PL2994528T3 - Organoidy zawierające wyizolowane komórki nerkowe oraz ich zastosowania - Google Patents

Organoidy zawierające wyizolowane komórki nerkowe oraz ich zastosowania

Info

Publication number
PL2994528T3
PL2994528T3 PL14730323.4T PL14730323T PL2994528T3 PL 2994528 T3 PL2994528 T3 PL 2994528T3 PL 14730323 T PL14730323 T PL 14730323T PL 2994528 T3 PL2994528 T3 PL 2994528T3
Authority
PL
Poland
Prior art keywords
organoids
renal cells
isolated renal
isolated
cells
Prior art date
Application number
PL14730323.4T
Other languages
English (en)
Polish (pl)
Inventor
Joydeep Basu
Andrew Bruce
Rusty KELLEY
Kelly Guthrie
Original Assignee
Prokidney
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prokidney filed Critical Prokidney
Publication of PL2994528T3 publication Critical patent/PL2994528T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0684Cells of the urinary tract or kidneys
    • C12N5/0686Kidney cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0697Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/25Urinary tract cells, renal cells
    • C12N2502/256Renal cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/28Vascular endothelial cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/003D culture
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/50Proteins
    • C12N2533/54Collagen; Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Materials For Medical Uses (AREA)
PL14730323.4T 2013-05-08 2014-05-08 Organoidy zawierające wyizolowane komórki nerkowe oraz ich zastosowania PL2994528T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361855146P 2013-05-08 2013-05-08
US201361855152P 2013-05-09 2013-05-09
PCT/US2014/037275 WO2014182885A2 (en) 2013-05-08 2014-05-08 Organoids comprising isolated renal cells and uses thereof

Publications (1)

Publication Number Publication Date
PL2994528T3 true PL2994528T3 (pl) 2024-04-22

Family

ID=50942860

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14730323.4T PL2994528T3 (pl) 2013-05-08 2014-05-08 Organoidy zawierające wyizolowane komórki nerkowe oraz ich zastosowania

Country Status (17)

Country Link
US (2) US20160101133A1 (https=)
EP (2) EP4299721A3 (https=)
JP (4) JP6490669B2 (https=)
KR (8) KR102710014B1 (https=)
CN (1) CN105378062A (https=)
AU (3) AU2014262670B2 (https=)
CA (1) CA2911291A1 (https=)
DK (1) DK2994528T3 (https=)
ES (1) ES2970230T3 (https=)
FI (1) FI2994528T3 (https=)
HR (1) HRP20240170T1 (https=)
HU (1) HUE065125T2 (https=)
PL (1) PL2994528T3 (https=)
PT (1) PT2994528T (https=)
RU (1) RU2722361C2 (https=)
SI (1) SI2994528T1 (https=)
WO (1) WO2014182885A2 (https=)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
RU2702721C2 (ru) 2012-10-24 2019-10-09 инРиджен Популяции клеток почек и их применение
MX2015017235A (es) 2013-06-13 2017-05-04 Orgenesis Ltd Poblaciones celulares, metodos de transdiferenciacion y metodos de uso de los mismos.
CN106661548B (zh) 2014-05-28 2020-12-11 儿童医院医疗中心 用于经由定向分化将前体细胞转化为胃组织的方法和系统
JP6804438B2 (ja) 2014-10-17 2020-12-23 チルドレンズ ホスピタル メディカル センター 多能性幹細胞を使用するヒト小腸のin vivoモデル、並びにそれを作製、及び使用する方法
US11192292B2 (en) 2014-12-05 2021-12-07 University Of Florida Research Foundation, Inc. 3D printing using phase changing matertials as support
MA41296A (fr) 2014-12-30 2017-11-07 Orgenesis Ltd Procédés de transdifférenciation et procédés d'utilisation de ceux-ci
WO2016130953A1 (en) 2015-02-13 2016-08-18 University Of Florida Research Foundation, Inc. High speed 3d printing system for wound and tissue replacement
JP6998215B2 (ja) 2015-05-08 2022-02-10 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド 3次元細胞培養のための成長培地
US11027483B2 (en) 2015-09-03 2021-06-08 University Of Florida Research Foundation, Inc. Valve incorporating temporary phase change material
WO2017041041A1 (en) * 2015-09-03 2017-03-09 The Brigham And Women's Hospital, Inc. Three-dimensional differentiation of epiblast spheroids to kidney organoids models stage-specific epithelial physiology, morphogenesis, and disease
WO2017049066A1 (en) * 2015-09-18 2017-03-23 University Of Florida Research Foundation, Incorporated Apparatus for culturing and interacting with a three-dimensional cell culture
WO2017096263A1 (en) 2015-12-04 2017-06-08 University Of Florida Research Foundation, Incorporated Crosslinkable or functionalizable polymers for 3d printing of soft materials
ES2929758T3 (es) 2016-05-05 2022-12-01 Childrens Hospital Med Ct Métodos para la fabricación in vitro de tejido del fondo gástrico y composiciones relacionadas con el mismo
CN111334463B (zh) * 2016-05-18 2024-02-20 学校法人庆应义塾 类器官培养用细胞培养基、培养方法及类器官
US11124644B2 (en) 2016-09-01 2021-09-21 University Of Florida Research Foundation, Inc. Organic microgel system for 3D printing of silicone structures
KR102729404B1 (ko) 2016-11-04 2024-11-14 칠드런즈 호스피탈 메디칼 센터 간 유사 장기 조성물 및 이를 제조 및 사용하는 방법
JP7068305B2 (ja) 2016-12-05 2022-05-16 チルドレンズ ホスピタル メディカル センター 結腸オルガノイドならびにその作製方法および使用方法
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
US12281334B2 (en) 2017-04-14 2025-04-22 Children's Hospital Medical Center Multi donor stem cell compositions and methods of making same
EP3635106A4 (en) 2017-05-08 2021-01-06 Orgenesis Ltd. POPULATIONS OF TRANSDIFFERENTIATED CELLS AND THEIR METHODS OF USE
WO2018220622A2 (en) * 2017-05-29 2018-12-06 Orgenesis Ltd. Compositions and methods for providing cell replacement therapy
WO2019006127A1 (en) * 2017-06-28 2019-01-03 Rutgers, The State University Of New Jersey ORGANOIDS DERIVED FROM A SINGLE RENAL CELL
EP3694603B1 (en) 2017-10-10 2026-04-08 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
US12379372B2 (en) 2017-12-21 2025-08-05 Children's Hospital Medical Center Digitalized human organoids and methods of using same
JP2019196342A (ja) * 2018-05-10 2019-11-14 学校法人大阪医科薬科大学 スタチン封入ナノ粒子製剤、それを含有する歯髄由来幹細胞及びそれを含む細胞製剤。
US12320800B2 (en) 2018-05-16 2025-06-03 University Of Washington High-throughput automation of organoids for identifying therapeutic strategies
KR102094929B1 (ko) * 2018-07-06 2020-03-30 한국생명공학연구원 신장 스페로이드 및 그의 제조 방법
KR102887406B1 (ko) 2018-07-26 2025-11-19 칠드런즈 호스피탈 메디칼 센터 간-담도-췌장 조직 및 이를 제조하는 방법
EP3843760A4 (en) * 2018-08-31 2022-11-09 Timothy Bertram COMPOSITIONS WITH CELL-DERIVED VESICLES AND THEIR USES
AU2019339410A1 (en) 2018-09-12 2021-04-15 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
KR102118807B1 (ko) 2018-11-26 2020-06-03 숭실대학교산학협력단 3차원 오가노이드 제조용 형상변화형 하이드로젤 몰드 조성물 및 이를 통해 제조된 몰드
KR20200065892A (ko) * 2018-11-30 2020-06-09 오가노이드사이언스 주식회사 오가노이드의 생체 이식용 조성물
WO2020160371A1 (en) 2019-02-01 2020-08-06 The University Of Hong Kong Innervated organoid compositions and methods of making same
ES2983230T3 (es) 2019-04-11 2024-10-22 Univ Of Pittsburgh Of The Commonwealthsystem Of Higher Education Procedimiento de trasplante de células mínimamente invasivo para inducir el desarrollo de organogénesis in vivo
WO2020243613A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
WO2020243633A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
US20230029554A1 (en) * 2019-12-12 2023-02-02 The Walter And Eliza Hall Institute Of Medecal Research Organoid cultures
US20230056414A1 (en) * 2020-08-26 2023-02-23 Gecoll Biomedical Co., Ltd. 3d cell culture gel kit and 3d cell culture method using the same
CN115400147A (zh) * 2021-05-26 2022-11-29 深圳市脉唐生物科技有限公司 一种用于治疗脓毒症的制剂
KR20230007766A (ko) * 2021-07-06 2023-01-13 서강대학교산학협력단 혈관화된 신장 오가노이드 형성을 위한 세포기질의 최적화 및 오가노이드 칩 개발
CN114507642B (zh) * 2022-03-17 2024-02-02 上海纽仁生物医药科技有限公司 一种动物神经系统周细胞单细胞的分离方法
CN114732832A (zh) * 2022-04-08 2022-07-12 宁夏医科大学总医院 一种防宫腔粘连的可植入物
CN116159182B (zh) * 2023-02-02 2024-09-24 中国科学院苏州纳米技术与纳米仿生研究所 用于治疗脊髓损伤的神经类器官-水凝胶体系及制备方法
WO2025080972A1 (en) * 2023-10-11 2025-04-17 Regents Of The University Of Minnesota Organoid-derived exosome products, methods of making, and methods of use
WO2025080843A1 (en) * 2023-10-12 2025-04-17 Prakash Narayan Selected renal cell population cells, characteristics and uses thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965125A (en) * 1995-10-25 1999-10-12 Transkaryotic Therapies, Inc. Hybrid matrix implants and explants
US6224893B1 (en) 1997-04-11 2001-05-01 Massachusetts Institute Of Technology Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
US6886568B2 (en) * 1998-04-08 2005-05-03 The Johns Hopkins University Method for fabricating cell-containing implants
US7326570B2 (en) * 2000-06-16 2008-02-05 The Regents Of The University Of California Induction of tubular morphogenesis using pleiotrophin
WO2003080038A1 (en) 2002-03-22 2003-10-02 Kissei Pharmaceutical Co., Ltd. Preventive or therapeutic agent for kidney disease
US20040101884A1 (en) * 2002-03-29 2004-05-27 Lu Dyung Aina M Molecules for disease detection and treatment
WO2007087402A2 (en) * 2006-01-24 2007-08-02 Brown University Cell aggregation and encapsulation device and method
CA2871840A1 (en) 2006-02-10 2007-08-23 Tengion, Inc. Scaffolds for organ reconstruction and augmentation
AU2007335753B2 (en) * 2006-12-18 2013-12-05 Ben Gurion University Of The Negev Scaffolding for tissue regeneration or repair
KR102428795B1 (ko) * 2008-11-12 2022-08-04 인리젠 분리된 신장 세포 및 이의 용도
GB201111244D0 (en) * 2011-06-30 2011-08-17 Konink Nl Akademie Van Wetenschappen Knaw Culture media for stem cells
TWI762890B (zh) * 2010-05-12 2022-05-01 開曼群島商英瑞金公司 生物活性腎細胞
WO2011156642A1 (en) * 2010-06-11 2011-12-15 Tengion, Inc. Erythropoietin-expressing adipose cell populations
CA3065694A1 (en) * 2010-11-10 2012-05-18 Inregen Methods of forming injectable formulations for providing regenerative effects to an organ such as a kidney
EP2714894B1 (en) * 2011-05-27 2019-10-30 DePuy Synthes Products, Inc. Bioartificial proximal tubule systems and methods of use
CN102366713A (zh) * 2011-09-02 2012-03-07 华中科技大学 一种具有生理功能的透析膜材料及其制备方法
US20140302491A1 (en) * 2011-10-28 2014-10-09 The Board Of Trustees Of The Leland Stanford Junior University Ex Vivo Culture, Proliferation and Expansion of Primary Tissue Organoids

Also Published As

Publication number Publication date
AU2023206151B2 (en) 2026-01-29
EP4299721A3 (en) 2024-04-24
DK2994528T3 (da) 2024-02-05
BR112015027996A8 (pt) 2017-10-10
KR102618557B1 (ko) 2023-12-28
HUE065125T2 (hu) 2024-05-28
EP2994528A2 (en) 2016-03-16
KR20160005037A (ko) 2016-01-13
KR102710014B1 (ko) 2024-09-26
KR102225312B1 (ko) 2021-03-10
WO2014182885A2 (en) 2014-11-13
KR20240144472A (ko) 2024-10-02
JP2019122381A (ja) 2019-07-25
KR20220005636A (ko) 2022-01-13
AU2020203860B2 (en) 2023-04-27
JP7493252B2 (ja) 2024-05-31
AU2014262670A1 (en) 2015-11-26
BR112015027996A2 (pt) 2017-09-12
WO2014182885A3 (en) 2015-04-16
RU2015152257A (ru) 2017-06-09
AU2023206151A1 (en) 2023-08-10
FI2994528T3 (fi) 2024-02-07
JP2022071069A (ja) 2022-05-13
RU2722361C2 (ru) 2020-05-29
KR102668827B1 (ko) 2024-05-27
CA2911291A1 (en) 2014-11-13
JP6490669B2 (ja) 2019-03-27
NZ752702A (en) 2021-11-26
CN105378062A (zh) 2016-03-02
PT2994528T (pt) 2024-02-13
HRP20240170T1 (hr) 2024-04-12
JP7062605B2 (ja) 2022-05-06
KR20240001290A (ko) 2024-01-03
EP2994528B1 (en) 2023-11-08
KR20230110834A (ko) 2023-07-25
US20220249569A1 (en) 2022-08-11
NZ713875A (en) 2021-11-26
AU2014262670B2 (en) 2020-07-09
KR20210029285A (ko) 2021-03-15
KR20240090622A (ko) 2024-06-21
AU2020203860A1 (en) 2020-07-02
KR102281921B1 (ko) 2021-07-28
JP2024105523A (ja) 2024-08-06
KR102556951B1 (ko) 2023-07-18
ES2970230T3 (es) 2024-05-27
KR20210094671A (ko) 2021-07-29
KR102349183B1 (ko) 2022-01-07
JP2016519930A (ja) 2016-07-11
EP4299721A2 (en) 2024-01-03
KR102757386B1 (ko) 2025-01-21
SI2994528T1 (sl) 2024-04-30
US20160101133A1 (en) 2016-04-14

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