HUE039775T2 - N-[(R)-l-[(S)-l-(4-aminometil-benzilkarbamoil)-2-fenil-etilkarbamoil]-2-(4-etoxifenil)- etil]-benzamid-hidroklorid polimorfjai - Google Patents
N-[(R)-l-[(S)-l-(4-aminometil-benzilkarbamoil)-2-fenil-etilkarbamoil]-2-(4-etoxifenil)- etil]-benzamid-hidroklorid polimorfjaiInfo
- Publication number
- HUE039775T2 HUE039775T2 HUE13737357A HUE13737357A HUE039775T2 HU E039775 T2 HUE039775 T2 HU E039775T2 HU E13737357 A HUE13737357 A HU E13737357A HU E13737357 A HUE13737357 A HU E13737357A HU E039775 T2 HUE039775 T2 HU E039775T2
- Authority
- HU
- Hungary
- Prior art keywords
- phenyl
- benzylcarbamoyl
- ethylcarbamoyl
- polymorphs
- aminomethyl
- Prior art date
Links
- DHNSEQGWKLRFOE-XJEPUKKESA-N n-[(2r)-1-[[(2s)-1-[[4-(aminomethyl)phenyl]methylamino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(4-ethoxyphenyl)-1-oxopropan-2-yl]benzamide;hydrochloride Chemical compound Cl.C1=CC(OCC)=CC=C1C[C@H](C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC=1C=CC(CN)=CC=1)NC(=O)C1=CC=CC=C1 DHNSEQGWKLRFOE-XJEPUKKESA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261668543P | 2012-07-06 | 2012-07-06 | |
| GB201212081A GB201212081D0 (en) | 2012-07-06 | 2012-07-06 | New polymorph |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE039775T2 true HUE039775T2 (hu) | 2019-02-28 |
Family
ID=46766283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE13737357A HUE039775T2 (hu) | 2012-07-06 | 2013-07-05 | N-[(R)-l-[(S)-l-(4-aminometil-benzilkarbamoil)-2-fenil-etilkarbamoil]-2-(4-etoxifenil)- etil]-benzamid-hidroklorid polimorfjai |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9512065B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2870137B8 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6367187B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2878319C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2679370T3 (cg-RX-API-DMAC7.html) |
| GB (1) | GB201212081D0 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE039775T2 (cg-RX-API-DMAC7.html) |
| PL (1) | PL2870137T3 (cg-RX-API-DMAC7.html) |
| TR (1) | TR201809681T4 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014006414A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2510407A (en) | 2013-02-04 | 2014-08-06 | Kalvista Pharmaceuticals Ltd | Aqueous suspensions of kallikrein inhibitors for parenteral administration |
| TWI636047B (zh) | 2013-08-14 | 2018-09-21 | 英商卡爾維斯塔製藥有限公司 | 雜環衍生物 |
| GB201421085D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | New enzyme inhibitors |
| GB201421083D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | Enzyme inhibitors |
| JP2019507746A (ja) | 2016-03-10 | 2019-03-22 | オクシュリオン エヌブイ | 胎盤増殖因子のアンタゴナイズによる後眼部線維症の阻害 |
| SMT202000382T1 (it) | 2016-05-31 | 2020-09-10 | Kalvista Pharmaceuticals Ltd | Derivati di pirazolo come inibitori di callicreina plasmatica |
| GB201609603D0 (en) * | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide |
| GB201609607D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts |
| JOP20190144A1 (ar) | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
| DK3555097T3 (da) | 2016-12-16 | 2022-07-25 | Janssen Pharmaceutica Nv | Imidazo[4,5-d]pyrrolo[2,3-b]pyridinforbindelser som inhibitorer af janus-kinaser |
| KR20240038146A (ko) | 2017-01-30 | 2024-03-22 | 얀센 바이오테크 인코포레이티드 | 활성 건선성 관절염의 치료를 위한 항-tnf 항체, 조성물, 및 방법 |
| MA47442A (fr) | 2017-02-07 | 2019-12-18 | Janssen Biotech Inc | Anticorps anti-tnf, compositions et méthodes pour le traitement de la spondylarthrite ankylosante active |
| PL3716952T3 (pl) | 2017-11-29 | 2022-05-02 | Kalvista Pharmaceuticals Limited | Postacie dawkowania zawierające inhibitor kalikreiny osoczowej |
| GB201719881D0 (en) | 2017-11-29 | 2018-01-10 | Kalvista Pharmaceuticals Ltd | Solid forms of plasma kallikrein inhibitor and salts thereof |
| TW202016110A (zh) | 2018-06-15 | 2020-05-01 | 比利時商健生藥品公司 | Ｊａｋ激酶家族之小分子抑制劑 |
| AR116951A1 (es) * | 2018-11-02 | 2021-06-30 | Biocryst Pharm Inc | Sales cristalinas de un inhibidor de calicreína plasmática |
| AU2020279987A1 (en) | 2019-05-23 | 2021-11-18 | Janssen Biotech, Inc. | Method of treating inflammatory bowel disease with a combination therapy of antibodies to IL-23 and TNF alpha |
| EP4010333A1 (en) | 2019-08-09 | 2022-06-15 | Kalvista Pharmaceuticals Limited | Plasma kallikrein inhibitors |
| GB201918994D0 (en) * | 2019-12-20 | 2020-02-05 | Kalvista Pharmaceuticals Ltd | Treatments of diabetic macular edema and impaired visual acuity |
| GB2591730A (en) | 2019-12-09 | 2021-08-11 | Kalvista Pharmaceuticals Ltd | New polymorphs |
| CA3183927A1 (en) | 2020-05-21 | 2021-11-25 | Janssen Biotech, Inc. | Method of treating inflammatory bowel disease with a combination therapy of antibodies to il-23 and tnf alpha |
| MX2023010642A (es) | 2021-03-11 | 2023-11-28 | Janssen Pharmaceutica Nv | Lorpucitinib para uso en el tratamiento de trastornos mediados por jak. |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5187157A (en) | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
| IT1223401B (it) * | 1987-12-02 | 1990-09-19 | Montedison Spa | Poliesteri aromatici liquido cristallini termotropici |
| GB9019558D0 (en) | 1990-09-07 | 1990-10-24 | Szelke Michael | Enzyme inhibitors |
| SE9301911D0 (sv) | 1993-06-03 | 1993-06-03 | Ab Astra | New peptide derivatives |
| US5589467A (en) | 1993-09-17 | 1996-12-31 | Novo Nordisk A/S | 2,5',N6-trisubstituted adenosine derivatives |
| IL112795A (en) * | 1994-03-04 | 2001-01-28 | Astrazeneca Ab | Peptide derivatives as antithrombic agents their preparation and pharmaceutical compositions containing them |
| US5914319A (en) * | 1995-02-27 | 1999-06-22 | Eli Lilly And Company | Antithrombotic agents |
| JP4179878B2 (ja) * | 2001-02-02 | 2008-11-12 | 中外製薬株式会社 | ペプチド誘導体 |
| GB0205527D0 (en) | 2002-03-08 | 2002-04-24 | Ferring Bv | Inhibitors |
| DE10301300B4 (de) | 2003-01-15 | 2009-07-16 | Curacyte Chemistry Gmbh | Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein |
| NZ592039A (en) | 2003-08-27 | 2013-03-28 | Ophthotech Corp | Combination therapy for the treatment of ocular neovascular disorders |
| JP2007530652A (ja) * | 2004-04-02 | 2007-11-01 | グラクソ グループ リミテッド | 化学物質、調製方法、及び、新規結晶形態 |
| US7453002B2 (en) * | 2004-06-15 | 2008-11-18 | Bristol-Myers Squibb Company | Five-membered heterocycles useful as serine protease inhibitors |
| US7750187B2 (en) * | 2004-11-30 | 2010-07-06 | Mallinckrodt Inc. | Crystallization method for benzphetamine |
| KR20080087817A (ko) * | 2005-12-14 | 2008-10-01 | 브리스톨-마이어스 스큅 컴퍼니 | 인자 ｘｉａ 억제제로서 아릴프로피온아미드,아릴아크릴아미드, 아릴프로핀아미드 또는 아릴메틸우레아유사체 |
| CA2658523C (en) | 2006-07-31 | 2012-06-12 | Activesite Pharmaceuticals, Inc. | Inhibitors of plasma kallikrein |
| DE102006050672A1 (de) | 2006-10-24 | 2008-04-30 | Curacyte Discovery Gmbh | Hemmstoffe des Plasmins und des Plasmakallikreins |
| MX2012006913A (es) | 2009-12-18 | 2012-08-23 | Activesite Pharmaceuticals Inc | Profarmacos de inhibidores de calicreina plasmatica. |
| EA022121B1 (ru) * | 2010-01-28 | 2015-11-30 | Зе Медисинс Компани (Лейпциг) Гмбх | Ингибиторы трипсиноподобных сериновых протеаз, их получение и применение |
| JP2013121919A (ja) | 2010-03-25 | 2013-06-20 | Astellas Pharma Inc | 血漿カリクレイン阻害剤 |
| WO2012004678A2 (en) | 2010-07-07 | 2012-01-12 | The Medicines Company (Leipzig) Gmbh | Serine protease inhibitors |
| US9290485B2 (en) | 2010-08-04 | 2016-03-22 | Novartis Ag | N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides |
| WO2012142308A1 (en) | 2011-04-13 | 2012-10-18 | Activesite Pharmaceuticals, Inc. | Prodrugs of inhibitors of plasma kallikrein |
| GB2494851A (en) | 2011-07-07 | 2013-03-27 | Kalvista Pharmaceuticals Ltd | Plasma kallikrein inhibitors |
-
2012
- 2012-07-06 GB GB201212081A patent/GB201212081D0/en not_active Ceased
-
2013
- 2013-07-05 PL PL13737357T patent/PL2870137T3/pl unknown
- 2013-07-05 TR TR2018/09681T patent/TR201809681T4/tr unknown
- 2013-07-05 JP JP2015519357A patent/JP6367187B2/ja not_active Expired - Fee Related
- 2013-07-05 US US14/413,086 patent/US9512065B2/en not_active Expired - Fee Related
- 2013-07-05 CA CA2878319A patent/CA2878319C/en active Active
- 2013-07-05 HU HUE13737357A patent/HUE039775T2/hu unknown
- 2013-07-05 EP EP13737357.7A patent/EP2870137B8/en active Active
- 2013-07-05 ES ES13737357.7T patent/ES2679370T3/es active Active
- 2013-07-05 WO PCT/GB2013/051781 patent/WO2014006414A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| PL2870137T3 (pl) | 2018-12-31 |
| GB201212081D0 (en) | 2012-08-22 |
| JP2015528798A (ja) | 2015-10-01 |
| ES2679370T3 (es) | 2018-08-24 |
| CA2878319C (en) | 2021-02-09 |
| EP2870137B1 (en) | 2018-05-16 |
| EP2870137A1 (en) | 2015-05-13 |
| EP2870137B8 (en) | 2018-07-18 |
| WO2014006414A1 (en) | 2014-01-09 |
| TR201809681T4 (tr) | 2018-07-23 |
| US9512065B2 (en) | 2016-12-06 |
| JP6367187B2 (ja) | 2018-08-01 |
| CA2878319A1 (en) | 2014-01-09 |
| US20150191421A1 (en) | 2015-07-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL2870137T3 (pl) | Polimorfy chlorowodorku N-[(R)-1-[(S)-1-(4-aminometylo-benzylokarbamoilo)-2-fenylo- etylokarbamoilo]-2-(4-etoksy-fenylo)-etylo]-benzamidu | |
| IL228979A (en) | A rich compound and a pharmacist's application for her | |
| IL239025B (en) | fxr agonist - for the treatment of lung diseases | |
| PL3290414T3 (pl) | Sposób otrzymywania n-[5-(3,5-difluorobenzylo)-1h-indazol-3-ilo]-4-(4-metylopiperazyn-1-ylo)-2-(tetrahydropiran-4-yloamino)benzamidu | |
| KR101452195B9 (ko) | 인트라 예측 모드를 유도하는 방법 및 장치 | |
| ZA201402492B (en) | Polymorphic form of pridopidine hydrochloride | |
| HUE048753T2 (hu) | Készülék egy intrapredikciós mód származtatására | |
| PL2902384T3 (pl) | Postać chlorowodorku iwabradyny | |
| HRP20180915T1 (hr) | Spojevi koji imaju aktivnost kao antagonist muskarinskog receptora i kao agonist beta2 adrenergijskog receptora | |
| CO6880070A2 (es) | Dosis combinada fija de bimatoprost y brimonidina | |
| GB201416418D0 (en) | Method and apparatus for security-aware elasticity of application and services | |
| EP2877967A4 (en) | QUALITY INTERPRETATION SYSTEM FOR RETROFITTING A MEDICAL DEVICE | |
| PL2535237T3 (pl) | Urządzenie do amortyzowania sił nacisku | |
| EP2784074A4 (en) | PYRAZOL CONNECTION AND ITS USE FOR MEDICAL PURPOSES | |
| AP2015008407A0 (en) | N-(2-(cyclic amine)ethyl) benzamide derivatives asP2X7 inhibitors | |
| SG11201404527QA (en) | Methods and intermediates for preparing pharmaceutical agents | |
| IL231945A0 (en) | Funding dosing regimen for s1p receptor modulator or agonist | |
| GB2492113B (en) | Shower heads and shower apparatus | |
| BR112013011643A2 (pt) | aparelho e método para supressão rápida de dor neuropática, oncológica e pediátrica, resistente a opiatos e a eletroanalgesia convencional | |
| EP2857012A4 (en) | AMBROXOL HYDROCHLORIDE COMPOSITION AND MANUFACTURING METHOD THEREFOR | |
| EP2756459A4 (en) | METHOD AND COMPOSITIONS FOR THE OBJECTIVE CHARACTERIZATION OF MEDICAL PICTURES | |
| EP2786567A4 (en) | VIDEO QUALITY MEASUREMENT CONSIDERING MULTIPLE ARTIFACTS | |
| ZA201306415B (en) | Peptide deformylase inhibitors | |
| PL2781509T5 (pl) | Nowy polimorf chlorowodorku iwabradyny i sposób jego otrzymywania | |
| EP2680846A4 (en) | USE OF N- (4-METHOXYPHENYL) -1-PHENYL-1H-PYRAZOL-3-AMINE AND COMPOUNDS ASSOCIATED THEREWITH |