CA2894432C - Compositions and methods for capture of cellular targets of bioactive agents - Google Patents
Compositions and methods for capture of cellular targets of bioactive agents Download PDFInfo
- Publication number
- CA2894432C CA2894432C CA2894432A CA2894432A CA2894432C CA 2894432 C CA2894432 C CA 2894432C CA 2894432 A CA2894432 A CA 2894432A CA 2894432 A CA2894432 A CA 2894432A CA 2894432 C CA2894432 C CA 2894432C
- Authority
- CA
- Canada
- Prior art keywords
- capture
- protein
- bioactive agent
- ligand
- cellular target
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261736426P | 2012-12-12 | 2012-12-12 | |
| US61/736,426 | 2012-12-12 | ||
| US201361788313P | 2013-03-15 | 2013-03-15 | |
| US61/788,313 | 2013-03-15 | ||
| PCT/US2013/074756 WO2014093671A1 (en) | 2012-12-12 | 2013-12-12 | Compositions and methods for capture of cellular targets of bioactive agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2894432A1 CA2894432A1 (en) | 2014-06-19 |
| CA2894432C true CA2894432C (en) | 2022-06-07 |
Family
ID=50934961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2894432A Active CA2894432C (en) | 2012-12-12 | 2013-12-12 | Compositions and methods for capture of cellular targets of bioactive agents |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9551705B2 (enExample) |
| EP (1) | EP2931305B1 (enExample) |
| JP (2) | JP6484178B2 (enExample) |
| KR (2) | KR102272233B1 (enExample) |
| CN (1) | CN104853767B (enExample) |
| AU (2) | AU2013359160B2 (enExample) |
| BR (1) | BR112015013715A2 (enExample) |
| CA (1) | CA2894432C (enExample) |
| IL (1) | IL239213B (enExample) |
| SG (1) | SG11201504520XA (enExample) |
| WO (1) | WO2014093671A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2012006616A (es) | 2009-12-09 | 2012-06-21 | Procter & Gamble | Productos para el cuidado de las telas y el hogar. |
| JP6522339B2 (ja) * | 2011-11-21 | 2019-05-29 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | カルボキシｘローダミン類似体 |
| JP6484178B2 (ja) * | 2012-12-12 | 2019-03-13 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | 生物活性剤の細胞標的の捕捉のための組成物および方法 |
| US11072812B2 (en) | 2013-03-15 | 2021-07-27 | Promega Corporation | Substrates for covalent tethering of proteins to functional groups or solid surfaces |
| US10168323B2 (en) | 2013-03-15 | 2019-01-01 | Promega Corporation | Compositions and methods for capture of cellular targets of bioactive agents |
| EP3304078B1 (en) * | 2015-06-05 | 2022-08-31 | Promega Corporation | Cell-permeable, cell-compatible, and cleavable linkers for covalent tethering of functional elements |
| US10458988B2 (en) * | 2017-03-03 | 2019-10-29 | Musc Foundation For Research Development | Biotinylated luminescent probe |
| US11709156B2 (en) | 2017-09-18 | 2023-07-25 | Waters Technologies Corporation | Use of vapor deposition coated flow paths for improved analytical analysis |
| US12181452B2 (en) | 2017-09-18 | 2024-12-31 | Waters Technologies Corporation | Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes |
| US11709155B2 (en) | 2017-09-18 | 2023-07-25 | Waters Technologies Corporation | Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes |
| US12180581B2 (en) | 2017-09-18 | 2024-12-31 | Waters Technologies Corporation | Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes |
| WO2020191339A1 (en) | 2019-03-20 | 2020-09-24 | Promega Corporation | Photoaffinity probes |
| US11918936B2 (en) | 2020-01-17 | 2024-03-05 | Waters Technologies Corporation | Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding |
| EP4628889A3 (en) | 2020-09-24 | 2025-12-10 | Waters Technologies Corporation | Chromatographic hardware improvements for the separation of reactive molecules |
| JP2022182394A (ja) * | 2021-05-28 | 2022-12-08 | 独立行政法人国立病院機構 | 抗原固相化デバイス |
| EP4370109A4 (en) * | 2021-07-14 | 2025-10-22 | Univ Maryland | SUBEROYLANILIDE HYDROXAMIC ACID (SAHA) DRUGS, CONJUGATES AND NANOPARTICLES, AND METHODS OF USE THEREOF |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5914095A (en) | 1989-04-07 | 1999-06-22 | Salutar, Inc. | Polychelants containg amide bonds |
| ES2136103T3 (es) | 1992-06-22 | 1999-11-16 | Kyowa Hakko Kogyo Kk | Procedimiento para la preparacion de derivados de estaurosporina. |
| ES2105332T3 (es) | 1992-10-14 | 1997-10-16 | Nycomed Imaging As | Polimeros quelantes. |
| US5756688A (en) | 1992-10-14 | 1998-05-26 | Sterling Winthrop Inc. | MR imaging compositions and methods |
| GB9503969D0 (en) | 1995-02-28 | 1995-04-19 | Sams Bernard | Incrementing mechanism |
| EP1254179A4 (en) | 2000-01-24 | 2005-06-01 | Univ Columbia | IN VIVO SCREEN USING CHEMICAL INDUCTORS |
| US20020168737A1 (en) | 2001-01-24 | 2002-11-14 | Cornish Virginia W. | Binding and catalysis screen for high throughput determination of protein function using chemical inducers of dimerization |
| ES2544527T3 (es) | 2002-07-31 | 2015-09-01 | Seattle Genetics, Inc. | Conjugados de fármacos y su uso para tratar el cáncer, una enfermedad autoinmune o una enfermedad infecciosa |
| US7429472B2 (en) | 2003-01-31 | 2008-09-30 | Promega Corporation | Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule |
| EP1594962B1 (en) | 2003-01-31 | 2014-08-27 | Promega Corporation | Covalent tethering of functional groups to proteins |
| KR100507796B1 (ko) | 2003-04-03 | 2005-08-17 | 한미약품 주식회사 | 생체내 반감기가 증가된 ｐｅｇ-생리활성 폴리펩티드 동종이량체 결합체 및 이의 제조방법 |
| US7425436B2 (en) | 2004-07-30 | 2008-09-16 | Promega Corporation | Covalent tethering of functional groups to proteins and substrates therefor |
| WO2007092579A2 (en) * | 2006-02-08 | 2007-08-16 | Promega Corporation | Compositions and methods for capturing and analyzing cross-linked biomolecules |
| JP5420198B2 (ja) * | 2008-06-16 | 2014-02-19 | オリンパス株式会社 | タンパク質相互作用解析方法、ポリヌクレオチド、および、組成物 |
| KR100891456B1 (ko) | 2008-11-06 | 2009-04-01 | 씨지케이 주식회사 | 생리활성물질에 대한 세포내 표적물질을 검출하는 방법 및 장치 |
| DK2456864T3 (en) * | 2009-05-01 | 2015-12-21 | Promega Corp | SYNTHETIC OPLOPHORUS luciferases WITH IMPROVED LIGHT MISSION |
| US8669103B2 (en) | 2010-11-02 | 2014-03-11 | Promega Corporation | Oplophorus-derived luciferases, novel coelenterazine substrates, and methods of use |
| JP6484178B2 (ja) | 2012-12-12 | 2019-03-13 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | 生物活性剤の細胞標的の捕捉のための組成物および方法 |
| US11072812B2 (en) * | 2013-03-15 | 2021-07-27 | Promega Corporation | Substrates for covalent tethering of proteins to functional groups or solid surfaces |
| US10168323B2 (en) | 2013-03-15 | 2019-01-01 | Promega Corporation | Compositions and methods for capture of cellular targets of bioactive agents |
| EP3304078B1 (en) * | 2015-06-05 | 2022-08-31 | Promega Corporation | Cell-permeable, cell-compatible, and cleavable linkers for covalent tethering of functional elements |
-
2013
- 2013-12-12 JP JP2015547559A patent/JP6484178B2/ja active Active
- 2013-12-12 AU AU2013359160A patent/AU2013359160B2/en active Active
- 2013-12-12 SG SG11201504520XA patent/SG11201504520XA/en unknown
- 2013-12-12 BR BR112015013715A patent/BR112015013715A2/pt not_active Application Discontinuation
- 2013-12-12 KR KR1020207024366A patent/KR102272233B1/ko active Active
- 2013-12-12 EP EP13862430.9A patent/EP2931305B1/en active Active
- 2013-12-12 CN CN201380064237.XA patent/CN104853767B/zh active Active
- 2013-12-12 US US14/104,814 patent/US9551705B2/en active Active
- 2013-12-12 CA CA2894432A patent/CA2894432C/en active Active
- 2013-12-12 KR KR1020157018280A patent/KR102227321B1/ko active Active
- 2013-12-12 WO PCT/US2013/074756 patent/WO2014093671A1/en not_active Ceased
-
2015
- 2015-06-04 IL IL239213A patent/IL239213B/en active IP Right Grant
-
2017
- 2017-01-10 US US15/402,879 patent/US10976312B2/en active Active
-
2019
- 2019-02-14 AU AU2019201035A patent/AU2019201035B9/en active Active
- 2019-02-15 JP JP2019025449A patent/JP6999589B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20140199712A1 (en) | 2014-07-17 |
| CN104853767B (zh) | 2017-04-05 |
| EP2931305B1 (en) | 2018-11-28 |
| JP2016502843A (ja) | 2016-02-01 |
| AU2013359160A1 (en) | 2015-07-09 |
| KR20200103867A (ko) | 2020-09-02 |
| BR112015013715A2 (pt) | 2017-09-26 |
| CA2894432A1 (en) | 2014-06-19 |
| IL239213A0 (en) | 2015-07-30 |
| US9551705B2 (en) | 2017-01-24 |
| KR102227321B1 (ko) | 2021-03-12 |
| CN104853767A (zh) | 2015-08-19 |
| AU2019201035A1 (en) | 2019-03-07 |
| JP6484178B2 (ja) | 2019-03-13 |
| EP2931305A4 (en) | 2016-08-17 |
| AU2019201035B2 (en) | 2020-09-03 |
| WO2014093671A1 (en) | 2014-06-19 |
| US20170115283A1 (en) | 2017-04-27 |
| AU2019201035B9 (en) | 2021-02-11 |
| KR20150093222A (ko) | 2015-08-17 |
| JP6999589B2 (ja) | 2022-02-04 |
| AU2013359160B2 (en) | 2018-11-15 |
| EP2931305A1 (en) | 2015-10-21 |
| IL239213B (en) | 2020-03-31 |
| AU2013359160A2 (en) | 2015-11-12 |
| US10976312B2 (en) | 2021-04-13 |
| KR102272233B1 (ko) | 2021-07-01 |
| JP2019092517A (ja) | 2019-06-20 |
| SG11201504520XA (en) | 2015-07-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20181114 |
|
| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 11TH ANNIV.) - STANDARD Year of fee payment: 11 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20241206 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT Effective date: 20241206 |