JP2014524444A5 - - Google Patents
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- Publication number
- JP2014524444A5 JP2014524444A5 JP2014526240A JP2014526240A JP2014524444A5 JP 2014524444 A5 JP2014524444 A5 JP 2014524444A5 JP 2014526240 A JP2014526240 A JP 2014526240A JP 2014526240 A JP2014526240 A JP 2014526240A JP 2014524444 A5 JP2014524444 A5 JP 2014524444A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- pharmaceutically acceptable
- pharmaceutical composition
- amino acid
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 132
- 239000008194 pharmaceutical composition Substances 0.000 claims description 75
- 235000002639 sodium chloride Nutrition 0.000 claims description 65
- 150000003839 salts Chemical class 0.000 claims description 62
- 150000001413 amino acids Chemical group 0.000 claims description 57
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 35
- 108010024409 linaclotide Proteins 0.000 claims description 32
- KXGCNMMJRFDFNR-WDRJZQOASA-N linaclotide Chemical compound C([C@H](NC(=O)[C@@H]1CSSC[C@H]2C(=O)N[C@H]3CSSC[C@H](N)C(=O)N[C@H](C(N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N2)=O)CSSC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(N)=O)NC3=O)C(=O)N[C@H](C(NCC(=O)N1)=O)[C@H](O)C)C(O)=O)C1=CC=C(O)C=C1 KXGCNMMJRFDFNR-WDRJZQOASA-N 0.000 claims description 32
- 229960000812 linaclotide Drugs 0.000 claims description 32
- 235000001014 amino acid Nutrition 0.000 claims description 16
- 229940024606 amino acid Drugs 0.000 claims description 16
- 208000002551 irritable bowel syndrome Diseases 0.000 claims description 14
- 102100034605 Atrial natriuretic peptide receptor 3 Human genes 0.000 claims description 12
- 101000924488 Homo sapiens Atrial natriuretic peptide receptor 3 Proteins 0.000 claims description 12
- 206010010774 Constipation Diseases 0.000 claims description 11
- 150000003141 primary amines Chemical class 0.000 claims description 10
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- 239000011777 magnesium Substances 0.000 claims description 9
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- 239000011572 manganese Substances 0.000 claims description 8
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 6
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- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 6
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- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 claims description 6
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- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 3
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- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims description 3
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 claims description 3
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- CPSYWNLKRDURMG-UHFFFAOYSA-L hydron;manganese(2+);phosphate Chemical compound [Mn+2].OP([O-])([O-])=O CPSYWNLKRDURMG-UHFFFAOYSA-L 0.000 claims description 3
- 208000003243 intestinal obstruction Diseases 0.000 claims description 3
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| HRP20192207T1 (hr) | 2010-08-11 | 2020-02-21 | Ironwood Pharmaceuticals, Inc. | Stabilne formulacije linaklotida |
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| UA119335C2 (uk) * | 2013-12-11 | 2019-06-10 | Айронвуд Фармасьютикалз, Інк. | Композиції лінаклотиду з затриманим вивільненням |
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| CN105176304A (zh) * | 2015-09-17 | 2015-12-23 | 安徽温禾新材料科技股份有限公司 | 一种木塑地板加工用底漆 |
| BR112018071821A2 (pt) * | 2016-04-25 | 2019-02-19 | Gelesis, Llc. | método para tratar constipação |
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| JP7599014B2 (ja) * | 2020-06-30 | 2024-12-12 | オクヴィルク，ゼレン | グアニル酸シクラーゼｃ（ｇｕｃｙ２ｃ）アゴニストおよび短鎖脂肪酸またはそのプロドラッグの組み合わせを含む医薬組成物 |
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-
2017
- 2017-10-11 JP JP2017197493A patent/JP2018002740A/ja not_active Withdrawn
-
2018
- 2018-02-27 US US15/906,744 patent/US20180186835A1/en not_active Abandoned
- 2018-10-26 US US16/171,524 patent/US20190062376A1/en not_active Abandoned
-
2019
- 2019-02-05 JP JP2019018657A patent/JP2019085415A/ja not_active Withdrawn
-
2020
- 2020-05-25 JP JP2020090285A patent/JP2020128424A/ja not_active Withdrawn
- 2020-10-09 US US17/066,802 patent/US20210032292A1/en not_active Abandoned
-
2021
- 2021-11-12 JP JP2021184756A patent/JP2022010265A/ja not_active Withdrawn
- 2021-12-30 US US17/566,241 patent/US20220119452A1/en not_active Abandoned
-
2023
- 2023-05-05 US US18/143,892 patent/US20230272007A1/en not_active Abandoned
- 2023-12-05 JP JP2023205346A patent/JP2024015204A/ja not_active Withdrawn
-
2025
- 2025-06-05 JP JP2025094194A patent/JP2025116257A/ja active Pending
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