JP6251682B2 - メラノーマ治療の治療の組み合わせ及び方法 - Google Patents
メラノーマ治療の治療の組み合わせ及び方法 Download PDFInfo
- Publication number
- JP6251682B2 JP6251682B2 JP2014538892A JP2014538892A JP6251682B2 JP 6251682 B2 JP6251682 B2 JP 6251682B2 JP 2014538892 A JP2014538892 A JP 2014538892A JP 2014538892 A JP2014538892 A JP 2014538892A JP 6251682 B2 JP6251682 B2 JP 6251682B2
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- JP
- Japan
- Prior art keywords
- antibody
- seq
- etbr
- mpk
- inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161552893P | 2011-10-28 | 2011-10-28 | |
US61/552,893 | 2011-10-28 | ||
US201261678978P | 2012-08-02 | 2012-08-02 | |
US61/678,978 | 2012-08-02 | ||
PCT/US2012/061533 WO2013063001A1 (en) | 2011-10-28 | 2012-10-24 | Therapeutic combinations and methods of treating melanoma |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017161010A Division JP2018027948A (ja) | 2011-10-28 | 2017-08-24 | メラノーマ治療の治療の組み合わせ及び方法 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2014532648A JP2014532648A (ja) | 2014-12-08 |
JP2014532648A5 JP2014532648A5 (pt) | 2015-12-17 |
JP6251682B2 true JP6251682B2 (ja) | 2017-12-20 |
Family
ID=48168400
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014538892A Expired - Fee Related JP6251682B2 (ja) | 2011-10-28 | 2012-10-24 | メラノーマ治療の治療の組み合わせ及び方法 |
JP2017161010A Withdrawn JP2018027948A (ja) | 2011-10-28 | 2017-08-24 | メラノーマ治療の治療の組み合わせ及び方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017161010A Withdrawn JP2018027948A (ja) | 2011-10-28 | 2017-08-24 | メラノーマ治療の治療の組み合わせ及び方法 |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP2776051A4 (pt) |
JP (2) | JP6251682B2 (pt) |
KR (1) | KR20140097205A (pt) |
CN (1) | CN104039340B (pt) |
AR (1) | AR088509A1 (pt) |
AU (1) | AU2012328980A1 (pt) |
BR (1) | BR112014009953A2 (pt) |
CA (1) | CA2850034A1 (pt) |
CL (1) | CL2014001092A1 (pt) |
CO (1) | CO7151543A2 (pt) |
EA (1) | EA201490879A1 (pt) |
IL (1) | IL232135A0 (pt) |
IN (1) | IN2014CN03062A (pt) |
MX (1) | MX2014004991A (pt) |
PE (1) | PE20142312A1 (pt) |
SG (1) | SG11201401815XA (pt) |
TW (1) | TW201325613A (pt) |
WO (1) | WO2013063001A1 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
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TW201840336A (zh) | 2011-08-01 | 2018-11-16 | 美商建南德克公司 | 利用pd-1軸結合拮抗劑及mek抑制劑治療癌症之方法 |
US9216170B2 (en) | 2012-03-19 | 2015-12-22 | Hoffmann-La Roche Inc. | Combination therapy for proliferative disorders |
AU2015289672A1 (en) | 2014-07-15 | 2017-03-02 | Genentech, Inc. | Compositions for treating cancer using PD-1 axis binding antagonists and MEK inhibitors |
BR112017006113A8 (pt) * | 2014-10-10 | 2018-04-24 | Pfizer | usos de auristatina, composições farmacêuticas, formas de dosagem para o tratamento de câncer e kits. |
EP3331542A4 (en) * | 2015-08-03 | 2019-04-03 | ENB Therapeutics, LLC | COMPOSITIONS AND METHODS OF TREATING CANCER ASSOCIATED WITH ETBR ACTIVATION |
FR3053042B1 (fr) | 2016-06-24 | 2018-08-10 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Anticorps dirige contre le sous-type b des recepteurs aux endothelines et ses utilisations |
MX2019008458A (es) | 2017-01-17 | 2019-12-02 | Heparegenix Gmbh | Inhibidores de proteina cinasa para promover la regeneracion hepatica o reducir o prevenir la muerte de hepatocitos. |
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IN2014CN03062A (pt) | 2015-07-31 |
CN104039340B (zh) | 2017-04-05 |
MX2014004991A (es) | 2014-05-22 |
EP2776051A4 (en) | 2015-06-17 |
TW201325613A (zh) | 2013-07-01 |
AR088509A1 (es) | 2014-06-11 |
AU2012328980A1 (en) | 2014-04-24 |
KR20140097205A (ko) | 2014-08-06 |
CN104039340A (zh) | 2014-09-10 |
CA2850034A1 (en) | 2013-05-02 |
EP2776051A1 (en) | 2014-09-17 |
EA201490879A1 (ru) | 2014-08-29 |
JP2014532648A (ja) | 2014-12-08 |
IL232135A0 (en) | 2014-05-28 |
WO2013063001A1 (en) | 2013-05-02 |
JP2018027948A (ja) | 2018-02-22 |
SG11201401815XA (en) | 2014-05-29 |
PE20142312A1 (es) | 2015-01-25 |
BR112014009953A2 (pt) | 2017-12-05 |
CL2014001092A1 (es) | 2014-07-25 |
CO7151543A2 (es) | 2014-12-29 |
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