JP6480910B6 - 無血清懸濁培養物系で組み換えレンチウイルスベクターを産生するための拡張可能な生産プロセス - Google Patents

無血清懸濁培養物系で組み換えレンチウイルスベクターを産生するための拡張可能な生産プロセス Download PDF

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JP6480910B6
JP6480910B6 JP2016503383A JP2016503383A JP6480910B6 JP 6480910 B6 JP6480910 B6 JP 6480910B6 JP 2016503383 A JP2016503383 A JP 2016503383A JP 2016503383 A JP2016503383 A JP 2016503383A JP 6480910 B6 JP6480910 B6 JP 6480910B6
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lentiviral vector
recombinant lentiviral
factor
vector
subjecting
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JP2016512700A (ja
JP2016512700A5 (enExample
JP6480910B2 (ja
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チー，グァン
フレイザー ライト，ジョン
フレイザー ライト，ジョン
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Children's Hospital of Philadelphia
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0091—Purification or manufacturing processes for gene therapy compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15051—Methods of production or purification of viral material

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Manufacturing & Machinery (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2016503383A 2013-03-15 2014-03-17 無血清懸濁培養物系で組み換えレンチウイルスベクターを産生するための拡張可能な生産プロセス Active JP6480910B6 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361787818P 2013-03-15 2013-03-15
US61/787,818 2013-03-15
PCT/US2014/030370 WO2014145578A1 (en) 2013-03-15 2014-03-17 Scalable manufacturing process to produce recombinant lentiviral vectors in serum-free suspension cell culture system

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JP2016512700A JP2016512700A (ja) 2016-05-09
JP2016512700A5 JP2016512700A5 (enExample) 2017-03-16
JP6480910B2 JP6480910B2 (ja) 2019-03-13
JP6480910B6 true JP6480910B6 (ja) 2019-04-03

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US (2) US20140323556A1 (enExample)
EP (1) EP2970920B1 (enExample)
JP (1) JP6480910B6 (enExample)
KR (1) KR102200278B1 (enExample)
CN (2) CN105378074A (enExample)
AU (1) AU2014232879B2 (enExample)
BR (1) BR112015022292A2 (enExample)
CA (1) CA2904366C (enExample)
DK (1) DK2970920T3 (enExample)
ES (1) ES2681434T3 (enExample)
IL (1) IL241058B (enExample)
MX (1) MX364690B (enExample)
PT (1) PT2970920T (enExample)
RU (1) RU2709678C2 (enExample)
WO (1) WO2014145578A1 (enExample)
ZA (1) ZA201506478B (enExample)

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WO2022143623A1 (zh) * 2020-12-29 2022-07-07 江苏金斯瑞蓬勃生物科技有限公司 高分散性的hek293t细胞株及其筛选方法
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Also Published As

Publication number Publication date
RU2709678C2 (ru) 2019-12-19
RU2015144057A (ru) 2017-04-27
AU2014232879B2 (en) 2020-03-05
MX2015012450A (es) 2016-04-25
EP2970920A1 (en) 2016-01-20
CN118256453A (zh) 2024-06-28
WO2014145578A1 (en) 2014-09-18
CA2904366C (en) 2023-07-04
AU2014232879A1 (en) 2015-09-24
US10994028B2 (en) 2021-05-04
BR112015022292A2 (pt) 2017-07-18
IL241058B (en) 2020-05-31
KR102200278B1 (ko) 2021-01-07
CN105378074A (zh) 2016-03-02
MX364690B (es) 2019-05-06
JP2016512700A (ja) 2016-05-09
US20140323556A1 (en) 2014-10-30
IL241058A0 (en) 2015-11-30
DK2970920T3 (en) 2018-08-06
EP2970920A4 (en) 2016-09-14
HK1219978A1 (en) 2017-04-21
US20170368201A1 (en) 2017-12-28
EP2970920B1 (en) 2018-04-25
KR20160024841A (ko) 2016-03-07
CA2904366A1 (en) 2014-09-18
JP6480910B2 (ja) 2019-03-13
PT2970920T (pt) 2018-07-30
ES2681434T3 (es) 2018-09-13
ZA201506478B (en) 2021-09-29

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