JP6332654B2 - ヒストンデメチラーゼ阻害剤 - Google Patents

ヒストンデメチラーゼ阻害剤 Download PDF

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Publication number
JP6332654B2
JP6332654B2 JP2016501713A JP2016501713A JP6332654B2 JP 6332654 B2 JP6332654 B2 JP 6332654B2 JP 2016501713 A JP2016501713 A JP 2016501713A JP 2016501713 A JP2016501713 A JP 2016501713A JP 6332654 B2 JP6332654 B2 JP 6332654B2
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JP
Japan
Prior art keywords
compound according
pyrimidin
alkyl
found
pyrido
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Japanese (ja)
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JP2016512834A (ja
JP2016512834A5 (enExample
Inventor
カノウニ，トウフィケ
スタッフォード，ジェフリー，アラン
ヴィール，ジェイムス，マービン
ウォレス，マイケル，ブレナン
Original Assignee
セルジーン クオンティセル リサーチ，インク．
セルジーン クオンティセル リサーチ，インク．
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Publication of JP2016512834A publication Critical patent/JP2016512834A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2016501713A 2013-03-15 2014-03-12 ヒストンデメチラーゼ阻害剤 Expired - Fee Related JP6332654B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361791406P 2013-03-15 2013-03-15
US61/791,406 2013-03-15
PCT/US2014/024998 WO2014151106A1 (en) 2013-03-15 2014-03-12 Histone demethylase inhibitors

Publications (3)

Publication Number Publication Date
JP2016512834A JP2016512834A (ja) 2016-05-09
JP2016512834A5 JP2016512834A5 (enExample) 2017-04-13
JP6332654B2 true JP6332654B2 (ja) 2018-05-30

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ID=51580888

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016501713A Expired - Fee Related JP6332654B2 (ja) 2013-03-15 2014-03-12 ヒストンデメチラーゼ阻害剤

Country Status (17)

Country Link
US (2) US9994562B2 (enExample)
EP (1) EP2970211B1 (enExample)
JP (1) JP6332654B2 (enExample)
AU (1) AU2014235280B2 (enExample)
CA (1) CA2903465A1 (enExample)
CY (1) CY1119476T1 (enExample)
DK (1) DK2970211T3 (enExample)
ES (1) ES2644828T3 (enExample)
HR (1) HRP20171609T1 (enExample)
HU (1) HUE034906T2 (enExample)
LT (1) LT2970211T (enExample)
PL (1) PL2970211T3 (enExample)
PT (1) PT2970211T (enExample)
RS (1) RS56561B1 (enExample)
SI (1) SI2970211T1 (enExample)
SM (1) SMT201700493T1 (enExample)
WO (1) WO2014151106A1 (enExample)

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US20170057955A1 (en) * 2015-08-26 2017-03-02 Dong-A Socio Holdings Co., Ltd. Pyridopyrimidinone Compounds for Modulating the Catalytic Activity of Histone Lysine Demethylases (KDMs)
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US10150754B2 (en) 2016-04-19 2018-12-11 Celgene Quanticel Research, Inc. Histone demethylase inhibitors
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TW202014193A (zh) 2018-05-03 2020-04-16 捷克科學院有機化學與生物化學研究所 包含碳環核苷酸之2’3’－環二核苷酸
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WO2020028097A1 (en) 2018-08-01 2020-02-06 Gilead Sciences, Inc. Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid
JP7158577B2 (ja) 2018-10-24 2022-10-21 ギリアード サイエンシーズ， インコーポレイテッド Ｐｄ－１／ｐｄ－ｌ１阻害剤
TWI721624B (zh) 2018-10-31 2021-03-11 美商基利科學股份有限公司 經取代之6-氮雜苯并咪唑化合物
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Also Published As

Publication number Publication date
PL2970211T3 (pl) 2018-01-31
SI2970211T1 (sl) 2017-12-29
JP2016512834A (ja) 2016-05-09
CA2903465A1 (en) 2014-09-25
US9994562B2 (en) 2018-06-12
WO2014151106A1 (en) 2014-09-25
US20160039808A1 (en) 2016-02-11
RS56561B1 (sr) 2018-02-28
US10526327B2 (en) 2020-01-07
SMT201700493T1 (it) 2017-11-15
CY1119476T1 (el) 2018-03-07
US20180319793A1 (en) 2018-11-08
EP2970211A1 (en) 2016-01-20
DK2970211T3 (en) 2017-10-16
AU2014235280B2 (en) 2017-08-31
PT2970211T (pt) 2017-10-31
HUE034906T2 (hu) 2018-03-28
LT2970211T (lt) 2017-10-25
EP2970211A4 (en) 2016-08-03
HRP20171609T1 (hr) 2017-12-15
ES2644828T3 (es) 2017-11-30
AU2014235280A1 (en) 2015-09-17
EP2970211B1 (en) 2017-07-26

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