 | 深圳市脉唐生物科技有限公司 | 一种用于治疗脓毒症的制剂 |
| KR20230007766A (ko) * | 2021-07-06 | 2023-01-13 | 서강대학교산학협력단 | 혈관화된 신장 오가노이드 형성을 위한 세포기질의 최적화 및 오가노이드 칩 개발 |
| CN114507642B (zh) * | 2022-03-17 | 2024-02-02 | 上海纽仁生物医药科技有限公司 | 一种动物神经系统周细胞单细胞的分离方法 |
| CN114732832A (zh) * | 2022-04-08 | 2022-07-12 | 宁夏医科大学总医院 | 一种防宫腔粘连的可植入物 |
| CN116159182B (zh) * | 2023-02-02 | 2024-09-24 | 中国科学院苏州纳米技术与纳米仿生研究所 | 用于治疗脊髓损伤的神经类器官-水凝胶体系及制备方法 |
| WO2025080972A1 (en) * | 2023-10-11 | 2025-04-17 | Regents Of The University Of Minnesota | Organoid-derived exosome products, methods of making, and methods of use |
| WO2025080843A1 (en) * | 2023-10-12 | 2025-04-17 | Prakash Narayan | Selected renal cell population cells, characteristics and uses thereof |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5965125A (en) * | 1995-10-25 | 1999-10-12 | Transkaryotic Therapies, Inc. | Hybrid matrix implants and explants |
| US6224893B1 (en) | 1997-04-11 | 2001-05-01 | Massachusetts Institute Of Technology | Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering |
| US6886568B2 (en) * | 1998-04-08 | 2005-05-03 | The Johns Hopkins University | Method for fabricating cell-containing implants |
| US7326570B2 (en) * | 2000-06-16 | 2008-02-05 | The Regents Of The University Of California | Induction of tubular morphogenesis using pleiotrophin |
| WO2003080038A1 (en) | 2002-03-22 | 2003-10-02 | Kissei Pharmaceutical Co., Ltd. | Preventive or therapeutic agent for kidney disease |
| US20040101884A1 (en) * | 2002-03-29 | 2004-05-27 | Lu Dyung Aina M | Molecules for disease detection and treatment |
| WO2007087402A2 (en) * | 2006-01-24 | 2007-08-02 | Brown University | Cell aggregation and encapsulation device and method |
| CA2871840A1 (en) | 2006-02-10 | 2007-08-23 | Tengion, Inc. | Scaffolds for organ reconstruction and augmentation |
| AU2007335753B2 (en) * | 2006-12-18 | 2013-12-05 | Ben Gurion University Of The Negev | Scaffolding for tissue regeneration or repair |
| KR102428795B1 (ko) * | 2008-11-12 | 2022-08-04 | 인리젠 | 분리된 신장 세포 및 이의 용도 |
| GB201111244D0 (en) * | 2011-06-30 | 2011-08-17 | Konink Nl Akademie Van Wetenschappen Knaw | Culture media for stem cells |
| TWI762890B (zh) * | 2010-05-12 | 2022-05-01 | 開曼群島商英瑞金公司 | 生物活性腎細胞 |
| WO2011156642A1 (en) * | 2010-06-11 | 2011-12-15 | Tengion, Inc. | Erythropoietin-expressing adipose cell populations |
| CA3065694A1 (en) * | 2010-11-10 | 2012-05-18 | Inregen | Methods of forming injectable formulations for providing regenerative effects to an organ such as a kidney |
| EP2714894B1 (en) * | 2011-05-27 | 2019-10-30 | DePuy Synthes Products, Inc. | Bioartificial proximal tubule systems and methods of use |
| CN102366713A (zh) * | 2011-09-02 | 2012-03-07 | 华中科技大学 | 一种具有生理功能的透析膜材料及其制备方法 |
| US20140302491A1 (en) * | 2011-10-28 | 2014-10-09 | The Board Of Trustees Of The Leland Stanford Junior University | Ex Vivo Culture, Proliferation and Expansion of Primary Tissue Organoids |
-
2014
- 2014-05-08 EP EP23208039.0A patent/EP4299721A3/en active Pending
- 2014-05-08 RU RU2015152257A patent/RU2722361C2/ru active
- 2014-05-08 KR KR1020247016715A patent/KR102710014B1/ko active Active
- 2014-05-08 CA CA2911291A patent/CA2911291A1/en active Pending
- 2014-05-08 PT PT147303234T patent/PT2994528T/pt unknown
- 2014-05-08 KR KR1020157031883A patent/KR102225312B1/ko active Active
- 2014-05-08 KR KR1020227000187A patent/KR102556951B1/ko active Active
- 2014-05-08 US US14/889,820 patent/US20160101133A1/en not_active Abandoned
- 2014-05-08 SI SI201432063T patent/SI2994528T1/sl unknown
- 2014-05-08 ES ES14730323T patent/ES2970230T3/es active Active
- 2014-05-08 KR KR1020237044395A patent/KR102668827B1/ko active Active
- 2014-05-08 DK DK14730323.4T patent/DK2994528T3/da active
- 2014-05-08 KR KR1020247031477A patent/KR102757386B1/ko active Active
- 2014-05-08 PL PL14730323.4T patent/PL2994528T3/pl unknown
- 2014-05-08 HR HRP20240170TT patent/HRP20240170T1/hr unknown
- 2014-05-08 EP EP14730323.4A patent/EP2994528B1/en active Active
- 2014-05-08 KR KR1020217006496A patent/KR102281921B1/ko active Active
- 2014-05-08 AU AU2014262670A patent/AU2014262670B2/en active Active
- 2014-05-08 KR KR1020217023058A patent/KR102349183B1/ko active Active
- 2014-05-08 KR KR1020237023969A patent/KR102618557B1/ko active Active
- 2014-05-08 HU HUE14730323A patent/HUE065125T2/hu unknown
- 2014-05-08 CN CN201480025693.8A patent/CN105378062A/zh active Pending
- 2014-05-08 WO PCT/US2014/037275 patent/WO2014182885A2/en not_active Ceased
- 2014-05-08 FI FIEP14730323.4T patent/FI2994528T3/fi active
- 2014-05-08 JP JP2016513062A patent/JP6490669B2/ja active Active
-
2019
- 2019-02-27 JP JP2019034989A patent/JP7062605B2/ja active Active
-
2020
- 2020-06-11 AU AU2020203860A patent/AU2020203860B2/en active Active
-
2022
- 2022-02-18 US US17/675,223 patent/US20220249569A1/en active Pending
- 2022-03-01 JP JP2022030862A patent/JP7493252B2/ja active Active
-
2023
- 2023-07-19 AU AU2023206151A patent/AU2023206151B2/en active Active
-
2024
- 2024-05-14 JP JP2024078330A patent/JP2024105523A/ja active Pending
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