JP6322189B2 - Ｍｉｒ−２１活性を調節するためのマイクロｒｎａ化合物及び方法 - Google Patents

Ｍｉｒ−２１活性を調節するためのマイクロｒｎａ化合物及び方法 Download PDF

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JP6322189B2
JP6322189B2 JP2015509097A JP2015509097A JP6322189B2 JP 6322189 B2 JP6322189 B2 JP 6322189B2 JP 2015509097 A JP2015509097 A JP 2015509097A JP 2015509097 A JP2015509097 A JP 2015509097A JP 6322189 B2 JP6322189 B2 JP 6322189B2
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nucleoside
certain embodiments
mir
fibrosis
nucleosides
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JP2015519891A (ja
JP2015519891A5 (OSRAM
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バルクリシェン バート
バルクリシェン バート
エリック マーカッソン
エリック マーカッソン
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レグルス セラピューティクス インコーポレイテッド
レグルス セラピューティクス インコーポレイテッド
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JP2015509097A 2012-04-25 2013-04-24 Ｍｉｒ−２１活性を調節するためのマイクロｒｎａ化合物及び方法 Active JP6322189B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261741783P 2012-04-25 2012-04-25
US61/741,783 2012-04-25
US201261717927P 2012-10-24 2012-10-24
US61/717,927 2012-10-24
US201361779913P 2013-03-13 2013-03-13
US61/779,913 2013-03-13
PCT/US2013/037913 WO2013163258A1 (en) 2012-04-25 2013-04-24 Microrna compounds and methods for modulating mir-21 activity

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JP2015519891A JP2015519891A (ja) 2015-07-16
JP2015519891A5 JP2015519891A5 (OSRAM) 2016-06-09
JP6322189B2 true JP6322189B2 (ja) 2018-05-09

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US (5) US8969317B2 (OSRAM)
EP (1) EP2841579B1 (OSRAM)
JP (1) JP6322189B2 (OSRAM)
KR (4) KR102369722B1 (OSRAM)
CN (1) CN104254607B (OSRAM)
AR (1) AR090825A1 (OSRAM)
AU (1) AU2013251696B2 (OSRAM)
BR (1) BR112014026639A8 (OSRAM)
CA (1) CA2869639A1 (OSRAM)
CL (3) CL2014002844A1 (OSRAM)
CO (1) CO7111303A2 (OSRAM)
CR (1) CR20140524A (OSRAM)
DO (1) DOP2014000233A (OSRAM)
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GT (1) GT201400221A (OSRAM)
IL (1) IL234904B (OSRAM)
IN (1) IN2014DN09134A (OSRAM)
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UA (1) UA117098C2 (OSRAM)
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JP2014511687A (ja) 2011-03-31 2014-05-19 モデルナ セラピューティクス インコーポレイテッド 工学操作された核酸の送達および製剤
CN113249381A (zh) 2011-04-25 2021-08-13 赛诺菲 用于调节mir-21活性的微rna化合物以及方法
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
PL3682905T3 (pl) 2011-10-03 2022-04-04 Modernatx, Inc. Modyfikowane nukleozydy, nukleotydy i kwasy nukleinowe oraz ich zastosowania
PL2791160T3 (pl) 2011-12-16 2022-06-20 Modernatx, Inc. Kompozycje zmodyfikowanego mrna
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
WO2013151665A2 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of proteins associated with human disease
US10501512B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
EP2836219A1 (en) * 2012-04-10 2015-02-18 INSERM - Institut National de la Santé et de la Recherche Médicale Methods for the treatment of nonalcoholic steatohepatitis
KR102369722B1 (ko) 2012-04-25 2022-03-04 사노피 마이크로rna 화합물 및 mir-21 활성 조절 방법
UA116639C2 (uk) * 2012-10-09 2018-04-25 Рег'Юлес Терап'Ютікс Інк. Способи лікування синдрому альпорта
WO2014059356A2 (en) * 2012-10-12 2014-04-17 Isis Pharmaceuticals, Inc. Selective antisense compounds and uses thereof
RS63237B1 (sr) 2012-11-26 2022-06-30 Modernatx Inc Terminalno modifikovana rnk
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
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