JP6484178B2 - 生物活性剤の細胞標的の捕捉のための組成物および方法 - Google Patents

生物活性剤の細胞標的の捕捉のための組成物および方法 Download PDF

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JP6484178B2
JP6484178B2 JP2015547559A JP2015547559A JP6484178B2 JP 6484178 B2 JP6484178 B2 JP 6484178B2 JP 2015547559 A JP2015547559 A JP 2015547559A JP 2015547559 A JP2015547559 A JP 2015547559A JP 6484178 B2 JP6484178 B2 JP 6484178B2
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capture
protein
bioactive agent
ligand
cellular target
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JP2016502843A5 (enExample
JP2016502843A (ja
Inventor
カロリン ダブリュ ヒトコ
カロリン ダブリュ ヒトコ
ロビン ハースト
ロビン ハースト
トーマス カークランド
トーマス カークランド
ディーター クラウベルト
ディーター クラウベルト
ポンチョ マイセンハイマー
ポンチョ マイセンハイマー
ニディー ナス
ニディー ナス
ラチェル エフ オハナ
ラチェル エフ オハナ
ポール オットー
ポール オットー
マルジェタ ウラー
マルジェタ ウラー
ハリー テツオ ウエダ
ハリー テツオ ウエダ
キース ウッド
キース ウッド
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Promega Corp
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Promega Corp
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2015547559A 2012-12-12 2013-12-12 生物活性剤の細胞標的の捕捉のための組成物および方法 Active JP6484178B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261736426P 2012-12-12 2012-12-12
US61/736,426 2012-12-12
US201361788313P 2013-03-15 2013-03-15
US61/788,313 2013-03-15
PCT/US2013/074756 WO2014093671A1 (en) 2012-12-12 2013-12-12 Compositions and methods for capture of cellular targets of bioactive agents

Related Child Applications (1)

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JP2019025449A Division JP6999589B2 (ja) 2012-12-12 2019-02-15 生物活性剤の細胞標的の捕捉のための組成物および方法

Publications (3)

Publication Number Publication Date
JP2016502843A JP2016502843A (ja) 2016-02-01
JP2016502843A5 JP2016502843A5 (enExample) 2019-02-07
JP6484178B2 true JP6484178B2 (ja) 2019-03-13

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JP2015547559A Active JP6484178B2 (ja) 2012-12-12 2013-12-12 生物活性剤の細胞標的の捕捉のための組成物および方法
JP2019025449A Active JP6999589B2 (ja) 2012-12-12 2019-02-15 生物活性剤の細胞標的の捕捉のための組成物および方法

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Country Link
US (2) US9551705B2 (enExample)
EP (1) EP2931305B1 (enExample)
JP (2) JP6484178B2 (enExample)
KR (2) KR102272233B1 (enExample)
CN (1) CN104853767B (enExample)
AU (2) AU2013359160B2 (enExample)
BR (1) BR112015013715A2 (enExample)
CA (1) CA2894432C (enExample)
IL (1) IL239213B (enExample)
SG (1) SG11201504520XA (enExample)
WO (1) WO2014093671A1 (enExample)

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WO2011072117A1 (en) 2009-12-09 2011-06-16 The Procter & Gamble Company Fabric and home care products
EP2782916B1 (en) 2011-11-21 2018-02-28 Promega Corporation Carboxy x rhodamine analogs
KR102272233B1 (ko) 2012-12-12 2021-07-01 프로메가 코포레이션 생체활성 제제의 세포 표적 포획을 위한 조성물 및 방법
US10168323B2 (en) 2013-03-15 2019-01-01 Promega Corporation Compositions and methods for capture of cellular targets of bioactive agents
US11072811B2 (en) 2013-03-15 2021-07-27 Promega Corporation Substrates for covalent tethering of proteins to functional groups or solid surfaces
JP6876002B2 (ja) * 2015-06-05 2021-05-26 プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ 機能的要素を共有結合により係留させるための細胞透過性、細胞適合性、かつ開裂可能であるリンカー
US10458988B2 (en) * 2017-03-03 2019-10-29 Musc Foundation For Research Development Biotinylated luminescent probe
US12180581B2 (en) 2017-09-18 2024-12-31 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US11709155B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US11709156B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved analytical analysis
US12181452B2 (en) 2017-09-18 2024-12-31 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
JP7584433B2 (ja) 2019-03-20 2024-11-15 プロメガ コーポレイション 光親和性プローブ
US11918936B2 (en) 2020-01-17 2024-03-05 Waters Technologies Corporation Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding
CN116391122A (zh) 2020-09-24 2023-07-04 沃特世科技公司 用于反应性分子分离的色谱硬件改进
JP2022182394A (ja) * 2021-05-28 2022-12-08 独立行政法人国立病院機構 抗原固相化デバイス
WO2023287984A1 (en) * 2021-07-14 2023-01-19 University Of Maryland, Baltimore Suberoylanilide hydroxamic acid (saha) drugs, conjugates, and nanoparticles, and methods of use thereof

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US5914095A (en) 1989-04-07 1999-06-22 Salutar, Inc. Polychelants containg amide bonds
US5344926A (en) 1992-06-22 1994-09-06 Kyowa Hakko Kogyo Co., Ltd. Process for producing staurosporine derivatives
US5756688A (en) 1992-10-14 1998-05-26 Sterling Winthrop Inc. MR imaging compositions and methods
KR950703582A (ko) 1992-10-14 1995-09-20 조이스 이. 마임스 킬레이트화 중합체(chelating polymers)
GB9503969D0 (en) 1995-02-28 1995-04-19 Sams Bernard Incrementing mechanism
EP1254179A4 (en) 2000-01-24 2005-06-01 Univ Columbia IN VIVO SCREEN USING CHEMICAL INDUCTORS
US20020168737A1 (en) * 2001-01-24 2002-11-14 Cornish Virginia W. Binding and catalysis screen for high throughput determination of protein function using chemical inducers of dimerization
CA2802205C (en) * 2002-07-31 2016-01-19 Seattle Genetics, Inc. Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
EP1594962B1 (en) 2003-01-31 2014-08-27 Promega Corporation Covalent tethering of functional groups to proteins
US7429472B2 (en) 2003-01-31 2008-09-30 Promega Corporation Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule
KR100507796B1 (ko) * 2003-04-03 2005-08-17 한미약품 주식회사 생체내 반감기가 증가된 ｐｅｇ-생리활성 폴리펩티드 동종이량체 결합체 및 이의 제조방법
US7425436B2 (en) 2004-07-30 2008-09-16 Promega Corporation Covalent tethering of functional groups to proteins and substrates therefor
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JP5420198B2 (ja) * 2008-06-16 2014-02-19 オリンパス株式会社 タンパク質相互作用解析方法、ポリヌクレオチド、および、組成物
KR100891456B1 (ko) * 2008-11-06 2009-04-01 씨지케이 주식회사 생리활성물질에 대한 세포내 표적물질을 검출하는 방법 및 장치
KR101665352B1 (ko) 2009-05-01 2016-10-12 프로메가 코포레이션 광 출력이 향상된 합성 오플로포러스 루시퍼라제
AU2011323418B2 (en) 2010-11-02 2017-07-27 Promega Corporation Novel coelenterazine substrates and methods of use
KR102272233B1 (ko) 2012-12-12 2021-07-01 프로메가 코포레이션 생체활성 제제의 세포 표적 포획을 위한 조성물 및 방법
US11072811B2 (en) * 2013-03-15 2021-07-27 Promega Corporation Substrates for covalent tethering of proteins to functional groups or solid surfaces
US10168323B2 (en) 2013-03-15 2019-01-01 Promega Corporation Compositions and methods for capture of cellular targets of bioactive agents
JP6876002B2 (ja) * 2015-06-05 2021-05-26 プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ 機能的要素を共有結合により係留させるための細胞透過性、細胞適合性、かつ開裂可能であるリンカー

Also Published As

Publication number Publication date
AU2013359160A2 (en) 2015-11-12
CN104853767B (zh) 2017-04-05
IL239213A0 (en) 2015-07-30
KR102272233B1 (ko) 2021-07-01
AU2013359160A1 (en) 2015-07-09
AU2019201035B2 (en) 2020-09-03
EP2931305A1 (en) 2015-10-21
CN104853767A (zh) 2015-08-19
US20140199712A1 (en) 2014-07-17
CA2894432C (en) 2022-06-07
IL239213B (en) 2020-03-31
KR102227321B1 (ko) 2021-03-12
AU2019201035A1 (en) 2019-03-07
CA2894432A1 (en) 2014-06-19
KR20150093222A (ko) 2015-08-17
SG11201504520XA (en) 2015-07-30
AU2013359160B2 (en) 2018-11-15
AU2019201035B9 (en) 2021-02-11
US9551705B2 (en) 2017-01-24
WO2014093671A1 (en) 2014-06-19
US10976312B2 (en) 2021-04-13
US20170115283A1 (en) 2017-04-27
EP2931305A4 (en) 2016-08-17
EP2931305B1 (en) 2018-11-28
JP6999589B2 (ja) 2022-02-04
KR20200103867A (ko) 2020-09-02
JP2016502843A (ja) 2016-02-01
JP2019092517A (ja) 2019-06-20
BR112015013715A2 (pt) 2017-09-26

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