KR102710014B1 - 단리된 신장 세포를 포함하는 오가노이드 및 이의 용도 - Google Patents

단리된 신장 세포를 포함하는 오가노이드 및 이의 용도 Download PDF

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KR102710014B1
KR102710014B1 KR1020247016715A KR20247016715A KR102710014B1 KR 102710014 B1 KR102710014 B1 KR 102710014B1 KR 1020247016715 A KR1020247016715 A KR 1020247016715A KR 20247016715 A KR20247016715 A KR 20247016715A KR 102710014 B1 KR102710014 B1 KR 102710014B1
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cells
cell
cell population
renal
population
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KR20240090622A (ko
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조이딥 바수
앤드류 브루스
러스티 켈리
켈리 거스리
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인리젠
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C12N5/0686—Kidney cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/25—Urinary tract cells, renal cells
    • C12N2502/256—Renal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/28—Vascular endothelial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Materials For Medical Uses (AREA)
KR1020247016715A 2013-05-08 2014-05-08 단리된 신장 세포를 포함하는 오가노이드 및 이의 용도 Active KR102710014B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020247031477A KR102757386B1 (ko) 2013-05-08 2014-05-08 단리된 신장 세포를 포함하는 오가노이드 및 이의 용도

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201361855146P 2013-05-08 2013-05-08
US61/855,146 2013-05-08
US201361855152P 2013-05-09 2013-05-09
US61/855,152 2013-05-09
PCT/US2014/037275 WO2014182885A2 (en) 2013-05-08 2014-05-08 Organoids comprising isolated renal cells and uses thereof
KR1020237044395A KR102668827B1 (ko) 2013-05-08 2014-05-08 단리된 신장 세포를 포함하는 오가노이드 및 이의 용도

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KR20240090622A KR20240090622A (ko) 2024-06-21
KR102710014B1 true KR102710014B1 (ko) 2024-09-26

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KR1020247016715A Active KR102710014B1 (ko) 2013-05-08 2014-05-08 단리된 신장 세포를 포함하는 오가노이드 및 이의 용도
KR1020157031883A Active KR102225312B1 (ko) 2013-05-08 2014-05-08 단리된 신장 세포를 포함하는 오가노이드 및 이의 용도
KR1020227000187A Active KR102556951B1 (ko) 2013-05-08 2014-05-08 단리된 신장 세포를 포함하는 오가노이드 및 이의 용도
KR1020237044395A Active KR102668827B1 (ko) 2013-05-08 2014-05-08 단리된 신장 세포를 포함하는 오가노이드 및 이의 용도
KR1020247031477A Active KR102757386B1 (ko) 2013-05-08 2014-05-08 단리된 신장 세포를 포함하는 오가노이드 및 이의 용도
KR1020217006496A Active KR102281921B1 (ko) 2013-05-08 2014-05-08 단리된 신장 세포를 포함하는 오가노이드 및 이의 용도
KR1020217023058A Active KR102349183B1 (ko) 2013-05-08 2014-05-08 단리된 신장 세포를 포함하는 오가노이드 및 이의 용도
KR1020237023969A Active KR102618557B1 (ko) 2013-05-08 2014-05-08 단리된 신장 세포를 포함하는 오가노이드 및 이의 용도

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KR1020157031883A Active KR102225312B1 (ko) 2013-05-08 2014-05-08 단리된 신장 세포를 포함하는 오가노이드 및 이의 용도
KR1020227000187A Active KR102556951B1 (ko) 2013-05-08 2014-05-08 단리된 신장 세포를 포함하는 오가노이드 및 이의 용도
KR1020237044395A Active KR102668827B1 (ko) 2013-05-08 2014-05-08 단리된 신장 세포를 포함하는 오가노이드 및 이의 용도
KR1020247031477A Active KR102757386B1 (ko) 2013-05-08 2014-05-08 단리된 신장 세포를 포함하는 오가노이드 및 이의 용도
KR1020217006496A Active KR102281921B1 (ko) 2013-05-08 2014-05-08 단리된 신장 세포를 포함하는 오가노이드 및 이의 용도
KR1020217023058A Active KR102349183B1 (ko) 2013-05-08 2014-05-08 단리된 신장 세포를 포함하는 오가노이드 및 이의 용도
KR1020237023969A Active KR102618557B1 (ko) 2013-05-08 2014-05-08 단리된 신장 세포를 포함하는 오가노이드 및 이의 용도

Country Status (17)

Country Link
US (2) US20160101133A1 (https=)
EP (2) EP4299721A3 (https=)
JP (4) JP6490669B2 (https=)
KR (8) KR102710014B1 (https=)
CN (1) CN105378062A (https=)
AU (3) AU2014262670B2 (https=)
CA (1) CA2911291A1 (https=)
DK (1) DK2994528T3 (https=)
ES (1) ES2970230T3 (https=)
FI (1) FI2994528T3 (https=)
HR (1) HRP20240170T1 (https=)
HU (1) HUE065125T2 (https=)
PL (1) PL2994528T3 (https=)
PT (1) PT2994528T (https=)
RU (1) RU2722361C2 (https=)
SI (1) SI2994528T1 (https=)
WO (1) WO2014182885A2 (https=)

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