JP6212032B2 - 脂質ベースのナノ粒子 - Google Patents

脂質ベースのナノ粒子 Download PDF

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Publication number
JP6212032B2
JP6212032B2 JP2014504057A JP2014504057A JP6212032B2 JP 6212032 B2 JP6212032 B2 JP 6212032B2 JP 2014504057 A JP2014504057 A JP 2014504057A JP 2014504057 A JP2014504057 A JP 2014504057A JP 6212032 B2 JP6212032 B2 JP 6212032B2
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JP
Japan
Prior art keywords
liposome composition
formula
conjugate
dspe
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2014504057A
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English (en)
Japanese (ja)
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JP2014523854A (ja
JP2014523854A5 (cg-RX-API-DMAC7.html
Inventor
アナプラガダ，アナント
エリックセン，ジェイソン，エル．
タニファム，エリック，エー．
ダスグプタ，インドラニ
クック，スティーブン，シー．
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University of Texas System
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University of Texas System
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46966277&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP6212032(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of Texas System filed Critical University of Texas System
Publication of JP2014523854A publication Critical patent/JP2014523854A/ja
Publication of JP2014523854A5 publication Critical patent/JP2014523854A5/ja
Application granted granted Critical
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1812—Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions
    • A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
JP2014504057A 2011-04-06 2012-04-06 脂質ベースのナノ粒子 Expired - Fee Related JP6212032B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161472605P 2011-04-06 2011-04-06
US61/472,605 2011-04-06
PCT/US2012/032649 WO2012139080A2 (en) 2011-04-06 2012-04-06 Lipid-based nanoparticles

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017176383A Division JP6533813B2 (ja) 2011-04-06 2017-09-14 脂質ベースのナノ粒子

Publications (3)

Publication Number Publication Date
JP2014523854A JP2014523854A (ja) 2014-09-18
JP2014523854A5 JP2014523854A5 (cg-RX-API-DMAC7.html) 2014-10-30
JP6212032B2 true JP6212032B2 (ja) 2017-10-18

Family

ID=46966277

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2014504057A Expired - Fee Related JP6212032B2 (ja) 2011-04-06 2012-04-06 脂質ベースのナノ粒子
JP2017176383A Expired - Fee Related JP6533813B2 (ja) 2011-04-06 2017-09-14 脂質ベースのナノ粒子
JP2019098174A Pending JP2019151664A (ja) 2011-04-06 2019-05-27 脂質ベースのナノ粒子

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2017176383A Expired - Fee Related JP6533813B2 (ja) 2011-04-06 2017-09-14 脂質ベースのナノ粒子
JP2019098174A Pending JP2019151664A (ja) 2011-04-06 2019-05-27 脂質ベースのナノ粒子

Country Status (14)

Country Link
US (1) US9801957B2 (cg-RX-API-DMAC7.html)
EP (2) EP2694116B1 (cg-RX-API-DMAC7.html)
JP (3) JP6212032B2 (cg-RX-API-DMAC7.html)
KR (2) KR101973063B1 (cg-RX-API-DMAC7.html)
CN (1) CN104144708B (cg-RX-API-DMAC7.html)
AU (3) AU2012239888B9 (cg-RX-API-DMAC7.html)
BR (1) BR112013025633A2 (cg-RX-API-DMAC7.html)
CA (1) CA2831480C (cg-RX-API-DMAC7.html)
DK (1) DK2694116T3 (cg-RX-API-DMAC7.html)
ES (1) ES2685824T3 (cg-RX-API-DMAC7.html)
MX (1) MX357227B (cg-RX-API-DMAC7.html)
PL (1) PL2694116T3 (cg-RX-API-DMAC7.html)
PT (1) PT2694116T (cg-RX-API-DMAC7.html)
WO (1) WO2012139080A2 (cg-RX-API-DMAC7.html)

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* Cited by examiner, † Cited by third party
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WO2012139080A2 (en) * 2011-04-06 2012-10-11 Board Of Regents Of The University Of Texas System Lipid-based nanoparticles
WO2013110013A1 (en) 2012-01-20 2013-07-25 Annapragada, Ananth Methods and compositions for objectively characterizing medical images
US9512092B2 (en) 2013-12-12 2016-12-06 Albert Einstein College Of Medicine, Inc. Retinoic acid receptor antagonists as chaperone-mediated autophagy modulators and uses thereof
MX371295B (es) * 2014-10-08 2020-01-24 Texas Childrens Hospital Formación de imágenes por irm de placas amiloides usando liposomas.
GB201509934D0 (en) 2015-06-08 2015-07-22 King S College London Nanoparticles
ES2985317T3 (es) * 2016-05-16 2024-11-05 Univ Texas Composiciones para la distribución de ARNt en nanopartículas y procedimientos de uso de las mismas
EP3548002B1 (en) * 2016-11-30 2025-04-30 Texas Children's Hospital Hydrophilic fluorinated molecules for liposomal 19f mri probes with unique mr signatures
US20200261605A1 (en) * 2019-01-24 2020-08-20 Alzeca Biosciences, LLC Functionalized liposomes for imaging misfolded proteins
KR102546470B1 (ko) * 2020-01-29 2023-06-21 텍사스 칠드런스 하스피탈 아밀로이드 침착의 mri용 표적 조영제
JP2023514991A (ja) * 2020-02-12 2023-04-12 テキサス チルドレンズ ホスピタル α－シンヌクレイン沈着物のＭＲＩのための標的造影剤
US11779664B2 (en) 2020-02-12 2023-10-10 Texas Children's Hospital Targeted contrast agents for MRI of alpha-synuclein deposition

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US5204085A (en) 1985-01-08 1993-04-20 Mallinckrodt Medical, Inc. Method for enhancing the safety of metal-ligand chelates as X-ray contrast agents
US5674468A (en) 1992-03-06 1997-10-07 Nycomed Imaging As Contrast agents comprising gas-containing or gas-generating polymer microparticles or microballoons
CA2185810A1 (en) 1994-03-28 1995-10-05 Jo Klaveness Liposomes
US6071532A (en) 1996-10-15 2000-06-06 Emory University Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof
ATE287700T1 (de) 1999-11-30 2005-02-15 Univ Arizona Strahlung-sensitive liposomen
US7029655B2 (en) * 2000-10-04 2006-04-18 California Institute Of Technology Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
US6821504B2 (en) * 2001-05-23 2004-11-23 New York University Detection of alzheimer's amyloid by magnetic resonance imaging
JP2005519129A (ja) 2002-03-05 2005-06-30 クリーブランド ステート ユニバーシティー エアロゾル薬物送達のための凝集粒子
US7605182B2 (en) 2003-05-01 2009-10-20 Aposense Ltd. Compounds that selectively bind to membranes of apoptotic cells
US7208174B2 (en) * 2003-12-18 2007-04-24 Hoffmann-La Roche Inc. Liposome compositions
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Also Published As

Publication number Publication date
CN104144708B (zh) 2017-07-28
US9801957B2 (en) 2017-10-31
DK2694116T3 (en) 2018-09-03
AU2012239888A1 (en) 2013-11-07
AU2017232156C1 (en) 2019-10-24
JP6533813B2 (ja) 2019-06-19
BR112013025633A2 (pt) 2017-08-08
EP2694116A2 (en) 2014-02-12
WO2012139080A2 (en) 2012-10-11
PL2694116T3 (pl) 2018-12-31
AU2012239888B9 (en) 2017-10-12
ES2685824T3 (es) 2018-10-11
CA2831480C (en) 2020-09-29
MX2013011231A (es) 2015-03-05
CN104144708A (zh) 2014-11-12
PT2694116T (pt) 2018-10-12
EP2694116A4 (en) 2015-06-03
KR102035187B1 (ko) 2019-11-08
EP2694116B1 (en) 2018-06-13
AU2017232156B2 (en) 2019-07-11
AU2017232156A1 (en) 2017-10-12
WO2012139080A3 (en) 2014-05-01
US20120258044A1 (en) 2012-10-11
JP2019151664A (ja) 2019-09-12
AU2012239888B2 (en) 2017-06-22
KR101973063B1 (ko) 2019-04-30
CA2831480A1 (en) 2012-10-11
AU2012239888A2 (en) 2014-05-08
JP2014523854A (ja) 2014-09-18
MX357227B (es) 2018-07-02
HK1203827A1 (en) 2015-11-06
KR20190031334A (ko) 2019-03-25
JP2018035167A (ja) 2018-03-08
EP3366313A1 (en) 2018-08-29
KR20140074868A (ko) 2014-06-18
AU2019246775A1 (en) 2019-10-31

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