JP6258298B2 - グリコシル化されている修飾フラビンアデニンジヌクレオチド依存性グルコース脱水素酵素 - Google Patents

グリコシル化されている修飾フラビンアデニンジヌクレオチド依存性グルコース脱水素酵素 Download PDF

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JP6258298B2
JP6258298B2 JP2015509459A JP2015509459A JP6258298B2 JP 6258298 B2 JP6258298 B2 JP 6258298B2 JP 2015509459 A JP2015509459 A JP 2015509459A JP 2015509459 A JP2015509459 A JP 2015509459A JP 6258298 B2 JP6258298 B2 JP 6258298B2
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adenine dinucleotide
flavin adenine
dependent glucose
glucose dehydrogenase
fad
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JP2015519892A (ja
JP2015519892A5 (enExample
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デュッフェル、ハルトムート
マイアー、トーマス
タッケ、ミヒャエル
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エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト
エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/54Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y101/00Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/05Oxidoreductases acting on the CH-OH group of donors (1.1) with a quinone or similar compound as acceptor (1.1.5)
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    • C12YENZYMES
    • C12Y101/00Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/99Oxidoreductases acting on the CH-OH group of donors (1.1) with other acceptors (1.1.99)
    • C12Y101/9901Glucose dehydrogenase (acceptor) (1.1.99.10)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose

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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2015509459A 2012-05-03 2013-05-03 グリコシル化されている修飾フラビンアデニンジヌクレオチド依存性グルコース脱水素酵素 Active JP6258298B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12166703.4 2012-05-03
EP12166703 2012-05-03
PCT/EP2013/059313 WO2013164477A1 (en) 2012-05-03 2013-05-03 A glycosylated modified flavin adenine dinucleotide dependent glucose dehydrogenase

Publications (3)

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JP2015519892A JP2015519892A (ja) 2015-07-16
JP2015519892A5 JP2015519892A5 (enExample) 2016-06-30
JP6258298B2 true JP6258298B2 (ja) 2018-01-10

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JP2015509459A Active JP6258298B2 (ja) 2012-05-03 2013-05-03 グリコシル化されている修飾フラビンアデニンジヌクレオチド依存性グルコース脱水素酵素

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US (1) US9637774B2 (enExample)
EP (1) EP2844747B1 (enExample)
JP (1) JP6258298B2 (enExample)
KR (1) KR101850178B1 (enExample)
CN (1) CN104271736B (enExample)
CA (1) CA2869527C (enExample)
WO (1) WO2013164477A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2647705B1 (en) 2010-12-02 2016-08-03 Kikkoman Corporation Flavin-bound glucose dehyrogenase, production method for flavin-bound glucose dehyrogenase, and yeast transformant used in same
JP6526572B2 (ja) * 2013-12-27 2019-06-05 キッコーマン株式会社 熱安定性が向上したフラビン結合型グルコースデヒドロゲナーゼ
KR20180040595A (ko) * 2015-07-23 2018-04-20 스마트자임 바이오파마 리미티드 혈당치를 측정하기 위한 조성물 및 방법
JP6901717B2 (ja) * 2016-08-29 2021-07-14 国立研究開発法人産業技術総合研究所 グルコースセンサ用試薬、グルコースセンサ、グルコースセンサの製造方法、および、グルコース測定装置
KR102728752B1 (ko) * 2017-03-31 2024-11-11 기꼬만 가부시키가이샤 Fad-의존형 글루코오스 탈수소효소를 이용하는 연속적인 글루코오스 모니터링 방법
JP2021078354A (ja) 2018-03-08 2021-05-27 有限会社アルティザイム・インターナショナル フラビンアデニンジヌクレオチドグルコース脱水素酵素とシトクロム分子との融合タンパク質
CN108486027A (zh) * 2018-04-04 2018-09-04 江南大学 一种fad为辅基的葡萄糖脱氢酶的生产、纯化方法
CN112851821B (zh) * 2021-01-12 2022-07-05 山东省科学院生物研究所 一种融合酶及所述融合酶在纸基生物传感器中的应用
CN113552198B (zh) * 2021-05-31 2024-03-26 武汉维尔博生物科技有限公司 一种基于高响应葡萄糖适配体的电化学传感器及其制备方法
EP4512395A1 (en) 2023-08-21 2025-02-26 Bio Even Composition comprising flavin adenine dinucleotide (fad), l-gsh, atp and myristic acid, alone or with a drug

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2083074B1 (en) * 2006-11-14 2011-01-19 Toyo Boseki Kabushiki Kaisha Modified flavine-adenine-dinucleotide-dependent glucose dehydrogenase
DE602007012130D1 (de) * 2006-11-14 2011-03-03 Toyo Boseki Modifizierte flavin-adenin-dinucleotid-abhängige glucose-dehydrogenase
JPWO2008102639A1 (ja) * 2007-02-20 2010-05-27 東洋紡績株式会社 グルコースの電気化学的定量方法、グルコース脱水素酵素組成物、及び、グルコース測定用電気化学センサー
CN101970656A (zh) * 2007-12-28 2011-02-09 池田食研株式会社 经修饰葡萄糖脱氢酶基因
JP5408125B2 (ja) * 2008-03-27 2014-02-05 東洋紡株式会社 糸状菌由来フラビンアデニンジヌクレオチド依存性グルコースデヒドロゲナーゼ(fadgdh)
JP2010054503A (ja) * 2008-08-01 2010-03-11 Toyobo Co Ltd グルコース脱水素酵素を用いたグルコースの電気化学測定法
JP2010057427A (ja) * 2008-09-04 2010-03-18 Toyobo Co Ltd グルコース脱水素酵素およびグルコースの電気化学測定法
WO2010126139A1 (ja) * 2009-04-30 2010-11-04 池田食研株式会社 蛋白質性電子メディエータ
JP2012029677A (ja) 2010-07-08 2012-02-16 Toyobo Co Ltd フラビンアデニンジヌクレオチド依存性グルコースデヒドロゲナーゼの基質特異性を改善するための方法
JP5811521B2 (ja) 2010-09-09 2015-11-11 東洋紡株式会社 フラビンアデニンジヌクレオチド依存性グルコースデヒドロゲナーゼの比活性を向上するための方法

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Publication number Publication date
CN104271736B (zh) 2020-06-05
EP2844747B1 (en) 2019-03-20
JP2015519892A (ja) 2015-07-16
KR101850178B1 (ko) 2018-05-31
US20150064733A1 (en) 2015-03-05
WO2013164477A1 (en) 2013-11-07
CA2869527A1 (en) 2013-11-07
CN104271736A (zh) 2015-01-07
EP2844747A1 (en) 2015-03-11
US9637774B2 (en) 2017-05-02
KR20150001775A (ko) 2015-01-06
HK1205757A1 (en) 2015-12-24
CA2869527C (en) 2021-05-04

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