JP6371286B2 - 子癇前症の予防及び治療方法 - Google Patents

子癇前症の予防及び治療方法 Download PDF

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JP6371286B2
JP6371286B2 JP2015530529A JP2015530529A JP6371286B2 JP 6371286 B2 JP6371286 B2 JP 6371286B2 JP 2015530529 A JP2015530529 A JP 2015530529A JP 2015530529 A JP2015530529 A JP 2015530529A JP 6371286 B2 JP6371286 B2 JP 6371286B2
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eclampsia
cells
pregnancy
stromal cells
agent according
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JP2015532656A (ja
JP2015532656A5 (enExample
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チャジュ、アイェレット
アブラハム、エイタン
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プルリステム リミテッド
プルリステム リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0653—Adipocytes; Adipose tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2015530529A 2012-09-04 2013-08-31 子癇前症の予防及び治療方法 Expired - Fee Related JP6371286B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261696442P 2012-09-04 2012-09-04
US61/696,442 2012-09-04
US201361815760P 2013-04-25 2013-04-25
US61/815,760 2013-04-25
US201361825037P 2013-05-19 2013-05-19
US61/825,037 2013-05-19
PCT/IB2013/058186 WO2014037863A1 (en) 2012-09-04 2013-08-31 Methods for prevention and treatment of preeclampsia

Publications (3)

Publication Number Publication Date
JP2015532656A JP2015532656A (ja) 2015-11-12
JP2015532656A5 JP2015532656A5 (enExample) 2016-10-13
JP6371286B2 true JP6371286B2 (ja) 2018-08-08

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JP2015530529A Expired - Fee Related JP6371286B2 (ja) 2012-09-04 2013-08-31 子癇前症の予防及び治療方法

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US (1) US9950014B2 (enExample)
EP (1) EP2892542B1 (enExample)
JP (1) JP6371286B2 (enExample)
KR (1) KR101921787B1 (enExample)
CN (1) CN104768559B (enExample)
AU (1) AU2013311289B2 (enExample)
CA (1) CA2882687A1 (enExample)
HK (1) HK1212239A1 (enExample)
IL (1) IL237528B (enExample)
SG (2) SG10201700435XA (enExample)
WO (1) WO2014037863A1 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101738323B1 (ko) 2007-09-19 2017-05-19 플루리스템 리미티드 지방 또는 태반 조직 유래의 부착 세포 및 이의 치료 용도
EP2303293A1 (en) 2008-05-27 2011-04-06 Pluristem Ltd. Methods of treating inflammatory colon diseases
SG190659A1 (en) 2008-09-02 2013-06-28 Pluristem Ltd Adherent cells from placenta tissue and use thereof in therapy
ES2553712T3 (es) 2009-11-30 2015-12-11 Pluristem Ltd. Células adherentes de la placenta y uso de las mismas en el tratamiento de enfermedad
WO2011147967A1 (en) 2010-05-27 2011-12-01 Georg Duda Skeletal muscle regeneration using mesenchymal stem cells
US8895291B2 (en) 2010-10-08 2014-11-25 Terumo Bct, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
WO2012127320A1 (en) 2011-03-22 2012-09-27 Pluristem Ltd. Methods for treating radiation or chemical injury
US9657266B2 (en) 2011-04-15 2017-05-23 Pluristem Ltd. Methods and systems for harvesting cells
WO2014098960A2 (en) * 2012-05-16 2014-06-26 The Johns Hopkins University Stem cells as an individualized maternal therapy for prevention of prematurity
SI2739720T1 (sl) 2012-09-06 2015-04-30 Pluristem Ltd. Naprave in postopki za gojenje celic
JP6612227B2 (ja) 2013-11-16 2019-11-27 テルモ ビーシーティー、インコーポレーテッド バイオリアクターにおける細胞増殖
WO2015132729A1 (en) 2014-03-04 2015-09-11 Pluristem Ltd. Systems and methods for growing and harvesting cells
US11008547B2 (en) 2014-03-25 2021-05-18 Terumo Bct, Inc. Passive replacement of media
WO2016049421A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled feed
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
WO2017205667A1 (en) 2016-05-25 2017-11-30 Terumo Bct, Inc. Cell expansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US20190224244A1 (en) * 2016-07-11 2019-07-25 Bonus Therapeutics Ltd. Cell compositions for tissue regeneration
EA201991371A1 (ru) * 2016-12-05 2019-12-30 Селулэрити, Инк. Лечение лимфедемы и связанных состояний с использованием плацентарных адгезивных клеток
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
WO2018184028A2 (en) 2017-03-31 2018-10-04 Terumo Bct, Inc. Cell expansion
KR102435297B1 (ko) * 2020-07-21 2022-08-22 부산대학교 산학협력단 임신중독증 조기진단용 바이오마커 조성물 및 이를 이용한 진단방법
GB2619893A (en) 2021-03-23 2023-12-20 Terumo Bct Inc Cell capture and expansion
CN114195875B (zh) * 2021-06-17 2022-07-12 南京市妇幼保健院 一种胎盘来源内源性多肽及其应用
US12209689B2 (en) 2022-02-28 2025-01-28 Terumo Kabushiki Kaisha Multiple-tube pinch valve assembly
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device
CN116747212B (zh) * 2023-07-04 2025-06-17 山东省妇幼保健院 6-姜酚在制备治疗先兆子痫药物中的应用

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5902741A (en) 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
US5629186A (en) 1994-04-28 1997-05-13 Lockheed Martin Corporation Porous matrix and method of its production
US6132463A (en) 1995-05-19 2000-10-17 Etex Corporation Cell seeding of ceramic compositions
EP1064353B1 (en) 1998-03-18 2002-11-06 Massachusetts Institute Of Technology Vascularized perfused microtissue/micro-organ arrays
US6153432A (en) 1999-01-29 2000-11-28 Zen-Bio, Inc Methods for the differentiation of human preadipocytes into adipocytes
WO2000046349A1 (en) 1999-02-04 2000-08-10 Technion Research & Development Foundation Ltd. Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells
PT1261694E (pt) 2000-02-26 2008-04-03 Artecel Inc Células estaminais pluripotentes produzidas a partir de células estromais derivadas de tecido adiposo e suas utilizações.
EP2198876B1 (en) * 2003-10-24 2012-12-05 Nora Therapeutics, Inc. A method for reducing the likelihood of implantation failure in a subject
RU2271817C1 (ru) * 2004-08-18 2006-03-20 ЗАО "РеМеТэкс" Биотрансплантат и способ лечения легочной гипертензии
ATE519109T1 (de) * 2004-12-21 2011-08-15 Univ Yale Präeklampsie-diagnose
PL2548951T3 (pl) 2006-03-23 2016-08-31 Pluristem Ltd Sposoby ekspansji komórek oraz zastosowania w terapii komórek i pożywek kondycjonowanych wytworzonych w ten sposób
US20110293583A1 (en) 2006-03-23 2011-12-01 Pluristem Ltd. Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy
US20110171182A1 (en) 2006-03-23 2011-07-14 Pluristem Ltd. Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy
CN101558151B (zh) * 2006-03-23 2015-10-21 普拉里斯坦有限公司 细胞扩增方法和藉此产生的细胞和条件培养基用于治疗的用途
KR101738323B1 (ko) 2007-09-19 2017-05-19 플루리스템 리미티드 지방 또는 태반 조직 유래의 부착 세포 및 이의 치료 용도
EP2303293A1 (en) 2008-05-27 2011-04-06 Pluristem Ltd. Methods of treating inflammatory colon diseases
WO2010017378A2 (en) * 2008-08-08 2010-02-11 Indiana University Research And Technology Corporation Methods and compositions for vasculogenic potential determination
WO2010026573A1 (en) 2008-09-02 2010-03-11 Pluristem Ltd. Methods of selection of cells for transplantation
SG190659A1 (en) 2008-09-02 2013-06-28 Pluristem Ltd Adherent cells from placenta tissue and use thereof in therapy
WO2010026574A2 (en) 2008-09-02 2010-03-11 Pluristem Ltd. Adherent cells from placenta tissue and use thereof in therapy
CN105021821B (zh) * 2008-10-31 2018-05-11 耶鲁大学 先兆子痫检测和治疗的方法和组合物
CN102282252B (zh) * 2008-11-19 2017-07-04 人类起源公司 羊膜来源的贴壁细胞
CA2776882A1 (en) * 2009-10-06 2011-04-14 The Cohen Mcniece Foundation Preparation and use of stromal cells for treatment of cardiac diseases
ES2553712T3 (es) 2009-11-30 2015-12-11 Pluristem Ltd. Células adherentes de la placenta y uso de las mismas en el tratamiento de enfermedad
US20130039892A1 (en) 2010-04-23 2013-02-14 Pluristem Ltd. Adherent stromal cells derived from plancentas of multiple donors and uses thereof
WO2011147967A1 (en) 2010-05-27 2011-12-01 Georg Duda Skeletal muscle regeneration using mesenchymal stem cells
KR20190114045A (ko) * 2010-12-17 2019-10-08 안트로제네시스 코포레이션 양막 유래 부착성 세포를 사용한, 면역-관련 질환 및 장애의 치료
US20140017209A1 (en) 2011-03-22 2014-01-16 Pluristem Ltd. Methods for treating radiation or chemical injury
US9657266B2 (en) 2011-04-15 2017-05-23 Pluristem Ltd. Methods and systems for harvesting cells
ITTO20111183A1 (it) * 2011-12-21 2013-06-22 Univ Degli Studi Torino Mezzo condizionato ottenuto da cellule staminali mesenchimali placentari e suo uso nel trattamento terapeutico della preeclampsia
SI2739720T1 (sl) 2012-09-06 2015-04-30 Pluristem Ltd. Naprave in postopki za gojenje celic
EP2914104B1 (en) 2012-10-31 2020-04-29 Pluristem Ltd. Method and device for thawing biological material
US10351910B2 (en) 2013-02-20 2019-07-16 Pluristem Ltd Gene and protein expression properties of adherent stromal cells cultured in 3D

Also Published As

Publication number Publication date
US20150216907A1 (en) 2015-08-06
KR20150047503A (ko) 2015-05-04
EP2892542B1 (en) 2018-04-04
HK1211242A1 (en) 2016-05-20
IL237528B (en) 2019-11-28
WO2014037863A1 (en) 2014-03-13
US9950014B2 (en) 2018-04-24
IL237528A0 (en) 2015-04-30
SG11201501065QA (en) 2015-03-30
AU2013311289B2 (en) 2017-11-16
CN104768559B (zh) 2019-01-22
AU2013311289A1 (en) 2015-03-05
SG10201700435XA (en) 2017-02-27
JP2015532656A (ja) 2015-11-12
EP2892542A1 (en) 2015-07-15
HK1212239A1 (en) 2016-06-10
KR101921787B1 (ko) 2018-11-23
CA2882687A1 (en) 2014-03-13
CN104768559A (zh) 2015-07-08

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