ATE429415T1 - Verfahren zur kristallisierung von benzphetamin - Google Patents
Verfahren zur kristallisierung von benzphetaminInfo
- Publication number
- ATE429415T1 ATE429415T1 AT05816270T AT05816270T ATE429415T1 AT E429415 T1 ATE429415 T1 AT E429415T1 AT 05816270 T AT05816270 T AT 05816270T AT 05816270 T AT05816270 T AT 05816270T AT E429415 T1 ATE429415 T1 AT E429415T1
- Authority
- AT
- Austria
- Prior art keywords
- crystallization
- organic medium
- temperature
- benzphetamine
- discovered
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- YXKTVDFXDRQTKV-HNNXBMFYSA-N benzphetamine Chemical compound C([C@H](C)N(C)CC=1C=CC=CC=1)C1=CC=CC=C1 YXKTVDFXDRQTKV-HNNXBMFYSA-N 0.000 title 1
- 229960002837 benzphetamine Drugs 0.000 title 1
- 238000002425 crystallisation Methods 0.000 abstract 5
- 230000008025 crystallization Effects 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 2
- ANFSNXAXVLRZCG-RSAXXLAASA-N benzphetamine hydrochloride Chemical compound [Cl-].C([C@H](C)[NH+](C)CC=1C=CC=CC=1)C1=CC=CC=C1 ANFSNXAXVLRZCG-RSAXXLAASA-N 0.000 abstract 2
- 229960003228 benzphetamine hydrochloride Drugs 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 238000005119 centrifugation Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 abstract 1
- 229960001252 methamphetamine Drugs 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/82—Purification; Separation; Stabilisation; Use of additives
- C07C209/84—Purification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63163504P | 2004-11-30 | 2004-11-30 | |
| US65658105P | 2005-02-25 | 2005-02-25 | |
| PCT/US2005/039448 WO2006060099A1 (en) | 2004-11-30 | 2005-11-02 | Crystallization method for benzphetamine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE429415T1 true ATE429415T1 (de) | 2009-05-15 |
Family
ID=35929609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05816270T ATE429415T1 (de) | 2004-11-30 | 2005-11-02 | Verfahren zur kristallisierung von benzphetamin |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7750187B2 (de) |
| EP (1) | EP1819661B1 (de) |
| JP (1) | JP2008521804A (de) |
| AT (1) | ATE429415T1 (de) |
| AU (1) | AU2005310229A1 (de) |
| CA (1) | CA2588724A1 (de) |
| DE (1) | DE602005014138D1 (de) |
| MX (1) | MX2007006281A (de) |
| WO (1) | WO2006060099A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008048254A1 (en) * | 2006-10-17 | 2008-04-24 | Mallinckrodt Inc. | Highly pure crystalline benzphetamine hydrochloride and processes for preparing |
| JP4914759B2 (ja) * | 2007-05-09 | 2012-04-11 | 住友化学株式会社 | 晶析方法 |
| US8569544B2 (en) * | 2009-08-19 | 2013-10-29 | Emcure Pharmaceuticals Limited | Process for preparation of benzphetamine and its pharmaceutically acceptable salts |
| GB201212081D0 (en) * | 2012-07-06 | 2012-08-22 | Kalvista Pharmaceuticals Ltd | New polymorph |
| CN110655466B (zh) * | 2019-01-16 | 2023-02-24 | 安徽贝克制药股份有限公司 | 盐酸苄非他明的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1854553A (en) | 1926-05-10 | 1932-04-19 | Nat Aniline & Chem Co Inc | Production of n-substituted amines |
| US2789138A (en) | 1952-06-02 | 1957-04-16 | Upjohn Co | d-nu-methyl-nu-benzyl-beta-phenyliso-propylamine |
| US3182060A (en) * | 1961-08-21 | 1965-05-04 | Du Pont | N, n'-disubstituted dicarboxamides and dithiocarboxamides prepared from monoenamines |
| FR2782M (fr) * | 1963-08-01 | 1964-09-07 | Amido Lab | Nouveaux médicaments actifs sur le systeme nerveux autonome et possédant des propriétés anorexigenes et stimulantes sur le systeme nerveux central. |
| US3676558A (en) | 1970-08-28 | 1972-07-11 | Upjohn Co | Anorexigenic compositions comprising 6-alkyl-1,2,3,4,5,6-hexahydroazepino 4,5-indoles as active ingredient and process of treatment |
| US4277420A (en) | 1979-09-24 | 1981-07-07 | Monsanto Company | Ephedrine and pseudoephedrine precursors |
| US4747920A (en) * | 1984-06-20 | 1988-05-31 | Battelle Memorial Institute | Solid-liquid separation process for fine particle suspensions by an electric and ultrasonic field |
| US5236922A (en) | 1984-08-20 | 1993-08-17 | Laboratoire L. Lafon | Method for treating depression using 1-(aminophenyl)-2-aminopropanone derivatives |
| CO5150225A1 (es) | 1999-03-19 | 2002-04-29 | Merck Sharp & Dohme | Derivados del tetrahidropirano y su uso como agentes terapeuticos |
| GB0020721D0 (en) | 2000-08-22 | 2000-10-11 | Merck Sharp & Dohme | Therapeutic agents |
| MX2007005873A (es) * | 2004-11-22 | 2007-07-04 | Mallinckrodt Inc | Procedimiento para la purificacion de clorhidrato de benzofetamina. |
-
2005
- 2005-11-02 US US11/719,001 patent/US7750187B2/en not_active Expired - Fee Related
- 2005-11-02 AT AT05816270T patent/ATE429415T1/de not_active IP Right Cessation
- 2005-11-02 JP JP2007543086A patent/JP2008521804A/ja not_active Withdrawn
- 2005-11-02 CA CA002588724A patent/CA2588724A1/en not_active Abandoned
- 2005-11-02 DE DE602005014138T patent/DE602005014138D1/de not_active Expired - Fee Related
- 2005-11-02 EP EP05816270A patent/EP1819661B1/de not_active Expired - Lifetime
- 2005-11-02 AU AU2005310229A patent/AU2005310229A1/en not_active Abandoned
- 2005-11-02 MX MX2007006281A patent/MX2007006281A/es not_active Application Discontinuation
- 2005-11-02 WO PCT/US2005/039448 patent/WO2006060099A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006060099A1 (en) | 2006-06-08 |
| JP2008521804A (ja) | 2008-06-26 |
| US7750187B2 (en) | 2010-07-06 |
| EP1819661B1 (de) | 2009-04-22 |
| MX2007006281A (es) | 2007-07-09 |
| EP1819661A1 (de) | 2007-08-22 |
| AU2005310229A1 (en) | 2006-06-08 |
| DE602005014138D1 (de) | 2009-06-04 |
| US20080262268A1 (en) | 2008-10-23 |
| CA2588724A1 (en) | 2006-06-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008526267A5 (de) | ||
| DE112008000893B8 (de) | Verfahren und Vorrichtung zum Herstellen von Siliziumeinkristallen und Siliziumeinkristallingot | |
| DE602004031446D1 (de) | Verfahren zur herstellung eines zellkonzentrats und einer zellzusammensetzung | |
| RU2012141149A (ru) | Способ очистки полипептидных растворов | |
| WO2009001676A1 (ja) | 油濁水再利用システム | |
| NZ752560A (en) | A thermo-responsive solution, and method of use therefor | |
| BR112015007898A2 (pt) | método e aparelho para reduzir milho contaminado por aflatoxina | |
| EP1737305A4 (de) | Verfahren zur vorbeugung oder verringerung der trübung in getränken unter verwendung von mit silan behandelten kieselsäurefiltermedien | |
| RU2017102893A (ru) | Способ отделения тритиевой воды от легкой воды | |
| MX2010000872A (es) | Un coagulante para uso en la purificacion de agua y un metodo de purificacion de agua y un aparato de purificacion de agua con aplicacion del mismo. | |
| WO2010109489A3 (en) | Method for producing clarified juice, packagible juice, ethanol and sugar from sugarcane and system thereof | |
| JP2014233699A5 (de) | ||
| DE60019098D1 (de) | Verfahren zur reinigung von polyhydroxyalkanoaten | |
| ATE429415T1 (de) | Verfahren zur kristallisierung von benzphetamin | |
| WO2008031246A3 (de) | Verfahren zur reinigung von ionischen flüssigkeiten | |
| AR081659A1 (es) | Procedimiento de obtencion de la forma cristalina ii del febuxostat | |
| RU2014127661A (ru) | Композиция метионина, предназначенная для корма для животных | |
| JP2009102263A5 (de) | ||
| WO2012010543A3 (de) | Verfahren zur klärung eines wein-gelägers | |
| ATE541037T1 (de) | Verfahren zur trennung und reinigung von nukleinsäure | |
| FR2873593B1 (fr) | Procede d'elimination de composes phenoliques polyhalogenes dans les boissons et notamment dans le vin | |
| ATE466010T1 (de) | Verfahren zur herstellung von candesartan | |
| WO2017080435A1 (zh) | 一种城市雨水处理工艺 | |
| EP1950214A4 (de) | Verfahren zur aufreinigung von episesamin | |
| RU2014104500A (ru) | Способ уменьшения образования акриламида при получении патоки |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |