JP6262733B2 - イミダゾリン誘導体、その製造法、およびそれらの医薬への適用 - Google Patents

イミダゾリン誘導体、その製造法、およびそれらの医薬への適用 Download PDF

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JP6262733B2
JP6262733B2 JP2015528857A JP2015528857A JP6262733B2 JP 6262733 B2 JP6262733 B2 JP 6262733B2 JP 2015528857 A JP2015528857 A JP 2015528857A JP 2015528857 A JP2015528857 A JP 2015528857A JP 6262733 B2 JP6262733 B2 JP 6262733B2
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dimethyl
oxo
compound
trifluoromethyl
mmol
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JP2015526487A5 (OSRAM
JP2015526487A (ja
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ルウ、ヘジュン
スン、ピアオヤン
フェイ、ホンボ
ジアン、ホンジエン
ワン、ハオウェイ
ドン、チン
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/08—Drugs for disorders of the urinary system of the prostate
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    • A—HUMAN NECESSITIES
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2015528857A 2012-09-04 2013-08-26 イミダゾリン誘導体、その製造法、およびそれらの医薬への適用 Active JP6262733B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201210323870.3 2012-09-04
CN201210323870 2012-09-04
PCT/CN2013/082273 WO2014036897A1 (zh) 2012-09-04 2013-08-26 咪唑啉类衍生物、其制备方法及其在医药上的应用

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JP2015526487A JP2015526487A (ja) 2015-09-10
JP2015526487A5 JP2015526487A5 (OSRAM) 2017-12-21
JP6262733B2 true JP6262733B2 (ja) 2018-01-17

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US (2) US9586947B2 (OSRAM)
EP (1) EP2894151B1 (OSRAM)
JP (1) JP6262733B2 (OSRAM)
KR (1) KR102189940B1 (OSRAM)
CN (1) CN103958480B (OSRAM)
AU (1) AU2013312587B2 (OSRAM)
BR (1) BR112015004637B1 (OSRAM)
CA (1) CA2883545C (OSRAM)
CY (1) CY1123649T1 (OSRAM)
DK (1) DK2894151T3 (OSRAM)
ES (1) ES2835248T3 (OSRAM)
HR (1) HRP20202050T1 (OSRAM)
HU (1) HUE052904T2 (OSRAM)
LT (1) LT2894151T (OSRAM)
MX (1) MX368844B (OSRAM)
PT (1) PT2894151T (OSRAM)
RS (1) RS61242B1 (OSRAM)
RU (1) RU2639145C2 (OSRAM)
SI (1) SI2894151T1 (OSRAM)
SM (1) SMT202000672T1 (OSRAM)
TW (1) TWI617546B (OSRAM)
WO (1) WO2014036897A1 (OSRAM)

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CN115850186B (zh) * 2023-02-07 2024-04-09 长沙泽达医药科技有限公司 一种乙撑硫脲衍生物的晶型及用途
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HK1198476A1 (zh) 2015-05-08
BR112015004637A2 (pt) 2017-07-04
US20170128422A1 (en) 2017-05-11
MX368844B (es) 2019-10-16
US9586947B2 (en) 2017-03-07
DK2894151T3 (da) 2021-01-11
CA2883545A1 (en) 2014-03-13
KR20150047591A (ko) 2015-05-04
TW201410655A (zh) 2014-03-16
RU2639145C2 (ru) 2017-12-20
CA2883545C (en) 2020-07-07
EP2894151A4 (en) 2016-01-20
CN103958480A (zh) 2014-07-30
US20150225381A1 (en) 2015-08-13
AU2013312587A1 (en) 2015-03-19
CN103958480B (zh) 2016-04-06
RU2015110122A (ru) 2016-10-27
EP2894151A1 (en) 2015-07-15
TWI617546B (zh) 2018-03-11
AU2013312587B2 (en) 2017-03-16
US9895355B2 (en) 2018-02-20
RS61242B1 (sr) 2021-01-29
JP2015526487A (ja) 2015-09-10
KR102189940B1 (ko) 2020-12-14
HUE052904T2 (hu) 2021-05-28
SMT202000672T1 (it) 2021-01-05
EP2894151B1 (en) 2020-11-11
PT2894151T (pt) 2020-12-07
HRP20202050T1 (hr) 2021-02-19
WO2014036897A1 (zh) 2014-03-13
BR112015004637B1 (pt) 2022-04-05
LT2894151T (lt) 2021-09-10
CY1123649T1 (el) 2022-03-24
MX2015002602A (es) 2015-06-10
ES2835248T3 (es) 2021-06-22

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