JP6463734B2 - 抗体を精製するための連続的多工程法 - Google Patents

抗体を精製するための連続的多工程法 Download PDF

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JP6463734B2
JP6463734B2 JP2016512344A JP2016512344A JP6463734B2 JP 6463734 B2 JP6463734 B2 JP 6463734B2 JP 2016512344 A JP2016512344 A JP 2016512344A JP 2016512344 A JP2016512344 A JP 2016512344A JP 6463734 B2 JP6463734 B2 JP 6463734B2
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chromatography
protein
buffer
passing
matrix
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JP2016519137A (ja
JP2016519137A5 (2
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ディディエ・デュテ
セリーヌ・エメット
ロール・ランドリク−ビュルタン
ブノワ・モーテス
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Sanofi SA
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Sanofi SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12—Purification

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Water Supply & Treatment (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
JP2016512344A 2013-05-06 2014-05-06 抗体を精製するための連続的多工程法 Active JP6463734B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13305593 2013-05-06
EP13305593.9 2013-05-06
PCT/EP2014/059246 WO2014180852A1 (en) 2013-05-06 2014-05-06 Continuous multistep process for purifying antibodies

Related Child Applications (1)

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JP2019002288A Division JP2019104735A (ja) 2013-05-06 2019-01-10 抗体を精製するための連続的多工程法

Publications (3)

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JP2016519137A JP2016519137A (ja) 2016-06-30
JP2016519137A5 JP2016519137A5 (2) 2017-06-01
JP6463734B2 true JP6463734B2 (ja) 2019-02-06

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JP2016512344A Active JP6463734B2 (ja) 2013-05-06 2014-05-06 抗体を精製するための連続的多工程法
JP2019002288A Pending JP2019104735A (ja) 2013-05-06 2019-01-10 抗体を精製するための連続的多工程法

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US (1) US10793622B2 (2)
EP (2) EP2994485B1 (2)
JP (2) JP6463734B2 (2)
KR (1) KR102272851B1 (2)
CN (2) CN105358572A (2)
AU (1) AU2014264697B2 (2)
BR (1) BR112015027812B1 (2)
CA (1) CA2911462C (2)
CY (1) CY1125281T1 (2)
DK (2) DK3301115T3 (2)
ES (2) ES2905675T3 (2)
HU (2) HUE057119T2 (2)
IL (1) IL242408B (2)
MX (1) MX368177B (2)
NO (1) NO2994485T3 (2)
RU (1) RU2662668C2 (2)
SG (1) SG11201508968XA (2)
TW (2) TWI675041B (2)
WO (1) WO2014180852A1 (2)

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Also Published As

Publication number Publication date
CA2911462A1 (en) 2014-11-13
SG11201508968XA (en) 2015-11-27
BR112015027812B1 (pt) 2021-03-30
JP2019104735A (ja) 2019-06-27
TWI631132B (zh) 2018-08-01
RU2662668C2 (ru) 2018-07-26
JP2016519137A (ja) 2016-06-30
EP2994485A1 (en) 2016-03-16
HUE057119T2 (hu) 2022-04-28
AU2014264697A1 (en) 2015-11-26
DK3301115T3 (da) 2022-01-31
EP3301115A1 (en) 2018-04-04
TW201908331A (zh) 2019-03-01
EP2994485B1 (en) 2018-01-10
CA2911462C (en) 2021-04-06
DK2994485T3 (en) 2018-04-23
ES2905675T3 (es) 2022-04-11
NO2994485T3 (2) 2018-06-09
AU2014264697B2 (en) 2019-08-22
MX2015015482A (es) 2016-03-21
RU2015151869A (ru) 2017-06-13
US10793622B2 (en) 2020-10-06
TWI675041B (zh) 2019-10-21
EP3301115B1 (en) 2021-11-10
TW201522363A (zh) 2015-06-16
BR112015027812A2 (pt) 2017-07-25
HUE038741T2 (hu) 2018-11-28
ES2665645T3 (es) 2018-04-26
CN105358572A (zh) 2016-02-24
WO2014180852A1 (en) 2014-11-13
MX368177B (es) 2019-09-23
KR20160005047A (ko) 2016-01-13
KR102272851B1 (ko) 2021-07-02
CN116003579A (zh) 2023-04-25
CY1125281T1 (el) 2023-06-09
IL242408B (en) 2020-04-30
US20160083454A1 (en) 2016-03-24

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