DK2948157T3 - APPLICATION OF A RE-MODIFIED INFECTIOUS MEASURED VIRUS WITH IMPROVED PROAPOPTOTIC PROPERTIES (MV DELTAC VIRUS) FOR CANCER THERAPY - Google Patents
APPLICATION OF A RE-MODIFIED INFECTIOUS MEASURED VIRUS WITH IMPROVED PROAPOPTOTIC PROPERTIES (MV DELTAC VIRUS) FOR CANCER THERAPY Download PDFInfo
- Publication number
- DK2948157T3 DK2948157T3 DK14701698.4T DK14701698T DK2948157T3 DK 2948157 T3 DK2948157 T3 DK 2948157T3 DK 14701698 T DK14701698 T DK 14701698T DK 2948157 T3 DK2948157 T3 DK 2948157T3
- Authority
- DK
- Denmark
- Prior art keywords
- cells
- pdcs
- deltac
- cancer
- tumour
- Prior art date
Links
- 208000015181 infectious disease Diseases 0.000 title claims description 151
- 230000002458 infectious effect Effects 0.000 title claims description 39
- 241000700605 Viruses Species 0.000 title description 49
- 230000001976 improved effect Effects 0.000 title description 4
- 230000000861 pro-apoptotic effect Effects 0.000 title description 4
- 238000011275 oncology therapy Methods 0.000 title 1
- 241000712079 Measles morbillivirus Species 0.000 claims description 295
- 210000004027 cell Anatomy 0.000 claims description 268
- 201000011510 cancer Diseases 0.000 claims description 175
- 206010028980 Neoplasm Diseases 0.000 claims description 155
- 201000001441 melanoma Diseases 0.000 claims description 45
- 108090000623 proteins and genes Proteins 0.000 claims description 42
- 230000003612 virological effect Effects 0.000 claims description 37
- 101710117545 C protein Proteins 0.000 claims description 36
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 claims description 32
- 238000000034 method Methods 0.000 claims description 31
- 201000005249 lung adenocarcinoma Diseases 0.000 claims description 30
- 238000011282 treatment Methods 0.000 claims description 29
- 229960005486 vaccine Drugs 0.000 claims description 29
- 238000000338 in vitro Methods 0.000 claims description 22
- 229960003213 live attenuated measles Drugs 0.000 claims description 17
- 208000006178 malignant mesothelioma Diseases 0.000 claims description 16
- 239000013592 cell lysate Substances 0.000 claims description 14
- 230000003213 activating effect Effects 0.000 claims description 11
- 239000004480 active ingredient Substances 0.000 claims description 8
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims description 7
- 239000002246 antineoplastic agent Substances 0.000 claims description 6
- 229940127089 cytotoxic agent Drugs 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 201000005282 malignant pleural mesothelioma Diseases 0.000 claims description 5
- 208000009956 adenocarcinoma Diseases 0.000 claims description 3
- 230000002685 pulmonary effect Effects 0.000 claims description 3
- 210000001787 dendrite Anatomy 0.000 claims 2
- 238000011084 recovery Methods 0.000 claims 1
- 210000005134 plasmacytoid dendritic cell Anatomy 0.000 description 227
- 210000004881 tumor cell Anatomy 0.000 description 144
- 230000014509 gene expression Effects 0.000 description 63
- 102100039064 Interleukin-3 Human genes 0.000 description 53
- 108010002386 Interleukin-3 Proteins 0.000 description 52
- 230000030833 cell death Effects 0.000 description 39
- 230000035800 maturation Effects 0.000 description 38
- 238000004519 manufacturing process Methods 0.000 description 37
- 239000002773 nucleotide Substances 0.000 description 34
- 125000003729 nucleotide group Chemical group 0.000 description 34
- 230000004044 response Effects 0.000 description 31
- 238000000684 flow cytometry Methods 0.000 description 27
- 230000004913 activation Effects 0.000 description 26
- 239000000427 antigen Substances 0.000 description 25
- 108091007433 antigens Proteins 0.000 description 25
- 102000036639 antigens Human genes 0.000 description 25
- 230000000259 anti-tumor effect Effects 0.000 description 24
- 206010073064 Epithelioid mesothelioma Diseases 0.000 description 23
- 208000014699 malignant epithelioid mesothelioma Diseases 0.000 description 23
- 210000001744 T-lymphocyte Anatomy 0.000 description 22
- 238000002474 experimental method Methods 0.000 description 22
- 210000003501 vero cell Anatomy 0.000 description 21
- 230000006698 induction Effects 0.000 description 20
- 230000035772 mutation Effects 0.000 description 19
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 description 18
- 102100039390 Toll-like receptor 7 Human genes 0.000 description 18
- 102000004082 Calreticulin Human genes 0.000 description 16
- 108090000549 Calreticulin Proteins 0.000 description 16
- 230000014102 antigen processing and presentation of exogenous peptide antigen via MHC class I Effects 0.000 description 16
- 239000002299 complementary DNA Substances 0.000 description 16
- 102000004169 proteins and genes Human genes 0.000 description 16
- 101000961414 Homo sapiens Membrane cofactor protein Proteins 0.000 description 15
- 241000699670 Mus sp. Species 0.000 description 14
- 230000002238 attenuated effect Effects 0.000 description 14
- 230000028993 immune response Effects 0.000 description 14
- 238000002360 preparation method Methods 0.000 description 14
- 238000010186 staining Methods 0.000 description 14
- 101100507655 Canis lupus familiaris HSPA1 gene Proteins 0.000 description 13
- 102100039373 Membrane cofactor protein Human genes 0.000 description 13
- 230000006907 apoptotic process Effects 0.000 description 13
- 210000004443 dendritic cell Anatomy 0.000 description 13
- 238000000316 virotherapy Methods 0.000 description 13
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 12
- 230000012010 growth Effects 0.000 description 12
- 230000010076 replication Effects 0.000 description 12
- 102100037907 High mobility group protein B1 Human genes 0.000 description 11
- 101001025337 Homo sapiens High mobility group protein B1 Proteins 0.000 description 11
- 230000004083 survival effect Effects 0.000 description 11
- 229910052720 vanadium Inorganic materials 0.000 description 11
- 102100035793 CD83 antigen Human genes 0.000 description 10
- 238000002965 ELISA Methods 0.000 description 10
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 description 10
- 108010075704 HLA-A Antigens Proteins 0.000 description 10
- 101150084044 P gene Proteins 0.000 description 10
- 102100029215 Signaling lymphocytic activation molecule Human genes 0.000 description 10
- 239000013612 plasmid Substances 0.000 description 10
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 description 9
- 102100040019 Interferon alpha-1/13 Human genes 0.000 description 9
- 108700026244 Open Reading Frames Proteins 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 108090000765 processed proteins & peptides Proteins 0.000 description 9
- 102000005962 receptors Human genes 0.000 description 9
- 108020003175 receptors Proteins 0.000 description 9
- 102000003952 Caspase 3 Human genes 0.000 description 8
- 108090000397 Caspase 3 Proteins 0.000 description 8
- 108020004705 Codon Proteins 0.000 description 8
- 108010088729 HLA-A*02:01 antigen Proteins 0.000 description 8
- 102100037850 Interferon gamma Human genes 0.000 description 8
- 108010074328 Interferon-gamma Proteins 0.000 description 8
- 108010067390 Viral Proteins Proteins 0.000 description 8
- 238000001727 in vivo Methods 0.000 description 8
- 230000001965 increasing effect Effects 0.000 description 8
- 239000012528 membrane Substances 0.000 description 8
- 230000000174 oncolytic effect Effects 0.000 description 8
- 229910052698 phosphorus Inorganic materials 0.000 description 8
- 206010057249 Phagocytosis Diseases 0.000 description 7
- 230000001640 apoptogenic effect Effects 0.000 description 7
- 238000003556 assay Methods 0.000 description 7
- 230000001419 dependent effect Effects 0.000 description 7
- 238000011534 incubation Methods 0.000 description 7
- 108020004707 nucleic acids Proteins 0.000 description 7
- 102000039446 nucleic acids Human genes 0.000 description 7
- 150000007523 nucleic acids Chemical class 0.000 description 7
- 230000008782 phagocytosis Effects 0.000 description 7
- 238000011160 research Methods 0.000 description 7
- 239000013598 vector Substances 0.000 description 7
- 108020004414 DNA Proteins 0.000 description 6
- 102000006354 HLA-DR Antigens Human genes 0.000 description 6
- 108010058597 HLA-DR Antigens Proteins 0.000 description 6
- 102000002689 Toll-like receptor Human genes 0.000 description 6
- 108020000411 Toll-like receptor Proteins 0.000 description 6
- 239000012228 culture supernatant Substances 0.000 description 6
- 230000005847 immunogenicity Effects 0.000 description 6
- 230000005764 inhibitory process Effects 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- 230000001717 pathogenic effect Effects 0.000 description 6
- 230000005945 translocation Effects 0.000 description 6
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 5
- 101150013553 CD40 gene Proteins 0.000 description 5
- 101000633780 Homo sapiens Signaling lymphocytic activation molecule Proteins 0.000 description 5
- 206010027406 Mesothelioma Diseases 0.000 description 5
- 108010074687 Signaling Lymphocytic Activation Molecule Family Member 1 Proteins 0.000 description 5
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 230000001413 cellular effect Effects 0.000 description 5
- 230000034994 death Effects 0.000 description 5
- 231100000517 death Toxicity 0.000 description 5
- 239000012894 fetal calf serum Substances 0.000 description 5
- 230000030279 gene silencing Effects 0.000 description 5
- 239000005090 green fluorescent protein Substances 0.000 description 5
- 230000002163 immunogen Effects 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 230000007246 mechanism Effects 0.000 description 5
- 239000002609 medium Substances 0.000 description 5
- 210000001616 monocyte Anatomy 0.000 description 5
- 230000037361 pathway Effects 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 239000006228 supernatant Substances 0.000 description 5
- 230000001960 triggered effect Effects 0.000 description 5
- 230000010472 type I IFN response Effects 0.000 description 5
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 4
- 102000008235 Toll-Like Receptor 9 Human genes 0.000 description 4
- 108010060818 Toll-Like Receptor 9 Proteins 0.000 description 4
- 239000000556 agonist Substances 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 210000000612 antigen-presenting cell Anatomy 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 210000000170 cell membrane Anatomy 0.000 description 4
- 230000009089 cytolysis Effects 0.000 description 4
- 230000000120 cytopathologic effect Effects 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 230000018109 developmental process Effects 0.000 description 4
- 238000010790 dilution Methods 0.000 description 4
- 239000012895 dilution Substances 0.000 description 4
- 230000002121 endocytic effect Effects 0.000 description 4
- 238000010166 immunofluorescence Methods 0.000 description 4
- 210000003292 kidney cell Anatomy 0.000 description 4
- 239000010410 layer Substances 0.000 description 4
- 201000005202 lung cancer Diseases 0.000 description 4
- 208000020816 lung neoplasm Diseases 0.000 description 4
- 239000006166 lysate Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 239000002953 phosphate buffered saline Substances 0.000 description 4
- 230000002441 reversible effect Effects 0.000 description 4
- 230000028327 secretion Effects 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 4
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 4
- 238000006467 substitution reaction Methods 0.000 description 4
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 4
- 108090000672 Annexin A5 Proteins 0.000 description 3
- 102000004121 Annexin A5 Human genes 0.000 description 3
- 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 description 3
- 206010008342 Cervix carcinoma Diseases 0.000 description 3
- 241000282552 Chlorocebus aethiops Species 0.000 description 3
- 101000852870 Homo sapiens Interferon alpha/beta receptor 1 Proteins 0.000 description 3
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 description 3
- 102100036714 Interferon alpha/beta receptor 1 Human genes 0.000 description 3
- 108010050904 Interferons Proteins 0.000 description 3
- 102000014150 Interferons Human genes 0.000 description 3
- 201000005505 Measles Diseases 0.000 description 3
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 3
- 108091081024 Start codon Proteins 0.000 description 3
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 description 3
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- KQNZDYYTLMIZCT-KQPMLPITSA-N brefeldin A Chemical compound O[C@@H]1\C=C\C(=O)O[C@@H](C)CCC\C=C\[C@@H]2C[C@H](O)C[C@H]21 KQNZDYYTLMIZCT-KQPMLPITSA-N 0.000 description 3
- JUMGSHROWPPKFX-UHFFFAOYSA-N brefeldin-A Natural products CC1CCCC=CC2(C)CC(O)CC2(C)C(O)C=CC(=O)O1 JUMGSHROWPPKFX-UHFFFAOYSA-N 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 238000004113 cell culture Methods 0.000 description 3
- 238000002659 cell therapy Methods 0.000 description 3
- 230000004637 cellular stress Effects 0.000 description 3
- 201000010881 cervical cancer Diseases 0.000 description 3
- 238000002512 chemotherapy Methods 0.000 description 3
- 238000004624 confocal microscopy Methods 0.000 description 3
- 230000000139 costimulatory effect Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 210000002443 helper t lymphocyte Anatomy 0.000 description 3
- 230000008348 humoral response Effects 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 230000001506 immunosuppresive effect Effects 0.000 description 3
- 230000000670 limiting effect Effects 0.000 description 3
- 238000011068 loading method Methods 0.000 description 3
- 210000000822 natural killer cell Anatomy 0.000 description 3
- 244000309459 oncolytic virus Species 0.000 description 3
- XJMOSONTPMZWPB-UHFFFAOYSA-M propidium iodide Chemical compound [I-].[I-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CCC[N+](C)(CC)CC)=C1C1=CC=CC=C1 XJMOSONTPMZWPB-UHFFFAOYSA-M 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 238000001262 western blot Methods 0.000 description 3
- FBFJOZZTIXSPPR-UHFFFAOYSA-N 1-(4-aminobutyl)-2-(ethoxymethyl)imidazo[4,5-c]quinolin-4-amine Chemical compound C1=CC=CC2=C(N(C(COCC)=N3)CCCCN)C3=C(N)N=C21 FBFJOZZTIXSPPR-UHFFFAOYSA-N 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
- 101710163595 Chaperone protein DnaK Proteins 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 2
- 101710178376 Heat shock 70 kDa protein Proteins 0.000 description 2
- 101710152018 Heat shock cognate 70 kDa protein Proteins 0.000 description 2
- 101710154606 Hemagglutinin Proteins 0.000 description 2
- 206010062016 Immunosuppression Diseases 0.000 description 2
- 102100022297 Integrin alpha-X Human genes 0.000 description 2
- 108010047761 Interferon-alpha Proteins 0.000 description 2
- 102000006992 Interferon-alpha Human genes 0.000 description 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 2
- 229930182816 L-glutamine Natural products 0.000 description 2
- 108060001084 Luciferase Proteins 0.000 description 2
- 239000005089 Luciferase Substances 0.000 description 2
- 241001529936 Murinae Species 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 102000011931 Nucleoproteins Human genes 0.000 description 2
- 108010061100 Nucleoproteins Proteins 0.000 description 2
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 2
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 2
- 102100034574 P protein Human genes 0.000 description 2
- 101710181008 P protein Proteins 0.000 description 2
- 241000711504 Paramyxoviridae Species 0.000 description 2
- 101710177166 Phosphoprotein Proteins 0.000 description 2
- 208000002151 Pleural effusion Diseases 0.000 description 2
- 101710176177 Protein A56 Proteins 0.000 description 2
- 239000012980 RPMI-1640 medium Substances 0.000 description 2
- 241000700584 Simplexvirus Species 0.000 description 2
- 208000000453 Skin Neoplasms Diseases 0.000 description 2
- 230000005867 T cell response Effects 0.000 description 2
- 229940124613 TLR 7/8 agonist Drugs 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000005904 anticancer immunity Effects 0.000 description 2
- 230000007910 cell fusion Effects 0.000 description 2
- 238000012054 celltiter-glo Methods 0.000 description 2
- 230000036755 cellular response Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 210000000349 chromosome Anatomy 0.000 description 2
- 238000003501 co-culture Methods 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 210000000805 cytoplasm Anatomy 0.000 description 2
- 230000001472 cytotoxic effect Effects 0.000 description 2
- 238000012137 double-staining Methods 0.000 description 2
- 102100035859 eIF5-mimic protein 2 Human genes 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 210000001163 endosome Anatomy 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000004927 fusion Effects 0.000 description 2
- 239000000185 hemagglutinin Substances 0.000 description 2
- 229960002751 imiquimod Drugs 0.000 description 2
- DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 230000004957 immunoregulator effect Effects 0.000 description 2
- 238000009169 immunotherapy Methods 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 229940079322 interferon Drugs 0.000 description 2
- 230000002601 intratumoral effect Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000002132 lysosomal effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 238000010172 mouse model Methods 0.000 description 2
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 description 2
- OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 description 2
- 210000004940 nucleus Anatomy 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 238000001243 protein synthesis Methods 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 238000001959 radiotherapy Methods 0.000 description 2
- 238000003753 real-time PCR Methods 0.000 description 2
- 230000007115 recruitment Effects 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 229960005322 streptomycin Drugs 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 229940044616 toll-like receptor 7 agonist Drugs 0.000 description 2
- 229940044655 toll-like receptor 9 agonist Drugs 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 238000013518 transcription Methods 0.000 description 2
- 230000035897 transcription Effects 0.000 description 2
- 230000014616 translation Effects 0.000 description 2
- 238000011277 treatment modality Methods 0.000 description 2
- 230000004614 tumor growth Effects 0.000 description 2
- 230000029812 viral genome replication Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
- 239000012109 Alexa Fluor 568 Substances 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 101150111062 C gene Proteins 0.000 description 1
- 108010052382 CD83 antigen Proteins 0.000 description 1
- -1 CD86 Proteins 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- 206010057248 Cell death Diseases 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
- 108020004635 Complementary DNA Proteins 0.000 description 1
- 101000899237 Corylus avellana Endoplasmic reticulum chaperone BiP Proteins 0.000 description 1
- 241000255925 Diptera Species 0.000 description 1
- 206010063045 Effusion Diseases 0.000 description 1
- 208000001382 Experimental Melanoma Diseases 0.000 description 1
- 102000001398 Granzyme Human genes 0.000 description 1
- 108060005986 Granzyme Proteins 0.000 description 1
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 1
- 102000004144 Green Fluorescent Proteins Human genes 0.000 description 1
- 208000031886 HIV Infections Diseases 0.000 description 1
- 208000037357 HIV infectious disease Diseases 0.000 description 1
- 108700010013 HMGB1 Proteins 0.000 description 1
- 102000055207 HMGB1 Human genes 0.000 description 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 description 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101001032342 Homo sapiens Interferon regulatory factor 7 Proteins 0.000 description 1
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 description 1
- 101150017040 I gene Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000712431 Influenza A virus Species 0.000 description 1
- 102100034343 Integrase Human genes 0.000 description 1
- 102100038070 Interferon regulatory factor 7 Human genes 0.000 description 1
- 108090000467 Interferon-beta Proteins 0.000 description 1
- 108091029795 Intergenic region Proteins 0.000 description 1
- 101000839464 Leishmania braziliensis Heat shock 70 kDa protein Proteins 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 101710169105 Minor spike protein Proteins 0.000 description 1
- 101710081079 Minor spike protein H Proteins 0.000 description 1
- 241000713869 Moloney murine leukemia virus Species 0.000 description 1
- 208000034578 Multiple myelomas Diseases 0.000 description 1
- 241000204031 Mycoplasma Species 0.000 description 1
- 206010028470 Mycoplasma infections Diseases 0.000 description 1
- 230000006051 NK cell activation Effects 0.000 description 1
- 230000006042 NK cell recruitment Effects 0.000 description 1
- 108700019961 Neoplasm Genes Proteins 0.000 description 1
- 102000048850 Neoplasm Genes Human genes 0.000 description 1
- 108091092724 Noncoding DNA Proteins 0.000 description 1
- 108700020796 Oncogene Proteins 0.000 description 1
- 239000012124 Opti-MEM Substances 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- 108010089430 Phosphoproteins Proteins 0.000 description 1
- 102000007982 Phosphoproteins Human genes 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 108010039918 Polylysine Proteins 0.000 description 1
- 101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 description 1
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- 108010001267 Protein Subunits Proteins 0.000 description 1
- 102000002067 Protein Subunits Human genes 0.000 description 1
- 101000933967 Pseudomonas phage KPP25 Major capsid protein Proteins 0.000 description 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
- 239000012979 RPMI medium Substances 0.000 description 1
- 108091028664 Ribonucleotide Proteins 0.000 description 1
- 108010044012 STAT1 Transcription Factor Proteins 0.000 description 1
- 102100029904 Signal transducer and activator of transcription 1-alpha/beta Human genes 0.000 description 1
- 241000580858 Simian-Human immunodeficiency virus Species 0.000 description 1
- 101710172711 Structural protein Proteins 0.000 description 1
- 101710137500 T7 RNA polymerase Proteins 0.000 description 1
- 229940124615 TLR 7 agonist Drugs 0.000 description 1
- 102100039360 Toll-like receptor 4 Human genes 0.000 description 1
- 108700019146 Transgenes Proteins 0.000 description 1
- 108020004417 Untranslated RNA Proteins 0.000 description 1
- 102000039634 Untranslated RNA Human genes 0.000 description 1
- 241000700618 Vaccinia virus Species 0.000 description 1
- 206010046865 Vaccinia virus infection Diseases 0.000 description 1
- 108010003533 Viral Envelope Proteins Proteins 0.000 description 1
- 108020000999 Viral RNA Proteins 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000013564 activation of immune response Effects 0.000 description 1
- 230000008649 adaptation response Effects 0.000 description 1
- 230000033289 adaptive immune response Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003322 aneuploid effect Effects 0.000 description 1
- 208000036878 aneuploidy Diseases 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 229940124650 anti-cancer therapies Drugs 0.000 description 1
- 230000003127 anti-melanomic effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 238000011319 anticancer therapy Methods 0.000 description 1
- 238000011394 anticancer treatment Methods 0.000 description 1
- 230000007416 antiviral immune response Effects 0.000 description 1
- 239000010425 asbestos Substances 0.000 description 1
- 230000003305 autocrine Effects 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000005773 cancer-related death Effects 0.000 description 1
- 239000000298 carbocyanine Substances 0.000 description 1
- 230000011748 cell maturation Effects 0.000 description 1
- 239000013553 cell monolayer Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 230000004940 costimulation Effects 0.000 description 1
- 238000009109 curative therapy Methods 0.000 description 1
- 230000002435 cytoreductive effect Effects 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000005860 defense response to virus Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 241001493065 dsRNA viruses Species 0.000 description 1
- 239000012645 endogenous antigen Substances 0.000 description 1
- 210000002472 endoplasmic reticulum Anatomy 0.000 description 1
- 108010048367 enhanced green fluorescent protein Proteins 0.000 description 1
- 244000309457 enveloped RNA virus Species 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
- 108091006047 fluorescent proteins Proteins 0.000 description 1
- 102000034287 fluorescent proteins Human genes 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 238000012268 genome sequencing Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 208000005017 glioblastoma Diseases 0.000 description 1
- 230000011132 hemopoiesis Effects 0.000 description 1
- 102000044446 human CD46 Human genes 0.000 description 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
- 230000028996 humoral immune response Effects 0.000 description 1
- 230000005934 immune activation Effects 0.000 description 1
- 239000012642 immune effector Substances 0.000 description 1
- 230000006058 immune tolerance Effects 0.000 description 1
- 230000001571 immunoadjuvant effect Effects 0.000 description 1
- 230000037449 immunogenic cell death Effects 0.000 description 1
- 230000006054 immunological memory Effects 0.000 description 1
- 229940121354 immunomodulator Drugs 0.000 description 1
- 210000003000 inclusion body Anatomy 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000001524 infective effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229940047124 interferons Drugs 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 229940124590 live attenuated vaccine Drugs 0.000 description 1
- 229940023012 live-attenuated vaccine Drugs 0.000 description 1
- 238000000464 low-speed centrifugation Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000001926 lymphatic effect Effects 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 108700030111 measles virus C Proteins 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000002752 melanocyte Anatomy 0.000 description 1
- 210000004779 membrane envelope Anatomy 0.000 description 1
- 230000015654 memory Effects 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000009126 molecular therapy Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 210000005088 multinucleated cell Anatomy 0.000 description 1
- 208000037971 neglected tropical disease Diseases 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000012379 oncolytic virotherapy Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 229940056360 penicillin g Drugs 0.000 description 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- QWYZFXLSWMXLDM-UHFFFAOYSA-M pinacyanol iodide Chemical compound [I-].C1=CC2=CC=CC=C2N(CC)C1=CC=CC1=CC=C(C=CC=C2)C2=[N+]1CC QWYZFXLSWMXLDM-UHFFFAOYSA-M 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000003757 reverse transcription PCR Methods 0.000 description 1
- 239000002336 ribonucleotide Substances 0.000 description 1
- 125000002652 ribonucleotide group Chemical group 0.000 description 1
- 229910052895 riebeckite Inorganic materials 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000009758 senescence Effects 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000017960 syncytium formation Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 208000007089 vaccinia Diseases 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 210000000605 viral structure Anatomy 0.000 description 1
- 230000007923 virulence factor Effects 0.000 description 1
- 239000000304 virulence factor Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
- A61K39/165—Mumps or measles virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18421—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18432—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18461—Methods of inactivation or attenuation
- C12N2760/18462—Methods of inactivation or attenuation by genetic engineering
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13305086.4A EP2759301A1 (en) | 2013-01-24 | 2013-01-24 | Use of a genetically modified infectious measles virus with enhanced pro-apoptotic properties (MV-DeltaC virus) |
| PCT/EP2014/051063 WO2014114605A1 (en) | 2013-01-24 | 2014-01-20 | Use of a genetically modified infectious measles virus with enhanced pro-apoptotic properties (mv-deltac virus) in cancer therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2948157T3 true DK2948157T3 (en) | 2019-01-07 |
Family
ID=47683672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14701698.4T DK2948157T3 (en) | 2013-01-24 | 2014-01-20 | APPLICATION OF A RE-MODIFIED INFECTIOUS MEASURED VIRUS WITH IMPROVED PROAPOPTOTIC PROPERTIES (MV DELTAC VIRUS) FOR CANCER THERAPY |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US9889193B2 (enExample) |
| EP (2) | EP2759301A1 (enExample) |
| JP (1) | JP6382223B2 (enExample) |
| CN (1) | CN107223055A (enExample) |
| BR (1) | BR112015017692B1 (enExample) |
| CA (1) | CA2898370C (enExample) |
| DK (1) | DK2948157T3 (enExample) |
| ES (1) | ES2700749T3 (enExample) |
| PL (1) | PL2948157T3 (enExample) |
| RU (1) | RU2700083C2 (enExample) |
| WO (1) | WO2014114605A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2759301A1 (en) * | 2013-01-24 | 2014-07-30 | Institut Pasteur | Use of a genetically modified infectious measles virus with enhanced pro-apoptotic properties (MV-DeltaC virus) |
| CN107085095A (zh) * | 2017-03-02 | 2017-08-22 | 江苏华冠生物技术股份有限公司 | 用作酶联试剂盒包被抗原的麻疹病毒裂解液的制备方法 |
| CA3082961A1 (en) * | 2017-12-01 | 2019-06-06 | Gerd Sutter | Immuno-modulated replication-efficient vaccinia virus strain |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7118740B1 (en) | 2000-09-22 | 2006-10-10 | Mayo Foundation For Medical Education And Research | Method for limiting the growth of cancer cells using an attenuated measles virus |
| PT1375512E (pt) | 2002-06-20 | 2009-09-23 | Pasteur Institut | Adnc infeccioso de uma estirpe de vacina aprovada do vírus do sarampo. utilização de composições imunogénicas |
| CA2432738A1 (en) | 2003-02-26 | 2004-08-26 | Philippe Despres | New dengue and west nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications |
| CA2508266A1 (fr) | 2005-06-20 | 2006-12-20 | Institut Pasteur | Polypeptides chimeriques et leurs applications therapeutiques contre une infection a flaviviridae |
| ES2423518T3 (es) | 2006-12-22 | 2013-09-20 | Institut Pasteur | Células y metodología para generar virus de ARN de cadena de sentido negativo no segmentada |
| EP2058003A1 (en) | 2007-10-10 | 2009-05-13 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Medicaments and methods for treating mesothelioma |
| EP2420242A1 (en) * | 2010-08-20 | 2012-02-22 | Lauer, Ulrich M. | Oncolytic measles virus |
| US9399062B2 (en) * | 2011-01-18 | 2016-07-26 | Christopher D. Richardson | PVRL4 (Nectin4) is a receptor for measles virus |
| EP2759301A1 (en) * | 2013-01-24 | 2014-07-30 | Institut Pasteur | Use of a genetically modified infectious measles virus with enhanced pro-apoptotic properties (MV-DeltaC virus) |
-
2013
- 2013-01-24 EP EP13305086.4A patent/EP2759301A1/en not_active Withdrawn
-
2014
- 2014-01-20 ES ES14701698T patent/ES2700749T3/es active Active
- 2014-01-20 BR BR112015017692-5A patent/BR112015017692B1/pt not_active IP Right Cessation
- 2014-01-20 PL PL14701698T patent/PL2948157T3/pl unknown
- 2014-01-20 EP EP14701698.4A patent/EP2948157B1/en active Active
- 2014-01-20 CA CA2898370A patent/CA2898370C/en active Active
- 2014-01-20 US US14/762,559 patent/US9889193B2/en active Active
- 2014-01-20 WO PCT/EP2014/051063 patent/WO2014114605A1/en not_active Ceased
- 2014-01-20 DK DK14701698.4T patent/DK2948157T3/en active
- 2014-01-20 CN CN201480017539.6A patent/CN107223055A/zh active Pending
- 2014-01-20 JP JP2015554120A patent/JP6382223B2/ja active Active
- 2014-01-20 RU RU2015128913A patent/RU2700083C2/ru active
-
2018
- 2018-01-25 US US15/880,133 patent/US10314905B2/en active Active
-
2019
- 2019-06-03 US US16/429,571 patent/US10980873B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| PL2948157T3 (pl) | 2019-03-29 |
| US9889193B2 (en) | 2018-02-13 |
| BR112015017692A2 (pt) | 2019-11-19 |
| US10314905B2 (en) | 2019-06-11 |
| ES2700749T3 (es) | 2019-02-19 |
| BR112015017692B1 (pt) | 2021-11-03 |
| US20180221469A1 (en) | 2018-08-09 |
| US10980873B2 (en) | 2021-04-20 |
| US20200016260A1 (en) | 2020-01-16 |
| CN107223055A (zh) | 2017-09-29 |
| CA2898370C (en) | 2020-01-14 |
| EP2948157B1 (en) | 2018-10-10 |
| CA2898370A1 (en) | 2014-07-31 |
| EP2948157A1 (en) | 2015-12-02 |
| WO2014114605A1 (en) | 2014-07-31 |
| JP6382223B2 (ja) | 2018-08-29 |
| RU2700083C2 (ru) | 2019-09-12 |
| EP2759301A1 (en) | 2014-07-30 |
| JP2016506722A (ja) | 2016-03-07 |
| RU2015128913A (ru) | 2017-03-02 |
| US20150359873A1 (en) | 2015-12-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6740340B2 (ja) | 免疫優性アデノウイルスエピトープに突然変異を有する腫瘍溶解性アデノウイルスおよび癌処置におけるそれらの使用 | |
| JP7391831B2 (ja) | Ｃａｒ ｔ細胞標的を発現する腫瘍溶解性ウイルス、及びその使用 | |
| JP5933565B2 (ja) | 組み換え改変ワクシニアウイルスアンカラインフルエンザワクチン | |
| KR102557390B1 (ko) | 비-구조 단백질의 단편으로 구성된 뎅기 바이러스 키메라 폴리에피토프 및 이의 뎅기 바이러스 감염에 대한 면역원성 조성물에서의 용도 | |
| KR20150038066A (ko) | 종양 세포, 암세포파괴 바이러스 벡터 및 면역 체크포인트 조절인자를 갖는 암 백신 시스템 | |
| KR20160113295A (ko) | B 세포 악성종양 및 다른 암을 치료하는데 유용한 자가 t 세포 및 그의 조성물의 생산 방법 | |
| DK2948157T3 (en) | APPLICATION OF A RE-MODIFIED INFECTIOUS MEASURED VIRUS WITH IMPROVED PROAPOPTOTIC PROPERTIES (MV DELTAC VIRUS) FOR CANCER THERAPY | |
| EA009525B1 (ru) | Рекомбинантный модифицированный вирус осповакцины ankara, содержащий ati-промотор вируса коровьей оспы, и способы применения вируса и промотора | |
| AU782255B2 (en) | Gene transfer vectors for treating autoimmune diseases and diseases with immunopathogenesis by therapy | |
| WO2025044922A2 (en) | Vectored dev avian influenza h9 vaccines | |
| US20180153976A1 (en) | Novel cmv pp65 targeting dna vaccine for cancer immunotherapy | |
| KR102476901B1 (ko) | 대장암 세포 특이적 감염 뉴캐슬병 바이러스를 이용한 대장암 치료용 암용해성 바이러스 및 이를 이용한 대장암 치료용 조성물 | |
| US20030099670A1 (en) | Influenza viruses with enhanced transcriptional and replicational capacities | |
| KR101908905B1 (ko) | 인플루엔자 바이러스의 h9 및 h5의 다중 아형에 대한 교차 면역반응을 형성하는 신규한 재조합 인플루엔자 바이러스 및 이를 포함하는 백신 | |
| US11077185B2 (en) | Vaccine to pathogenic immune activation cells during infections | |
| WO2025044920A2 (en) | New dev vectors for avian vaccines | |
| WO2025044919A2 (en) | New dev vectors | |
| TW202521570A (zh) | 用於禽類疫苗的新型ｄｅｖ載體 | |
| RU2678060C1 (ru) | Рекомбинантный онколитический штамм вируса осповакцины Л-ИВП_oncoM, содержащий гены, кодирующие гранулоцитарно-макрофагальный колониестимулирующий фактор и полиэпитопный иммуноген, состоящий из эпитопов антигенов, гиперэкспрессирующихся опухолевыми клетками при меланоме | |
| CN114836391A (zh) | 一种重组t4噬菌体及其在制备流感病毒鼻内递送vlp疫苗中的应用 | |
| BRPI0806285A2 (pt) | sequência geneticamente modificada do antìgeno asp-2 de trypanosoma cruzi, proteìna recombinante asp-2 e vìrus geneticamente modificados que expressam o antìgeno asp-2 recombinante |