JP6378772B2 - 慢性疼痛のためのマルチプロテアーゼ（ｍｕｌｔｉｐｒｏｔｅａｓｅ）治療薬 - Google Patents

慢性疼痛のためのマルチプロテアーゼ（ｍｕｌｔｉｐｒｏｔｅａｓｅ）治療薬 Download PDF

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Publication number
JP6378772B2
JP6378772B2 JP2016541634A JP2016541634A JP6378772B2 JP 6378772 B2 JP6378772 B2 JP 6378772B2 JP 2016541634 A JP2016541634 A JP 2016541634A JP 2016541634 A JP2016541634 A JP 2016541634A JP 6378772 B2 JP6378772 B2 JP 6378772B2
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bont
endopeptidase
composition
pain
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JP2017501715A (ja
JP2017501715A5 (enExample
Inventor
オリバー ドリー，ジェイムズ
オリバー ドリー，ジェイムズ
ワン，チアフー
メン，チエンホイ
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ダブリン シティー ユニバーシティー
ダブリン シティー ユニバーシティー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2016541634A 2013-12-23 2014-12-19 慢性疼痛のためのマルチプロテアーゼ（ｍｕｌｔｉｐｒｏｔｅａｓｅ）治療薬 Expired - Fee Related JP6378772B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361920053P 2013-12-23 2013-12-23
US61/920,053 2013-12-23
US14/244,162 2014-04-03
US14/244,162 US9216210B2 (en) 2013-12-23 2014-04-03 Multiprotease therapeutics for chronic pain
PCT/EP2014/078732 WO2015097087A1 (en) 2013-12-23 2014-12-19 Multiprotease therapeutics for chronic pain

Publications (3)

Publication Number Publication Date
JP2017501715A JP2017501715A (ja) 2017-01-19
JP2017501715A5 JP2017501715A5 (enExample) 2018-02-01
JP6378772B2 true JP6378772B2 (ja) 2018-08-22

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JP2016541634A Expired - Fee Related JP6378772B2 (ja) 2013-12-23 2014-12-19 慢性疼痛のためのマルチプロテアーゼ（ｍｕｌｔｉｐｒｏｔｅａｓｅ）治療薬

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US (2) US9216210B2 (enExample)
EP (1) EP3087089B1 (enExample)
JP (1) JP6378772B2 (enExample)
KR (1) KR101900582B1 (enExample)
CN (2) CN105916875A (enExample)
AU (1) AU2014372689B2 (enExample)
CA (1) CA2934986C (enExample)
DK (1) DK3087089T3 (enExample)
ES (1) ES2671493T3 (enExample)
PL (1) PL3087089T3 (enExample)
PT (1) PT3087089T (enExample)
WO (1) WO2015097087A1 (enExample)
ZA (1) ZA201605051B (enExample)

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US11707510B2 (en) * 2018-02-16 2023-07-25 Preclinics Discovery Gmbh Nucleic acid-based botulinum neurotoxin for therapeutic use
GB201815844D0 (en) * 2018-09-28 2018-11-14 Ipsen Biopharm Ltd Therapeutic & comestic uses of botulinum neurotoxin serotype e
FR3114739B1 (fr) * 2020-10-06 2022-08-26 Centre Nat Rech Scient Nouveaux peptoides et leur utilisation dans la prevention ou le traitement de la douleur chronique
WO2023105289A1 (en) 2021-12-06 2023-06-15 Dublin City University Methods and compositions for the treatment of pain

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Also Published As

Publication number Publication date
CN105916875A (zh) 2016-08-31
EP3087089A1 (en) 2016-11-02
WO2015097087A1 (en) 2015-07-02
CA2934986C (en) 2019-08-20
ZA201605051B (en) 2017-09-27
US9216210B2 (en) 2015-12-22
PT3087089T (pt) 2018-05-28
AU2014372689B2 (en) 2018-02-01
CA2934986A1 (en) 2015-07-02
KR20160096201A (ko) 2016-08-12
US20160230159A1 (en) 2016-08-11
US10457927B2 (en) 2019-10-29
US20150174217A1 (en) 2015-06-25
KR101900582B1 (ko) 2018-09-19
AU2014372689A1 (en) 2016-07-21
ES2671493T3 (es) 2018-06-06
DK3087089T3 (en) 2018-06-06
PL3087089T3 (pl) 2018-10-31
EP3087089B1 (en) 2018-02-21
JP2017501715A (ja) 2017-01-19
CN112708630A (zh) 2021-04-27

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