CA2878319C - Polymorphs of n-[(r)-1-[(s)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethylcarbamoyl]-2-(4-ethoxy-phenyl)-ethyl]-benzamide hydrochloride - Google Patents
Polymorphs of n-[(r)-1-[(s)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethylcarbamoyl]-2-(4-ethoxy-phenyl)-ethyl]-benzamide hydrochloride Download PDFInfo
- Publication number
- CA2878319C CA2878319C CA2878319A CA2878319A CA2878319C CA 2878319 C CA2878319 C CA 2878319C CA 2878319 A CA2878319 A CA 2878319A CA 2878319 A CA2878319 A CA 2878319A CA 2878319 C CA2878319 C CA 2878319C
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- phenyl
- solid form
- ethyl
- plasma kallikrein
- ethoxy
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261668543P | 2012-07-06 | 2012-07-06 | |
| GB1212081.2 | 2012-07-06 | ||
| GB201212081A GB201212081D0 (en) | 2012-07-06 | 2012-07-06 | New polymorph |
| US61/668,543 | 2012-07-06 | ||
| PCT/GB2013/051781 WO2014006414A1 (en) | 2012-07-06 | 2013-07-05 | Polymorphs of|n-[(r)-1 -[(s)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethylcarbamoy l]-2-(4-e|thoxy-phenyl)-ethyl]-benzamide hydrochloride |
Publications (2)
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|---|---|
| CA2878319A1 CA2878319A1 (en) | 2014-01-09 |
| CA2878319C true CA2878319C (en) | 2021-02-09 |
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| CA2878319A Active CA2878319C (en) | 2012-07-06 | 2013-07-05 | Polymorphs of n-[(r)-1-[(s)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethylcarbamoyl]-2-(4-ethoxy-phenyl)-ethyl]-benzamide hydrochloride |
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| US (1) | US9512065B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2870137B8 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6367187B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2878319C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2679370T3 (cg-RX-API-DMAC7.html) |
| GB (1) | GB201212081D0 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE039775T2 (cg-RX-API-DMAC7.html) |
| PL (1) | PL2870137T3 (cg-RX-API-DMAC7.html) |
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| WO (1) | WO2014006414A1 (cg-RX-API-DMAC7.html) |
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| GB2510407A (en) | 2013-02-04 | 2014-08-06 | Kalvista Pharmaceuticals Ltd | Aqueous suspensions of kallikrein inhibitors for parenteral administration |
| TWI636047B (zh) | 2013-08-14 | 2018-09-21 | 英商卡爾維斯塔製藥有限公司 | 雜環衍生物 |
| GB201421085D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | New enzyme inhibitors |
| GB201421083D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | Enzyme inhibitors |
| JP2019507746A (ja) | 2016-03-10 | 2019-03-22 | オクシュリオン エヌブイ | 胎盤増殖因子のアンタゴナイズによる後眼部線維症の阻害 |
| SMT202000382T1 (it) | 2016-05-31 | 2020-09-10 | Kalvista Pharmaceuticals Ltd | Derivati di pirazolo come inibitori di callicreina plasmatica |
| GB201609603D0 (en) * | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide |
| GB201609607D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts |
| JOP20190144A1 (ar) | 2016-12-16 | 2019-06-16 | Janssen Pharmaceutica Nv | إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز |
| DK3555097T3 (da) | 2016-12-16 | 2022-07-25 | Janssen Pharmaceutica Nv | Imidazo[4,5-d]pyrrolo[2,3-b]pyridinforbindelser som inhibitorer af janus-kinaser |
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| GB201918994D0 (en) * | 2019-12-20 | 2020-02-05 | Kalvista Pharmaceuticals Ltd | Treatments of diabetic macular edema and impaired visual acuity |
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| IT1223401B (it) * | 1987-12-02 | 1990-09-19 | Montedison Spa | Poliesteri aromatici liquido cristallini termotropici |
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| EA022121B1 (ru) * | 2010-01-28 | 2015-11-30 | Зе Медисинс Компани (Лейпциг) Гмбх | Ингибиторы трипсиноподобных сериновых протеаз, их получение и применение |
| JP2013121919A (ja) | 2010-03-25 | 2013-06-20 | Astellas Pharma Inc | 血漿カリクレイン阻害剤 |
| WO2012004678A2 (en) | 2010-07-07 | 2012-01-12 | The Medicines Company (Leipzig) Gmbh | Serine protease inhibitors |
| US9290485B2 (en) | 2010-08-04 | 2016-03-22 | Novartis Ag | N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides |
| WO2012142308A1 (en) | 2011-04-13 | 2012-10-18 | Activesite Pharmaceuticals, Inc. | Prodrugs of inhibitors of plasma kallikrein |
| GB2494851A (en) | 2011-07-07 | 2013-03-27 | Kalvista Pharmaceuticals Ltd | Plasma kallikrein inhibitors |
-
2012
- 2012-07-06 GB GB201212081A patent/GB201212081D0/en not_active Ceased
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2013
- 2013-07-05 PL PL13737357T patent/PL2870137T3/pl unknown
- 2013-07-05 TR TR2018/09681T patent/TR201809681T4/tr unknown
- 2013-07-05 JP JP2015519357A patent/JP6367187B2/ja not_active Expired - Fee Related
- 2013-07-05 US US14/413,086 patent/US9512065B2/en not_active Expired - Fee Related
- 2013-07-05 CA CA2878319A patent/CA2878319C/en active Active
- 2013-07-05 HU HUE13737357A patent/HUE039775T2/hu unknown
- 2013-07-05 EP EP13737357.7A patent/EP2870137B8/en active Active
- 2013-07-05 ES ES13737357.7T patent/ES2679370T3/es active Active
- 2013-07-05 WO PCT/GB2013/051781 patent/WO2014006414A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| PL2870137T3 (pl) | 2018-12-31 |
| GB201212081D0 (en) | 2012-08-22 |
| JP2015528798A (ja) | 2015-10-01 |
| ES2679370T3 (es) | 2018-08-24 |
| HUE039775T2 (hu) | 2019-02-28 |
| EP2870137B1 (en) | 2018-05-16 |
| EP2870137A1 (en) | 2015-05-13 |
| EP2870137B8 (en) | 2018-07-18 |
| WO2014006414A1 (en) | 2014-01-09 |
| TR201809681T4 (tr) | 2018-07-23 |
| US9512065B2 (en) | 2016-12-06 |
| JP6367187B2 (ja) | 2018-08-01 |
| CA2878319A1 (en) | 2014-01-09 |
| US20150191421A1 (en) | 2015-07-09 |
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