JP6404667B2 - 透明化粧料および該透明化粧料の製造方法 - Google Patents
透明化粧料および該透明化粧料の製造方法 Download PDFInfo
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- JP6404667B2 JP6404667B2 JP2014205349A JP2014205349A JP6404667B2 JP 6404667 B2 JP6404667 B2 JP 6404667B2 JP 2014205349 A JP2014205349 A JP 2014205349A JP 2014205349 A JP2014205349 A JP 2014205349A JP 6404667 B2 JP6404667 B2 JP 6404667B2
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
水を含んでいる水相を有する透明化粧料であって、
エチルヘキシルグリセリン、ビサボロールおよびポリ−ε−リシンよりなる群から選ばれる一種以上である難溶性防腐剤を含有し、
多価アルコールと界面活性剤を混合した後に前記難溶性防腐剤を添加した混合物を、前記水相に添加して前記難溶性防腐剤を可溶化したことを特徴とするものである。
エチルヘキシルグリセリン、ビサボロールおよびポリ−ε−リシンよりなる群から選ばれる一種以上である難溶性防腐剤を含有し、
多価アルコールと界面活性剤を混合した後に、前記難溶性防腐剤を添加して混合して混合物を作製し、前記混合物を前記水相に添加して前記難溶性防腐剤を可溶化したことを特徴とするものである。
本発明の透明化粧料は、水相を有する透明化粧料であって、エチルヘキシルグリセリン、ビサボロールおよびポリ−ε−リシンよりなる群から選ばれる一種以上である難溶性防腐剤を含有し、多価アルコールと界面活性剤を混合した後に前記難溶性防腐剤を添加した混合物を、前記水相に添加して前記難溶性防腐剤を可溶化したことを特徴とするものである。また、本発明の透明化粧料の製造方法は、水相を有する透明化粧料の製造方法であって、エチルヘキシルグリセリン、ビサボロールおよびポリ−ε−リシンよりなる群から選ばれる一種以上である難溶性防腐剤を含有し、多価アルコールと界面活性剤を混合した後に、前記難溶性防腐剤を添加して混合して混合物を作製し、前記混合物を前記水相に添加して前記難溶性防腐剤を可溶化したことを特徴とするものである。通常、透明化粧料を作るときには、可溶化成分とともにエタノールに溶解して、各種水溶性成分を溶解した水相に添加する。この場合、前記難溶性防腐剤を可溶化することができるときもあるが、化粧料には香料、精油、油溶性薬剤、紫外線吸収剤等の他の油溶性成分を配合することが通常であるため、可溶化できないことも多い。そこで、本発明では、前記多価アルコールと前記界面活性剤を混合した後に前記難溶性防腐剤を添加した混合物を、水を主成分とする水相に添加することで、安定的に可溶化できるものである。
下記表1記載の処方に従って、予備調合物1〜5を作製した。
下記表2記載の処方に従って、実施例1および比較例1〜3の化粧水を作製した。実施例1では、予備調合物1にポリリジン−10を加えて混合し、さらに混合用の水を加えて粘度を下げて安定化した後に、水相に添加して化粧水を作製した。また、比較例1は、表2中の成分を混合して作製した。さらに、比較例2は、エタノールにエチルヘキシルグリセリンとPEG−60水添ヒマシ油とを混合した後に、水相に添加した。さらにまた、比較例3は、ポリリジン−10とビサボロールとをPEG−60水添ヒマシ油と混合した後に、水相に添加した。なお、ここで、表中*1のポリリジン−10は、一丸ファルコス社製のポリリジン 10(商品名)であり、他の表中のものも同様である。
下記表3記載の処方に従って、実施例2〜5の化粧水を作製した。実施例1と同様に、予備調合物5にポリリジン−10等を加えて混合し、さらに混合用の水を加えて粘度を下げて安定化した後に、水相に添加して化粧水を作製した。また、防腐力を下記防腐力試験に基づいて行った。実施例2の結果を下記表4に示し、実施例3の結果を下記表5に示し、実施例4の結果を下記表6に示し、実施例5の結果を下記表7に示した。
防腐力試験は、4種類または5種類の菌を約104〜107/mLに調整し、それを各実施例の化粧料に接種し、一般細菌は30℃、真菌は25℃で培養した。培養直後、当日、2日目、7日目、14日目および28日目の試験液の10倍希釈液を作製し、寒天培地に接種し培養した。形成されたコロニーをカウントし、生菌数に換算した。表中数値が0.00E+00ならば、培養液の培養後の試験液0.1mL中に菌が検出されないことを示す。
下記表8記載の処方に従って、実施例6〜8のシャンプーを作製した。実施例1と同様に、予備調合物5にポリリジン−10等を加えて混合し、さらに混合用の水を加えて粘度を下げて安定化した後に、水相に添加してシャンプーを作製した。また、防腐力を上記防腐力試験に基づいて行った。実施例6の結果を下記表9に示し、実施例7の結果を下記表10に示し、実施例8の結果を下記表11に示した。なお、表8中*2のアンホレックス COKは、ミヨシ油脂株式会社のカリ石鹸素地(31.9%液)である。
試験はフィンチャンバー(径8mm)を用いて24時間閉塞により実施した。被験者は年齢23から75歳(平均年齢39歳)の健常な男性および女性志願者40名(男性7名、女性33名)を対象とし、実施例の各サンプルをフィンチャンバーのろ紙に浸し、被験者の上腕屈側部に24時間貼付した。フィンチャンバー除去1時間後(1回目)と24時間後(2回目)の状態を、下記表12の判定基準にしたがって判定した。判定後、下記表12に基づいてスコアを合計し、被験者数で除して平均スコアを求めた。
Claims (5)
- 水相を有する透明化粧料の製造方法であって、
エチルヘキシルグリセリン、ビサボロールおよびポリ−ε−リシンよりなる群から選ばれる一種以上である難溶性防腐剤を含有し、
多価アルコールと界面活性剤を混合した後に、前記難溶性防腐剤を添加して混合して混合物を作製し、前記混合物を前記水相に添加して前記難溶性防腐剤を可溶化したことを特徴とする透明化粧料の製造方法。 - 前記難溶性防腐剤がエチルヘキシルグリセリン、ビサボロールおよびポリ−ε−リシンよりなる群から選ばれる二種以上であり、透明化粧料中の前記難溶性防腐剤の配合量が0.1〜1.0質量%である請求項1記載の透明化粧料の製造方法。
- 前記界面活性剤が、HLBが10〜20の水溶性非イオン界面活性剤を二種以上含むものであり、透明化粧料中の前記界面活性剤の配合量が2.0質量%以下である請求項1または2記載の透明化粧料の製造方法。
- 前記多価アルコールが、グリセリン、1,3−ブチレングリコール、プロパンジオール、1,2−ヘキサンジオールおよびジプロピレングリコールよりなる群から選ばれる一種以上である請求項1〜3のうちいずれか一項に記載の透明化粧料の製造方法。
- メチルパラベン、エチルパラベン、安息香酸、安息香酸塩、サリチル酸、サリチル酸塩、フェノキシエタノールおよび水溶性カチオン抗菌剤よりなる群から選ばれる一種以上である水溶性防腐剤を含有しない請求項1〜4のうちいずれか一項に記載の透明化粧料の製造方法。
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