JP2015532656A5 - - Google Patents
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- Publication number
- JP2015532656A5 JP2015532656A5 JP2015530529A JP2015530529A JP2015532656A5 JP 2015532656 A5 JP2015532656 A5 JP 2015532656A5 JP 2015530529 A JP2015530529 A JP 2015530529A JP 2015530529 A JP2015530529 A JP 2015530529A JP 2015532656 A5 JP2015532656 A5 JP 2015532656A5
- Authority
- JP
- Japan
- Prior art keywords
- therapeutic
- agent according
- prophylactic agent
- eclampsia
- stromal cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003795 chemical substances by application Substances 0.000 claims 26
- 230000000069 prophylactic effect Effects 0.000 claims 24
- 230000001225 therapeutic effect Effects 0.000 claims 24
- 230000001464 adherent effect Effects 0.000 claims 16
- 210000002536 stromal cell Anatomy 0.000 claims 14
- 201000011461 pre-eclampsia Diseases 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 7
- 230000035935 pregnancy Effects 0.000 claims 7
- 208000002296 eclampsia Diseases 0.000 claims 5
- 230000003169 placental effect Effects 0.000 claims 4
- 210000002966 serum Anatomy 0.000 claims 3
- 102100037241 Endoglin Human genes 0.000 claims 2
- 101000595923 Homo sapiens Placenta growth factor Proteins 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 102100035194 Placenta growth factor Human genes 0.000 claims 2
- 239000000853 adhesive Substances 0.000 claims 2
- 230000001070 adhesive effect Effects 0.000 claims 2
- 210000003754 fetus Anatomy 0.000 claims 2
- 239000003550 marker Substances 0.000 claims 2
- 230000008774 maternal effect Effects 0.000 claims 2
- 239000005022 packaging material Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 102100022464 5'-nucleotidase Human genes 0.000 claims 1
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 1
- 206010004272 Benign hydatidiform mole Diseases 0.000 claims 1
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 1
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 108010036395 Endoglin Proteins 0.000 claims 1
- 206010048554 Endothelial dysfunction Diseases 0.000 claims 1
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 1
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 1
- 101000881679 Homo sapiens Endoglin Proteins 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims 1
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 claims 1
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 1
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 1
- 208000006937 Hydatidiform mole Diseases 0.000 claims 1
- 208000020060 Increased inflammatory response Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 102100022338 Integrin alpha-M Human genes 0.000 claims 1
- 102100025304 Integrin beta-1 Human genes 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000025972 Maternal Obesity Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 1
- 208000034702 Multiple pregnancies Diseases 0.000 claims 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 1
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims 1
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 1
- 108010053096 Vascular Endothelial Growth Factor Receptor-1 Proteins 0.000 claims 1
- 102100033178 Vascular endothelial growth factor receptor 1 Human genes 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 230000008694 endothelial dysfunction Effects 0.000 claims 1
- 201000007116 gestational trophoblastic neoplasm Diseases 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 230000010412 perfusion Effects 0.000 claims 1
- 210000002826 placenta Anatomy 0.000 claims 1
- 210000005059 placental tissue Anatomy 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 201000005665 thrombophilia Diseases 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261696442P | 2012-09-04 | 2012-09-04 | |
| US61/696,442 | 2012-09-04 | ||
| US201361815760P | 2013-04-25 | 2013-04-25 | |
| US61/815,760 | 2013-04-25 | ||
| US201361825037P | 2013-05-19 | 2013-05-19 | |
| US61/825,037 | 2013-05-19 | ||
| PCT/IB2013/058186 WO2014037863A1 (en) | 2012-09-04 | 2013-08-31 | Methods for prevention and treatment of preeclampsia |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015532656A JP2015532656A (ja) | 2015-11-12 |
| JP2015532656A5 true JP2015532656A5 (enExample) | 2016-10-13 |
| JP6371286B2 JP6371286B2 (ja) | 2018-08-08 |
Family
ID=49354724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015530529A Expired - Fee Related JP6371286B2 (ja) | 2012-09-04 | 2013-08-31 | 子癇前症の予防及び治療方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9950014B2 (enExample) |
| EP (1) | EP2892542B1 (enExample) |
| JP (1) | JP6371286B2 (enExample) |
| KR (1) | KR101921787B1 (enExample) |
| CN (1) | CN104768559B (enExample) |
| AU (1) | AU2013311289B2 (enExample) |
| CA (1) | CA2882687A1 (enExample) |
| HK (1) | HK1212239A1 (enExample) |
| IL (1) | IL237528B (enExample) |
| SG (2) | SG10201700435XA (enExample) |
| WO (1) | WO2014037863A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101738323B1 (ko) | 2007-09-19 | 2017-05-19 | 플루리스템 리미티드 | 지방 또는 태반 조직 유래의 부착 세포 및 이의 치료 용도 |
| EP2303293A1 (en) | 2008-05-27 | 2011-04-06 | Pluristem Ltd. | Methods of treating inflammatory colon diseases |
| SG190659A1 (en) | 2008-09-02 | 2013-06-28 | Pluristem Ltd | Adherent cells from placenta tissue and use thereof in therapy |
| ES2553712T3 (es) | 2009-11-30 | 2015-12-11 | Pluristem Ltd. | Células adherentes de la placenta y uso de las mismas en el tratamiento de enfermedad |
| WO2011147967A1 (en) | 2010-05-27 | 2011-12-01 | Georg Duda | Skeletal muscle regeneration using mesenchymal stem cells |
| US8895291B2 (en) | 2010-10-08 | 2014-11-25 | Terumo Bct, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
| WO2012127320A1 (en) | 2011-03-22 | 2012-09-27 | Pluristem Ltd. | Methods for treating radiation or chemical injury |
| US9657266B2 (en) | 2011-04-15 | 2017-05-23 | Pluristem Ltd. | Methods and systems for harvesting cells |
| WO2014098960A2 (en) * | 2012-05-16 | 2014-06-26 | The Johns Hopkins University | Stem cells as an individualized maternal therapy for prevention of prematurity |
| SI2739720T1 (sl) | 2012-09-06 | 2015-04-30 | Pluristem Ltd. | Naprave in postopki za gojenje celic |
| JP6612227B2 (ja) | 2013-11-16 | 2019-11-27 | テルモ ビーシーティー、インコーポレーテッド | バイオリアクターにおける細胞増殖 |
| WO2015132729A1 (en) | 2014-03-04 | 2015-09-11 | Pluristem Ltd. | Systems and methods for growing and harvesting cells |
| US11008547B2 (en) | 2014-03-25 | 2021-05-18 | Terumo Bct, Inc. | Passive replacement of media |
| WO2016049421A1 (en) | 2014-09-26 | 2016-03-31 | Terumo Bct, Inc. | Scheduled feed |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| WO2017205667A1 (en) | 2016-05-25 | 2017-11-30 | Terumo Bct, Inc. | Cell expansion |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| US20190224244A1 (en) * | 2016-07-11 | 2019-07-25 | Bonus Therapeutics Ltd. | Cell compositions for tissue regeneration |
| EA201991371A1 (ru) * | 2016-12-05 | 2019-12-30 | Селулэрити, Инк. | Лечение лимфедемы и связанных состояний с использованием плацентарных адгезивных клеток |
| US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| WO2018184028A2 (en) | 2017-03-31 | 2018-10-04 | Terumo Bct, Inc. | Cell expansion |
| KR102435297B1 (ko) * | 2020-07-21 | 2022-08-22 | 부산대학교 산학협력단 | 임신중독증 조기진단용 바이오마커 조성물 및 이를 이용한 진단방법 |
| GB2619893A (en) | 2021-03-23 | 2023-12-20 | Terumo Bct Inc | Cell capture and expansion |
| CN114195875B (zh) * | 2021-06-17 | 2022-07-12 | 南京市妇幼保健院 | 一种胎盘来源内源性多肽及其应用 |
| US12209689B2 (en) | 2022-02-28 | 2025-01-28 | Terumo Kabushiki Kaisha | Multiple-tube pinch valve assembly |
| USD1099116S1 (en) | 2022-09-01 | 2025-10-21 | Terumo Bct, Inc. | Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device |
| CN116747212B (zh) * | 2023-07-04 | 2025-06-17 | 山东省妇幼保健院 | 6-姜酚在制备治疗先兆子痫药物中的应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5902741A (en) | 1986-04-18 | 1999-05-11 | Advanced Tissue Sciences, Inc. | Three-dimensional cartilage cultures |
| US5629186A (en) | 1994-04-28 | 1997-05-13 | Lockheed Martin Corporation | Porous matrix and method of its production |
| US6132463A (en) | 1995-05-19 | 2000-10-17 | Etex Corporation | Cell seeding of ceramic compositions |
| EP1064353B1 (en) | 1998-03-18 | 2002-11-06 | Massachusetts Institute Of Technology | Vascularized perfused microtissue/micro-organ arrays |
| US6153432A (en) | 1999-01-29 | 2000-11-28 | Zen-Bio, Inc | Methods for the differentiation of human preadipocytes into adipocytes |
| WO2000046349A1 (en) | 1999-02-04 | 2000-08-10 | Technion Research & Development Foundation Ltd. | Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells |
| PT1261694E (pt) | 2000-02-26 | 2008-04-03 | Artecel Inc | Células estaminais pluripotentes produzidas a partir de células estromais derivadas de tecido adiposo e suas utilizações. |
| EP2198876B1 (en) * | 2003-10-24 | 2012-12-05 | Nora Therapeutics, Inc. | A method for reducing the likelihood of implantation failure in a subject |
| RU2271817C1 (ru) * | 2004-08-18 | 2006-03-20 | ЗАО "РеМеТэкс" | Биотрансплантат и способ лечения легочной гипертензии |
| ATE519109T1 (de) * | 2004-12-21 | 2011-08-15 | Univ Yale | Präeklampsie-diagnose |
| PL2548951T3 (pl) | 2006-03-23 | 2016-08-31 | Pluristem Ltd | Sposoby ekspansji komórek oraz zastosowania w terapii komórek i pożywek kondycjonowanych wytworzonych w ten sposób |
| US20110293583A1 (en) | 2006-03-23 | 2011-12-01 | Pluristem Ltd. | Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy |
| US20110171182A1 (en) | 2006-03-23 | 2011-07-14 | Pluristem Ltd. | Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy |
| CN101558151B (zh) * | 2006-03-23 | 2015-10-21 | 普拉里斯坦有限公司 | 细胞扩增方法和藉此产生的细胞和条件培养基用于治疗的用途 |
| KR101738323B1 (ko) | 2007-09-19 | 2017-05-19 | 플루리스템 리미티드 | 지방 또는 태반 조직 유래의 부착 세포 및 이의 치료 용도 |
| EP2303293A1 (en) | 2008-05-27 | 2011-04-06 | Pluristem Ltd. | Methods of treating inflammatory colon diseases |
| WO2010017378A2 (en) * | 2008-08-08 | 2010-02-11 | Indiana University Research And Technology Corporation | Methods and compositions for vasculogenic potential determination |
| WO2010026573A1 (en) | 2008-09-02 | 2010-03-11 | Pluristem Ltd. | Methods of selection of cells for transplantation |
| SG190659A1 (en) | 2008-09-02 | 2013-06-28 | Pluristem Ltd | Adherent cells from placenta tissue and use thereof in therapy |
| WO2010026574A2 (en) | 2008-09-02 | 2010-03-11 | Pluristem Ltd. | Adherent cells from placenta tissue and use thereof in therapy |
| CN105021821B (zh) * | 2008-10-31 | 2018-05-11 | 耶鲁大学 | 先兆子痫检测和治疗的方法和组合物 |
| CN102282252B (zh) * | 2008-11-19 | 2017-07-04 | 人类起源公司 | 羊膜来源的贴壁细胞 |
| CA2776882A1 (en) * | 2009-10-06 | 2011-04-14 | The Cohen Mcniece Foundation | Preparation and use of stromal cells for treatment of cardiac diseases |
| ES2553712T3 (es) | 2009-11-30 | 2015-12-11 | Pluristem Ltd. | Células adherentes de la placenta y uso de las mismas en el tratamiento de enfermedad |
| US20130039892A1 (en) | 2010-04-23 | 2013-02-14 | Pluristem Ltd. | Adherent stromal cells derived from plancentas of multiple donors and uses thereof |
| WO2011147967A1 (en) | 2010-05-27 | 2011-12-01 | Georg Duda | Skeletal muscle regeneration using mesenchymal stem cells |
| KR20190114045A (ko) * | 2010-12-17 | 2019-10-08 | 안트로제네시스 코포레이션 | 양막 유래 부착성 세포를 사용한, 면역-관련 질환 및 장애의 치료 |
| US20140017209A1 (en) | 2011-03-22 | 2014-01-16 | Pluristem Ltd. | Methods for treating radiation or chemical injury |
| US9657266B2 (en) | 2011-04-15 | 2017-05-23 | Pluristem Ltd. | Methods and systems for harvesting cells |
| ITTO20111183A1 (it) * | 2011-12-21 | 2013-06-22 | Univ Degli Studi Torino | Mezzo condizionato ottenuto da cellule staminali mesenchimali placentari e suo uso nel trattamento terapeutico della preeclampsia |
| SI2739720T1 (sl) | 2012-09-06 | 2015-04-30 | Pluristem Ltd. | Naprave in postopki za gojenje celic |
| EP2914104B1 (en) | 2012-10-31 | 2020-04-29 | Pluristem Ltd. | Method and device for thawing biological material |
| US10351910B2 (en) | 2013-02-20 | 2019-07-16 | Pluristem Ltd | Gene and protein expression properties of adherent stromal cells cultured in 3D |
-
2013
- 2013-08-31 US US14/425,960 patent/US9950014B2/en active Active
- 2013-08-31 HK HK16100329.4A patent/HK1212239A1/xx unknown
- 2013-08-31 SG SG10201700435XA patent/SG10201700435XA/en unknown
- 2013-08-31 SG SG11201501065QA patent/SG11201501065QA/en unknown
- 2013-08-31 WO PCT/IB2013/058186 patent/WO2014037863A1/en not_active Ceased
- 2013-08-31 EP EP13776574.9A patent/EP2892542B1/en active Active
- 2013-08-31 JP JP2015530529A patent/JP6371286B2/ja not_active Expired - Fee Related
- 2013-08-31 AU AU2013311289A patent/AU2013311289B2/en not_active Ceased
- 2013-08-31 CA CA2882687A patent/CA2882687A1/en not_active Abandoned
- 2013-08-31 CN CN201380046256.XA patent/CN104768559B/zh not_active Expired - Fee Related
- 2013-08-31 KR KR1020157005124A patent/KR101921787B1/ko not_active Expired - Fee Related
-
2015
- 2015-03-03 IL IL23752815A patent/IL237528B/en active IP Right Grant
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