JP6476208B2 - エバネセント波生成装置およびその実施方法 - Google Patents
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- 238000000034 method Methods 0.000 title claims description 7
- 239000007788 liquid Substances 0.000 claims description 37
- 239000013307 optical fiber Substances 0.000 claims description 36
- 239000000835 fiber Substances 0.000 claims description 10
- 238000006073 displacement reaction Methods 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000005259 measurement Methods 0.000 claims description 3
- 239000005387 chalcogenide glass Substances 0.000 claims description 2
- 230000001902 propagating effect Effects 0.000 claims description 2
- 238000003466 welding Methods 0.000 claims description 2
- 239000000523 sample Substances 0.000 description 22
- 239000012472 biological sample Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 230000035945 sensitivity Effects 0.000 description 4
- 210000005069 ears Anatomy 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000013060 biological fluid Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000000018 DNA microarray Methods 0.000 description 1
- 238000004566 IR spectroscopy Methods 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
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- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
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- 230000008021 deposition Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
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- 229910052742 iron Inorganic materials 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000005476 soldering Methods 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000010183 spectrum analysis Methods 0.000 description 1
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- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
- G01N21/43—Refractivity; Phase-affecting properties, e.g. optical path length by measuring critical angle
- G01N21/431—Dip refractometers, e.g. using optical fibres
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- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3577—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
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- A—HUMAN NECESSITIES
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
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- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
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- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
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- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/02—Optical fibres with cladding with or without a coating
- G02B6/02395—Glass optical fibre with a protective coating, e.g. two layer polymer coating deposited directly on a silica cladding surface during fibre manufacture
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L2300/0609—Holders integrated in container to position an object
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0654—Lenses; Optical fibres
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/065—Valves, specific forms thereof with moving parts sliding valves
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- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/4738—Diffuse reflection, e.g. also for testing fluids, fibrous materials
- G01N2021/4764—Special kinds of physical applications
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- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/08—Optical fibres; light guides
- G01N2201/0846—Fibre interface with sample, e.g. for spatial resolution
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/08—Optical fibres; light guides
- G01N2201/088—Using a sensor fibre
- G01N2201/0886—Using a sensor fibre and using OTDR
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Description
a)受け手段に液体試料を配置することと、
b)所定時間中に、導波管の外面に液体試料を含浸させることと、
c)接触破壊手段を作動して、液体試料と光ファイバーとの間の接触を断つこととを含む。
Claims (13)
- 少なくとも1つの波長で光の伝播を可能にし、外向きにエバネセント波を生成する導波管(42)を有するサポート(14)を備える装置(10)であって、該導波管(42)と接触すると液体試料を受け、該導波管に該液体試料の一部を含浸させるよう構成された液体試料を受けるための手段と、液体試料と導波管(42)との間の接触を壊すための作動可能手段であって、サポート(14)に対して可動であり、かつ、該受け手段(60)の少なくとも一部を備える部材(58)を備え、該可動部材(58)は、該受け手段が導波管と接触すると液体試料を受けるよう適合された第1位置と、液体試料が該導波管(42)と接触しなくなるよう該受け手段(60)が構成される第2位置との間で可動である、該作動可能手段とを備えることを特徴とする、前記装置。
- 前記可動部材(58)は、その第1及び第2位置の間で前記サポート(14)上を並進可動であるよう取り付けられ、該サポート(14)は、その第1及び第2位置の間で該可動部材(58)の動きを案内する手段(70、72)を備えることを特徴とする、請求項1記載の装置。
- 前記可動部材(58)がその第2位置に移動した時、該可動部材(58)の第2位置から第1位置への移動を係止するための手段(64)を備えることを特徴とする、請求項1又は2記載の装置。
- 前記係止手段(64)は、前記サポート(14)又は前記可動部材(58)の一方に形成され、かつ該可動部材(58)のその第2位置から第1位置への移動において、該サポート(14)又は該可動部材(58)の他方で変位ストップとして用いるよう構成された非復帰ピンまたはフィンガーを備えることを特徴とする、請求項3記載の装置。
- 前記サポート上のカバー(44)を形成し、該サポート(14)と共に、前記導波管部分(42)を収納するエンクロージャ(52)を画定する部分を備えることを特徴とする、請求項1〜4のいずれか1項記載の装置。
- 前記導波管(42)は前記サポートに取り付けられ、前記カバー(44)は、例えば溶接によって該サポートに密封されることを特徴とする、請求項1〜5のいずれか1項記載の装置。
- 前記可動部材(58)は、前記導波管(42)部分の光の伝播の軸(40)に実質的に垂直な方向(34)に沿って並進可動であるよう取り付けられ、該可動部材(58)は、前記エンクロージャ内に収納され、前記サポート(14)と該導波管部分(42)との間を可動である液体試料を受けるための液溜め(60)を備える部分(58a)を備え、該可動部材の第1位置では、該液溜め(60)は導波管部分(42)に対し直角に配置され、第2位置では、該液溜め(60)は該導波管部分(42)から離れて位置することを特徴とする、請求項5又は6記載の装置。
- 前記カバー(44)は、前記可動部材(58)がその第1位置にある時、該可動部材の受領液溜め(60)の反対側の前記エンクロージャ(52)内に開口する開口部(62)を備えることを特徴とする、請求項7記載の装置。
- 前記導波管を加熱する手段を備えることを特徴とする、請求項1〜8のいずれか1項記載の装置。
- 前記導波管は、カルコゲニドグラスファイバー等、少なくとも1つの赤外波長で光を伝播できる材料から作られることを特徴とする、請求項1〜9のいずれか1項記載の装置。
- 請求項1〜10のいずれか1項記載の装置を備えることを特徴とする、分光測定システム(12)。
- a)前記受け手段(60)に液体試料を配置することと、
b)所定時間中に、前記導波管の外面に該液体試料を含浸させることと、
c)前記接触破壊手段を作動して、該液体試料と前記光ファイバーとの間の接触を断つこととを含むことを特徴とする、請求項1〜10のいずれか1項記載の装置を実行する方法。 - 前記ステップc)で得た前記装置を、請求項11記載の分光システム(12)内に配置することを含むことを特徴とする、請求項12記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1450661A FR3016964B1 (fr) | 2014-01-27 | 2014-01-27 | Dispositif a ondes evanescentes, et procede de mise en oeuvre |
FR1450661 | 2014-01-27 | ||
PCT/FR2015/050168 WO2015110767A1 (fr) | 2014-01-27 | 2015-01-23 | Dispositif a ondes évanescentes, et procédé de mise en oeuvre |
Publications (2)
Publication Number | Publication Date |
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JP2017509898A JP2017509898A (ja) | 2017-04-06 |
JP6476208B2 true JP6476208B2 (ja) | 2019-02-27 |
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JP2016565573A Active JP6476208B2 (ja) | 2014-01-27 | 2015-01-23 | エバネセント波生成装置およびその実施方法 |
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Country | Link |
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US (1) | US10054540B2 (ja) |
EP (1) | EP3099221B1 (ja) |
JP (1) | JP6476208B2 (ja) |
KR (1) | KR102356389B1 (ja) |
CN (1) | CN106102562B (ja) |
CA (1) | CA2937725C (ja) |
ES (1) | ES2656770T3 (ja) |
FR (1) | FR3016964B1 (ja) |
WO (1) | WO2015110767A1 (ja) |
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CN105932540B (zh) * | 2016-05-31 | 2018-10-26 | 复旦大学 | 一种产生均匀倏逝波场的系统 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01287447A (ja) * | 1988-05-16 | 1989-11-20 | Fujikura Ltd | 液体検知センサ |
CN2662247Y (zh) * | 2003-04-25 | 2004-12-08 | 谭玉山 | 基于白光反射干涉频谱变化规律的光纤阵列生物芯片 |
JP2007101327A (ja) * | 2005-10-03 | 2007-04-19 | Fdk Corp | 表面プラズモン共鳴センサおよびそれを用いた測定方法と測定装置 |
EP1944599A3 (en) * | 2007-01-11 | 2008-11-12 | Fujifilm Corporation | Fluorescence analysis apparatus |
JP5099765B2 (ja) * | 2007-12-28 | 2012-12-19 | 独立行政法人産業技術総合研究所 | 酵素活性の高感度測定方法 |
WO2009131535A1 (en) * | 2008-04-23 | 2009-10-29 | Oesterlund Lars | Optical sensor unit for evanescence wave spectroscopy |
US9040285B2 (en) * | 2008-12-18 | 2015-05-26 | Koninklijkle Philips N.V. | Sensing device for sensing a fluid |
FR2958403B1 (fr) | 2010-04-01 | 2013-04-05 | Univ Rennes | Capteur a ondes infrarouges evanescentes et son procede de fabrication |
FR2978547B1 (fr) | 2011-07-29 | 2014-11-28 | Diafir | Capteur a fibre optique a ondes evanescentes |
-
2014
- 2014-01-27 FR FR1450661A patent/FR3016964B1/fr active Active
-
2015
- 2015-01-23 KR KR1020167022953A patent/KR102356389B1/ko active IP Right Grant
- 2015-01-23 WO PCT/FR2015/050168 patent/WO2015110767A1/fr active Application Filing
- 2015-01-23 CN CN201580006084.2A patent/CN106102562B/zh active Active
- 2015-01-23 CA CA2937725A patent/CA2937725C/fr active Active
- 2015-01-23 ES ES15705656.5T patent/ES2656770T3/es active Active
- 2015-01-23 EP EP15705656.5A patent/EP3099221B1/fr active Active
- 2015-01-23 US US15/114,631 patent/US10054540B2/en active Active
- 2015-01-23 JP JP2016565573A patent/JP6476208B2/ja active Active
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Publication number | Publication date |
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CA2937725A1 (fr) | 2015-07-30 |
CN106102562B (zh) | 2019-08-02 |
FR3016964A1 (fr) | 2015-07-31 |
JP2017509898A (ja) | 2017-04-06 |
CN106102562A (zh) | 2016-11-09 |
EP3099221A1 (fr) | 2016-12-07 |
WO2015110767A1 (fr) | 2015-07-30 |
KR102356389B1 (ko) | 2022-01-26 |
US20160356705A1 (en) | 2016-12-08 |
US10054540B2 (en) | 2018-08-21 |
FR3016964B1 (fr) | 2017-05-26 |
KR20160146658A (ko) | 2016-12-21 |
ES2656770T3 (es) | 2018-02-28 |
CA2937725C (fr) | 2021-10-19 |
EP3099221B1 (fr) | 2017-11-08 |
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