JP6195909B2 - 核内輸送調節因子およびその使用 - Google Patents

核内輸送調節因子およびその使用 Download PDF

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JP6195909B2
JP6195909B2 JP2015511713A JP2015511713A JP6195909B2 JP 6195909 B2 JP6195909 B2 JP 6195909B2 JP 2015511713 A JP2015511713 A JP 2015511713A JP 2015511713 A JP2015511713 A JP 2015511713A JP 6195909 B2 JP6195909 B2 JP 6195909B2
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compound
cancer
disease
group
cells
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JP2015516434A5 (member.php
JP2015516434A (ja
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サンダナヤカ，ヴィンセント，ピー．
シェクター，シャロン
シャチャム，シャロン
マッコーリー，ジララ
バログル，エルカン
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カリオファーム セラピューティクス，インコーポレイテッド
カリオファーム セラピューティクス，インコーポレイテッド
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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  • Pulmonology (AREA)
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  • Child & Adolescent Psychology (AREA)
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  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2015511713A 2012-05-09 2013-05-09 核内輸送調節因子およびその使用 Active JP6195909B2 (ja)

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Application Number Priority Date Filing Date Title
US201261644802P 2012-05-09 2012-05-09
US61/644,802 2012-05-09
US201361798188P 2013-03-15 2013-03-15
US61/798,188 2013-03-15
PCT/US2013/040404 WO2013170068A2 (en) 2012-05-09 2013-05-09 Nuclear transport modulators and uses thereof

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JP2015516434A JP2015516434A (ja) 2015-06-11
JP2015516434A5 JP2015516434A5 (member.php) 2016-06-30
JP6195909B2 true JP6195909B2 (ja) 2017-09-13

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JP2015511713A Active JP6195909B2 (ja) 2012-05-09 2013-05-09 核内輸送調節因子およびその使用
JP2017160341A Withdrawn JP2018012715A (ja) 2012-05-09 2017-08-23 核内輸送調節因子およびその使用
JP2018154275A Withdrawn JP2018172444A (ja) 2012-05-09 2018-08-20 核内輸送調節因子およびその使用
JP2019206852A Active JP6818849B2 (ja) 2012-05-09 2019-11-15 核内輸送調節因子およびその使用
JP2020218700A Withdrawn JP2021063104A (ja) 2012-05-09 2020-12-28 核内輸送調節因子およびその使用

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JP2018154275A Withdrawn JP2018172444A (ja) 2012-05-09 2018-08-20 核内輸送調節因子およびその使用
JP2019206852A Active JP6818849B2 (ja) 2012-05-09 2019-11-15 核内輸送調節因子およびその使用
JP2020218700A Withdrawn JP2021063104A (ja) 2012-05-09 2020-12-28 核内輸送調節因子およびその使用

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EP (3) EP3404027B1 (member.php)
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Cited By (1)

* Cited by examiner, † Cited by third party
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JP2018012715A (ja) * 2012-05-09 2018-01-25 カリオファーム セラピューティクス，インコーポレイテッド 核内輸送調節因子およびその使用

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WO2011109799A1 (en) 2010-03-05 2011-09-09 Karyopharm Therapeutics, Inc. Nuclear transport modulatiors and uses thereof
CA2824808A1 (en) 2011-01-17 2012-07-26 Karyopharm Therapeutics, Inc. Olefin containing nuclear transport modulators and uses thereof
KR102022715B1 (ko) 2011-07-29 2019-09-18 카리오팜 쎄라퓨틱스, 인코포레이티드 핵 수송 조절인자 및 이의 용도
CN117229268A (zh) 2011-07-29 2023-12-15 卡尔约药物治疗公司 含酰肼的核运输调节剂及其用途
TWI568722B (zh) 2012-06-15 2017-02-01 葛蘭馬克製藥公司 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物
CA2897200C (en) 2013-01-14 2021-07-06 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors
SG10201912524QA (en) 2013-01-15 2020-04-29 Incyte Holdings Corp Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors
EP2968278B8 (en) * 2013-03-15 2019-05-22 Karyopharm Therapeutics Inc. Methods of promoting wound healing using crm1 inhibitors
WO2014205393A1 (en) * 2013-06-21 2014-12-24 Karyopharm Therapeutics Inc. Nuclear transport modulators and uses thereof
BR112015032071B1 (pt) 2013-06-21 2022-06-14 Karyopharm Therapeutics Inc Modulares do transporte nuclear e suas utilizações
SG11201601259YA (en) 2013-08-23 2016-03-30 Incyte Corp Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors
RU2663222C2 (ru) * 2014-05-13 2018-08-02 КьюЭсЭй ГЛОБАЛ ИНК. Устройство и способ получения источников гамма-излучения из обогащенного иридия
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
WO2016010897A1 (en) 2014-07-14 2016-01-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors
AU2015301484B2 (en) 2014-08-15 2020-02-20 Karyopharm Therapeutics Inc. Polymorphs of selinexor
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