JP6271541B2 - パルスの光による角膜の架橋のためのシステム及び方法 - Google Patents

パルスの光による角膜の架橋のためのシステム及び方法 Download PDF

Info

Publication number
JP6271541B2
JP6271541B2 JP2015523065A JP2015523065A JP6271541B2 JP 6271541 B2 JP6271541 B2 JP 6271541B2 JP 2015523065 A JP2015523065 A JP 2015523065A JP 2015523065 A JP2015523065 A JP 2015523065A JP 6271541 B2 JP6271541 B2 JP 6271541B2
Authority
JP
Japan
Prior art keywords
cornea
riboflavin
cross
linking
corneal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2015523065A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015526156A (ja
JP2015526156A5 (enExample
Inventor
フリードマン,マーク・ディー
カマエフ,パーヴェル
シェア,エヴァン
エディントン,ウィリアム
ロード−オヤルボ,サラ
ミューラー,デイビッド
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Avedro Inc
Original Assignee
Avedro Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48141636&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP6271541(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Avedro Inc filed Critical Avedro Inc
Publication of JP2015526156A publication Critical patent/JP2015526156A/ja
Publication of JP2015526156A5 publication Critical patent/JP2015526156A5/ja
Application granted granted Critical
Publication of JP6271541B2 publication Critical patent/JP6271541B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008Introducing ophthalmic products into the ocular cavity or retaining products therein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/0079Methods or devices for eye surgery using non-laser electromagnetic radiation, e.g. non-coherent light or microwaves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525Isoalloxazines, e.g. riboflavins, vitamin B2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0613Apparatus adapted for a specific treatment
    • A61N5/062Photodynamic therapy, i.e. excitation of an agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/10Ophthalmic agents for accommodation disorders, e.g. myopia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/008Methods or devices for eye surgery using laser
    • A61F2009/00861Methods or devices for eye surgery using laser adapted for treatment at a particular location
    • A61F2009/00872Cornea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/013Instruments for compensation of ocular refraction ; Instruments for use in cornea removal, for reshaping or performing incisions in the cornea

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2015523065A 2012-07-16 2012-10-31 パルスの光による角膜の架橋のためのシステム及び方法 Active JP6271541B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261671798P 2012-07-16 2012-07-16
US61/671,798 2012-07-16
US201261699226P 2012-09-10 2012-09-10
US61/699,226 2012-09-10
PCT/US2012/062843 WO2013059837A2 (en) 2012-07-16 2012-10-31 Systems and methods for corneal cross-linking with pulsed light

Publications (3)

Publication Number Publication Date
JP2015526156A JP2015526156A (ja) 2015-09-10
JP2015526156A5 JP2015526156A5 (enExample) 2015-12-24
JP6271541B2 true JP6271541B2 (ja) 2018-01-31

Family

ID=48141636

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015523065A Active JP6271541B2 (ja) 2012-07-16 2012-10-31 パルスの光による角膜の架橋のためのシステム及び方法

Country Status (4)

Country Link
US (1) US9707126B2 (enExample)
EP (3) EP2872081B2 (enExample)
JP (1) JP6271541B2 (enExample)
WO (2) WO2013059837A2 (enExample)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8574277B2 (en) * 2009-10-21 2013-11-05 Avedro Inc. Eye therapy
EP2547298B1 (en) * 2010-03-19 2019-05-08 Avedro, Inc. Systems for applying and monitoring eye therapy
US9622911B2 (en) 2010-09-30 2017-04-18 Cxl Ophthalmics, Llc Ophthalmic treatment device, system, and method of use
US9044308B2 (en) 2011-05-24 2015-06-02 Avedro, Inc. Systems and methods for reshaping an eye feature
JP6122845B2 (ja) 2011-06-02 2017-04-26 アヴェドロ・インコーポレーテッドAvedro,Inc. 時間ベースの光活性剤の送達又は光活性マーカの存在をモニターするシステム及び方法
EP2830627B1 (en) 2012-03-29 2024-05-01 Epion Therapeutics, Inc. Ocular treatment solutions, delivery devices and delivery augmentation methods
WO2013148895A1 (en) 2012-03-29 2013-10-03 Cxl Ophthalmics, Llc Ocular cross-linking system and method for sealing corneal wounds
EP2830637B1 (en) 2012-03-29 2024-08-21 Epion Therapeutics, Inc. Compositions and methods for treating or preventing diseases associated with oxidative stress
TWI588560B (zh) 2012-04-05 2017-06-21 布萊恩荷登視覺協會 用於屈光不正之鏡片、裝置、方法及系統
US9201250B2 (en) 2012-10-17 2015-12-01 Brien Holden Vision Institute Lenses, devices, methods and systems for refractive error
RU2015114118A (ru) 2012-10-17 2016-12-10 Альберт ДАКСЕР Устройство и способ облучения глаза
WO2014059465A1 (en) 2012-10-17 2014-04-24 Brien Holden Vision Institute Lenses, devices, methods and systems for refractive error
US9498114B2 (en) 2013-06-18 2016-11-22 Avedro, Inc. Systems and methods for determining biomechanical properties of the eye for applying treatment
US9498122B2 (en) 2013-06-18 2016-11-22 Avedro, Inc. Systems and methods for determining biomechanical properties of the eye for applying treatment
ES2871378T3 (es) * 2013-10-30 2021-10-28 Alcon Inc Control de reticulación
WO2015130944A1 (en) * 2014-02-28 2015-09-03 Massachusetts Eye & Ear Infirmary Methods for cross-linking corneal collagen with verteporfin for the treatment of disorders of the eye
AU2015315113B2 (en) 2014-09-09 2020-03-05 LumiThera, Inc. Multi-wavelength phototherapy devices, systems, and methods for the non-invasive treatment of damaged or diseased tissue
WO2016069628A1 (en) * 2014-10-27 2016-05-06 Avedro, Inc. Systems and methods for cross-linking treatments of an eye
WO2016077747A1 (en) 2014-11-13 2016-05-19 Avedro, Inc. Multipass virtually imaged phased array etalon
DE102014016990B3 (de) * 2014-11-18 2016-02-11 Wavelight Gmbh Düseneinheit zur Vernetzung von Augengewebe
JP6674462B2 (ja) 2014-12-02 2020-04-01 アヴェドロ・インコーポレーテッドAvedro,Inc. 眼の架橋処置のためのシステム、方法及び組成物
EP3285704B1 (en) 2015-04-24 2020-11-18 Avedro Inc. Systems for photoactivating a photosensitizer applied to an eye
WO2016191342A1 (en) 2015-05-22 2016-12-01 Avedro, Inc. Systems and methods for monitoring cross-linking activity for corneal treatments
CN116832158A (zh) 2015-07-21 2023-10-03 艾维德洛公司 用光敏剂治疗眼睛的系统和方法
CN108024831A (zh) 2015-10-23 2018-05-11 纽约市哥伦比亚大学理事会 由激光诱导的组织中的胶原交联
US10646372B2 (en) 2015-12-03 2020-05-12 Avedro, Inc. Systems and methods for treating an eye with a mask device
ITUB20160237A1 (it) * 2016-01-26 2017-07-26 Vision Engineering Italy Soc A Responsabilita Limitata Apparato di controllo del dosaggio di un agente cromoforo in un tessuto corneale e procedimento per dosare un agente cromoforo in un tessuto corneale
EP3442481B1 (en) 2016-04-13 2023-06-28 Avedro, Inc. Systems for delivering drugs to an eye
EP3827793A1 (en) 2016-08-08 2021-06-02 Avedro, Inc. Systems and methods for cross-linking treatments of an eye
WO2018132563A1 (en) 2017-01-11 2018-07-19 Avedro, Inc. Systems and methods for determining cross-linking distribution in a cornea and/or structural characteristics of a cornea
WO2018156593A1 (en) * 2017-02-21 2018-08-30 Avedro, Inc. Formulations for eye treatments
US11666481B1 (en) 2017-12-01 2023-06-06 The Trustees Of Columbia University In The City Of New York Diagnosis and treatment of collagen-containing tissues
RU2682494C1 (ru) * 2017-12-12 2019-03-19 Государственное бюджетное учреждение "Уфимский научно-исследовательский институт глазных болезней Академии наук Республики Башкортостан" Способ лечения кератэктазий методом импульсного акселерированного ультрафиолетового кросслинкинга роговицы
EP3743026A4 (en) * 2018-01-26 2021-10-27 The Trustees Of Columbia University In The City Of New York PROCESS, COMPUTER READABLE MEDIA AND CORNEA TREATMENT SYSTEMS
CA3093065A1 (en) 2018-03-05 2019-09-12 Avedro, Inc. System for eye tracking during eye treatment
WO2019173762A1 (en) 2018-03-08 2019-09-12 Avedro, Inc. Micro-devices for treatment of an eye
RU2676451C1 (ru) * 2018-03-19 2018-12-28 Федеральное государственное автономное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Способ кросслинкинга роговичного коллагена с помощью фемтосекундного лазера в эксперименте
JP7504083B2 (ja) 2018-09-19 2024-06-21 アヴェドロ・インコーポレーテッド 角膜拡張障害を治療するシステム及び方法
CN113316411B (zh) 2018-09-19 2025-01-17 艾维德洛公司 用于眼部治疗期间的眼部追踪的系统及方法
WO2020077015A1 (en) 2018-10-09 2020-04-16 Avedro, Inc. Photoactivation systems and methods for corneal cross-linking treatments
US10932864B2 (en) 2018-11-28 2021-03-02 Rxsight, Inc. Tracking-based illumination control system
US11013593B2 (en) 2018-12-02 2021-05-25 Rxsight, Inc. Light adjustable lens tracking system and method
EP3890741A1 (en) 2018-12-04 2021-10-13 Avedro Inc. Compounds and compositions for eye treatments
CN113811527B (zh) 2019-01-25 2024-12-31 艾弗德罗股份有限公司 双(双吖丙啶)衍生物作为光交联剂治疗角膜扩张性疾病
JP7571038B2 (ja) 2019-02-26 2024-10-22 アヴェドロ・インコーポレーテッド 眼の架橋処置のためのシステム及び方法
IT201900011985A1 (it) * 2019-07-17 2021-01-17 Vision Eng Italy Srl Formulazione liquida, in particolare per trattare un tessuto corneale
WO2021026405A1 (en) 2019-08-06 2021-02-11 Avedro, Inc. Photoactivation systems and methods for corneal cross-linking treatments
AU2020400100A1 (en) 2019-12-13 2022-05-26 Alcon Inc. System and method of corneal cross-linking
WO2021117001A1 (en) * 2019-12-13 2021-06-17 Alcon Inc. System and method of determining incision depths in eyes
US20210322461A1 (en) * 2020-04-15 2021-10-21 Alpha Phase Technologies LLC Method of cross-linking collagen
EP4262648A4 (en) * 2020-12-17 2024-11-06 Avedro, Inc. TREATMENTS FOR EYE INFECTION
AU2022232309A1 (en) 2021-03-08 2023-10-12 Avedro, Inc. Systems and methods for generating patient-specific corneal cross-linking treatment patterns
US20220338729A1 (en) * 2021-04-27 2022-10-27 Johnson & Johnson Vision Care, Inc. System and method for identifying presbyopia
WO2025235247A1 (en) * 2024-05-06 2025-11-13 Saks Asher Abraham Ophthalmological devices and methods for treatment of corneal tissue

Family Cites Families (208)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4034750A (en) 1975-04-22 1977-07-12 Maurice Seiderman Electrochemically linking collagen fibrils to animal tissue
US4161013A (en) 1977-05-23 1979-07-10 Massachusetts Institute Of Technology Electromechanochemical device
US4326529A (en) 1978-05-26 1982-04-27 The United States Of America As Represented By The United States Department Of Energy Corneal-shaping electrode
US4805616A (en) 1980-12-08 1989-02-21 Pao David S C Bipolar probes for ophthalmic surgery and methods of performing anterior capsulotomy
US4381007A (en) 1981-04-30 1983-04-26 The United States Of America As Represented By The United States Department Of Energy Multipolar corneal-shaping electrode with flexible removable skirt
US4712543A (en) 1982-01-20 1987-12-15 Baron Neville A Process for recurving the cornea of an eye
US4665913A (en) 1983-11-17 1987-05-19 Lri L.P. Method for ophthalmological surgery
US5484432A (en) 1985-09-27 1996-01-16 Laser Biotech, Inc. Collagen treatment apparatus
US4764007A (en) 1986-02-24 1988-08-16 The United States Of America As Represented By The Secretary Of The Air Force Glare susceptibility tester
GB8606821D0 (en) 1986-03-19 1986-04-23 Pa Consulting Services Corneal reprofiling
US5019074A (en) 1987-03-09 1991-05-28 Summit Technology, Inc. Laser reprofiling system employing an erodable mask
US4891043A (en) 1987-05-28 1990-01-02 Board Of Trustees Of The University Of Illinois System for selective release of liposome encapsulated material via laser radiation
US5171318A (en) 1987-11-09 1992-12-15 Chiron Ophthalmics, Inc. Treated corneal prosthetic device
US4969912A (en) 1988-02-18 1990-11-13 Kelman Charles D Human collagen processing and autoimplant use
US4881543A (en) 1988-06-28 1989-11-21 Massachusetts Institute Of Technology Combined microwave heating and surface cooling of the cornea
US5152759A (en) 1989-06-07 1992-10-06 University Of Miami, School Of Medicine, Dept. Of Ophthalmology Noncontact laser microsurgical apparatus
US5103005A (en) 1989-07-21 1992-04-07 Coors Biotech, Inc. Method for recovery of riboflavin
US5016615A (en) 1990-02-20 1991-05-21 Riverside Research Institute Local application of medication with ultrasound
US5490849A (en) 1990-07-13 1996-02-13 Smith; Robert F. Uniform-radiation caustic surface for photoablation
US5779696A (en) 1990-07-23 1998-07-14 Sunrise Technologies International, Inc. Method and apparatus for performing corneal reshaping to correct ocular refractive errors
US6342053B1 (en) 1990-07-23 2002-01-29 Laser Biotech, Inc. Apparatus for cornea reshaping
US6325792B1 (en) 1991-11-06 2001-12-04 Casimir A. Swinger Ophthalmic surgical laser and method
US5171254A (en) 1991-11-19 1992-12-15 Sher Neal A Eye fixation device
RU2086215C1 (ru) 1992-03-17 1997-08-10 Александр Иосифович Симановский Способ определения истинного внутриглазного давления, коэффициента легкости оттока и минутного объема продуцирования камерной влаги
US6450641B2 (en) 1992-06-02 2002-09-17 Lasersight Technologies, Inc. Method of corneal analysis using a checkered placido apparatus
JP2965101B2 (ja) 1992-07-31 1999-10-18 株式会社ニデック 眼科装置
US5891131A (en) 1993-02-01 1999-04-06 Arizona Board Of Regents Method and apparatus for automated simulation and design of corneal refractive procedures
WO1994024545A1 (en) 1993-04-15 1994-10-27 Board Of Regents, The University Of Texas System Raman spectrometer
US5461212A (en) 1993-06-04 1995-10-24 Summit Technology, Inc. Astigmatic laser ablation of surfaces
AU716040B2 (en) 1993-06-24 2000-02-17 Bausch & Lomb Incorporated Ophthalmic pachymeter and method of making ophthalmic determinations
US20020042612A1 (en) 1997-10-27 2002-04-11 Hood Larry L. Method and apparatus for modifications of visual acuity by thermal means
US20020002369A1 (en) 1993-08-23 2002-01-03 Hood Larry L. Method and apparatus for modifying visual acuity by moving a focal point of energy within a cornea
US5634921A (en) 1993-08-23 1997-06-03 Hood; Larry Method and apparatus for modifications of visual acuity by thermal means
CN1143900A (zh) 1994-02-09 1997-02-26 克尔阿维森公司 将角膜曲面整形的电外科手术方法
JP3263275B2 (ja) 1994-04-05 2002-03-04 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 生体組織のレーザー処理のための装置並びに火焔状斑点母斑のレーザー処理装置
US6293938B1 (en) 1994-04-08 2001-09-25 Summit Technology, Inc. Photo-refractive keratectomy
JPH09511671A (ja) 1994-08-22 1997-11-25 イオメド インコーポレイテッド 水和水段を組み込んだイオントフォレティック(iontophoretic)デリバリー装置
RU2098057C1 (ru) 1994-10-20 1997-12-10 Ольга Александровна Киселева Способ лечения отслойки сетчатки, осложненной субретинальным швартообразованием
HU213450B (en) 1995-04-26 1997-06-30 Ladanyi Jozsef Gel contains gelatin and process for producing it
US5910110A (en) 1995-06-07 1999-06-08 Mentor Ophthalmics, Inc. Controlling pressure in the eye during surgery
US6033396A (en) 1995-11-06 2000-03-07 Huang; David Apparatus and method for performing laser thermal keratoplasty with minimized regression
US6520956B1 (en) 1995-11-06 2003-02-18 David Huang Apparatus and method for performing laser thermal keratoplasty with minimized regression
US7452358B2 (en) 1996-01-05 2008-11-18 Thermage, Inc. RF electrode assembly for handpiece
US7141049B2 (en) 1999-03-09 2006-11-28 Thermage, Inc. Handpiece for treatment of tissue
US20070244496A1 (en) 1996-02-07 2007-10-18 Hellenkamp Johann F Automatic surgical device and control assembly for cutting a cornea
DE19614823A1 (de) 1996-04-15 1997-10-16 Mann Gerhard Chem Pharm Fab Ophthalmische Zusammensetzung mit verlängerter Verweilzeit am Auge
US6726684B1 (en) 1996-07-16 2004-04-27 Arthrocare Corporation Methods for electrosurgical spine surgery
US20060149343A1 (en) 1996-12-02 2006-07-06 Palomar Medical Technologies, Inc. Cooling system for a photocosmetic device
RU2127099C1 (ru) 1997-04-07 1999-03-10 Борзенок Сергей Анатольевич Глазные капли "неокератоник"
RU2127100C1 (ru) 1997-04-17 1999-03-10 Борзенок Сергей Анатольевич Глазные капли "пиротоник"
US6302876B1 (en) 1997-05-27 2001-10-16 Visx Corporation Systems and methods for imaging corneal profiles
RU2121825C1 (ru) 1997-06-24 1998-11-20 Межотраслевой научно-технический комплекс "Микрохирургия глаза" Глазные капли "интертоник"
US6104959A (en) 1997-07-31 2000-08-15 Microwave Medical Corp. Method and apparatus for treating subcutaneous histological features
US6007499A (en) 1997-10-31 1999-12-28 University Of Washington Method and apparatus for medical procedures using high-intensity focused ultrasound
RU2130762C1 (ru) 1997-12-10 1999-05-27 Федоров Святослав Николаевич Устройство для офтальмохирургических операций
US20080027328A1 (en) 1997-12-29 2008-01-31 Julia Therapeutics, Llc Multi-focal treatment of skin with acoustic energy
US5885275A (en) 1998-01-15 1999-03-23 Diomed, Inc. Medical spacing guide
US6161544A (en) 1998-01-28 2000-12-19 Keratoform, Inc. Methods for accelerated orthokeratology
US20020013577A1 (en) 1998-03-06 2002-01-31 Frey Rudolph W. Laser beam delivery and eye tracking system
BR9908692A (pt) 1998-03-09 2001-12-04 Ista Pharmaceuticals Inc Uso de agentes de enrijecimento corneal emortocerotologia enzimática
US6188500B1 (en) 1998-04-03 2001-02-13 Psc Scanning, Inc. Method for generating multiple scan lines in a thin scanner
US6398753B2 (en) 1998-04-03 2002-06-04 Mcdaniel David H. Ultrasound enhancement of percutaneous drug absorption
AU3970799A (en) 1998-05-04 1999-11-23 Board Of Regents Combined fluorescence and reflectance spectroscopy
US6099521A (en) 1998-05-26 2000-08-08 Shadduck; John H. Semiconductor contact lens cooling system and technique for light-mediated eye therapies
US6162210A (en) 1998-08-06 2000-12-19 Shadduck; John H. Laser mediated treatments for presbyopia and hyperopia
DE69902549T2 (de) 1998-08-19 2003-04-17 Alcon, Inc. Gerät und verfahren zur messung von fehlsichtigkeiten eines menschlichen auges
US6101411A (en) 1998-09-24 2000-08-08 Newsome; David A. Dilation enhancer
US6218360B1 (en) 1998-11-19 2001-04-17 The Schepens Eye Research Institute Collagen based biomaterials and methods of preparation and use
US6402739B1 (en) 1998-12-08 2002-06-11 Y-Beam Technologies, Inc. Energy application with cooling
US6617963B1 (en) 1999-02-26 2003-09-09 Sri International Event-recording devices with identification codes
EP1158919B1 (en) 1999-03-09 2005-06-29 Thermage, Inc. Apparatus for treatment of tissue
WO2000074648A2 (en) 1999-06-04 2000-12-14 Sunrise Technologies International, Inc. Prevention of regression in refractive keratoplasty
JP2002058695A (ja) 1999-09-03 2002-02-26 Carl Zeiss Jena Gmbh 眼の照射方法及び装置
US6946440B1 (en) 1999-09-15 2005-09-20 Dewoolfson Bruce H Composition for stabilizing corneal tissue during or after orthokeratology lens wear
US6319273B1 (en) 1999-12-16 2001-11-20 Light Sciences Corporation Illuminating device for treating eye disease
US6673067B1 (en) 2000-01-31 2004-01-06 Gholam A. Peyman System and method for thermally and chemically treating cells at sites of interest in the body to impede cell proliferation
US7073510B2 (en) 2000-02-11 2006-07-11 The General Hospital Corporation Photochemical tissue bonding
CA2399414A1 (en) 2000-02-11 2001-08-16 The General Hospital Corporation Photochemical tissue bonding
US8215314B2 (en) 2000-02-11 2012-07-10 The General Hospital Corporation Photochemical tissue bonding
US6949093B1 (en) 2000-03-21 2005-09-27 Minu, L.L.C. Adjustable universal implant blank for modifying corneal curvature and methods of modifying corneal curvature therewith
US6494878B1 (en) 2000-05-12 2002-12-17 Ceramoptec Industries, Inc. System and method for accurate optical treatment of an eye's fundus
US20020164379A1 (en) 2000-06-29 2002-11-07 Toru Nishihara Oxygen-containing ophthalmic composition
AU2001291159A1 (en) 2000-09-20 2002-04-02 Shahinian Jr., Lee Self-preserved nasal, inhalable, and topical ophthalmic preparations and medications
JP2004510825A (ja) 2000-10-13 2004-04-08 ザ ジョンズ ホプキンズ ユニバーシティ レーザ視力矯正手術後の角膜と上皮下のもやを防止するためのプラスミノゲンアクチベータ(plasminogenactivator)
US20020099363A1 (en) 2001-01-23 2002-07-25 Woodward Benjamin W. Radiation treatment system and method of using same
US7753943B2 (en) 2001-02-06 2010-07-13 Qlt Inc. Reduced fluence rate PDT
US7044945B2 (en) 2001-03-30 2006-05-16 Sand Bruce J Prevention of regression in thermal ciliary muscle tendinoplasty
US6766042B2 (en) 2001-04-26 2004-07-20 Memphis Eye & Contact Associates System to automatically detect eye corneal striae
US6918904B1 (en) 2001-11-07 2005-07-19 Minu, L.L.C. Method of reshaping the cornea by controlled thermal delivery
US20070135805A1 (en) 2001-11-07 2007-06-14 Minu Telesystems Llc Device and method for reshaping the cornea
US9155652B2 (en) 2001-11-07 2015-10-13 Gholam A. Peyman Method for laser correction of refractive errors of an eye with a thin cornea
US20050149006A1 (en) 2001-11-07 2005-07-07 Peyman Gholam A. Device and method for reshaping the cornea
US20070142828A1 (en) 2001-11-07 2007-06-21 Minu, Llc Method and system for altering the refractive properties of the eye
US9681942B2 (en) 2001-11-07 2017-06-20 Gholam A. Peyman Method for prevention of rejection and sever encapsulation of a supportive or functioning implant
US7130835B2 (en) 2002-03-28 2006-10-31 Bausch & Lomb Incorporated System and method for predictive ophthalmic correction
WO2003085376A2 (en) 2002-04-03 2003-10-16 The Regents Of The University Of California System and method for quantitative or qualitative measurement of exogenous substances in tissue and other materials using laser-induced fluorescence spectroscopy
ES2238555T3 (es) 2002-04-05 2005-09-01 Sis Ag Surgical Instrument Systems Dispositivo y procedimiento de determinacion de los valores de medicion geometricos de un ojo.
US6758564B2 (en) 2002-06-14 2004-07-06 Physical Sciences, Inc. Line-scan laser ophthalmoscope
CA2511767A1 (en) 2002-12-09 2004-06-24 The Trustees Of Dartmouth College Electrically-induced thermokeratoplasty systems and method
US7377917B2 (en) 2002-12-09 2008-05-27 The Trustees Of Dartmouth College Feedback control of thermokeratoplasty treatments
US20060177430A1 (en) 2002-12-20 2006-08-10 Chakshu Research Inc Treatment of ocular disorders with ophthalmic formulations containing methylsulfonylmethane as a transport enhancer
US7004902B2 (en) 2003-03-21 2006-02-28 Reichert, Inc. Method and apparatus for measuring biomechanical characteristics of corneal tissue
US20110098790A1 (en) 2009-10-26 2011-04-28 Albert Daxer Methods for treating corneal disease
US7223275B2 (en) 2003-05-27 2007-05-29 Yichieh Shiuey System for cutting the cornea of an eye
US20050096515A1 (en) 2003-10-23 2005-05-05 Geng Z. J. Three-dimensional surface image guided adaptive therapy system
ATE427725T1 (de) 2004-02-03 2009-04-15 Iroc Ag Ophtalmologische vorrichtung
US8571648B2 (en) 2004-05-07 2013-10-29 Aesthera Apparatus and method to apply substances to tissue
JP2007536272A (ja) 2004-05-07 2007-12-13 ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 近視の処置法
ITMI20041625A1 (it) 2004-08-06 2004-11-06 Roberto Pinelli Apparato per la correzione della presbiopia
US20060135957A1 (en) 2004-12-21 2006-06-22 Dorin Panescu Method and apparatus to align a probe with a cornea
US8394084B2 (en) 2005-01-10 2013-03-12 Optimedica Corporation Apparatus for patterned plasma-mediated laser trephination of the lens capsule and three dimensional phaco-segmentation
US20060276777A1 (en) 2005-04-08 2006-12-07 Coroneo Minas T Corneal shaping
US20060287662A1 (en) 2005-05-26 2006-12-21 Ntk Enterprises, Inc. Device, system, and method for epithelium protection during cornea reshaping
WO2007001926A2 (en) 2005-06-24 2007-01-04 Hyperbranch Medical Technology, Inc. Low-swelling hydrogel sealants for wound repair
US20070027509A1 (en) 2005-07-29 2007-02-01 Eisenberg Elliot S Automated panretinal laser photocoagulation
US7292347B2 (en) 2005-08-01 2007-11-06 Mitutoyo Corporation Dual laser high precision interferometer
US20070048340A1 (en) 2005-08-31 2007-03-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Multi step patterning of a skin surface
US20070055227A1 (en) 2005-09-08 2007-03-08 Refractec, Inc. Probe used for an ocular procedure
US20070074722A1 (en) 2005-09-21 2007-04-05 Kurve Technology, Inc. Medicament delivery control, monitoring, and reporting system and method
WO2007044309A2 (en) 2005-10-05 2007-04-19 Vasix Corporation Device and method for inhibiting age complex formation
EP1779891A1 (en) 2005-10-28 2007-05-02 Abdula Kurkayev Method of activating a photosensitizer
WO2007053826A2 (en) 2005-10-31 2007-05-10 Crs & Associates Method and apparatus for measuring the deformation characteristics of an object
DE102005056958A1 (de) 2005-11-29 2007-06-06 Rowiak Gmbh Verfahren und Vorrichtung zum Bearbeiten eines Werkstücks
US20070203547A1 (en) 2005-12-15 2007-08-30 Costello Benedict J Medical device identification
US20090171305A1 (en) 2006-01-05 2009-07-02 El Hage Sami G Combination therapy for long-lasting ckr
US20080177220A1 (en) 2006-01-06 2008-07-24 The Curators Of The University Of Missouri Ultrasound-Mediated Transcleral Drug Delivery
RU2309713C1 (ru) 2006-03-17 2007-11-10 ЗАО "Екатеринбургский центр МНТК "Микрохирургия глаза" Способ лечения начальных стадий кератоконуса путем эксимерлазерной хирургии
US8182471B2 (en) 2006-03-17 2012-05-22 Amo Manufacturing Usa, Llc. Intrastromal refractive correction systems and methods
US20090130176A1 (en) 2006-03-30 2009-05-21 Leila Bossy-Nobs Intraocular lens with drug delivery system attached thereto
EP2004209B1 (en) 2006-04-13 2013-07-24 Euclid Systems Corporation Composition and method for stabilizing corneal tissue after refractive surgery
US8624721B2 (en) 2006-04-17 2014-01-07 Warsaw Orthopedic, Inc. Method and apparatus for embedding a transmitter into a tool, and a system for monitoring the tool
EP2016456A4 (en) 2006-04-20 2010-08-25 Xceed Imaging Ltd THROUGH OPTICAL SYSTEM AND METHOD FOR PROVIDING AN ENLARGED SHARPNESS DURING THE FIGURE
WO2007127172A2 (en) 2006-04-27 2007-11-08 The Trustees Of Columbia University In The City Of New York Layered bio-adhesive compositions and uses thereof
US20090276042A1 (en) 2006-05-03 2009-11-05 Vision Crc Limited Biological Polysiloxanes
EP2656780B1 (en) 2006-05-26 2016-04-27 The Cleveland Clinic Foundation System for measuring biomechanical properties in an eye
US20070282313A1 (en) 2006-06-01 2007-12-06 University Of Southern California Method and apparatus to guide laser corneal surgery with optical measurement
DE102006030219A1 (de) 2006-06-30 2008-01-03 Iroc Ag Bestrahlungssystem für medizinische Anwendungen
JP3940161B1 (ja) 2006-07-03 2007-07-04 朝日インテック株式会社 医療用ガイドワイヤ、医療用ガイドワイヤとマイクロカテーテルとの組立体、および医療用ガイドワイヤとバルーンカテーテルとガイディングカテーテルとの組立体
US20080015660A1 (en) 2006-07-13 2008-01-17 Priavision, Inc. Method And Apparatus For Photo-Chemical Oculoplasty/Keratoplasty
US20080063627A1 (en) 2006-09-12 2008-03-13 Surmodics, Inc. Tissue graft materials containing biocompatible agent and methods of making and using same
KR101551590B1 (ko) 2006-10-24 2015-09-08 캘리포니아 인스티튜트 오브 테크놀로지 신체 조직의 물리적 및/또는 화학적 성질에 영향을 주는 광화학적 요법
US8466203B2 (en) 2006-12-06 2013-06-18 David Choohyun Paik Method of stabilizing human eye tissue by reaction with nitrite and related agents such as nitro compounds
WO2008070848A2 (en) 2006-12-07 2008-06-12 Priavision, Inc. Method and material for in situ corneal structural augmentation
US9566030B2 (en) 2007-02-01 2017-02-14 Ls Biopath, Inc. Optical system for detection and characterization of abnormal tissue and cells
WO2008124009A2 (en) 2007-04-02 2008-10-16 The Cleveland Clinic Foundation Treating glaucoma
WO2008137637A2 (en) 2007-05-04 2008-11-13 The General Hospital Corporation Methods, arrangements and systems for obtaining information associated with a sample using brillouin microscopy
US8992516B2 (en) 2007-07-19 2015-03-31 Avedro, Inc. Eye therapy system
US8202272B2 (en) 2007-07-19 2012-06-19 Avedro, Inc. Eye therapy system
WO2009025763A2 (en) 2007-08-16 2009-02-26 Schepens Eye Research Institute Therapeutic compositions for treatment of inflammation of ocular and adnexal tissues
US8603081B2 (en) 2007-08-23 2013-12-10 Ntk Enterprises, Inc. System and method for defining and controlling LTK and other surgical eye procedures to produce little or no stromal collagen shrinkage
US20090192437A1 (en) 2007-09-24 2009-07-30 The Johns Hopkins University Wearable photoactivator for ocular therapeutic applications and uses thereof
WO2009073213A1 (en) 2007-12-05 2009-06-11 Avedro, Inc. Eye therapy system
US20100057060A1 (en) * 2007-12-07 2010-03-04 Seros Medical, Llc In Situ UV/Riboflavin Ocular Treatment System
US20090149923A1 (en) 2007-12-07 2009-06-11 21X Corporation Dba Priavision, Inc. Method for equi-dosed time fractionated pulsed uva irradiation of collagen/riboflavin mixtures for ocular structural augmentation
US8348935B2 (en) 2008-01-23 2013-01-08 Avedro, Inc. System and method for reshaping an eye feature
WO2009114513A2 (en) 2008-03-14 2009-09-17 Euclid Systems Corporation Ultraviolet irradiation to treat corneal weakness disorders
US9125735B2 (en) 2008-04-04 2015-09-08 Forsight Labs, Llc Method of correcting vision using corneal onlays
EP2296580A2 (en) 2008-04-04 2011-03-23 Forsight Labs, Llc Corneal onlay devices and methods
EP2276420B1 (en) 2008-04-04 2021-10-06 Journey1, Inc. Device to treat an eye having an epithelium with a defect
WO2009132221A1 (en) 2008-04-23 2009-10-29 The Cleveland Clinic Foundation Method for modeling biomechanical properties of an eye
US7898656B2 (en) 2008-04-30 2011-03-01 The General Hospital Corporation Apparatus and method for cross axis parallel spectroscopy
US20090275929A1 (en) 2008-04-30 2009-11-05 Amo Development, Llc System and method for controlling measurement in an eye during ophthalmic procedure
WO2010011119A1 (es) 2008-07-22 2010-01-28 Choza Remero Andres Abelino Solución oftálmica para engrosar córneas
EP2349148A1 (en) 2008-08-08 2011-08-03 Glostrup Hospital System and method for treatment of lens related disorders
RU2391078C2 (ru) 2008-08-14 2010-06-10 Сергей Игоревич Анисимов Способ лечения кератоконуса воздействием ультрафиолетового излучения и устройство для его осуществления (варианты)
IT1393402B1 (it) 2008-08-28 2012-04-20 Sooft Italia Spa Uso di enhancer eventualmente con riboflavina, nonche' relative composizioni oftalmiche per cross-linking corneale del cheratocono o di altre patologie ectasiche corneali
DE102008046834A1 (de) 2008-09-11 2010-03-18 Iroc Ag Steuerprogramm zum Steuern elektromagnetischer Strahlung für eine Quervernetzung von Augengewebe
US20100082018A1 (en) 2008-09-26 2010-04-01 Daryus Panthakey Method and system for reshaping the cornea
WO2010039854A1 (en) 2008-09-30 2010-04-08 Neal Marshall Eye therapy system
US8258768B2 (en) 2008-12-12 2012-09-04 Schneider Electric USA, Inc. Low EMI producing switch-mode power supply within an intelligent electronic device
US8226232B2 (en) 2008-12-17 2012-07-24 Technion Research And Development Foundation, Ltd. System and method for fast retinal imaging
US8496651B2 (en) 2009-01-27 2013-07-30 Technolas Perfect Vision Gmbh System and method for refractive surgery with augmentation by intrastromal corrective procedure
WO2010093772A1 (en) 2009-02-12 2010-08-19 Alcon Research, Ltd. Method and apparatus for ocular surface imaging
EP2395953A4 (en) 2009-02-12 2013-06-19 Univ Rochester ABERRATION CONTROL BY THE RETICULATION OF THE CORNEAL COLLAGEN COMBINED WITH THE BEAMFORMING TECHNIQUE
EP2253321A1 (en) 2009-05-06 2010-11-24 Roberto Pinelli Collyrium for the treatment of conial cornea with "cross-linking" trans-epithelial technique
US20100286156A1 (en) 2009-05-06 2010-11-11 Roberto Pinelli Collyrium For The Treatment Of Conical Cornea With Cross-Linking Trans-Epithelial Technique
US20100318017A1 (en) 2009-06-11 2010-12-16 Lewis Scott E Method of improving vision using contact lenses and corneal collagen crosslinking
EP2464387A4 (en) 2009-08-12 2013-05-15 Seros Medical Llc DEUTERATED WATER SOLUTION AND RIBOFLAVIN FOR EXTENDED OXYGEN SINGULET LIFETIME IN THE TREATMENT OF OCULAR TISSUE AND METHOD OF USE
US8710099B2 (en) 2009-09-10 2014-04-29 New York University Treatment of cancer using the sodium salt of a benzoic acid derivative
US8518028B2 (en) 2009-09-30 2013-08-27 Abbott Medical Optics Inc. Methods for enhancing accommodation of a natural lens of an eye
US8574277B2 (en) 2009-10-21 2013-11-05 Avedro Inc. Eye therapy
US20110098809A1 (en) 2009-10-23 2011-04-28 John Wardle Ocular Implant System and Method
US20120215155A1 (en) 2010-03-19 2012-08-23 Avedro Inc. Controlled cross-linking initiation and corneal topography feedback systems for directing cross-linking
US20120283621A1 (en) 2010-03-19 2012-11-08 Avedro, Inc. Sterilizing application of cross-linking agent
EP2547298B1 (en) 2010-03-19 2019-05-08 Avedro, Inc. Systems for applying and monitoring eye therapy
WO2011130356A2 (en) 2010-04-13 2011-10-20 Avedro, Inc. Systems and methods for activating cross-linking in an eye
RU2428152C1 (ru) 2010-04-19 2011-09-10 Сергей Васильевич Безик Способ мобилизации интраокулярной линзы для удаления вторичной катаракты с использованием бимануальной автоматизированной системы аспирации-ирригации при наличии фимоза переднего капсулорексиса
EP2907490A1 (de) 2010-04-21 2015-08-19 IROC Innocross AG Vorrichtung für die vernetzung von okulärem gewebe mit elektromagnetischer strahlung
DE102010020194B4 (de) 2010-05-07 2022-09-08 Carl Zeiss Meditec Ag Vorrichtung zur Stabilisierung der Augenhornhaut
KG1376C1 (en) 2010-05-31 2011-08-30 M A Medvedev Method for keratoconus treatment
IT1400982B1 (it) 2010-07-05 2013-07-05 Pinelli Collirio osmotico trans-epiteliale per la cura del cheratocono.
US20120083772A1 (en) 2010-09-30 2012-04-05 Curveright Llc Corneal treatment system and method
US9622911B2 (en) 2010-09-30 2017-04-18 Cxl Ophthalmics, Llc Ophthalmic treatment device, system, and method of use
US8111394B1 (en) 2011-04-01 2012-02-07 IsoSpec Technologies, LP Raman spectrometer for monitoring traces of dissolved organic and inorganic substances
RU2456971C1 (ru) 2011-04-19 2012-07-27 Федеральное государственное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова Федерального агентства по высокотехнологичной медицинской помощи" Способ лечения прогрессирующего кератоконуса
US20120302862A1 (en) 2011-04-29 2012-11-29 The General Hospital Corporation Methods and arrangements for obtaining information and providing analysis for biological tissues
WO2012158991A2 (en) 2011-05-18 2012-11-22 Avedro, Inc. Controlled application of cross-linking agent
US9044308B2 (en) 2011-05-24 2015-06-02 Avedro, Inc. Systems and methods for reshaping an eye feature
US10813791B2 (en) 2011-06-02 2020-10-27 University Of Rochester Method for modifying the refractive index of ocular tissues and applications thereof
JP6122845B2 (ja) 2011-06-02 2017-04-26 アヴェドロ・インコーポレーテッドAvedro,Inc. 時間ベースの光活性剤の送達又は光活性マーカの存在をモニターするシステム及び方法
WO2012174453A2 (en) 2011-06-15 2012-12-20 Sybotics, Llc Systems and methods for binocular iris imaging
EP2760397A4 (en) 2011-10-02 2015-06-24 Avedro Inc SYSTEM AND METHOD FOR APPLYING AND MONITORING EYE THERAPY
US20150088231A1 (en) 2012-03-28 2015-03-26 Cxl Ophthalmics, Llc Ocular treatment system and method using red and gold phototherapy
EP2830627B1 (en) 2012-03-29 2024-05-01 Epion Therapeutics, Inc. Ocular treatment solutions, delivery devices and delivery augmentation methods
EP2830637B1 (en) 2012-03-29 2024-08-21 Epion Therapeutics, Inc. Compositions and methods for treating or preventing diseases associated with oxidative stress
WO2013148895A1 (en) 2012-03-29 2013-10-03 Cxl Ophthalmics, Llc Ocular cross-linking system and method for sealing corneal wounds
DE102013211854B4 (de) 2013-06-21 2017-01-05 Universität Rostock Verfahren und Vorrichtung zur Bestimmung einer spektralen Änderung von gestreutem Licht
WO2020264222A1 (en) 2019-06-25 2020-12-30 DeepMap Inc. Image-based keypoint generation

Also Published As

Publication number Publication date
EP2872082A4 (en) 2016-03-23
EP2872081B1 (en) 2022-06-08
WO2013059837A2 (en) 2013-04-25
JP2015526156A (ja) 2015-09-10
EP2872081B2 (en) 2025-07-16
US20130060187A1 (en) 2013-03-07
WO2014014521A1 (en) 2014-01-23
EP2872081A4 (en) 2016-03-30
EP2872082A1 (en) 2015-05-20
EP4074294A1 (en) 2022-10-19
US9707126B2 (en) 2017-07-18
EP2872081A2 (en) 2015-05-20
EP2872082B1 (en) 2020-09-09
WO2013059837A3 (en) 2013-06-27

Similar Documents

Publication Publication Date Title
JP6271541B2 (ja) パルスの光による角膜の架橋のためのシステム及び方法
US20130245536A1 (en) Systems and methods for corneal cross-linking with pulsed light
US20140066835A1 (en) Systems and methods for corneal cross-linking with pulsed light
JP7615386B2 (ja) 眼をマスク装置で処置するためのシステムおよび方法
JP6933377B2 (ja) 光増感剤を用いた眼の処置用システム及び方法
US9814903B2 (en) Ophthalmic phototherapy system and associated method
US9592405B2 (en) Ophthalmic phototherapy device and associated treatment method
US20120289886A1 (en) Controlled application of cross-linking agent
US20080015660A1 (en) Method And Apparatus For Photo-Chemical Oculoplasty/Keratoplasty
US20140113009A1 (en) Controlled application of cross-linking agent
EP3212140A1 (en) Systems and methods for cross-linking treatments of an eye
WO2011019940A2 (en) Deuterated water and riboflavin solution for extending singlet oxygen lifetimes in treatment of ocular tissue and method for use
CN105682620A (zh) 交联控制
WO2014071408A1 (en) Systems and methods for reshaping an eye feature
Shetty et al. Corneal Cross linkage-An Optical Marvel

Legal Events

Date Code Title Description
RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20150313

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20151029

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20151029

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20160826

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160830

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20161125

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170123

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170627

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170919

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20171205

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20171227

R150 Certificate of patent or registration of utility model

Ref document number: 6271541

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250