CN104853767B - 用于捕获生物活性剂的细胞标靶的组合物和方法 - Google Patents

用于捕获生物活性剂的细胞标靶的组合物和方法 Download PDF

Info

Publication number
CN104853767B
CN104853767B CN201380064237.XA CN201380064237A CN104853767B CN 104853767 B CN104853767 B CN 104853767B CN 201380064237 A CN201380064237 A CN 201380064237A CN 104853767 B CN104853767 B CN 104853767B
Authority
CN
China
Prior art keywords
capture
cell
protein
cellular targets
albumen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201380064237.XA
Other languages
English (en)
Chinese (zh)
Other versions
CN104853767A (zh
Inventor
C·W·希特科
R·赫斯特
T·柯克兰
D·克劳贝特
P·迈森海默
N·纳思
R·F·奥哈纳
P·奥托
M·乌尔赫
H·T·优伊达
K·伍德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pu Luomaige Co
Original Assignee
Pu Luomaige Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pu Luomaige Co filed Critical Pu Luomaige Co
Publication of CN104853767A publication Critical patent/CN104853767A/zh
Application granted granted Critical
Publication of CN104853767B publication Critical patent/CN104853767B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201380064237.XA 2012-12-12 2013-12-12 用于捕获生物活性剂的细胞标靶的组合物和方法 Active CN104853767B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261736426P 2012-12-12 2012-12-12
US61/736,426 2012-12-12
US201361788313P 2013-03-15 2013-03-15
US61/788,313 2013-03-15
PCT/US2013/074756 WO2014093671A1 (en) 2012-12-12 2013-12-12 Compositions and methods for capture of cellular targets of bioactive agents

Publications (2)

Publication Number Publication Date
CN104853767A CN104853767A (zh) 2015-08-19
CN104853767B true CN104853767B (zh) 2017-04-05

Family

ID=50934961

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380064237.XA Active CN104853767B (zh) 2012-12-12 2013-12-12 用于捕获生物活性剂的细胞标靶的组合物和方法

Country Status (11)

Country Link
US (2) US9551705B2 (enExample)
EP (1) EP2931305B1 (enExample)
JP (2) JP6484178B2 (enExample)
KR (2) KR102272233B1 (enExample)
CN (1) CN104853767B (enExample)
AU (2) AU2013359160B2 (enExample)
BR (1) BR112015013715A2 (enExample)
CA (1) CA2894432C (enExample)
IL (1) IL239213B (enExample)
SG (1) SG11201504520XA (enExample)
WO (1) WO2014093671A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4159833A3 (en) 2009-12-09 2023-07-26 The Procter & Gamble Company Fabric and home care products
EP2782916B1 (en) * 2011-11-21 2018-02-28 Promega Corporation Carboxy x rhodamine analogs
BR112015013715A2 (pt) 2012-12-12 2017-09-26 Promega Corp sistema, método para capturar o alvo celular, lisado celular e ligante de captura.
US10168323B2 (en) 2013-03-15 2019-01-01 Promega Corporation Compositions and methods for capture of cellular targets of bioactive agents
US11072811B2 (en) 2013-03-15 2021-07-27 Promega Corporation Substrates for covalent tethering of proteins to functional groups or solid surfaces
JP6876002B2 (ja) * 2015-06-05 2021-05-26 プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ 機能的要素を共有結合により係留させるための細胞透過性、細胞適合性、かつ開裂可能であるリンカー
US10458988B2 (en) * 2017-03-03 2019-10-29 Musc Foundation For Research Development Biotinylated luminescent probe
US11709155B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US12180581B2 (en) 2017-09-18 2024-12-31 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US11709156B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved analytical analysis
US12181452B2 (en) 2017-09-18 2024-12-31 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
WO2020191339A1 (en) 2019-03-20 2020-09-24 Promega Corporation Photoaffinity probes
US11918936B2 (en) 2020-01-17 2024-03-05 Waters Technologies Corporation Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding
US12352734B2 (en) 2020-09-24 2025-07-08 Waters Technologies Corporation Chromatographic hardware improvements for separation of reactive molecules
JP2022182394A (ja) * 2021-05-28 2022-12-08 独立行政法人国立病院機構 抗原固相化デバイス
EP4370109A4 (en) * 2021-07-14 2025-10-22 Univ Maryland SUBEROYLANILIDE HYDROXAMIC ACID (SAHA) DRUGS, CONJUGATES AND NANOPARTICLES, AND METHODS OF USE THEREOF

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5914095A (en) 1989-04-07 1999-06-22 Salutar, Inc. Polychelants containg amide bonds
EP0575955B1 (en) 1992-06-22 1999-09-15 Kyowa Hakko Kogyo Co., Ltd. Process for producing staurosporine derivatives
US5756688A (en) 1992-10-14 1998-05-26 Sterling Winthrop Inc. MR imaging compositions and methods
WO1994009056A1 (en) 1992-10-14 1994-04-28 Sterling Winthrop Inc. Chelating polymers
GB9503969D0 (en) 1995-02-28 1995-04-19 Sams Bernard Incrementing mechanism
US20020004202A1 (en) 2000-01-24 2002-01-10 Cornish Virginia W. In vivo screen using chemical inducers of dimerization
US20020168737A1 (en) * 2001-01-24 2002-11-14 Cornish Virginia W. Binding and catalysis screen for high throughput determination of protein function using chemical inducers of dimerization
DK1545613T3 (da) 2002-07-31 2011-11-14 Seattle Genetics Inc Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom
US7429472B2 (en) 2003-01-31 2008-09-30 Promega Corporation Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule
EP2455457B1 (en) 2003-01-31 2015-03-11 Promega Corporation Covalent tethering of functional groups to proteins
KR100507796B1 (ko) 2003-04-03 2005-08-17 한미약품 주식회사 생체내 반감기가 증가된 ｐｅｇ-생리활성 폴리펩티드 동종이량체 결합체 및 이의 제조방법
US7425436B2 (en) 2004-07-30 2008-09-16 Promega Corporation Covalent tethering of functional groups to proteins and substrates therefor
EP1989548A2 (en) * 2006-02-08 2008-11-12 Promega Corporation Compositions and methods for capturing and analyzing cross-linked biomolecules
JP5420198B2 (ja) * 2008-06-16 2014-02-19 オリンパス株式会社 タンパク質相互作用解析方法、ポリヌクレオチド、および、組成物
KR100891456B1 (ko) 2008-11-06 2009-04-01 씨지케이 주식회사 생리활성물질에 대한 세포내 표적물질을 검출하는 방법 및 장치
WO2010127368A1 (en) 2009-05-01 2010-11-04 Promega Corporation Synthetic oplophorus luciferases with enhanced light output
SG10202103336SA (en) * 2010-11-02 2021-04-29 Promega Corp Novel coelenterazine substrates and methods of use
BR112015013715A2 (pt) 2012-12-12 2017-09-26 Promega Corp sistema, método para capturar o alvo celular, lisado celular e ligante de captura.
US10168323B2 (en) 2013-03-15 2019-01-01 Promega Corporation Compositions and methods for capture of cellular targets of bioactive agents
US11072811B2 (en) * 2013-03-15 2021-07-27 Promega Corporation Substrates for covalent tethering of proteins to functional groups or solid surfaces
JP6876002B2 (ja) * 2015-06-05 2021-05-26 プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ 機能的要素を共有結合により係留させるための細胞透過性、細胞適合性、かつ開裂可能であるリンカー

Also Published As

Publication number Publication date
US10976312B2 (en) 2021-04-13
KR20200103867A (ko) 2020-09-02
KR20150093222A (ko) 2015-08-17
CA2894432A1 (en) 2014-06-19
IL239213A0 (en) 2015-07-30
EP2931305A4 (en) 2016-08-17
AU2019201035B2 (en) 2020-09-03
AU2019201035A1 (en) 2019-03-07
KR102272233B1 (ko) 2021-07-01
US9551705B2 (en) 2017-01-24
JP2019092517A (ja) 2019-06-20
JP6999589B2 (ja) 2022-02-04
AU2019201035B9 (en) 2021-02-11
AU2013359160B2 (en) 2018-11-15
EP2931305A1 (en) 2015-10-21
AU2013359160A1 (en) 2015-07-09
EP2931305B1 (en) 2018-11-28
BR112015013715A2 (pt) 2017-09-26
JP2016502843A (ja) 2016-02-01
CA2894432C (en) 2022-06-07
SG11201504520XA (en) 2015-07-30
CN104853767A (zh) 2015-08-19
KR102227321B1 (ko) 2021-03-12
US20170115283A1 (en) 2017-04-27
US20140199712A1 (en) 2014-07-17
JP6484178B2 (ja) 2019-03-13
IL239213B (en) 2020-03-31
WO2014093671A1 (en) 2014-06-19
AU2013359160A2 (en) 2015-11-12

Similar Documents

Publication Publication Date Title
CN104853767B (zh) 用于捕获生物活性剂的细胞标靶的组合物和方法
US12221648B2 (en) Substrates for covalent tethering of proteins to functional groups or solid surfaces
Wang et al. M13 phage: a versatile building block for a highly specific analysis platform
Williams et al. Creating protein affinity reagents by combining peptide ligands on synthetic DNA scaffolds
US11667648B2 (en) Cell-permeable, cell-compatible, and cleavable linkers for covalent tethering of functional elements
US10168323B2 (en) Compositions and methods for capture of cellular targets of bioactive agents
CN103403011A (zh) 三官能交联试剂
Watanabe et al. Interactions between peptides containing nucleobase amino acids and T7 phages displaying S. cerevisiae proteins
Kodadek Synthetic receptors with antibody-like binding affinities
Liu et al. Protein-Formatted Biomarker Enrichment Tag for the Detection of Carcinoembryonic Antigen
JP2007091736A (ja) 結合性タンパク分子

Legal Events

Date Code Title Description
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant