CN104768559B - 用于预防和治疗先兆子痫的方法 - Google Patents

用于预防和治疗先兆子痫的方法 Download PDF

Info

Publication number
CN104768559B
CN104768559B CN201380046256.XA CN201380046256A CN104768559B CN 104768559 B CN104768559 B CN 104768559B CN 201380046256 A CN201380046256 A CN 201380046256A CN 104768559 B CN104768559 B CN 104768559B
Authority
CN
China
Prior art keywords
cell
purposes
eclampsia
gestation
adherent substrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201380046256.XA
Other languages
English (en)
Chinese (zh)
Other versions
CN104768559A (zh
Inventor
A·查祖特
E·阿伯拉罕
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pra Biotechnology Co ltd
Original Assignee
Pluristem Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pluristem Ltd filed Critical Pluristem Ltd
Publication of CN104768559A publication Critical patent/CN104768559A/zh
Application granted granted Critical
Publication of CN104768559B publication Critical patent/CN104768559B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48Reproductive organs
    • A61K35/50Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0603Embryonic cells ; Embryoid bodies
    • C12N5/0605Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0653Adipocytes; Adipose tissue
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/003D culture

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201380046256.XA 2012-09-04 2013-08-31 用于预防和治疗先兆子痫的方法 Expired - Fee Related CN104768559B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261696442P 2012-09-04 2012-09-04
US61/696,442 2012-09-04
US201361815760P 2013-04-25 2013-04-25
US61/815,760 2013-04-25
US201361825037P 2013-05-19 2013-05-19
US61/825,037 2013-05-19
PCT/IB2013/058186 WO2014037863A1 (en) 2012-09-04 2013-08-31 Methods for prevention and treatment of preeclampsia

Publications (2)

Publication Number Publication Date
CN104768559A CN104768559A (zh) 2015-07-08
CN104768559B true CN104768559B (zh) 2019-01-22

Family

ID=49354724

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380046256.XA Expired - Fee Related CN104768559B (zh) 2012-09-04 2013-08-31 用于预防和治疗先兆子痫的方法

Country Status (11)

Country Link
US (1) US9950014B2 (enExample)
EP (1) EP2892542B1 (enExample)
JP (1) JP6371286B2 (enExample)
KR (1) KR101921787B1 (enExample)
CN (1) CN104768559B (enExample)
AU (1) AU2013311289B2 (enExample)
CA (1) CA2882687A1 (enExample)
HK (1) HK1212239A1 (enExample)
IL (1) IL237528B (enExample)
SG (2) SG10201700435XA (enExample)
WO (1) WO2014037863A1 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101738323B1 (ko) 2007-09-19 2017-05-19 플루리스템 리미티드 지방 또는 태반 조직 유래의 부착 세포 및 이의 치료 용도
EP2303293A1 (en) 2008-05-27 2011-04-06 Pluristem Ltd. Methods of treating inflammatory colon diseases
SG190659A1 (en) 2008-09-02 2013-06-28 Pluristem Ltd Adherent cells from placenta tissue and use thereof in therapy
ES2553712T3 (es) 2009-11-30 2015-12-11 Pluristem Ltd. Células adherentes de la placenta y uso de las mismas en el tratamiento de enfermedad
WO2011147967A1 (en) 2010-05-27 2011-12-01 Georg Duda Skeletal muscle regeneration using mesenchymal stem cells
US8895291B2 (en) 2010-10-08 2014-11-25 Terumo Bct, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
WO2012127320A1 (en) 2011-03-22 2012-09-27 Pluristem Ltd. Methods for treating radiation or chemical injury
US9657266B2 (en) 2011-04-15 2017-05-23 Pluristem Ltd. Methods and systems for harvesting cells
WO2014098960A2 (en) * 2012-05-16 2014-06-26 The Johns Hopkins University Stem cells as an individualized maternal therapy for prevention of prematurity
SI2739720T1 (sl) 2012-09-06 2015-04-30 Pluristem Ltd. Naprave in postopki za gojenje celic
JP6612227B2 (ja) 2013-11-16 2019-11-27 テルモ ビーシーティー、インコーポレーテッド バイオリアクターにおける細胞増殖
WO2015132729A1 (en) 2014-03-04 2015-09-11 Pluristem Ltd. Systems and methods for growing and harvesting cells
US11008547B2 (en) 2014-03-25 2021-05-18 Terumo Bct, Inc. Passive replacement of media
WO2016049421A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled feed
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
WO2017205667A1 (en) 2016-05-25 2017-11-30 Terumo Bct, Inc. Cell expansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US20190224244A1 (en) * 2016-07-11 2019-07-25 Bonus Therapeutics Ltd. Cell compositions for tissue regeneration
EA201991371A1 (ru) * 2016-12-05 2019-12-30 Селулэрити, Инк. Лечение лимфедемы и связанных состояний с использованием плацентарных адгезивных клеток
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
WO2018184028A2 (en) 2017-03-31 2018-10-04 Terumo Bct, Inc. Cell expansion
KR102435297B1 (ko) * 2020-07-21 2022-08-22 부산대학교 산학협력단 임신중독증 조기진단용 바이오마커 조성물 및 이를 이용한 진단방법
GB2619893A (en) 2021-03-23 2023-12-20 Terumo Bct Inc Cell capture and expansion
CN114195875B (zh) * 2021-06-17 2022-07-12 南京市妇幼保健院 一种胎盘来源内源性多肽及其应用
US12209689B2 (en) 2022-02-28 2025-01-28 Terumo Kabushiki Kaisha Multiple-tube pinch valve assembly
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device
CN116747212B (zh) * 2023-07-04 2025-06-17 山东省妇幼保健院 6-姜酚在制备治疗先兆子痫药物中的应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005039505A2 (en) * 2003-10-24 2005-05-06 Nora, Llc Compositions and methods for healthy pregnancy
CN101163970A (zh) * 2004-12-21 2008-04-16 耶鲁大学 先兆子痫的诊断
CN101558151A (zh) * 2006-03-23 2009-10-14 普拉里斯坦有限公司 细胞扩增方法和藉此产生的细胞和条件培养基用于治疗的用途
CN102483418A (zh) * 2008-10-31 2012-05-30 耶鲁大学 先兆子痫检测和治疗的方法和组合物
US20120164114A1 (en) * 2010-12-17 2012-06-28 Abbot Stewart Treatment of immune-related diseases and disorders using amnion derived adherent cells

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5902741A (en) 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
US5629186A (en) 1994-04-28 1997-05-13 Lockheed Martin Corporation Porous matrix and method of its production
US6132463A (en) 1995-05-19 2000-10-17 Etex Corporation Cell seeding of ceramic compositions
EP1064353B1 (en) 1998-03-18 2002-11-06 Massachusetts Institute Of Technology Vascularized perfused microtissue/micro-organ arrays
US6153432A (en) 1999-01-29 2000-11-28 Zen-Bio, Inc Methods for the differentiation of human preadipocytes into adipocytes
WO2000046349A1 (en) 1999-02-04 2000-08-10 Technion Research & Development Foundation Ltd. Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells
PT1261694E (pt) 2000-02-26 2008-04-03 Artecel Inc Células estaminais pluripotentes produzidas a partir de células estromais derivadas de tecido adiposo e suas utilizações.
RU2271817C1 (ru) * 2004-08-18 2006-03-20 ЗАО "РеМеТэкс" Биотрансплантат и способ лечения легочной гипертензии
PL2548951T3 (pl) 2006-03-23 2016-08-31 Pluristem Ltd Sposoby ekspansji komórek oraz zastosowania w terapii komórek i pożywek kondycjonowanych wytworzonych w ten sposób
US20110293583A1 (en) 2006-03-23 2011-12-01 Pluristem Ltd. Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy
US20110171182A1 (en) 2006-03-23 2011-07-14 Pluristem Ltd. Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy
KR101738323B1 (ko) 2007-09-19 2017-05-19 플루리스템 리미티드 지방 또는 태반 조직 유래의 부착 세포 및 이의 치료 용도
EP2303293A1 (en) 2008-05-27 2011-04-06 Pluristem Ltd. Methods of treating inflammatory colon diseases
WO2010017378A2 (en) * 2008-08-08 2010-02-11 Indiana University Research And Technology Corporation Methods and compositions for vasculogenic potential determination
WO2010026573A1 (en) 2008-09-02 2010-03-11 Pluristem Ltd. Methods of selection of cells for transplantation
SG190659A1 (en) 2008-09-02 2013-06-28 Pluristem Ltd Adherent cells from placenta tissue and use thereof in therapy
WO2010026574A2 (en) 2008-09-02 2010-03-11 Pluristem Ltd. Adherent cells from placenta tissue and use thereof in therapy
CN102282252B (zh) * 2008-11-19 2017-07-04 人类起源公司 羊膜来源的贴壁细胞
CA2776882A1 (en) * 2009-10-06 2011-04-14 The Cohen Mcniece Foundation Preparation and use of stromal cells for treatment of cardiac diseases
ES2553712T3 (es) 2009-11-30 2015-12-11 Pluristem Ltd. Células adherentes de la placenta y uso de las mismas en el tratamiento de enfermedad
US20130039892A1 (en) 2010-04-23 2013-02-14 Pluristem Ltd. Adherent stromal cells derived from plancentas of multiple donors and uses thereof
WO2011147967A1 (en) 2010-05-27 2011-12-01 Georg Duda Skeletal muscle regeneration using mesenchymal stem cells
US20140017209A1 (en) 2011-03-22 2014-01-16 Pluristem Ltd. Methods for treating radiation or chemical injury
US9657266B2 (en) 2011-04-15 2017-05-23 Pluristem Ltd. Methods and systems for harvesting cells
ITTO20111183A1 (it) * 2011-12-21 2013-06-22 Univ Degli Studi Torino Mezzo condizionato ottenuto da cellule staminali mesenchimali placentari e suo uso nel trattamento terapeutico della preeclampsia
SI2739720T1 (sl) 2012-09-06 2015-04-30 Pluristem Ltd. Naprave in postopki za gojenje celic
EP2914104B1 (en) 2012-10-31 2020-04-29 Pluristem Ltd. Method and device for thawing biological material
US10351910B2 (en) 2013-02-20 2019-07-16 Pluristem Ltd Gene and protein expression properties of adherent stromal cells cultured in 3D

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005039505A2 (en) * 2003-10-24 2005-05-06 Nora, Llc Compositions and methods for healthy pregnancy
CN101163970A (zh) * 2004-12-21 2008-04-16 耶鲁大学 先兆子痫的诊断
CN101558151A (zh) * 2006-03-23 2009-10-14 普拉里斯坦有限公司 细胞扩增方法和藉此产生的细胞和条件培养基用于治疗的用途
CN102483418A (zh) * 2008-10-31 2012-05-30 耶鲁大学 先兆子痫检测和治疗的方法和组合物
US20120164114A1 (en) * 2010-12-17 2012-06-28 Abbot Stewart Treatment of immune-related diseases and disorders using amnion derived adherent cells

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
先兆子痫和正常孕妇外周血辅助性T细胞及其细胞因子的变化;陈慧等;《实用医学杂志》;20081231;第24卷(第18期);第3120-3122页 *

Also Published As

Publication number Publication date
US20150216907A1 (en) 2015-08-06
KR20150047503A (ko) 2015-05-04
EP2892542B1 (en) 2018-04-04
HK1211242A1 (en) 2016-05-20
IL237528B (en) 2019-11-28
JP6371286B2 (ja) 2018-08-08
WO2014037863A1 (en) 2014-03-13
US9950014B2 (en) 2018-04-24
IL237528A0 (en) 2015-04-30
SG11201501065QA (en) 2015-03-30
AU2013311289B2 (en) 2017-11-16
AU2013311289A1 (en) 2015-03-05
SG10201700435XA (en) 2017-02-27
JP2015532656A (ja) 2015-11-12
EP2892542A1 (en) 2015-07-15
HK1212239A1 (en) 2016-06-10
KR101921787B1 (ko) 2018-11-23
CA2882687A1 (en) 2014-03-13
CN104768559A (zh) 2015-07-08

Similar Documents

Publication Publication Date Title
JP6371286B2 (ja) 子癇前症の予防及び治療方法
JP6967228B2 (ja) 治療方法
US20200306319A1 (en) Methods for treating radiation or chemical injury
KR101505382B1 (ko) 인간 배아 줄기 세포 및 그의 유도체를 포함하는 조성물, 그의 사용 방법 및 제조 방법
US20130156726A1 (en) Endometrial stem cells and methods of making and using same
BRPI0709349A2 (pt) métodos para expansão celular e usos de células e de meios condicionados produzidos através deles para terapia
BRPI0815946B1 (pt) artigo de fabricação
EP2331957A1 (en) Methods of selection of cells for transplantation
JP2020500512A (ja) 筋幹細胞のインビトロ産生
JP2017119646A (ja) 性ホルモン分泌促進剤及び生殖細胞増殖促進剤
JP7255805B2 (ja) 多能性幹細胞による胎児発育不全に伴う脳障害の改善及び治療
EP4502143A1 (en) Medium composition for preparing intestinal organoid
CN112807296A (zh) 琥珀酸在诊断或治疗自然流产中的应用
US12083149B2 (en) Amelioration and treatment of chronic lung disease using pluripotent stem cells
HK1211242B (zh) 用於预防和治疗先兆子痫的方法
RU2675354C1 (ru) Способ стимуляции веса плода на ранних сроках беременности в эксперименте
US20250009936A1 (en) Tissue regeneration with in vitro activated effector cells
CN116440164A (zh) 一种用于哺乳动物生殖系统抗衰的生物制品及其制备方法和应用
CN116440165A (zh) 一种用于哺乳动物皮肤和/或毛囊抗衰的生物制品及其制备方法和应用
CN116098921A (zh) 一种具有哺乳动物大脑系统抗衰作用的生物制品及其制备方法和应用
EP3852772A1 (en) Pharmaceutical product for preventing or treating alzheimer's disease
HK1106549A (en) Suitable for inhuman mammals embryonal tissue: cells transplantation, preparation and other uses
HK1188812B (en) Methods for treating radiation or chemical injury

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
EXSB Decision made by sipo to initiate substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1211242

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant
CP01 Change in the name or title of a patent holder

Address after: Haifa

Patentee after: Pra Biotechnology Co.,Ltd.

Address before: Haifa

Patentee before: PLURISTEM Ltd.

CP01 Change in the name or title of a patent holder
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20190122

CF01 Termination of patent right due to non-payment of annual fee