JP2015526487A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015526487A5 JP2015526487A5 JP2015528857A JP2015528857A JP2015526487A5 JP 2015526487 A5 JP2015526487 A5 JP 2015526487A5 JP 2015528857 A JP2015528857 A JP 2015528857A JP 2015528857 A JP2015528857 A JP 2015528857A JP 2015526487 A5 JP2015526487 A5 JP 2015526487A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- alkyl
- pharmaceutically acceptable
- mesomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210323870.3 | 2012-09-04 | ||
| CN201210323870 | 2012-09-04 | ||
| PCT/CN2013/082273 WO2014036897A1 (zh) | 2012-09-04 | 2013-08-26 | 咪唑啉类衍生物、其制备方法及其在医药上的应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015526487A JP2015526487A (ja) | 2015-09-10 |
| JP2015526487A5 true JP2015526487A5 (OSRAM) | 2017-12-21 |
| JP6262733B2 JP6262733B2 (ja) | 2018-01-17 |
Family
ID=50236528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015528857A Active JP6262733B2 (ja) | 2012-09-04 | 2013-08-26 | イミダゾリン誘導体、その製造法、およびそれらの医薬への適用 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US9586947B2 (OSRAM) |
| EP (1) | EP2894151B1 (OSRAM) |
| JP (1) | JP6262733B2 (OSRAM) |
| KR (1) | KR102189940B1 (OSRAM) |
| CN (1) | CN103958480B (OSRAM) |
| AU (1) | AU2013312587B2 (OSRAM) |
| BR (1) | BR112015004637B1 (OSRAM) |
| CA (1) | CA2883545C (OSRAM) |
| CY (1) | CY1123649T1 (OSRAM) |
| DK (1) | DK2894151T3 (OSRAM) |
| ES (1) | ES2835248T3 (OSRAM) |
| HR (1) | HRP20202050T1 (OSRAM) |
| HU (1) | HUE052904T2 (OSRAM) |
| LT (1) | LT2894151T (OSRAM) |
| MX (1) | MX368844B (OSRAM) |
| PT (1) | PT2894151T (OSRAM) |
| RS (1) | RS61242B1 (OSRAM) |
| RU (1) | RU2639145C2 (OSRAM) |
| SI (1) | SI2894151T1 (OSRAM) |
| SM (1) | SMT202000672T1 (OSRAM) |
| TW (1) | TWI617546B (OSRAM) |
| WO (1) | WO2014036897A1 (OSRAM) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2639145C2 (ru) * | 2012-09-04 | 2017-12-20 | Шанхай Хэнжуй Фармасьютикал Ко., Лтд. | Производные оксотиоимидазолидина, способы их получения и их применение в медицине в качестве ингибиторов андрогенного рецептора |
| US12312316B2 (en) | 2015-01-20 | 2025-05-27 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| US11352351B2 (en) * | 2015-01-20 | 2022-06-07 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| RU2018105094A (ru) * | 2015-07-13 | 2019-08-14 | Арвинас, Инк. | Модуляторы протеолиза на основе аланина и связанные с ними способы применения |
| WO2017041622A1 (zh) * | 2015-09-10 | 2017-03-16 | 江苏恒瑞医药股份有限公司 | 一种雄性激素受体抑制剂的结晶形式及其制备方法 |
| CN106518773A (zh) * | 2015-09-10 | 2017-03-22 | 江苏恒瑞医药股份有限公司 | 一种雄性激素受体抑制剂的结晶形式及其制备方法 |
| TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
| US9963433B2 (en) * | 2016-01-29 | 2018-05-08 | Wayne State University | Anticancer drugs including the chemical structures of an androgen receptor ligand and a histone deacetylase inhibitor |
| KR20180109991A (ko) * | 2016-02-19 | 2018-10-08 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 이미다졸린 유도체를 함유하는 약학적 조성물 |
| CA3030181A1 (en) * | 2016-07-08 | 2018-01-11 | Janssen Pharmaceutica Nv | Substituted hydantoin and thiohydantoin derivatives as androgen receptor antagonists |
| WO2018009694A1 (en) * | 2016-07-08 | 2018-01-11 | Janssen Pharmaceutica Nv | Thiohydantoin androgen receptor antagonists for the treatment of cancer |
| US20200000776A1 (en) | 2017-02-13 | 2020-01-02 | Kangpu Biopharmaceuticals, Ltd. | Combination treating prostate cancer, pharmaceutical composition and treatment method |
| CN109912509B (zh) * | 2017-12-13 | 2021-02-26 | 江苏恒瑞医药股份有限公司 | 一种雄性激素受体抑制剂的晶型及其制备方法 |
| CN110684046B (zh) * | 2018-07-06 | 2023-05-12 | 江苏恒瑞医药股份有限公司 | 一种新的咪唑啉类衍生物的制备方法 |
| CN108976171B (zh) * | 2018-08-27 | 2020-06-16 | 长沙泽达医药科技有限公司 | 化合物、组合物及其在药物制备中的用途 |
| AU2019344897B2 (en) | 2018-09-18 | 2024-01-18 | Nikang Therapeutics, Inc. | Tri-substituted heteroaryl derivatives AS SRC homology-2 phosphatase inhibitors |
| WO2020083187A1 (zh) * | 2018-10-22 | 2020-04-30 | 江苏恒瑞医药股份有限公司 | 一种ar拮抗剂联合parp抑制剂在制备治疗前列腺癌的药物中的用途 |
| FI3897636T3 (fi) * | 2018-12-19 | 2025-02-03 | Celgene Corp | Substituoituja 3-((3-aminofenyyli)amino)piperidiini-2,6-dioniyhdisteitä, niiden koostumuksia ja menetelmiä niillä annettavia hoitoja varten |
| KR102864064B1 (ko) | 2018-12-19 | 2025-09-24 | 셀진 코포레이션 | 치환된 3-((3-아미노페닐)아미노)피페리딘-2,6-디온 화합물, 이의 조성물, 및 이를 사용한 치료 방법 |
| GB201908511D0 (en) | 2019-06-13 | 2019-07-31 | Adorx Therapeutics Ltd | Hydroxamate compounds |
| CN113929628A (zh) * | 2020-06-29 | 2022-01-14 | 江苏恒瑞医药股份有限公司 | 一种咪唑啉衍生物的制备方法 |
| CN113024513A (zh) * | 2021-03-22 | 2021-06-25 | 中国药科大学 | 新型雄激素受体降解剂、制备方法和医药用途 |
| CN115850186B (zh) * | 2023-02-07 | 2024-04-09 | 长沙泽达医药科技有限公司 | 一种乙撑硫脲衍生物的晶型及用途 |
| CN118993935B (zh) * | 2024-10-23 | 2025-02-14 | 江苏恒瑞医药股份有限公司 | 咪唑啉衍生物或其盐的制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6713474B2 (en) | 1998-09-18 | 2004-03-30 | Abbott Gmbh & Co. Kg | Pyrrolopyrimidines as therapeutic agents |
| SE0100902D0 (sv) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
| RU2304140C2 (ru) | 2001-12-27 | 2007-08-10 | Дайити Фармасьютикал Ко., Лтд. | ИНГИБИТОРЫ ПРОДУЦИРОВАНИЯ / СЕКРЕЦИИ β-АМИЛОИДНОГО БЕЛКА |
| AU2003279442A1 (en) * | 2002-10-04 | 2004-04-23 | Laboratoires Fournier S.A. | 2-thiohydantoine derivative compounds and use thereof for the treatment of diabetes |
| CN101676270A (zh) | 2004-09-09 | 2010-03-24 | 中外制药株式会社 | 新型四氢咪唑衍生物及其用途 |
| US20070015782A1 (en) | 2005-04-15 | 2007-01-18 | Eisai Co., Ltd. | Benzimidazole compound |
| US7709517B2 (en) * | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
| RS52274B2 (sr) * | 2005-05-13 | 2018-05-31 | Univ California | Jedinjenje diarilhidantoina |
| CA2838448A1 (en) | 2006-06-27 | 2008-01-03 | Takeda Pharmaceutical Company Limited | Fused cyclic compounds |
| EA019647B1 (ru) | 2009-02-10 | 2014-05-30 | Астразенека Аб | ПРОИЗВОДНЫЕ ТРИАЗОЛО[4,3-b]ПИРИДАЗИНА И ИХ ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ |
| CN101817787B (zh) * | 2009-02-26 | 2013-07-24 | 童友之 | 抗前列腺癌的雄性激素受体拮抗剂 |
| US8710086B2 (en) * | 2009-04-09 | 2014-04-29 | Medivation Technologies, Inc. | Substituted di-arylhydantoin and di-arylthiohydantoin compounds and methods of use thereof |
| WO2011008543A2 (en) | 2009-06-29 | 2011-01-20 | University Of Delaware | Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal |
| US8383651B2 (en) | 2009-09-22 | 2013-02-26 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the CB2 receptor |
| WO2011103196A1 (en) | 2010-02-17 | 2011-08-25 | Amgen Inc. | Aryl carboxamide derivatives as sodium channel inhibitors for treatment of pain |
| RU2434851C1 (ru) | 2010-07-22 | 2011-11-27 | Александр Васильевич Иващенко | Циклические n, n'-диарилтиомочевины или n, n'-диарилмочевины - антагонисты андрогенных рецепторов, противораковое средство, способ получения и применения |
| WO2012015723A1 (en) | 2010-07-26 | 2012-02-02 | Bristol-Myers Squibb Company | Sulfonamide compounds useful as cyp17 inhibitors |
| WO2012050868A1 (en) | 2010-09-28 | 2012-04-19 | Georgia Tech Research Corporation | Histone deacetylase (hdac) inhibitors targeting prostate tumors and methods of making and using thereof |
| UA113501C2 (xx) | 2010-11-03 | 2017-02-10 | Пестицидні композиції і пов'язані з ними способи | |
| CA2829322C (en) | 2011-03-10 | 2017-01-10 | Suzhou Kintor Pharmaceuticals, Inc. | Substituted thioimidazolidinone androgen receptor antagonists and uses thereof |
| RU2639145C2 (ru) * | 2012-09-04 | 2017-12-20 | Шанхай Хэнжуй Фармасьютикал Ко., Лтд. | Производные оксотиоимидазолидина, способы их получения и их применение в медицине в качестве ингибиторов андрогенного рецептора |
-
2013
- 2013-08-26 RU RU2015110122A patent/RU2639145C2/ru active
- 2013-08-26 BR BR112015004637-1A patent/BR112015004637B1/pt active IP Right Grant
- 2013-08-26 WO PCT/CN2013/082273 patent/WO2014036897A1/zh not_active Ceased
- 2013-08-26 LT LTEP13835193.7T patent/LT2894151T/lt unknown
- 2013-08-26 HU HUE13835193A patent/HUE052904T2/hu unknown
- 2013-08-26 EP EP13835193.7A patent/EP2894151B1/en active Active
- 2013-08-26 HR HRP20202050TT patent/HRP20202050T1/hr unknown
- 2013-08-26 AU AU2013312587A patent/AU2013312587B2/en active Active
- 2013-08-26 SI SI201331826T patent/SI2894151T1/sl unknown
- 2013-08-26 ES ES13835193T patent/ES2835248T3/es active Active
- 2013-08-26 JP JP2015528857A patent/JP6262733B2/ja active Active
- 2013-08-26 KR KR1020157007651A patent/KR102189940B1/ko active Active
- 2013-08-26 MX MX2015002602A patent/MX368844B/es active IP Right Grant
- 2013-08-26 US US14/425,207 patent/US9586947B2/en active Active
- 2013-08-26 CN CN201380004069.5A patent/CN103958480B/zh active Active
- 2013-08-26 DK DK13835193.7T patent/DK2894151T3/da active
- 2013-08-26 CA CA2883545A patent/CA2883545C/en active Active
- 2013-08-26 RS RS20201565A patent/RS61242B1/sr unknown
- 2013-08-26 PT PT138351937T patent/PT2894151T/pt unknown
- 2013-08-26 SM SM20200672T patent/SMT202000672T1/it unknown
- 2013-08-30 TW TW102131223A patent/TWI617546B/zh active
-
2017
- 2017-01-20 US US15/411,517 patent/US9895355B2/en active Active
-
2020
- 2020-12-18 CY CY20201101202T patent/CY1123649T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015526487A5 (OSRAM) | ||
| RU2015110122A (ru) | Производные имидазолина, способы их получения и их применение в медицине | |
| TWI674258B (zh) | Ｄｎａ烷化劑 | |
| JP2017533968A5 (OSRAM) | ||
| WO2017195216A4 (en) | Cyclopropyl-amide compounds as dual lsd1/hdac inhibitors | |
| CN110582483A (zh) | 含邻氨基杂芳环炔基的化合物及其制备方法和用途 | |
| JP2007509116A5 (OSRAM) | ||
| JP2017526727A5 (OSRAM) | ||
| JP2013518106A5 (OSRAM) | ||
| RU2014113679A (ru) | N-(2-амино-6,6-дифтор-4,4а,5,6,7,7а-гексагидро-циклопента[e][1,3]оксазин-4-ил)-фенил)-амиды в качестве ингибиторов бета-секретазы 1 | |
| JP2014185188A (ja) | フェニルおよびベンゾジオキシニル置換インダゾール誘導体 | |
| JP2011116780A5 (OSRAM) | ||
| CA2727378A1 (en) | New co-crystal compound of rivaroxaban and malonic acid | |
| JP2012522847A5 (OSRAM) | ||
| IL228072A (en) | Quinazoline compound is converted to alkyl and methods of use | |
| JP2018527328A (ja) | 置換３−（３−アニリノ−１−シクロヘキシル−１ｈ−ベンズイミダゾール−５−イル）プロパン酸誘導体を調製する方法 | |
| JP2013521301A5 (OSRAM) | ||
| WO2014031755A1 (en) | Fendiline derivatives and methods of use thereof | |
| JP2019535825A5 (OSRAM) | ||
| RU2012126112A (ru) | Соединение, некоторые его новые формы, фармацевтические композиции на его основе и способы получения и применения | |
| JP2009531363A5 (OSRAM) | ||
| JP5575357B2 (ja) | 組織因子産生抑制剤 | |
| AU2015367540B2 (en) | Substituted Pyridyl-cycloalkyl-carboxylic acids, compositions containing them and medical uses thereof | |
| JP2018516873A5 (OSRAM) | ||
| RU2013125756A (ru) | Твердые формы (s)-2-амино-3-(4-(2-амино-6-((r)-1-(4-хлор-2-(3-метил-1н-пиразол-1-ил)фенил)-2,2,2-трифторэтокси)пиримидин-4-ил)фенил)пропановой кислоты |