JP6198533B2 - 小片薄膜の製造方法及び小片薄膜分散液 - Google Patents
小片薄膜の製造方法及び小片薄膜分散液 Download PDFInfo
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- JP6198533B2 JP6198533B2 JP2013183914A JP2013183914A JP6198533B2 JP 6198533 B2 JP6198533 B2 JP 6198533B2 JP 2013183914 A JP2013183914 A JP 2013183914A JP 2013183914 A JP2013183914 A JP 2013183914A JP 6198533 B2 JP6198533 B2 JP 6198533B2
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Description
第一実施形態の製造方法は、図1に示すように、フィルム形成剤を含有する薄膜原液を調製する原液調製工程と、薄膜原液をベースフィルム3上にコーティングし、コーティングされた薄膜原液を乾燥させ薄膜1とする薄膜形成工程(図1(a)参照)と、ベースフィルム3を全厚さにわたり切断することなく、ベースフィルム3に支持された薄膜1を切断する剥離前切断工程(図1(b)参照)と、ベースフィルム3上の薄膜1に、通気性を有するキャリアフィルム4を重ね合わせ(図1(c)参照)、キャリアフィルム4を通して吸気した状態でベースフィルム3をキャリアフィルム4に対して離反する方向に相対的に移動させ、ベースフィルム3から薄膜1を剥離すると共に、薄膜1をキャリアフィルム4に支持させる剥離工程(図1(d),(e)参照)とを具備している。
第二実施形態の製造方法は、図3に示すように、フィルム形成剤を含有する液体をベースフィルム3上にコーティングし乾燥させて薄膜1を形成する薄膜形成工程(図3(a)参照)と、ベースフィルム3上に形成された薄膜1上に、通気性を有するキャリアフィル4ムを重ね合わせ(図3(b)参照)、キャリアフィルム4を通して吸気した状態でベースフィルム3をキャリアフィルム4に対して離反する方向に相対的に移動させ、ベースフィルム3から薄膜1を剥離すると共に、薄膜1をキャリアフィルム4に支持させる剥離工程(図3(c)参照)と、キャリアフィルム4を切断することなく、キャリアフィルム4に支持された薄膜1を切断する剥離後切断工程(図3(d)参照)とを具備している。
キャリアフィルムから離脱させた小片薄膜は、化粧料、うがい薬等の医薬成分を含有する液体に分散させ、小片薄膜分散液とすることができる。或いは、金属を含有する小片薄膜を注射液に分散させ、小片薄膜分散液とすることができる。
次に、第三実施形態の製造方法について、図4を用いて説明する。第三実施形態の製造方法は、フィルム形成剤を含有する液体をベースフィルム3上にコーティングし乾燥させて薄膜1とする薄膜形成工程(図4(a)参照)と、ベースフィルム3を全厚さにわたり切断することなく、ベースフィルム3に支持された薄膜1を切断する剥離前切断工程(図4(b)参照)と、ベースフィルム3上の薄膜1に、通気性を有するキャリアフィル4ムを重ね合わせ(図4(c)参照)、キャリアフィルム4を通して吸気した状態でベースフィルム3をキャリアフィルム4に対して離反する方向に相対的に移動させ、ベースフィルム3から薄膜1を剥離すると共に、薄膜1をキャリアフィルム4に支持させる剥離工程(図4(d)参照)と、切断された状態の薄膜1を支持しているキャリアフィルム4を、薄膜1の切断線1bより外側で全厚さにわたり切断するキャリア切断工程(図4(e)参照)と、を具備している。
第三実施形態により製造される小片薄膜は、図4に例示するように、目元に貼る化粧パックに適した形状とすることができる。この場合、薄膜には、上述の化粧料を含有させることができる。小片薄膜を化粧パックとして使用する場合、キャリアフィルムを剥がしながら薄膜のみを皮膚に貼付しても、薄膜側を皮膚に接触させてキャリアフィルムごと皮膚に貼付してもよい。通気性を有するキャリアフィルムは透水性も有するため、キャリアフィルムの上から水、湯、化粧水などを供給して、化粧パックをすることができる。また、小片薄膜の厚さを60nm〜100nmとすれば、皮膚に密着しやすいことに加え、非常に薄いために顔に貼付した状態で目立たない化粧パックとなる。
薄膜に含有させる医薬成分は特に限定されないが、抗菌剤として塩化セチルピリジニウム、プロタミン、メントール等を、抗真菌剤としてアムホテリシンB、ミコナゾール等を、抗ウィルス剤としてアシクロビル、塩酸オセルタミビル等を、抗炎症剤としてグリチルリチン酸、グリチルリチン酸ジカリウム等を、解熱鎮痛剤としてアセトアミノフェン、アセチルサリチル酸等を、抗アレルギー剤としてフマル酸チトケフェン、塩酸オガクゼル等を、ステロイド・ホルモン剤としてプレドニゾロン、エストラジオール等を、鎮咳去痰薬としてノスカピン、グアイフェネシン、チペピジンヒベンズ塩酸等を、麻酔薬としてリドカイン、テトラカイン、ジブカイン等を、骨・カルシウム代謝薬としてアルファカルシドール、アレンドロン酸ナトリウム等を、抗リウマチ薬としてメトトレキサート、インフリキシマブ等を、糖尿病薬としてボグリボース、塩酸ピオグチタゾン等を、抗血栓薬としてワルファリンカリウム、塩酸チクロビジン等を、降圧剤としてアテノール、ニフェジピン、カプトリル、炉サルタンカリウム等を、狭心症治療薬として亜硝酸アミル、塩酸トリメタジジン等を、抗不整脈薬として塩酸プロカインアミド、塩酸ベラパミル等を、心不全薬・昇圧剤としてジギトキシン、塩酸ドパミン等を、血管拡張剤として塩酸イソクスプリン、塩酸トラゾリン等を、利尿剤としてフロセミド等を、気管支拡張剤として塩酸エフェドリン、臭素イブラトロピウム等を、消化性潰瘍治療薬としてオメプラゾール、ファモチジン等を、向精神薬として塩酸クロルプロマジン、マレイン酸フルボキサミン等を、睡眠薬・抗不安薬としてバルビタール、トリアゾラム等を、使用可能である。
歯周病薬を含有した小片薄膜を歯肉に貼付することにより、歯周病を予防することができる。歯周病薬としては、アモキシシリン、オフロキサシン、ミノサイクリン、アムホテリシンB、メトロニダゾールを例示することができる。また、歯周病薬の中には、歯のエナメル質や象牙質に悪い影響を与える成分が存在する。そのため、歯周病薬を歯肉に塗布したり、歯周病薬を含有する小片薄膜を歯肉に貼付したり歯周ポケットに入れたりする際、歯の表面にマスキング用の小片薄膜を貼付することにより、歯周病薬が歯に影響を与えるおそれを低減することができる。歯表面に貼付するマスキング用の小片薄膜は、口腔内の水分で溶解しにくいフィルム形成剤で形成されていることが望ましく、かかるフィルム形成剤としてはポリ乳酸、キチン、キトサン、アルギン酸、ヒルアロン酸、フィブロイン、コラーゲン、等を例示することができる。
眼科領域の薬物成分を小片薄膜に含有させ、小片薄膜を直接眼球に貼付して使用する。液体状の目薬とは異なり流れ落ちることがないため、必要量の薬物成分を確実に患部に作用させることができる。また、小片薄膜の厚さを60nm〜100nmとすれば、視界に影響を与えるおそれがなく、異物感も少ない。
3 ベースフィルム
4 キャリアフィルム
10 気圧供給機構
15 吸着支持部
20 キャリア供給機構
30 キャリア回収機構
40 ベース供給機構
50 ベース回収機構
60 駆動機構
90 切断機構
100 切断・剥離装置
Claims (6)
- フィルム形成剤を含有する液体をベースフィルム上にコーティングし乾燥させて薄膜を形成する薄膜形成工程と、
前記ベースフィルム上に形成された前記薄膜上に、通気性を有するキャリアフィルムを重ね合わせ、該キャリアフィルムを通して吸気した状態で前記ベースフィルムを前記キャリアフィルムに対して離反する方向に相対的に移動させ、前記ベースフィルムから前記薄膜を剥離すると共に、前記薄膜を前記キャリアフィルムに支持させる剥離工程と、
該剥離工程の前に行われ、前記ベースフィルムを全厚さにわたり切断することなく、前記ベースフィルムに支持された前記薄膜を切断する剥離前切断工程、及び、前記剥離工程の後に行われ、前記キャリアフィルムを切断することなく又は前記キャリアフィルムと共に、前記キャリアフィルムに支持された前記薄膜を切断する剥離後切断工程、の何れか一方と
を具備することを特徴とする小片薄膜の製造方法。 - 前記剥離後切断工程を具備し、
前記剥離後切断工程では、前記薄膜を、前記薄膜を支持している前記キャリアフィルムと共に同一の形状及び大きさに切断する
ことを特徴とする請求項1に記載の小片薄膜の製造方法。 - 切断された状態の前記薄膜を支持している前記キャリアフィルムに、前記薄膜とは反対側から通気し、前記薄膜を前記キャリアフィルムから離脱させる薄膜離脱工程を、更に具備する
ことを特徴とする請求項1または請求項2に記載の小片薄膜の製造方法。 - 請求項3に記載の小片薄膜の製造方法により製造された小片薄膜が、化粧料を含有する液体に分散している
ことを特徴とする小片薄膜分散液。 - 請求項3に記載の小片薄膜の製造方法により製造された小片薄膜が、医薬成分を含有する液体に分散している
ことを特徴とする小片薄膜分散液。 - 請求項3に記載の小片薄膜の製造方法により製造された小片薄膜は、前記薄膜に金属を含有するものであり、注射液に分散している
ことを特徴とする小片薄膜分散液。
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