JP6367187B2 - Ｎ−［（ｒ）−１−［（ｓ）−１−（４−アミノメチル−ベンジルカルバモイル）−２−フェニルエチルカルバモイル］−２−（４−エトキシ−フェニル）−エチル］−ベンズアミド塩酸塩の多形体 - Google Patents
Ｎ−［（ｒ）−１−［（ｓ）−１−（４−アミノメチル−ベンジルカルバモイル）−２−フェニルエチルカルバモイル］−２−（４−エトキシ−フェニル）−エチル］−ベンズアミド塩酸塩の多形体 Download PDFInfo
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- JP6367187B2 JP6367187B2 JP2015519357A JP2015519357A JP6367187B2 JP 6367187 B2 JP6367187 B2 JP 6367187B2 JP 2015519357 A JP2015519357 A JP 2015519357A JP 2015519357 A JP2015519357 A JP 2015519357A JP 6367187 B2 JP6367187 B2 JP 6367187B2
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- phenyl
- crystalline polymorph
- ethoxy
- ethyl
- aminomethyl
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- DHNSEQGWKLRFOE-XJEPUKKESA-N n-[(2r)-1-[[(2s)-1-[[4-(aminomethyl)phenyl]methylamino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(4-ethoxyphenyl)-1-oxopropan-2-yl]benzamide;hydrochloride Chemical compound Cl.C1=CC(OCC)=CC=C1C[C@H](C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC=1C=CC(CN)=CC=1)NC(=O)C1=CC=CC=C1 DHNSEQGWKLRFOE-XJEPUKKESA-N 0.000 title claims description 23
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Applications Claiming Priority (5)
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| US201261668543P | 2012-07-06 | 2012-07-06 | |
| GB1212081.2 | 2012-07-06 | ||
| GB201212081A GB201212081D0 (en) | 2012-07-06 | 2012-07-06 | New polymorph |
| US61/668,543 | 2012-07-06 | ||
| PCT/GB2013/051781 WO2014006414A1 (en) | 2012-07-06 | 2013-07-05 | Polymorphs of|n-[(r)-1 -[(s)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethylcarbamoy l]-2-(4-e|thoxy-phenyl)-ethyl]-benzamide hydrochloride |
Publications (3)
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| JP2015528798A JP2015528798A (ja) | 2015-10-01 |
| JP2015528798A5 JP2015528798A5 (cg-RX-API-DMAC7.html) | 2016-08-12 |
| JP6367187B2 true JP6367187B2 (ja) | 2018-08-01 |
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| EP (1) | EP2870137B8 (cg-RX-API-DMAC7.html) |
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| ES (1) | ES2679370T3 (cg-RX-API-DMAC7.html) |
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| WO (1) | WO2014006414A1 (cg-RX-API-DMAC7.html) |
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| GB2510407A (en) | 2013-02-04 | 2014-08-06 | Kalvista Pharmaceuticals Ltd | Aqueous suspensions of kallikrein inhibitors for parenteral administration |
| TWI636047B (zh) | 2013-08-14 | 2018-09-21 | 英商卡爾維斯塔製藥有限公司 | 雜環衍生物 |
| GB201421085D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | New enzyme inhibitors |
| GB201421083D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | Enzyme inhibitors |
| JP2019507746A (ja) | 2016-03-10 | 2019-03-22 | オクシュリオン エヌブイ | 胎盤増殖因子のアンタゴナイズによる後眼部線維症の阻害 |
| SMT202000382T1 (it) | 2016-05-31 | 2020-09-10 | Kalvista Pharmaceuticals Ltd | Derivati di pirazolo come inibitori di callicreina plasmatica |
| GB201609603D0 (en) * | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide |
| GB201609607D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts |
| JOP20190144A1 (ar) | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
| DK3555097T3 (da) | 2016-12-16 | 2022-07-25 | Janssen Pharmaceutica Nv | Imidazo[4,5-d]pyrrolo[2,3-b]pyridinforbindelser som inhibitorer af janus-kinaser |
| KR20240038146A (ko) | 2017-01-30 | 2024-03-22 | 얀센 바이오테크 인코포레이티드 | 활성 건선성 관절염의 치료를 위한 항-tnf 항체, 조성물, 및 방법 |
| MA47442A (fr) | 2017-02-07 | 2019-12-18 | Janssen Biotech Inc | Anticorps anti-tnf, compositions et méthodes pour le traitement de la spondylarthrite ankylosante active |
| PL3716952T3 (pl) | 2017-11-29 | 2022-05-02 | Kalvista Pharmaceuticals Limited | Postacie dawkowania zawierające inhibitor kalikreiny osoczowej |
| GB201719881D0 (en) | 2017-11-29 | 2018-01-10 | Kalvista Pharmaceuticals Ltd | Solid forms of plasma kallikrein inhibitor and salts thereof |
| TW202016110A (zh) | 2018-06-15 | 2020-05-01 | 比利時商健生藥品公司 | Ｊａｋ激酶家族之小分子抑制劑 |
| AR116951A1 (es) * | 2018-11-02 | 2021-06-30 | Biocryst Pharm Inc | Sales cristalinas de un inhibidor de calicreína plasmática |
| AU2020279987A1 (en) | 2019-05-23 | 2021-11-18 | Janssen Biotech, Inc. | Method of treating inflammatory bowel disease with a combination therapy of antibodies to IL-23 and TNF alpha |
| EP4010333A1 (en) | 2019-08-09 | 2022-06-15 | Kalvista Pharmaceuticals Limited | Plasma kallikrein inhibitors |
| GB201918994D0 (en) * | 2019-12-20 | 2020-02-05 | Kalvista Pharmaceuticals Ltd | Treatments of diabetic macular edema and impaired visual acuity |
| GB2591730A (en) | 2019-12-09 | 2021-08-11 | Kalvista Pharmaceuticals Ltd | New polymorphs |
| CA3183927A1 (en) | 2020-05-21 | 2021-11-25 | Janssen Biotech, Inc. | Method of treating inflammatory bowel disease with a combination therapy of antibodies to il-23 and tnf alpha |
| MX2023010642A (es) | 2021-03-11 | 2023-11-28 | Janssen Pharmaceutica Nv | Lorpucitinib para uso en el tratamiento de trastornos mediados por jak. |
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| US5187157A (en) | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
| IT1223401B (it) * | 1987-12-02 | 1990-09-19 | Montedison Spa | Poliesteri aromatici liquido cristallini termotropici |
| GB9019558D0 (en) | 1990-09-07 | 1990-10-24 | Szelke Michael | Enzyme inhibitors |
| SE9301911D0 (sv) | 1993-06-03 | 1993-06-03 | Ab Astra | New peptide derivatives |
| US5589467A (en) | 1993-09-17 | 1996-12-31 | Novo Nordisk A/S | 2,5',N6-trisubstituted adenosine derivatives |
| IL112795A (en) * | 1994-03-04 | 2001-01-28 | Astrazeneca Ab | Peptide derivatives as antithrombic agents their preparation and pharmaceutical compositions containing them |
| US5914319A (en) * | 1995-02-27 | 1999-06-22 | Eli Lilly And Company | Antithrombotic agents |
| JP4179878B2 (ja) * | 2001-02-02 | 2008-11-12 | 中外製薬株式会社 | ペプチド誘導体 |
| GB0205527D0 (en) | 2002-03-08 | 2002-04-24 | Ferring Bv | Inhibitors |
| DE10301300B4 (de) | 2003-01-15 | 2009-07-16 | Curacyte Chemistry Gmbh | Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein |
| NZ592039A (en) | 2003-08-27 | 2013-03-28 | Ophthotech Corp | Combination therapy for the treatment of ocular neovascular disorders |
| JP2007530652A (ja) * | 2004-04-02 | 2007-11-01 | グラクソ グループ リミテッド | 化学物質、調製方法、及び、新規結晶形態 |
| US7453002B2 (en) * | 2004-06-15 | 2008-11-18 | Bristol-Myers Squibb Company | Five-membered heterocycles useful as serine protease inhibitors |
| US7750187B2 (en) * | 2004-11-30 | 2010-07-06 | Mallinckrodt Inc. | Crystallization method for benzphetamine |
| KR20080087817A (ko) * | 2005-12-14 | 2008-10-01 | 브리스톨-마이어스 스큅 컴퍼니 | 인자 ｘｉａ 억제제로서 아릴프로피온아미드,아릴아크릴아미드, 아릴프로핀아미드 또는 아릴메틸우레아유사체 |
| CA2658523C (en) | 2006-07-31 | 2012-06-12 | Activesite Pharmaceuticals, Inc. | Inhibitors of plasma kallikrein |
| DE102006050672A1 (de) | 2006-10-24 | 2008-04-30 | Curacyte Discovery Gmbh | Hemmstoffe des Plasmins und des Plasmakallikreins |
| MX2012006913A (es) | 2009-12-18 | 2012-08-23 | Activesite Pharmaceuticals Inc | Profarmacos de inhibidores de calicreina plasmatica. |
| EA022121B1 (ru) * | 2010-01-28 | 2015-11-30 | Зе Медисинс Компани (Лейпциг) Гмбх | Ингибиторы трипсиноподобных сериновых протеаз, их получение и применение |
| JP2013121919A (ja) | 2010-03-25 | 2013-06-20 | Astellas Pharma Inc | 血漿カリクレイン阻害剤 |
| WO2012004678A2 (en) | 2010-07-07 | 2012-01-12 | The Medicines Company (Leipzig) Gmbh | Serine protease inhibitors |
| US9290485B2 (en) | 2010-08-04 | 2016-03-22 | Novartis Ag | N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides |
| WO2012142308A1 (en) | 2011-04-13 | 2012-10-18 | Activesite Pharmaceuticals, Inc. | Prodrugs of inhibitors of plasma kallikrein |
| GB2494851A (en) | 2011-07-07 | 2013-03-27 | Kalvista Pharmaceuticals Ltd | Plasma kallikrein inhibitors |
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- 2012-07-06 GB GB201212081A patent/GB201212081D0/en not_active Ceased
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- 2013-07-05 PL PL13737357T patent/PL2870137T3/pl unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| PL2870137T3 (pl) | 2018-12-31 |
| GB201212081D0 (en) | 2012-08-22 |
| JP2015528798A (ja) | 2015-10-01 |
| ES2679370T3 (es) | 2018-08-24 |
| CA2878319C (en) | 2021-02-09 |
| HUE039775T2 (hu) | 2019-02-28 |
| EP2870137B1 (en) | 2018-05-16 |
| EP2870137A1 (en) | 2015-05-13 |
| EP2870137B8 (en) | 2018-07-18 |
| WO2014006414A1 (en) | 2014-01-09 |
| TR201809681T4 (tr) | 2018-07-23 |
| US9512065B2 (en) | 2016-12-06 |
| CA2878319A1 (en) | 2014-01-09 |
| US20150191421A1 (en) | 2015-07-09 |
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