JP6312592B2 - 消化器疾患の治療 - Google Patents

消化器疾患の治療 Download PDF

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Publication number
JP6312592B2
JP6312592B2 JP2014526240A JP2014526240A JP6312592B2 JP 6312592 B2 JP6312592 B2 JP 6312592B2 JP 2014526240 A JP2014526240 A JP 2014526240A JP 2014526240 A JP2014526240 A JP 2014526240A JP 6312592 B2 JP6312592 B2 JP 6312592B2
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Prior art keywords
peptide
pharmaceutically acceptable
pharmaceutical composition
acceptable salt
weight
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Japanese (ja)
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JP2014524444A5 (enExample
JP2014524444A (ja
Inventor
マルコ ケスラー，
マルコ ケスラー，
アンジェリカ フレツセン，
アンジェリカ フレツセン，
ホン チャオ，
ホン チャオ，
ロバート ソリンガ，
ロバート ソリンガ，
ブラディミール ボルチェノク，
ブラディミール ボルチェノク，
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Ironwood Pharmaceuticals Inc
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Ironwood Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/34—Organic compounds containing sulfur
    • C11D3/3436—Organic compounds containing sulfur containing disulfide groups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2014526240A 2011-08-17 2012-08-17 消化器疾患の治療 Active JP6312592B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161524699P 2011-08-17 2011-08-17
US61/524,699 2011-08-17
PCT/US2012/051289 WO2013025969A1 (en) 2011-08-17 2012-08-17 Treatments for gastrointestinal disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017197493A Division JP2018002740A (ja) 2011-08-17 2017-10-11 消化器疾患の治療

Publications (3)

Publication Number Publication Date
JP2014524444A JP2014524444A (ja) 2014-09-22
JP2014524444A5 JP2014524444A5 (enExample) 2015-10-01
JP6312592B2 true JP6312592B2 (ja) 2018-04-18

Family

ID=46759071

Family Applications (7)

Application Number Title Priority Date Filing Date
JP2014526240A Active JP6312592B2 (ja) 2011-08-17 2012-08-17 消化器疾患の治療
JP2017197493A Withdrawn JP2018002740A (ja) 2011-08-17 2017-10-11 消化器疾患の治療
JP2019018657A Withdrawn JP2019085415A (ja) 2011-08-17 2019-02-05 消化器疾患の治療
JP2020090285A Withdrawn JP2020128424A (ja) 2011-08-17 2020-05-25 消化器疾患の治療
JP2021184756A Withdrawn JP2022010265A (ja) 2011-08-17 2021-11-12 消化器疾患の治療
JP2023205346A Pending JP2024015204A (ja) 2011-08-17 2023-12-05 消化器疾患の治療
JP2025094194A Pending JP2025116257A (ja) 2011-08-17 2025-06-05 消化器疾患の治療

Family Applications After (6)

Application Number Title Priority Date Filing Date
JP2017197493A Withdrawn JP2018002740A (ja) 2011-08-17 2017-10-11 消化器疾患の治療
JP2019018657A Withdrawn JP2019085415A (ja) 2011-08-17 2019-02-05 消化器疾患の治療
JP2020090285A Withdrawn JP2020128424A (ja) 2011-08-17 2020-05-25 消化器疾患の治療
JP2021184756A Withdrawn JP2022010265A (ja) 2011-08-17 2021-11-12 消化器疾患の治療
JP2023205346A Pending JP2024015204A (ja) 2011-08-17 2023-12-05 消化器疾患の治療
JP2025094194A Pending JP2025116257A (ja) 2011-08-17 2025-06-05 消化器疾患の治療

Country Status (11)

Country Link
US (6) US9708371B2 (enExample)
EP (1) EP2776055B1 (enExample)
JP (7) JP6312592B2 (enExample)
CN (1) CN104053449B (enExample)
CA (1) CA2846230A1 (enExample)
DK (1) DK2776055T3 (enExample)
ES (1) ES2614864T3 (enExample)
HU (1) HUE032237T2 (enExample)
MX (1) MX347354B (enExample)
PL (1) PL2776055T3 (enExample)
WO (1) WO2013025969A1 (enExample)

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UA119335C2 (uk) * 2013-12-11 2019-06-10 Айронвуд Фармасьютикалз, Інк. Композиції лінаклотиду з затриманим вивільненням
WO2016125064A1 (en) * 2015-02-02 2016-08-11 Aurobindo Pharma Ltd Stable compositions comprising linaclotide
CN105176304A (zh) * 2015-09-17 2015-12-23 安徽温禾新材料科技股份有限公司 一种木塑地板加工用底漆
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MA47112A (fr) * 2016-12-21 2019-10-30 Ironwood Pharmaceuticals Inc Procédés de traitement du syndrome du côlon irritable avec des formulations à libération modifiée ou retardée de linaclotide
CN114206324A (zh) * 2019-06-10 2022-03-18 硬木药品公司 治疗与腹泻占主导的肠易激综合征相关的腹部疼痛
WO2022002369A1 (en) * 2020-06-30 2022-01-06 Ocvirk Soeren Pharmaceutical composition comprising a combination of a guanylate cyclase c (gucy2c) agonist and a short-chain fatty acid or prodrug thereof
CN113720947A (zh) * 2021-10-18 2021-11-30 珠海润都制药股份有限公司 一种去甲基伊托必利亚硝胺的检测方法
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US20210032292A1 (en) 2021-02-04
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