JP6214657B2 - ヒト免疫不全ウイルス複製阻害剤 - Google Patents
ヒト免疫不全ウイルス複製阻害剤 Download PDFInfo
- Publication number
- JP6214657B2 JP6214657B2 JP2015527515A JP2015527515A JP6214657B2 JP 6214657 B2 JP6214657 B2 JP 6214657B2 JP 2015527515 A JP2015527515 A JP 2015527515A JP 2015527515 A JP2015527515 A JP 2015527515A JP 6214657 B2 JP6214657 B2 JP 6214657B2
- Authority
- JP
- Japan
- Prior art keywords
- tert
- butoxy
- acetic acid
- dioxa
- tetraazahexacyclo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- SCSKQHGHSGOQOS-PSDZNPJRSA-N CC(C)(C)O[C@H](C(O)=O)c(c(C)nc1cc-2n[n]11)c1N(CC1)CCC1(C)/C=C/C=C\CCc1ccccc1-c1cccc-2c1 Chemical compound CC(C)(C)O[C@H](C(O)=O)c(c(C)nc1cc-2n[n]11)c1N(CC1)CCC1(C)/C=C/C=C\CCc1ccccc1-c1cccc-2c1 SCSKQHGHSGOQOS-PSDZNPJRSA-N 0.000 description 1
- HANFDNAKFLXLSV-XIFFEERXSA-N CC(C)(C)O[C@H](C(O)=O)c(c(C)nc1cc-2n[n]11)c1N(CC1)CCC1(C)CCCCCCc1ccccc1-c1cccc-2c1 Chemical compound CC(C)(C)O[C@H](C(O)=O)c(c(C)nc1cc-2n[n]11)c1N(CC1)CCC1(C)CCCCCCc1ccccc1-c1cccc-2c1 HANFDNAKFLXLSV-XIFFEERXSA-N 0.000 description 1
- QNHCUEYHMKHFHZ-WRAWZCCESA-N CC(C)(C)O[C@H](C(OC)=O)c(c(C)nc1c2)c(-c(cc3)cc4c3OCC[C@H]4CCCCOc3c-4cccc3)[n]1nc2-c1cccc-4c1 Chemical compound CC(C)(C)O[C@H](C(OC)=O)c(c(C)nc1c2)c(-c(cc3)cc4c3OCC[C@H]4CCCCOc3c-4cccc3)[n]1nc2-c1cccc-4c1 QNHCUEYHMKHFHZ-WRAWZCCESA-N 0.000 description 1
- GAWSZJCLDKAJAW-ZZMOXNGHSA-N CC(C)(C)O[C@H](C(OC)=O)c(c(C)nc1c2)c(-c(ccc(OCC3)c4N3C/C=C/CCc3cccc-5c3)c4Cl)[n]1nc2-c1cc-5ccc1 Chemical compound CC(C)(C)O[C@H](C(OC)=O)c(c(C)nc1c2)c(-c(ccc(OCC3)c4N3C/C=C/CCc3cccc-5c3)c4Cl)[n]1nc2-c1cc-5ccc1 GAWSZJCLDKAJAW-ZZMOXNGHSA-N 0.000 description 1
- CXAIOJIHWSUYRD-HKBQPEDESA-N CC(C)(C)O[C@H](C(OC)=O)c(c(C)nc1cc(-c2cc(-c3cc(C(F)(F)F)ccc3O)ccc2)n[n]11)c1N(CC1)CCC1(C)OCC=C Chemical compound CC(C)(C)O[C@H](C(OC)=O)c(c(C)nc1cc(-c2cc(-c3cc(C(F)(F)F)ccc3O)ccc2)n[n]11)c1N(CC1)CCC1(C)OCC=C CXAIOJIHWSUYRD-HKBQPEDESA-N 0.000 description 1
- DLNWMDLPJPGRIH-VWLOTQADSA-N CC(C)(C)O[C@H](C(OC)=O)c(c(C)nc1cc(-c2cc(Br)ccc2)n[n]11)c1N(CC1)CCC1(C)OCC=C Chemical compound CC(C)(C)O[C@H](C(OC)=O)c(c(C)nc1cc(-c2cc(Br)ccc2)n[n]11)c1N(CC1)CCC1(C)OCC=C DLNWMDLPJPGRIH-VWLOTQADSA-N 0.000 description 1
- XDCADFBGVBKALR-HKBQPEDESA-N CC(C)(C)O[C@H](C(OC)=O)c(c(C)nc1cc(-c2cccc(-c(c(O)c3)ccc3F)c2)n[n]11)c1N(CC1)CCC1(C)OCC=C Chemical compound CC(C)(C)O[C@H](C(OC)=O)c(c(C)nc1cc(-c2cccc(-c(c(O)c3)ccc3F)c2)n[n]11)c1N(CC1)CCC1(C)OCC=C XDCADFBGVBKALR-HKBQPEDESA-N 0.000 description 1
- VPLPWULVNFGHGO-MZNKCQHYSA-N CC(C)(C)O[C@H](C(OC)=O)c(c(C)nc1cc-2n[n]11)c1N(CC1)CCC1(C)COC/C=C/CCc1ccccc1-c1cccc-2c1 Chemical compound CC(C)(C)O[C@H](C(OC)=O)c(c(C)nc1cc-2n[n]11)c1N(CC1)CCC1(C)COC/C=C/CCc1ccccc1-c1cccc-2c1 VPLPWULVNFGHGO-MZNKCQHYSA-N 0.000 description 1
- LZQMKLLEWNOCCA-UHFFFAOYSA-N CC(C)(C)[O-4]C(C(O)=O)c(c(C)nc1c2)c(-c(cc3F)cc4c3OCCN4CCCCCc3c-4cccc3)[n]1nc2-c1cc-4ccc1 Chemical compound CC(C)(C)[O-4]C(C(O)=O)c(c(C)nc1c2)c(-c(cc3F)cc4c3OCCN4CCCCCc3c-4cccc3)[n]1nc2-c1cc-4ccc1 LZQMKLLEWNOCCA-UHFFFAOYSA-N 0.000 description 1
- XJGLKZJLIXOCRB-UHFFFAOYSA-N CC(C)(C)[O-4]C(C(OC)=O)c(c(C)nc1c2)c(-c(cc3F)cc4c3OCCN4CC=C)[n]1nc2-c1cc(-c2ccccc2CCC=C)ccc1 Chemical compound CC(C)(C)[O-4]C(C(OC)=O)c(c(C)nc1c2)c(-c(cc3F)cc4c3OCCN4CC=C)[n]1nc2-c1cc(-c2ccccc2CCC=C)ccc1 XJGLKZJLIXOCRB-UHFFFAOYSA-N 0.000 description 1
- KSNOFMBHCAGULO-UHFFFAOYSA-N CC1(C)OB(c(cc2F)cc3c2OCCN3CC=C)OC1(C)C Chemical compound CC1(C)OB(c(cc2F)cc3c2OCCN3CC=C)OC1(C)C KSNOFMBHCAGULO-UHFFFAOYSA-N 0.000 description 1
- SDSSOFXNNKFCPE-UHFFFAOYSA-N CN(CC(OB(c1ccccc1CCC=C)O1)=O)CC1=O Chemical compound CN(CC(OB(c1ccccc1CCC=C)O1)=O)CC1=O SDSSOFXNNKFCPE-UHFFFAOYSA-N 0.000 description 1
- LIDHCSXTMSQAQK-QIIIRZTJSA-N C[C@@H](/C=N/CCOC(C)(CC1)CCN1c1c([C@@H](C(O)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1ccncc1-c1cccc-3c1 Chemical compound C[C@@H](/C=N/CCOC(C)(CC1)CCN1c1c([C@@H](C(O)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1ccncc1-c1cccc-3c1 LIDHCSXTMSQAQK-QIIIRZTJSA-N 0.000 description 1
- WRJYLABXLMJHFV-SPFKFGNLSA-N C[C@@H](C/C=C/COC(C)(CC1)CCN1c1c([C@@H](C(O)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc(ccc(C)c1)c1-c1cccc-3c1 Chemical compound C[C@@H](C/C=C/COC(C)(CC1)CCN1c1c([C@@H](C(O)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc(ccc(C)c1)c1-c1cccc-3c1 WRJYLABXLMJHFV-SPFKFGNLSA-N 0.000 description 1
- RPBJAKCLYAXHCN-GGOOWQFJSA-N C[C@@H](C/C=C/COC(C)(CC1)CCN1c1c([C@@H](C(O)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1ccc(C)c(F)c1-c1cccc-3c1 Chemical compound C[C@@H](C/C=C/COC(C)(CC1)CCN1c1c([C@@H](C(O)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1ccc(C)c(F)c1-c1cccc-3c1 RPBJAKCLYAXHCN-GGOOWQFJSA-N 0.000 description 1
- PGELZYLOKZTIHE-DCUOSEHISA-N C[C@@H](C/C=C/COC(C)(CC1)CCN1c1c([C@@H](C(OC)=O)OC(C)(C)C)c(C)nc2cc(-c(cc3)c4)n[n]12)Oc1cccc(F)c1-c4c3F Chemical compound C[C@@H](C/C=C/COC(C)(CC1)CCN1c1c([C@@H](C(OC)=O)OC(C)(C)C)c(C)nc2cc(-c(cc3)c4)n[n]12)Oc1cccc(F)c1-c4c3F PGELZYLOKZTIHE-DCUOSEHISA-N 0.000 description 1
- OQKOWQJBXNXVAL-VIYHJVHISA-N C[C@@H](C/C=C\COC(C)(CC1)CCN1c1c(C(C(O)=O)[O-4]C(C)(C)C)c(C)nc2cc-3n[n]12)Oc1cc(F)ccc1-c1cccc-3c1 Chemical compound C[C@@H](C/C=C\COC(C)(CC1)CCN1c1c(C(C(O)=O)[O-4]C(C)(C)C)c(C)nc2cc-3n[n]12)Oc1cc(F)ccc1-c1cccc-3c1 OQKOWQJBXNXVAL-VIYHJVHISA-N 0.000 description 1
- OGYNPJIREZDYQI-CRFKOJLDSA-N C[C@@H](C/C=C\COC(C)(CC1)CCN1c1c([C@@H](C(OC)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1ccc(C)cc1-c1cccc-3c1 Chemical compound C[C@@H](C/C=C\COC(C)(CC1)CCN1c1c([C@@H](C(OC)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1ccc(C)cc1-c1cccc-3c1 OGYNPJIREZDYQI-CRFKOJLDSA-N 0.000 description 1
- CVKULBDZZYFAPG-NSHDSACASA-N C[C@@H](CC=C)Oc1cccc(Cl)c1-c1cc(Br)ccc1F Chemical compound C[C@@H](CC=C)Oc1cccc(Cl)c1-c1cc(Br)ccc1F CVKULBDZZYFAPG-NSHDSACASA-N 0.000 description 1
- QYTGNHIUXQXHRC-FDLYHPRCSA-N C[C@@H](CC=C)Oc1cccc(Cl)c1-c1cccc(-c2n[n]3c(N(CC4)CCC4(C)OCC=C)c(C(C(OC)=O)[O-4]C(C)(C)C)c(C)nc3c2)c1 Chemical compound C[C@@H](CC=C)Oc1cccc(Cl)c1-c1cccc(-c2n[n]3c(N(CC4)CCC4(C)OCC=C)c(C(C(OC)=O)[O-4]C(C)(C)C)c(C)nc3c2)c1 QYTGNHIUXQXHRC-FDLYHPRCSA-N 0.000 description 1
- BJUFYBQDPVNSLS-LHAPQZOASA-N C[C@@H](CCCCOC(C)(CC1)CCN1c1c([C@@H](C(OC)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1cc(F)c(C)cc1-c1cccc-3c1 Chemical compound C[C@@H](CCCCOC(C)(CC1)CCN1c1c([C@@H](C(OC)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1cc(F)c(C)cc1-c1cccc-3c1 BJUFYBQDPVNSLS-LHAPQZOASA-N 0.000 description 1
- WQVKIUDQOPILAN-LHAPQZOASA-N C[C@@H](CCCCOC(C)(CC1)CCN1c1c([C@@H](C(OC)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1ccc(C)c(F)c1-c1cc-3ccc1 Chemical compound C[C@@H](CCCCOC(C)(CC1)CCN1c1c([C@@H](C(OC)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1ccc(C)c(F)c1-c1cc-3ccc1 WQVKIUDQOPILAN-LHAPQZOASA-N 0.000 description 1
- KCBOBIHKIHLPSV-CYFIQEHSSA-N C[C@@H](CCCCOC(C)(CC1)CCN1c1c([C@@H](C(OC)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1ccc(C)cc1-c1cccc-3c1 Chemical compound C[C@@H](CCCCOC(C)(CC1)CCN1c1c([C@@H](C(OC)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1ccc(C)cc1-c1cccc-3c1 KCBOBIHKIHLPSV-CYFIQEHSSA-N 0.000 description 1
- 0 C[C@@](C(C1)[*@@]1C=CCOC(C)(CC1)CCN1c1c([C@@](C(OC)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1cc(C)ccc1-c1cccc-3c1 Chemical compound C[C@@](C(C1)[*@@]1C=CCOC(C)(CC1)CCN1c1c([C@@](C(OC)=O)OC(C)(C)C)c(C)nc2cc-3n[n]12)Oc1cc(C)ccc1-c1cccc-3c1 0.000 description 1
- LXLAYZCOPUSIAB-AWEZNQCLSA-N Cc1nc2cc(-c3cc(Br)ccc3)n[n]2c(I)c1[C@@H](C(OC)=O)O Chemical compound Cc1nc2cc(-c3cc(Br)ccc3)n[n]2c(I)c1[C@@H](C(OC)=O)O LXLAYZCOPUSIAB-AWEZNQCLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261683772P | 2012-08-16 | 2012-08-16 | |
| US61/683,772 | 2012-08-16 | ||
| US201361818572P | 2013-05-02 | 2013-05-02 | |
| US61/818,572 | 2013-05-02 | ||
| US13/959,268 US8906929B2 (en) | 2012-08-16 | 2013-08-05 | Inhibitors of human immunodeficiency virus replication |
| US13/959,268 | 2013-08-05 | ||
| PCT/US2013/054532 WO2014028384A1 (en) | 2012-08-16 | 2013-08-12 | Inhibitors of human immunodeficiency virus replication |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015524841A JP2015524841A (ja) | 2015-08-27 |
| JP2015524841A5 JP2015524841A5 (enExample) | 2016-09-15 |
| JP6214657B2 true JP6214657B2 (ja) | 2017-10-18 |
Family
ID=50100460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015527515A Expired - Fee Related JP6214657B2 (ja) | 2012-08-16 | 2013-08-12 | ヒト免疫不全ウイルス複製阻害剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8906929B2 (enExample) |
| EP (1) | EP2888266B1 (enExample) |
| JP (1) | JP6214657B2 (enExample) |
| KR (1) | KR20150042830A (enExample) |
| CN (1) | CN104583214B (enExample) |
| AU (1) | AU2013302873B2 (enExample) |
| BR (1) | BR112015003175A2 (enExample) |
| CA (1) | CA2882077A1 (enExample) |
| EA (1) | EA201590358A1 (enExample) |
| ES (1) | ES2619960T3 (enExample) |
| IL (1) | IL237154A (enExample) |
| MX (1) | MX2015001899A (enExample) |
| SG (1) | SG11201500887QA (enExample) |
| TW (1) | TW201412750A (enExample) |
| WO (1) | WO2014028384A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12013500015A1 (en) | 2010-07-02 | 2013-02-18 | Gilead Sciences Inc | 2 -quinolinyl- acetic acid derivatives as hiv antiviral compounds |
| AP2013006706A0 (en) | 2010-07-02 | 2013-02-28 | Gilead Sciences Inc | Napht-2-ylacetic acid derivatives to treat AIDS |
| UA111841C2 (uk) | 2011-04-21 | 2016-06-24 | Гіліад Сайєнсіз, Інк. | Сполуки бензотіазолу та їх фармацевтичне застосування |
| WO2013103738A1 (en) | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | Napthalene acetic acid derivatives against hiv infection |
| US9376392B2 (en) | 2012-01-04 | 2016-06-28 | Gilead Sciences, Inc. | 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS |
| US9096586B2 (en) | 2012-04-20 | 2015-08-04 | Gilead Sciences, Inc. | Therapeutic compounds |
| US8906929B2 (en) | 2012-08-16 | 2014-12-09 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| US9663536B2 (en) | 2013-03-13 | 2017-05-30 | VIIV Healthcare UK (No.5) Limited | Inhibitors of human immunodeficiency virus replication |
| JP6268656B2 (ja) | 2013-03-14 | 2018-01-31 | ビーブ・ヘルスケア・ユーケイ・（ナンバー５）・リミテッドＶｉｉＶ Ｈｅａｌｔｈｃａｒｅ ＵＫ （Ｎｏ．５） Ｌｉｍｉｔｅｄ | ヒト免疫不全ウイルス複製の阻害剤 |
| WO2015123182A1 (en) * | 2014-02-12 | 2015-08-20 | Bristol-Myers Squibb Company | Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication |
| ES2654242T3 (es) | 2014-02-12 | 2018-02-12 | Viiv Healthcare (No.5) Limited | Macrociclos de benzotiazol como inhibidores de la réplica del virus de la inmunodeficiencia humana |
| WO2015126743A1 (en) | 2014-02-18 | 2015-08-27 | Bristol-Myers Squibb Company | Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication |
| US9932353B2 (en) * | 2014-02-18 | 2018-04-03 | Viiv Healthcare Uk (No. 5) Limited | Imidazopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication |
| US9409922B2 (en) | 2014-02-18 | 2016-08-09 | Bristol-Myers Squibb Company | Imidazopyridine macrocycles as inhibitors of human immunodeficiency virus replication |
| US9273067B2 (en) | 2014-02-19 | 2016-03-01 | Bristol-Myers Squibb Company | Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication |
| EP3107913B1 (en) | 2014-02-19 | 2018-07-04 | VIIV Healthcare UK (No.5) Limited | Inhibitors of human immunodeficiency virus replication |
| WO2015126376A1 (en) * | 2014-02-19 | 2015-08-27 | Bristol-Myers Squibb Company | Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication |
| PT3116880T (pt) | 2014-02-20 | 2018-05-10 | Viiv Healthcare Uk No 5 Ltd | Macrociclos de ácido piridin-3-il acético como inibidores da replicação do vírus da imunodeficiência humana |
| WO2015174511A1 (ja) * | 2014-05-16 | 2015-11-19 | 塩野義製薬株式会社 | Ｈｉｖ複製阻害作用を有する３環性複素環誘導体 |
| EP3305789A4 (en) | 2015-05-29 | 2018-11-21 | Shionogi & Co., Ltd. | Nitrogen-containing tricyclic derivative having hiv replication inhibitory activity |
| EP3334741A1 (en) | 2015-08-10 | 2018-06-20 | VIIV Healthcare UK (No.5) Limited | Imidazopyridine macrocycles as inhibitors of human immunodeficiency virus replication |
| KR102652866B1 (ko) | 2017-04-06 | 2024-04-02 | 엥방티바 | Ｙａｐ/ｔａｚ-ｔｅａｄ 상호작용의 억제제인 신규 화합물 및 악성 중피종의 치료에서의 이들의 용도 |
| EP3632908A1 (en) | 2018-10-02 | 2020-04-08 | Inventiva | Inhibitors of the yap/taz-tead interaction and their use in the treatment of cancer |
| IL286328B1 (en) | 2019-03-22 | 2026-04-01 | Gilead Sciences Inc | Tricyclic bridging compounds of carbamoylpyridone and their pharmaceutical use |
| CR20220418A (es) | 2020-02-24 | 2022-10-10 | Gilead Sciences Inc | Compuestos tetracíclicos para el tratamiento de infecciones por vih |
| CA3192145A1 (en) | 2020-09-30 | 2022-04-07 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and uses thereof |
| JP7591155B2 (ja) | 2021-01-19 | 2024-11-27 | ギリアード サイエンシーズ， インコーポレイテッド | 置換ピリドトリアジン化合物及びその使用 |
| TWI856796B (zh) | 2022-04-06 | 2024-09-21 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB427857A (en) | 1934-08-02 | 1935-05-01 | Newsum Sons & Company Ltd H | A new or improved system of construction for skeleton structures, particularly vehicle body frames and door frames |
| US7939545B2 (en) | 2006-05-16 | 2011-05-10 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
| EP2574610A1 (en) | 2007-11-15 | 2013-04-03 | Gilead Sciences, Inc. | Inhibitors of human immonodeficiency virus replication |
| HRP20120328T2 (hr) | 2007-11-15 | 2012-09-30 | Gilead Sciences | Inhibitori replikacije virusa humane imunodeficijencije |
| CA2705338A1 (en) | 2007-11-16 | 2009-05-22 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
| WO2009062285A1 (en) | 2007-11-16 | 2009-05-22 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
| EP2215298B1 (en) | 2007-11-23 | 2014-03-26 | Koninklijke Philips N.V. | Compartment |
| TW200942243A (en) * | 2008-03-05 | 2009-10-16 | Biocryst Pharm Inc | Antiviral therapeutic agents |
| US8129398B2 (en) * | 2008-03-19 | 2012-03-06 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| GB0813980D0 (en) | 2008-07-31 | 2008-09-10 | Univ St Andrews | Control of relaxation oscillations in intracavity optical parametric oscillato rs |
| JP5331404B2 (ja) | 2008-08-01 | 2013-10-30 | 国立大学法人 東京医科歯科大学 | 先天性異常症の染色体欠失の検出方法 |
| GB0908394D0 (en) | 2009-05-15 | 2009-06-24 | Univ Leuven Kath | Novel viral replication inhibitors |
| US8338441B2 (en) * | 2009-05-15 | 2012-12-25 | Gilead Sciences, Inc. | Inhibitors of human immunodeficiency virus replication |
| GB0913636D0 (en) | 2009-08-05 | 2009-09-16 | Univ Leuven Kath | Novel viral replication inhibitors |
| US20120232062A1 (en) * | 2009-10-20 | 2012-09-13 | Eiger Biopharmaceuticals, Inc. | Azaindazoles to treat flaviviridae virus infection |
| KR101483834B1 (ko) | 2009-12-23 | 2015-01-16 | 카트호리이케 유니버시타이트 로이펜 | 항바이러스 화합물 |
| RU2567385C2 (ru) * | 2010-04-02 | 2015-11-10 | ЯНССЕН Ар ЭНД Ди АЙРЛЭНД | Макроциклические ингибиторы интегразы |
| PH12013500015A1 (en) | 2010-07-02 | 2013-02-18 | Gilead Sciences Inc | 2 -quinolinyl- acetic acid derivatives as hiv antiviral compounds |
| AP2013006706A0 (en) | 2010-07-02 | 2013-02-28 | Gilead Sciences Inc | Napht-2-ylacetic acid derivatives to treat AIDS |
| US8633200B2 (en) | 2010-09-08 | 2014-01-21 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| CN103429595B (zh) | 2010-11-15 | 2015-10-21 | Viiv保健英国有限公司 | Hiv复制的抑制剂 |
| BR112013011737A2 (pt) * | 2010-11-15 | 2016-08-09 | Univ Leuven Kath | composto, uso de um composto composição farmacêutica, e, método de tratamento ou prevenção de uma infecção por hiv |
| US8791108B2 (en) | 2011-08-18 | 2014-07-29 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| US8629276B2 (en) | 2012-02-15 | 2014-01-14 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| US9034882B2 (en) | 2012-03-05 | 2015-05-19 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| US9006235B2 (en) | 2012-03-06 | 2015-04-14 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
| US8906929B2 (en) | 2012-08-16 | 2014-12-09 | Bristol-Myers Squibb Company | Inhibitors of human immunodeficiency virus replication |
-
2013
- 2013-08-05 US US13/959,268 patent/US8906929B2/en not_active Expired - Fee Related
- 2013-08-12 KR KR20157006290A patent/KR20150042830A/ko not_active Withdrawn
- 2013-08-12 CA CA2882077A patent/CA2882077A1/en active Pending
- 2013-08-12 SG SG11201500887QA patent/SG11201500887QA/en unknown
- 2013-08-12 EP EP13750479.1A patent/EP2888266B1/en not_active Not-in-force
- 2013-08-12 AU AU2013302873A patent/AU2013302873B2/en not_active Ceased
- 2013-08-12 CN CN201380043596.7A patent/CN104583214B/zh not_active Expired - Fee Related
- 2013-08-12 JP JP2015527515A patent/JP6214657B2/ja not_active Expired - Fee Related
- 2013-08-12 MX MX2015001899A patent/MX2015001899A/es unknown
- 2013-08-12 ES ES13750479.1T patent/ES2619960T3/es active Active
- 2013-08-12 WO PCT/US2013/054532 patent/WO2014028384A1/en not_active Ceased
- 2013-08-12 EA EA201590358A patent/EA201590358A1/ru unknown
- 2013-08-12 BR BR112015003175A patent/BR112015003175A2/pt active Search and Examination
- 2013-08-15 TW TW102129364A patent/TW201412750A/zh unknown
-
2015
- 2015-02-09 IL IL237154A patent/IL237154A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2619960T3 (es) | 2017-06-27 |
| AU2013302873B2 (en) | 2017-02-02 |
| KR20150042830A (ko) | 2015-04-21 |
| SG11201500887QA (en) | 2015-03-30 |
| MX2015001899A (es) | 2015-05-07 |
| CA2882077A1 (en) | 2014-02-20 |
| IL237154A0 (en) | 2015-04-30 |
| WO2014028384A1 (en) | 2014-02-20 |
| CN104583214A (zh) | 2015-04-29 |
| BR112015003175A2 (pt) | 2017-08-08 |
| IL237154A (en) | 2017-03-30 |
| EP2888266B1 (en) | 2017-01-11 |
| TW201412750A (zh) | 2014-04-01 |
| EP2888266A1 (en) | 2015-07-01 |
| JP2015524841A (ja) | 2015-08-27 |
| US20140051692A1 (en) | 2014-02-20 |
| EA201590358A1 (ru) | 2015-05-29 |
| AU2013302873A1 (en) | 2015-04-02 |
| CN104583214B (zh) | 2017-06-09 |
| US8906929B2 (en) | 2014-12-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2888266B1 (en) | Inhibitors of human immunodeficiency virus replication | |
| CN105189503B (zh) | 人免疫缺陷病毒复制的抑制剂 | |
| US9580431B2 (en) | Inhibitors of human immunodeficiency virus replication | |
| KR102345924B1 (ko) | Hiv 인테그라제 억제제로서 유용한 테트라시클릭 헤테로사이클 화합물 | |
| EP2970301B1 (en) | Inhibitors of human immunodeficiency virus replication | |
| US9273067B2 (en) | Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication | |
| WO2015123182A1 (en) | Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication | |
| WO2015126743A1 (en) | Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication | |
| EP3114129A1 (en) | Imidazopyridine macrocycles as inhibitors of human immunodeficiency virus replication | |
| US10125148B2 (en) | Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication | |
| EP3116879A1 (en) | Imidazopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20160219 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160727 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20160727 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20170427 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20170509 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170703 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20170829 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20170919 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6214657 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| LAPS | Cancellation because of no payment of annual fees |