PL2970211T3 - Inhibitory demetylazy histonowej - Google Patents
Inhibitory demetylazy histonowejInfo
- Publication number
- PL2970211T3 PL2970211T3 PL14768099T PL14768099T PL2970211T3 PL 2970211 T3 PL2970211 T3 PL 2970211T3 PL 14768099 T PL14768099 T PL 14768099T PL 14768099 T PL14768099 T PL 14768099T PL 2970211 T3 PL2970211 T3 PL 2970211T3
- Authority
- PL
- Poland
- Prior art keywords
- histone demethylase
- demethylase inhibitors
- inhibitors
- histone
- demethylase
- Prior art date
Links
- 102000008157 Histone Demethylases Human genes 0.000 title 1
- 108010074870 Histone Demethylases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361791406P | 2013-03-15 | 2013-03-15 | |
| EP14768099.5A EP2970211B1 (en) | 2013-03-15 | 2014-03-12 | Histone demethylase inhibitors |
| PCT/US2014/024998 WO2014151106A1 (en) | 2013-03-15 | 2014-03-12 | Histone demethylase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2970211T3 true PL2970211T3 (pl) | 2018-01-31 |
Family
ID=51580888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL14768099T PL2970211T3 (pl) | 2013-03-15 | 2014-03-12 | Inhibitory demetylazy histonowej |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9994562B2 (pl) |
| EP (1) | EP2970211B1 (pl) |
| JP (1) | JP6332654B2 (pl) |
| AU (1) | AU2014235280B2 (pl) |
| CA (1) | CA2903465A1 (pl) |
| CY (1) | CY1119476T1 (pl) |
| DK (1) | DK2970211T3 (pl) |
| ES (1) | ES2644828T3 (pl) |
| HR (1) | HRP20171609T1 (pl) |
| HU (1) | HUE034906T2 (pl) |
| LT (1) | LT2970211T (pl) |
| PL (1) | PL2970211T3 (pl) |
| PT (1) | PT2970211T (pl) |
| RS (1) | RS56561B1 (pl) |
| SI (1) | SI2970211T1 (pl) |
| SM (1) | SMT201700493T1 (pl) |
| WO (1) | WO2014151106A1 (pl) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102160320B1 (ko) | 2012-10-02 | 2020-09-28 | 에피테라퓨틱스 에이피에스 | 히스톤 탈메틸효소의 저해제 |
| SI2961736T1 (en) | 2013-02-27 | 2018-06-29 | Gilead Sciences, Inc. | Histone demethylase inhibitors |
| SI2970211T1 (sl) | 2013-03-15 | 2017-12-29 | Quanticel Pharmaceuticals Inc. | Inhibitorji histon demetilaze |
| MX2017002451A (es) | 2014-08-27 | 2017-05-23 | Gilead Sciences Inc | Compuestos y metodos para inhibir histona desmetilasas. |
| US10030017B2 (en) | 2014-09-17 | 2018-07-24 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| WO2016044429A1 (en) | 2014-09-17 | 2016-03-24 | Quanticel Pharmaceuticals, Inc. | Histone demethylase inhibitors |
| US9834550B2 (en) | 2014-10-29 | 2017-12-05 | Dong-A St Co., Ltd. | Pyridopyrimidinone compounds for modulating the catalytic activity of histone lysine demethylases (KDMs) |
| EP3242875B1 (en) * | 2015-01-09 | 2022-02-23 | Genentech, Inc. | 4,5-dihydroimidazole derivatives and their use as histone demethylase (kdm2b) inhibitors |
| WO2016112284A1 (en) * | 2015-01-09 | 2016-07-14 | Genentech, Inc. | (piperidin-3-yl)(naphthalen-2-yl)methanone derivatives and related compounds as inhibitors of the histone demethylase kdm2b for the treatment of cancer |
| US20170057955A1 (en) * | 2015-08-26 | 2017-03-02 | Dong-A Socio Holdings Co., Ltd. | Pyridopyrimidinone Compounds for Modulating the Catalytic Activity of Histone Lysine Demethylases (KDMs) |
| ES2921009T3 (es) * | 2016-03-15 | 2022-08-16 | Celgene Quanticel Res Inc | Inhibidores de desmetilasas de histonas |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| WO2017205078A1 (en) | 2016-05-27 | 2017-11-30 | Gilead Sciences, Inc. | Methods for treating hepatitis b virus infections using ns5a, ns5b or ns3 inhibitors |
| BR102017010009A2 (pt) | 2016-05-27 | 2017-12-12 | Gilead Sciences, Inc. | Compounds for the treatment of hepatitis b virus infection |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| US10640499B2 (en) | 2016-09-02 | 2020-05-05 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| ES2906581T3 (es) | 2016-09-02 | 2022-04-19 | Gilead Sciences Inc | Compuestos moduladores de los receptores tipo Toll |
| BR112019007450A2 (pt) | 2016-10-14 | 2020-07-07 | Precision Biosciences, Inc. | meganucleases modificadas específicas para sequências de reconhecimento no genoma do vírus da hepatite b |
| TWI714820B (zh) | 2017-01-31 | 2021-01-01 | 美商基利科學股份有限公司 | 替諾福韋艾拉酚胺(tenofovir alafenamide)之晶型 |
| JOP20180008A1 (ar) | 2017-02-02 | 2019-01-30 | Gilead Sciences Inc | مركبات لعلاج إصابة بعدوى فيروس الالتهاب الكبدي b |
| WO2018175670A1 (en) * | 2017-03-22 | 2018-09-27 | The Research Foundation For The State University Of New York | Matrix metalloproteinase-9 hemopexin domain inhibitors and methods of treatment using same |
| JOP20180040A1 (ar) | 2017-04-20 | 2019-01-30 | Gilead Sciences Inc | مثبطات pd-1/pd-l1 |
| CN111566120B (zh) | 2017-12-20 | 2023-09-29 | 捷克共和国有机化学与生物化学研究所 | 活化sting转接蛋白的具有膦酸酯键的3’3’环状二核苷酸 |
| EP3728282B1 (en) | 2017-12-20 | 2023-11-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| CN111712494A (zh) | 2018-02-13 | 2020-09-25 | 吉利德科学公司 | Pd-1/pd-l1抑制剂 |
| CA3091142C (en) | 2018-02-26 | 2023-04-11 | Gilead Sciences, Inc. | Substituted pyrrolizine compounds and uses thereof |
| WO2019195181A1 (en) | 2018-04-05 | 2019-10-10 | Gilead Sciences, Inc. | Antibodies and fragments thereof that bind hepatitis b virus protein x |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | ２，２，─環二核苷酸 |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| US11142750B2 (en) | 2018-04-12 | 2021-10-12 | Precision Biosciences, Inc. | Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome |
| EP4600247A3 (en) | 2018-04-19 | 2025-11-19 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| WO2019211799A1 (en) | 2018-05-03 | 2019-11-07 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide |
| KR20230159715A (ko) | 2018-07-13 | 2023-11-21 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| WO2020028097A1 (en) | 2018-08-01 | 2020-02-06 | Gilead Sciences, Inc. | Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid |
| AU2019366355B2 (en) | 2018-10-24 | 2022-10-13 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| CN117105933A (zh) | 2018-10-31 | 2023-11-24 | 吉利德科学公司 | 具有hpk1抑制活性的取代的6-氮杂苯并咪唑化合物 |
| CN113227089B (zh) | 2018-10-31 | 2024-07-05 | 吉利德科学公司 | 作为hpk1抑制剂的取代的6-氮杂苯并咪唑化合物 |
| US20220143061A1 (en) | 2019-03-07 | 2022-05-12 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotides and prodrugs thereof |
| EP3934757B1 (en) | 2019-03-07 | 2023-02-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 2'3'-cyclic dinucleotides and prodrugs thereof |
| EP3935065A1 (en) | 2019-03-07 | 2022-01-12 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
| TWI751516B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI751517B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| EP3972695A1 (en) | 2019-05-23 | 2022-03-30 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
| JP7295283B2 (ja) | 2019-06-25 | 2023-06-20 | ギリアード サイエンシーズ， インコーポレイテッド | Ｆｌｔ３ｌ－ｆｃ融合タンパク質及び使用方法 |
| WO2021011891A1 (en) | 2019-07-18 | 2021-01-21 | Gilead Sciences, Inc. | Long-acting formulations of tenofovir alafenamide |
| EP4017476A1 (en) | 2019-08-19 | 2022-06-29 | Gilead Sciences, Inc. | Pharmaceutical formulations of tenofovir alafenamide |
| HRP20241379T1 (hr) | 2019-09-30 | 2024-12-20 | Gilead Sciences, Inc. | Cjepiva za hbv i postupci za liječenje hbv |
| ES3022990T3 (en) | 2019-12-06 | 2025-05-29 | Prec Biosciences Inc | Optimized engineered meganucleases having specificity for a recognition sequence in the hepatitis b virus genome |
| TWI845826B (zh) | 2020-03-20 | 2024-06-21 | 美商基利科學股份有限公司 | 4'-c-經取代-2-鹵基-2'-去氧腺苷核苷之前藥及其製造與使用方法 |
| MX2023001507A (es) | 2020-08-07 | 2023-03-06 | Gilead Sciences Inc | Profarmacos de analogos de nucleotidos de fosfonamida y su uso farmaceutico. |
| TWI815194B (zh) | 2020-10-22 | 2023-09-11 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
| TW202348237A (zh) | 2021-05-13 | 2023-12-16 | 美商基利科學股份有限公司 | TLR8調節化合物及抗HBV siRNA療法之組合 |
| EP4359415A1 (en) | 2021-06-23 | 2024-05-01 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| JP7686091B2 (ja) | 2021-06-23 | 2025-05-30 | ギリアード サイエンシーズ， インコーポレイテッド | ジアシルグリセロールキナーゼ調節化合物 |
| CN117480155A (zh) | 2021-06-23 | 2024-01-30 | 吉利德科学公司 | 二酰基甘油激酶调节化合物 |
| CN117377671A (zh) | 2021-06-23 | 2024-01-09 | 吉利德科学公司 | 二酰基甘油激酶调节化合物 |
| WO2025240246A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with ribavirin |
| US20250345389A1 (en) | 2024-05-13 | 2025-11-13 | Gilead Sciences, Inc. | Combination therapies |
| US20250345390A1 (en) | 2024-05-13 | 2025-11-13 | Gilead Sciences, Inc. | Combination therapies |
| WO2025240242A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with ribavirin |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5034393A (en) * | 1989-07-27 | 1991-07-23 | Dowelanco | Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives |
| HRP970371A2 (en) * | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
| EP1485380B1 (en) | 2002-03-15 | 2010-05-19 | Vertex Pharmaceuticals Incorporated | Azolylaminoazines as inhibitors of protein kinases |
| EP2292620A3 (en) * | 2003-07-14 | 2011-06-22 | Arena Pharmaceuticals, Inc. | Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prohylaxis and treatment of disorders related thereto |
| AU2005290081B2 (en) | 2004-08-23 | 2010-12-02 | Merck Sharp & Dohme Corp. | Inhibitors of Akt activity |
| US20110319409A1 (en) * | 2010-06-23 | 2011-12-29 | Cox Christopher D | 7-aza-quinazoline pde10 inhibitors |
| GB201112607D0 (en) * | 2011-07-22 | 2011-09-07 | Glaxo Group Ltd | Novel compounds |
| SI2970211T1 (sl) | 2013-03-15 | 2017-12-29 | Quanticel Pharmaceuticals Inc. | Inhibitorji histon demetilaze |
| WO2016044429A1 (en) | 2014-09-17 | 2016-03-24 | Quanticel Pharmaceuticals, Inc. | Histone demethylase inhibitors |
-
2014
- 2014-03-12 SI SI201430421T patent/SI2970211T1/sl unknown
- 2014-03-12 EP EP14768099.5A patent/EP2970211B1/en active Active
- 2014-03-12 JP JP2016501713A patent/JP6332654B2/ja not_active Expired - Fee Related
- 2014-03-12 WO PCT/US2014/024998 patent/WO2014151106A1/en not_active Ceased
- 2014-03-12 PT PT147680995T patent/PT2970211T/pt unknown
- 2014-03-12 SM SM20170493T patent/SMT201700493T1/it unknown
- 2014-03-12 PL PL14768099T patent/PL2970211T3/pl unknown
- 2014-03-12 HR HRP20171609TT patent/HRP20171609T1/hr unknown
- 2014-03-12 ES ES14768099.5T patent/ES2644828T3/es active Active
- 2014-03-12 AU AU2014235280A patent/AU2014235280B2/en not_active Ceased
- 2014-03-12 CA CA2903465A patent/CA2903465A1/en not_active Abandoned
- 2014-03-12 RS RS20171070A patent/RS56561B1/sr unknown
- 2014-03-12 DK DK14768099.5T patent/DK2970211T3/en active
- 2014-03-12 LT LTEP14768099.5T patent/LT2970211T/lt unknown
- 2014-03-12 HU HUE14768099A patent/HUE034906T2/hu unknown
- 2014-03-12 US US14/774,335 patent/US9994562B2/en active Active
-
2017
- 2017-10-23 CY CY20171101101T patent/CY1119476T1/el unknown
-
2018
- 2018-05-04 US US15/971,912 patent/US10526327B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2903465A1 (en) | 2014-09-25 |
| JP6332654B2 (ja) | 2018-05-30 |
| AU2014235280B2 (en) | 2017-08-31 |
| SMT201700493T1 (it) | 2017-11-15 |
| PT2970211T (pt) | 2017-10-31 |
| EP2970211A1 (en) | 2016-01-20 |
| US20160039808A1 (en) | 2016-02-11 |
| AU2014235280A1 (en) | 2015-09-17 |
| EP2970211B1 (en) | 2017-07-26 |
| EP2970211A4 (en) | 2016-08-03 |
| WO2014151106A1 (en) | 2014-09-25 |
| JP2016512834A (ja) | 2016-05-09 |
| US9994562B2 (en) | 2018-06-12 |
| US20180319793A1 (en) | 2018-11-08 |
| LT2970211T (lt) | 2017-10-25 |
| CY1119476T1 (el) | 2018-03-07 |
| RS56561B1 (sr) | 2018-02-28 |
| DK2970211T3 (en) | 2017-10-16 |
| SI2970211T1 (sl) | 2017-12-29 |
| ES2644828T3 (es) | 2017-11-30 |
| US10526327B2 (en) | 2020-01-07 |
| HUE034906T2 (hu) | 2018-03-28 |
| HRP20171609T1 (hr) | 2017-12-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL280820A (en) | Histone deacetylase inhibitors | |
| LT2970211T (lt) | Histono demetilazės inhibitoriai | |
| ZA201505007B (en) | Histone demethylase inhibitors | |
| SMT201800070T1 (it) | Inibiorti di istone demetilasi | |
| IL242388B (en) | New histone deacetylase inhibitors | |
| IL240439A0 (en) | Inhibitors of histone demethylases | |
| IL249629A0 (en) | Histone demethylase inhibitors | |
| ZA201506156B (en) | Novel inhibitors | |
| IL251103A0 (en) | Histone demethylase inhibitors | |
| IL251179A0 (en) | Histone demethylase inhibitors | |
| IL245737B (en) | Glucosylceramide synthase inhibitors | |
| IL251184A0 (en) | Histone demethylase inhibitors | |
| PT2961736T (pt) | Inibidores de histona desmetilases |