HRP20171609T1 - Inhibitori histon demetilaze - Google Patents
Inhibitori histon demetilaze Download PDFInfo
- Publication number
- HRP20171609T1 HRP20171609T1 HRP20171609TT HRP20171609T HRP20171609T1 HR P20171609 T1 HRP20171609 T1 HR P20171609T1 HR P20171609T T HRP20171609T T HR P20171609TT HR P20171609 T HRP20171609 T HR P20171609T HR P20171609 T1 HRP20171609 T1 HR P20171609T1
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- heterocyclyl
- compound according
- heteroaryl
- carbocyclyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361791406P | 2013-03-15 | 2013-03-15 | |
| EP14768099.5A EP2970211B1 (en) | 2013-03-15 | 2014-03-12 | Histone demethylase inhibitors |
| PCT/US2014/024998 WO2014151106A1 (en) | 2013-03-15 | 2014-03-12 | Histone demethylase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20171609T1 true HRP20171609T1 (hr) | 2017-12-15 |
Family
ID=51580888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20171609TT HRP20171609T1 (hr) | 2013-03-15 | 2014-03-12 | Inhibitori histon demetilaze |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9994562B2 (enExample) |
| EP (1) | EP2970211B1 (enExample) |
| JP (1) | JP6332654B2 (enExample) |
| AU (1) | AU2014235280B2 (enExample) |
| CA (1) | CA2903465A1 (enExample) |
| CY (1) | CY1119476T1 (enExample) |
| DK (1) | DK2970211T3 (enExample) |
| ES (1) | ES2644828T3 (enExample) |
| HR (1) | HRP20171609T1 (enExample) |
| HU (1) | HUE034906T2 (enExample) |
| LT (1) | LT2970211T (enExample) |
| PL (1) | PL2970211T3 (enExample) |
| PT (1) | PT2970211T (enExample) |
| RS (1) | RS56561B1 (enExample) |
| SI (1) | SI2970211T1 (enExample) |
| SM (1) | SMT201700493T1 (enExample) |
| WO (1) | WO2014151106A1 (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2015003959A (es) | 2012-10-02 | 2015-11-16 | Epitherapeutics Aps | Inhibidores de histona demetilasas. |
| AU2014222756B2 (en) | 2013-02-27 | 2018-07-26 | Gilead Sciences, Inc. | Inhibitors of histone demethylases |
| DK2970211T3 (en) | 2013-03-15 | 2017-10-16 | Quanticel Pharmaceuticals Inc | HISTONDEMETHYLASE INHIBITORS |
| KR20170040805A (ko) | 2014-08-27 | 2017-04-13 | 길리애드 사이언시즈, 인코포레이티드 | 히스톤 데메틸라제를 억제하기 위한 화합물 및 방법 |
| US10030017B2 (en) | 2014-09-17 | 2018-07-24 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| KR20170048591A (ko) | 2014-09-17 | 2017-05-08 | 셀젠 콴티셀 리서치, 인크. | 히스톤 데메틸라제 억제제 |
| CN107001358A (zh) | 2014-10-29 | 2017-08-01 | 东亚St株式会社 | 调节组蛋白赖氨酸脱甲基酶(kdm)催化活性的新型吡啶并嘧啶酮化合物 |
| CN107406414B (zh) * | 2015-01-09 | 2022-04-19 | 基因泰克公司 | 作为用于治疗癌症的组蛋白脱甲基酶kdm2b的抑制剂的(哌啶-3-基)(萘-2-基)甲酮衍生物 |
| WO2016112251A1 (en) * | 2015-01-09 | 2016-07-14 | Genentech, Inc. | 4,5-dihydroimidazole derivatives and their use as histone demethylase (kdm2b) inhibitors |
| US20170057955A1 (en) * | 2015-08-26 | 2017-03-02 | Dong-A Socio Holdings Co., Ltd. | Pyridopyrimidinone Compounds for Modulating the Catalytic Activity of Histone Lysine Demethylases (KDMs) |
| ES2921009T3 (es) * | 2016-03-15 | 2022-08-16 | Celgene Quanticel Res Inc | Inhibidores de desmetilasas de histonas |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
| KR102202984B1 (ko) | 2016-05-27 | 2021-01-13 | 길리애드 사이언시즈, 인코포레이티드 | Ns5a, ns5b 또는 ns3 억제제를 사용하여 b형 간염 바이러스 감염을 치료하는 방법 |
| BR102017010009A2 (pt) | 2016-05-27 | 2017-12-12 | Gilead Sciences, Inc. | Compounds for the treatment of hepatitis b virus infection |
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| CN117402852A (zh) | 2016-10-14 | 2024-01-16 | 精密生物科学公司 | 对乙肝病毒基因组中的识别序列特异性的工程化大范围核酸酶 |
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| JOP20180008A1 (ar) | 2017-02-02 | 2019-01-30 | Gilead Sciences Inc | مركبات لعلاج إصابة بعدوى فيروس الالتهاب الكبدي b |
| US11040947B2 (en) * | 2017-03-22 | 2021-06-22 | The Research Foundation For The State University Of New York | Substituted quinazolines as matrix metalloproteinase-9 hemopexin domain inhibitors |
| JOP20180040A1 (ar) | 2017-04-20 | 2019-01-30 | Gilead Sciences Inc | مثبطات pd-1/pd-l1 |
| CN111511754B (zh) | 2017-12-20 | 2023-09-12 | 捷克共和国有机化学与生物化学研究所 | 活化sting转接蛋白的具有膦酸酯键的2’3’环状二核苷酸 |
| AU2018392213B2 (en) | 2017-12-20 | 2021-03-04 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein |
| UA126458C2 (uk) | 2018-02-13 | 2022-10-05 | Гіліад Сайєнсіз, Інк. | Інгібітори pd-1/pd-l1 |
| ES2962605T3 (es) | 2018-02-26 | 2024-03-20 | Gilead Sciences Inc | Compuestos de pirrolizina sustituidos como inhibidores de la replicación del VHB |
| WO2019195181A1 (en) | 2018-04-05 | 2019-10-10 | Gilead Sciences, Inc. | Antibodies and fragments thereof that bind hepatitis b virus protein x |
| TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | ２，２，─環二核苷酸 |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| US11142750B2 (en) | 2018-04-12 | 2021-10-12 | Precision Biosciences, Inc. | Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome |
| US10899735B2 (en) | 2018-04-19 | 2021-01-26 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| TW202014193A (zh) | 2018-05-03 | 2020-04-16 | 捷克科學院有機化學與生物化學研究所 | 包含碳環核苷酸之2’3’－環二核苷酸 |
| EP3820572B1 (en) | 2018-07-13 | 2023-08-16 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| WO2020028097A1 (en) | 2018-08-01 | 2020-02-06 | Gilead Sciences, Inc. | Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid |
| AU2019366355B2 (en) | 2018-10-24 | 2022-10-13 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| JP7273172B2 (ja) | 2018-10-31 | 2023-05-12 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｐｋ１阻害活性を有する置換６－アザベンゾイミダゾール化合物 |
| BR112021008255A2 (pt) | 2018-10-31 | 2021-08-03 | Gilead Sciences, Inc. | compostos de 6-azabenzimidazol substituídos como inibidores de hpk1 |
| WO2020178770A1 (en) | 2019-03-07 | 2020-09-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotides and prodrugs thereof |
| US12318403B2 (en) | 2019-03-07 | 2025-06-03 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2′3′-cyclic dinucleotides and prodrugs thereof |
| US11766447B2 (en) | 2019-03-07 | 2023-09-26 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3′3′-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
| TWI751516B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI751517B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| EP3972695A1 (en) | 2019-05-23 | 2022-03-30 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
| MX2021015452A (es) | 2019-06-25 | 2022-02-11 | Gilead Sciences Inc | Proteinas de fusion flt3l-fc y metodos de uso. |
| WO2021011891A1 (en) | 2019-07-18 | 2021-01-21 | Gilead Sciences, Inc. | Long-acting formulations of tenofovir alafenamide |
| US20220296619A1 (en) | 2019-08-19 | 2022-09-22 | Gilead Sciences, Inc. | Pharmaceutical formulations of tenofovir alafenamide |
| IL315295A (en) | 2019-09-30 | 2024-10-01 | Gilead Sciences Inc | Hbv vaccines and methods treating hbv |
| WO2021113765A1 (en) | 2019-12-06 | 2021-06-10 | Precision Biosciences, Inc. | Optimized engineered meganucleases having specificity for a recognition sequence in the hepatitis b virus genome |
| JP2023518433A (ja) | 2020-03-20 | 2023-05-01 | ギリアード サイエンシーズ， インコーポレイテッド | ４’－ｃ－置換－２－ハロ－２’－デオキシアデノシンヌクレオシドのプロドラッグ並びにその製造法及び使用法 |
| EP4192474B1 (en) | 2020-08-07 | 2025-09-10 | Gilead Sciences, Inc. | Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use |
| TWI815194B (zh) | 2020-10-22 | 2023-09-11 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
| TW202310852A (zh) | 2021-05-13 | 2023-03-16 | 美商基利科學股份有限公司 | ＴＬＲ８調節化合物及抗ＨＢＶ ｓｉＲＮＡ療法之組合 |
| KR20240005901A (ko) | 2021-06-23 | 2024-01-12 | 길리애드 사이언시즈, 인코포레이티드 | 디아실글리세롤 키나제 조절 화합물 |
| EP4359411A1 (en) | 2021-06-23 | 2024-05-01 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| KR20240023629A (ko) | 2021-06-23 | 2024-02-22 | 길리애드 사이언시즈, 인코포레이티드 | 디아실글리세롤 키나제 조절 화합물 |
| CR20230585A (es) | 2021-06-23 | 2024-02-19 | Gilead Sciences Inc | Compuestos Moduladores de Diacilglicerol Quinasa. |
| WO2025240242A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with ribavirin |
| US20250345389A1 (en) | 2024-05-13 | 2025-11-13 | Gilead Sciences, Inc. | Combination therapies |
| WO2025240246A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with ribavirin |
| US20250345390A1 (en) | 2024-05-13 | 2025-11-13 | Gilead Sciences, Inc. | Combination therapies |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5034393A (en) * | 1989-07-27 | 1991-07-23 | Dowelanco | Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives |
| HRP970371A2 (en) * | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
| US20040009981A1 (en) | 2002-03-15 | 2004-01-15 | David Bebbington | Compositions useful as inhibitors of protein kinases |
| KR20060056944A (ko) * | 2003-07-14 | 2006-05-25 | 아레나 파마슈티칼스, 인크. | 대사 조절제로서 융합된 아릴 및 헤테로아릴 유도체 및이에 관련된 장애의 예방 또는 치료 |
| CA2576172A1 (en) | 2004-08-23 | 2006-04-06 | Merck & Co., Inc. | Inhibitors of akt activity |
| US20110319409A1 (en) * | 2010-06-23 | 2011-12-29 | Cox Christopher D | 7-aza-quinazoline pde10 inhibitors |
| GB201112607D0 (en) | 2011-07-22 | 2011-09-07 | Glaxo Group Ltd | Novel compounds |
| DK2970211T3 (en) | 2013-03-15 | 2017-10-16 | Quanticel Pharmaceuticals Inc | HISTONDEMETHYLASE INHIBITORS |
| KR20170048591A (ko) | 2014-09-17 | 2017-05-08 | 셀젠 콴티셀 리서치, 인크. | 히스톤 데메틸라제 억제제 |
-
2014
- 2014-03-12 DK DK14768099.5T patent/DK2970211T3/en active
- 2014-03-12 JP JP2016501713A patent/JP6332654B2/ja not_active Expired - Fee Related
- 2014-03-12 HR HRP20171609TT patent/HRP20171609T1/hr unknown
- 2014-03-12 LT LTEP14768099.5T patent/LT2970211T/lt unknown
- 2014-03-12 HU HUE14768099A patent/HUE034906T2/hu unknown
- 2014-03-12 PL PL14768099T patent/PL2970211T3/pl unknown
- 2014-03-12 ES ES14768099.5T patent/ES2644828T3/es active Active
- 2014-03-12 AU AU2014235280A patent/AU2014235280B2/en not_active Ceased
- 2014-03-12 SM SM20170493T patent/SMT201700493T1/it unknown
- 2014-03-12 CA CA2903465A patent/CA2903465A1/en not_active Abandoned
- 2014-03-12 EP EP14768099.5A patent/EP2970211B1/en active Active
- 2014-03-12 US US14/774,335 patent/US9994562B2/en active Active
- 2014-03-12 SI SI201430421T patent/SI2970211T1/sl unknown
- 2014-03-12 RS RS20171070A patent/RS56561B1/sr unknown
- 2014-03-12 WO PCT/US2014/024998 patent/WO2014151106A1/en not_active Ceased
- 2014-03-12 PT PT147680995T patent/PT2970211T/pt unknown
-
2017
- 2017-10-23 CY CY20171101101T patent/CY1119476T1/el unknown
-
2018
- 2018-05-04 US US15/971,912 patent/US10526327B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CY1119476T1 (el) | 2018-03-07 |
| RS56561B1 (sr) | 2018-02-28 |
| PL2970211T3 (pl) | 2018-01-31 |
| WO2014151106A1 (en) | 2014-09-25 |
| EP2970211B1 (en) | 2017-07-26 |
| AU2014235280A1 (en) | 2015-09-17 |
| PT2970211T (pt) | 2017-10-31 |
| US9994562B2 (en) | 2018-06-12 |
| AU2014235280B2 (en) | 2017-08-31 |
| EP2970211A1 (en) | 2016-01-20 |
| EP2970211A4 (en) | 2016-08-03 |
| SMT201700493T1 (it) | 2017-11-15 |
| US20160039808A1 (en) | 2016-02-11 |
| LT2970211T (lt) | 2017-10-25 |
| SI2970211T1 (sl) | 2017-12-29 |
| US10526327B2 (en) | 2020-01-07 |
| JP6332654B2 (ja) | 2018-05-30 |
| JP2016512834A (ja) | 2016-05-09 |
| DK2970211T3 (en) | 2017-10-16 |
| US20180319793A1 (en) | 2018-11-08 |
| ES2644828T3 (es) | 2017-11-30 |
| CA2903465A1 (en) | 2014-09-25 |
| HUE034906T2 (hu) | 2018-03-28 |
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