JP6382223B2 - 癌治療における、遺伝的に改変された、増強されたアポトーシス促進性を有する感染性麻疹ウイルス（ｍｖ−ｄｅｌｔａｃウイルス）の使用 - Google Patents

癌治療における、遺伝的に改変された、増強されたアポトーシス促進性を有する感染性麻疹ウイルス（ｍｖ−ｄｅｌｔａｃウイルス）の使用 Download PDF

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JP6382223B2
JP6382223B2 JP2015554120A JP2015554120A JP6382223B2 JP 6382223 B2 JP6382223 B2 JP 6382223B2 JP 2015554120 A JP2015554120 A JP 2015554120A JP 2015554120 A JP2015554120 A JP 2015554120A JP 6382223 B2 JP6382223 B2 JP 6382223B2
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cells
deltac
pdc
cancer
tumor
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JP2016506722A5 (enExample
JP2016506722A (ja
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フレデリック・タンギー
マルク・グレゴワール
ジャン−フランソワ・フォンテノー
ジャン−バティスト・ギエルム
シャンタル・コンブレデ
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Institut National de la Sante et de la Recherche Medicale INSERM
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
    • C12N2760/18421—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
    • C12N2760/18432—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
    • C12N2760/18434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
    • C12N2760/18461—Methods of inactivation or attenuation
    • C12N2760/18462—Methods of inactivation or attenuation by genetic engineering

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  • Health & Medical Sciences (AREA)
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  • Immunology (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2015554120A 2013-01-24 2014-01-20 癌治療における、遺伝的に改変された、増強されたアポトーシス促進性を有する感染性麻疹ウイルス（ｍｖ−ｄｅｌｔａｃウイルス）の使用 Active JP6382223B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13305086.4A EP2759301A1 (en) 2013-01-24 2013-01-24 Use of a genetically modified infectious measles virus with enhanced pro-apoptotic properties (MV-DeltaC virus)
EP13305086.4 2013-01-24
PCT/EP2014/051063 WO2014114605A1 (en) 2013-01-24 2014-01-20 Use of a genetically modified infectious measles virus with enhanced pro-apoptotic properties (mv-deltac virus) in cancer therapy

Publications (3)

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JP2016506722A JP2016506722A (ja) 2016-03-07
JP2016506722A5 JP2016506722A5 (enExample) 2016-10-20
JP6382223B2 true JP6382223B2 (ja) 2018-08-29

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JP2015554120A Active JP6382223B2 (ja) 2013-01-24 2014-01-20 癌治療における、遺伝的に改変された、増強されたアポトーシス促進性を有する感染性麻疹ウイルス（ｍｖ−ｄｅｌｔａｃウイルス）の使用

Country Status (11)

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US (3) US9889193B2 (enExample)
EP (2) EP2759301A1 (enExample)
JP (1) JP6382223B2 (enExample)
CN (1) CN107223055A (enExample)
BR (1) BR112015017692B1 (enExample)
CA (1) CA2898370C (enExample)
DK (1) DK2948157T3 (enExample)
ES (1) ES2700749T3 (enExample)
PL (1) PL2948157T3 (enExample)
RU (1) RU2700083C2 (enExample)
WO (1) WO2014114605A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2759301A1 (en) * 2013-01-24 2014-07-30 Institut Pasteur Use of a genetically modified infectious measles virus with enhanced pro-apoptotic properties (MV-DeltaC virus)
CN107085095A (zh) * 2017-03-02 2017-08-22 江苏华冠生物技术股份有限公司 用作酶联试剂盒包被抗原的麻疹病毒裂解液的制备方法
CA3082961A1 (en) * 2017-12-01 2019-06-06 Gerd Sutter Immuno-modulated replication-efficient vaccinia virus strain

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7118740B1 (en) 2000-09-22 2006-10-10 Mayo Foundation For Medical Education And Research Method for limiting the growth of cancer cells using an attenuated measles virus
PT1375512E (pt) 2002-06-20 2009-09-23 Pasteur Institut Adnc infeccioso de uma estirpe de vacina aprovada do vírus do sarampo. utilização de composições imunogénicas
CA2432738A1 (en) 2003-02-26 2004-08-26 Philippe Despres New dengue and west nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications
CA2508266A1 (fr) 2005-06-20 2006-12-20 Institut Pasteur Polypeptides chimeriques et leurs applications therapeutiques contre une infection a flaviviridae
ES2423518T3 (es) 2006-12-22 2013-09-20 Institut Pasteur Células y metodología para generar virus de ARN de cadena de sentido negativo no segmentada
EP2058003A1 (en) 2007-10-10 2009-05-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Medicaments and methods for treating mesothelioma
EP2420242A1 (en) * 2010-08-20 2012-02-22 Lauer, Ulrich M. Oncolytic measles virus
US9399062B2 (en) * 2011-01-18 2016-07-26 Christopher D. Richardson PVRL4 (Nectin4) is a receptor for measles virus
EP2759301A1 (en) * 2013-01-24 2014-07-30 Institut Pasteur Use of a genetically modified infectious measles virus with enhanced pro-apoptotic properties (MV-DeltaC virus)

Also Published As

Publication number Publication date
PL2948157T3 (pl) 2019-03-29
DK2948157T3 (en) 2019-01-07
US9889193B2 (en) 2018-02-13
BR112015017692A2 (pt) 2019-11-19
US10314905B2 (en) 2019-06-11
ES2700749T3 (es) 2019-02-19
BR112015017692B1 (pt) 2021-11-03
US20180221469A1 (en) 2018-08-09
US10980873B2 (en) 2021-04-20
US20200016260A1 (en) 2020-01-16
CN107223055A (zh) 2017-09-29
CA2898370C (en) 2020-01-14
EP2948157B1 (en) 2018-10-10
CA2898370A1 (en) 2014-07-31
EP2948157A1 (en) 2015-12-02
WO2014114605A1 (en) 2014-07-31
RU2700083C2 (ru) 2019-09-12
EP2759301A1 (en) 2014-07-30
JP2016506722A (ja) 2016-03-07
RU2015128913A (ru) 2017-03-02
US20150359873A1 (en) 2015-12-17

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