JP6195856B2 - 神経調節装置に関するバイオマーカーのサンプリングならびに関連システムおよび方法 - Google Patents
神経調節装置に関するバイオマーカーのサンプリングならびに関連システムおよび方法 Download PDFInfo
- Publication number
- JP6195856B2 JP6195856B2 JP2014561173A JP2014561173A JP6195856B2 JP 6195856 B2 JP6195856 B2 JP 6195856B2 JP 2014561173 A JP2014561173 A JP 2014561173A JP 2014561173 A JP2014561173 A JP 2014561173A JP 6195856 B2 JP6195856 B2 JP 6195856B2
- Authority
- JP
- Japan
- Prior art keywords
- neuromodulation
- sampling
- nerve
- renal
- lumen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/14—Devices for taking samples of blood ; Measuring characteristics of blood in vivo, e.g. gas concentration within the blood, pH-value of blood
- A61B5/1405—Devices for taking blood samples
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/15003—Source of blood for venous or arterial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/20—Measuring for diagnostic purposes; Identification of persons for measuring urological functions restricted to the evaluation of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/20—Measuring for diagnostic purposes; Identification of persons for measuring urological functions restricted to the evaluation of the urinary system
- A61B5/201—Assessing renal or kidney functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
- A61B5/4029—Detecting, measuring or recording for evaluating the nervous system for evaluating the peripheral nervous systems
- A61B5/4035—Evaluating the autonomic nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6851—Guide wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6852—Catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6852—Catheters
- A61B5/6853—Catheters with a balloon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6852—Catheters
- A61B5/6858—Catheters with a distal basket, e.g. expandable basket
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36121—Production of neurotransmitters; Modulation of genes expression
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B10/007—Devices for taking samples of body liquids for taking urine samples
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00166—Multiple lumina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
- A61B2018/0022—Balloons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
- A61B2018/0022—Balloons
- A61B2018/00232—Balloons having an irregular shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00273—Anchoring means for temporary attachment of a device to tissue
- A61B2018/00279—Anchoring means for temporary attachment of a device to tissue deployable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00345—Vascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00345—Vascular system
- A61B2018/00404—Blood vessels other than those in or around the heart
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00434—Neural system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00505—Urinary tract
- A61B2018/00511—Kidney
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00642—Sensing and controlling the application of energy with feedback, i.e. closed loop control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0212—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques using an instrument inserted into a body lumen, e.g. catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150229—Pumps for assisting the blood sampling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150992—Blood sampling from a fluid line external to a patient, such as a catheter line, combined with an infusion line; Blood sampling from indwelling needle sets, e.g. sealable ports, luer couplings or valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4848—Monitoring or testing the effects of treatment, e.g. of medication
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0551—Spinal or peripheral nerve electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36135—Control systems using physiological parameters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/34—Genitourinary disorders
- G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Surgery (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Physiology (AREA)
- Urology & Nephrology (AREA)
- Radiology & Medical Imaging (AREA)
- Optics & Photonics (AREA)
- Neurosurgery (AREA)
- Otolaryngology (AREA)
- Cardiology (AREA)
- Plasma & Fusion (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Electromagnetism (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261608625P | 2012-03-08 | 2012-03-08 | |
| US201261608626P | 2012-03-08 | 2012-03-08 | |
| US61/608,625 | 2012-03-08 | ||
| US61/608,626 | 2012-03-08 | ||
| US201261746528P | 2012-12-27 | 2012-12-27 | |
| US61/746,528 | 2012-12-27 | ||
| PCT/US2013/030041 WO2013134733A2 (en) | 2012-03-08 | 2013-03-08 | Biomarker sampling in the context of neuromodulation devices and associated systems and methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015513437A JP2015513437A (ja) | 2015-05-14 |
| JP2015513437A5 JP2015513437A5 (https=) | 2016-04-14 |
| JP6195856B2 true JP6195856B2 (ja) | 2017-09-13 |
Family
ID=47915358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014561173A Active JP6195856B2 (ja) | 2012-03-08 | 2013-03-08 | 神経調節装置に関するバイオマーカーのサンプリングならびに関連システムおよび方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (7) | US9510777B2 (https=) |
| EP (2) | EP2822496B1 (https=) |
| JP (1) | JP6195856B2 (https=) |
| CN (2) | CN104271062B (https=) |
| AU (1) | AU2013229776B2 (https=) |
| RU (1) | RU2644933C2 (https=) |
| WO (1) | WO2013134733A2 (https=) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7653438B2 (en) | 2002-04-08 | 2010-01-26 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
| US20050153309A1 (en) | 2003-12-22 | 2005-07-14 | David Hoon | Method and apparatus for in vivo surveillance of circulating biological components |
| US20070021803A1 (en) | 2005-07-22 | 2007-01-25 | The Foundry Inc. | Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction |
| US9662163B2 (en) | 2008-10-21 | 2017-05-30 | Hermes Innovations Llc | Endometrial ablation devices and systems |
| US8540708B2 (en) | 2008-10-21 | 2013-09-24 | Hermes Innovations Llc | Endometrial ablation method |
| US11896282B2 (en) | 2009-11-13 | 2024-02-13 | Hermes Innovations Llc | Tissue ablation systems and method |
| US12256984B2 (en) | 2010-10-25 | 2025-03-25 | Medtronic Ireland Manufacturing Unlimited Company | Catheter apparatuses having multi-electrode arrays for renal neuromodulation and associated systems and methods |
| CN107007348B (zh) | 2010-10-25 | 2019-05-31 | 美敦力Af卢森堡有限责任公司 | 用于神经调节治疗的估算及反馈的装置、系统及方法 |
| EP3287067B1 (en) | 2011-11-07 | 2019-10-30 | Medtronic Ardian Luxembourg S.à.r.l. | Endovascular nerve monitoring devices and associated systems |
| AU2012347470B2 (en) | 2011-12-09 | 2017-02-02 | Medtronic Ireland Manufacturing Unlimited Company | Therapeutic neuromodulation of the hepatic system |
| WO2013134543A1 (en) | 2012-03-08 | 2013-09-12 | Medtronic Ardian Luxembourg Sarl | Immune system neuromodulation and associated systems and methods |
| CN104271062B (zh) | 2012-03-08 | 2017-07-07 | 美敦力Af卢森堡有限责任公司 | 采用神经调节装置的生物标志物取样和相关系统及方法 |
| CN107374723B (zh) * | 2012-05-11 | 2020-08-28 | 美敦力Af卢森堡有限责任公司 | 导管设备 |
| EP2914186B1 (en) | 2012-11-05 | 2019-03-13 | Relievant Medsystems, Inc. | Systems for creating curved paths through bone and modulating nerves within the bone |
| US9867660B2 (en) * | 2013-03-13 | 2018-01-16 | Medtronic Cryocath Lp | Vein occlusion assessment using temperature |
| US10543037B2 (en) | 2013-03-15 | 2020-01-28 | Medtronic Ardian Luxembourg S.A.R.L. | Controlled neuromodulation systems and methods of use |
| US11160454B2 (en) * | 2013-04-08 | 2021-11-02 | Sunnybrook Research Institute | System and method for imaging biomarkers indicative of cardiac thermal ablation lesions |
| WO2014194200A1 (en) | 2013-05-30 | 2014-12-04 | Creasey Graham H | Topical neurological stimulation |
| US11229789B2 (en) | 2013-05-30 | 2022-01-25 | Neurostim Oab, Inc. | Neuro activator with controller |
| CN105473089A (zh) | 2013-06-05 | 2016-04-06 | 麦特文申公司 | 靶标神经纤维的调节 |
| US9339332B2 (en) | 2013-08-30 | 2016-05-17 | Medtronic Ardian Luxembourg S.A.R.L. | Neuromodulation catheters with nerve monitoring features for transmitting digital neural signals and associated systems and methods |
| US9326816B2 (en) | 2013-08-30 | 2016-05-03 | Medtronic Ardian Luxembourg S.A.R.L. | Neuromodulation systems having nerve monitoring assemblies and associated devices, systems, and methods |
| EP4059563B1 (en) * | 2014-01-27 | 2023-09-27 | Medtronic Ireland Manufacturing Unlimited Company | Neuromodulation catheters having jacketed neuromodulation elements and related devices |
| US9980766B1 (en) | 2014-03-28 | 2018-05-29 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and systems for renal neuromodulation |
| US20170072228A1 (en) | 2014-03-31 | 2017-03-16 | University Of Washington | Methods and systems for selectively disrupting tissue with high intensity focused ultrasound |
| WO2015153909A2 (en) | 2014-04-02 | 2015-10-08 | Chevillet John R | High intensity focused ultrasound and methods of performing non-invasive biopsies using same |
| US10610292B2 (en) | 2014-04-25 | 2020-04-07 | Medtronic Ardian Luxembourg S.A.R.L. | Devices, systems, and methods for monitoring and/or controlling deployment of a neuromodulation element within a body lumen and related technology |
| US20150327924A1 (en) | 2014-05-16 | 2015-11-19 | Medtronic Ardian Luxembourg S.A.R.L. | Systems, devices, and methods for modulating renal nerve tissue |
| WO2016033543A1 (en) * | 2014-08-28 | 2016-03-03 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for assessing efficacy of renal neuromodulation and associated systems and devices |
| US10801066B2 (en) | 2014-09-05 | 2020-10-13 | American University Of Beirut | Determination of risk for development of cardiovascular disease by measuring urinary levels of podocin and nephrin messenger RNA |
| US20160095615A1 (en) * | 2014-10-01 | 2016-04-07 | Hermes Innovations, LLC | Surgical device and method of use |
| EP3791817B1 (en) | 2014-10-01 | 2024-05-22 | Medtronic Ardian Luxembourg S.à.r.l. | Systems for evaluating neuromodulation therapy via hemodynamic responses |
| JP2017536187A (ja) | 2014-12-03 | 2017-12-07 | メタベンション インコーポレイテッド | 神経または他の組織を調節するためのシステムおよび方法 |
| WO2016100720A1 (en) | 2014-12-17 | 2016-06-23 | Medtronic Ardian Luxembourg S.A.R.L. | Systems and methods for assessing sympathetic nervous system tone for renal neuromodulation therapy |
| WO2016115208A1 (en) * | 2015-01-14 | 2016-07-21 | University Of Southern California | Multi-sensor platform for diagnosing catheter status |
| US11077301B2 (en) | 2015-02-21 | 2021-08-03 | NeurostimOAB, Inc. | Topical nerve stimulator and sensor for bladder control |
| US11650213B2 (en) * | 2015-03-30 | 2023-05-16 | Entvantage Diagnostics, Inc. | Devices and assays for diagnosis of viral and bacterial infections |
| US20160287178A1 (en) * | 2015-03-30 | 2016-10-06 | St. Jude Medical Coordination Center Bvba | Sensor guide wire having a proximal tube with improved torque performance and maintained low bending stiffness |
| US20170086901A1 (en) * | 2015-09-29 | 2017-03-30 | Cryomedix, Llc | Catheter for renal denervation |
| US12207863B2 (en) | 2015-10-29 | 2025-01-28 | Innoblative Designs, Inc. | Screen sphere tissue ablation devices and methods |
| CN120959691A (zh) * | 2016-02-01 | 2025-11-18 | 美敦力爱尔兰制造无限责任公司 | 用于监测和评估神经调节疗法的系统和方法 |
| US10736692B2 (en) | 2016-04-28 | 2020-08-11 | Medtronic Ardian Luxembourg S.A.R.L. | Neuromodulation and associated systems and methods for the treatment of cancer |
| US10524859B2 (en) | 2016-06-07 | 2020-01-07 | Metavention, Inc. | Therapeutic tissue modulation devices and methods |
| CN109561890A (zh) | 2016-06-09 | 2019-04-02 | 海马切克公司 | 用于检测和可逆地捕获活体内体液中的细胞的收集器 |
| JP2019536509A (ja) | 2016-10-17 | 2019-12-19 | イノブレイティブ デザインズ, インコーポレイテッド | 処置デバイスおよび方法 |
| US10231784B2 (en) | 2016-10-28 | 2019-03-19 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and systems for optimizing perivascular neuromodulation therapy using computational fluid dynamics |
| JP6875757B2 (ja) | 2016-11-08 | 2021-05-26 | イノブレイティブ デザインズ, インコーポレイテッド | 電気手術の組織および脈管シールデバイス |
| US10646713B2 (en) * | 2017-02-22 | 2020-05-12 | Medtronic Ardian Luxembourg S.A.R.L. | Systems, devices, and associated methods for treating patients via renal neuromodulation to reduce a risk of developing cognitive impairment |
| JP6881064B2 (ja) * | 2017-06-16 | 2021-06-02 | オムロンヘルスケア株式会社 | 血圧のNa/K比感受性を評価する装置、方法およびプログラム |
| US11559357B2 (en) | 2017-06-23 | 2023-01-24 | Intuitive Surgical Operations, Inc. | Systems and methods for navigating to a target location during a medical procedure |
| US10945788B2 (en) * | 2017-07-05 | 2021-03-16 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for treating depression in patients via renal neuromodulation |
| AU2018204841B2 (en) * | 2017-07-05 | 2023-08-10 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for treating post-traumatic stress disorder in patients via renal neuromodulation |
| US11284934B2 (en) | 2017-07-05 | 2022-03-29 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for treating sleep disorders in patients via renal neuromodulation |
| US11786297B2 (en) | 2017-07-26 | 2023-10-17 | Innoblative Designs, Inc. | Minimally invasive articulating assembly having ablation capabilities |
| US10850095B2 (en) | 2017-08-08 | 2020-12-01 | Pulse Biosciences, Inc. | Treatment of tissue by the application of energy |
| US11590345B2 (en) | 2017-08-08 | 2023-02-28 | Pulse Biosciences, Inc. | Treatment of tissue by the application of energy |
| US10857347B2 (en) | 2017-09-19 | 2020-12-08 | Pulse Biosciences, Inc. | Treatment instrument and high-voltage connectors for robotic surgical system |
| EP3706856A4 (en) | 2017-11-07 | 2021-08-18 | Neurostim Oab, Inc. | NON-INVASIVE NERVOUS ACTIVATOR WITH ADAPTIVE CIRCUIT |
| US12082917B2 (en) | 2018-01-24 | 2024-09-10 | Medtronic Ireland Manufacturing Unlimited Company | Systems, devices, and methods for assessing efficacy of renal neuromodulation therapy |
| JP7404254B2 (ja) * | 2018-03-09 | 2023-12-25 | ゼネラル・エレクトリック・カンパニイ | 超音波ニューロモジュレーション技術 |
| CN108563121B (zh) * | 2018-04-12 | 2021-06-15 | 南京航空航天大学 | 基于历史数据的微波加热温度场智能监控方法 |
| US11413084B2 (en) | 2018-07-03 | 2022-08-16 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for treating eating disorders in patients via renal neuromodulation |
| US10974079B2 (en) | 2018-08-29 | 2021-04-13 | General Electric Company | Neuromodulation techniques |
| US11633120B2 (en) | 2018-09-04 | 2023-04-25 | Medtronic Ardian Luxembourg S.A.R.L. | Systems and methods for assessing efficacy of renal neuromodulation therapy |
| CN109288521B (zh) * | 2018-09-16 | 2021-06-15 | 华北理工大学 | 一种应用于脊柱康复系统的表面肌电检测装置 |
| US11318330B2 (en) | 2018-09-26 | 2022-05-03 | General Electric Company | Neuromodulation techniques |
| JP7536313B2 (ja) * | 2018-11-21 | 2024-08-20 | エイシーズ メディカル エルエルシー | 医療装置用の検出システム及び方法 |
| US11571569B2 (en) | 2019-02-15 | 2023-02-07 | Pulse Biosciences, Inc. | High-voltage catheters for sub-microsecond pulsing |
| US11426610B2 (en) | 2019-04-30 | 2022-08-30 | General Electric Company | Neuromodulation techniques for perturbation of physiological systems |
| US20200367962A1 (en) * | 2019-05-20 | 2020-11-26 | Innoblative Designs, Inc. | Minimally invasive assembly for lung ablation |
| US11554214B2 (en) | 2019-06-26 | 2023-01-17 | Meditrina, Inc. | Fluid management system |
| US11458311B2 (en) | 2019-06-26 | 2022-10-04 | Neurostim Technologies Llc | Non-invasive nerve activator patch with adaptive circuit |
| AU2020346827B2 (en) * | 2019-09-12 | 2026-03-12 | Relievant Medsystems, Inc. | Systems and methods for tissue modulation |
| WO2021113616A1 (en) * | 2019-12-05 | 2021-06-10 | The Board Of Regents Of The University Of Texas System | Urine analysis devices and methods for real time monitoring of kidney function |
| KR20220115802A (ko) | 2019-12-16 | 2022-08-18 | 뉴로스팀 테크놀로지스 엘엘씨 | 부스트 전하 전달 기능이 있는 비침습적 신경 액티베이터 |
| US20230061046A1 (en) * | 2020-01-22 | 2023-03-02 | Regents Of The University Of Minnesota | Systems and methods for responsive ultrasound stimulation for immuno-modulation treatment |
| CN111603152A (zh) * | 2020-04-26 | 2020-09-01 | 杨铭轲 | 一种有创血压测量装置 |
| US12527622B2 (en) | 2021-04-26 | 2026-01-20 | Innoblative Designs, Inc. | System for minimally invasive tissue ablation and sealing |
| US20220358152A1 (en) * | 2021-05-10 | 2022-11-10 | International Business Machines Corporation | Model performance through text-to-text transformation via distant supervision from target and auxiliary tasks |
| CN113633282A (zh) * | 2021-07-19 | 2021-11-12 | 上海安通医疗科技有限公司 | 一种肾动脉交感神经活性测量系统 |
| CN113633283A (zh) * | 2021-07-29 | 2021-11-12 | 上海安通医疗科技有限公司 | 一种介入式肾动脉交感神经活性检测系统 |
| CN116819093A (zh) * | 2023-06-15 | 2023-09-29 | 中国人民解放军军事科学院军事医学研究院 | 电磁辐射敏感的神经细胞相关血清学标志物及其应用 |
| WO2025190725A1 (en) * | 2024-03-15 | 2025-09-18 | Koninklijke Philips N.V. | Catheter-based procedures with procedure room detection of biomarkers in patient blood and associated devices, systems, and methods |
Family Cites Families (648)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2130758A (en) | 1935-06-01 | 1938-09-20 | E J Rose Mfg Company Of Califo | Electrode for diathermy treatment and the like |
| US2276995A (en) | 1938-01-22 | 1942-03-17 | A J Ginsberg | Electrotherapy |
| US2276996A (en) | 1940-11-30 | 1942-03-17 | A J Ginsberg | Non-radio-interfering therapeutic apparatus |
| US3181535A (en) | 1957-10-04 | 1965-05-04 | Diapulse Mfg Corp Of America | Athermapeutic apparatus |
| US3043310A (en) | 1959-04-24 | 1962-07-10 | Diapulse Mfg Corp Of America | Treatment head for athermapeutic apparatus |
| US3127895A (en) | 1962-07-02 | 1964-04-07 | Dynapower System Corp | Therapeutic pulse generation and control circuit |
| US3270746A (en) | 1963-08-26 | 1966-09-06 | Dynapower Systems Corp | High-performance electrotherapeutic treatment head |
| US3329149A (en) | 1964-10-28 | 1967-07-04 | Dynapower Systems Corp Of Cali | Supporting arm for electrotherapeutic treatment head |
| US3563246A (en) | 1967-04-24 | 1971-02-16 | Intelectron Corp | Method and apparatus for improving neural performance in human subjects by electrotherapy |
| US3522811A (en) | 1969-02-13 | 1970-08-04 | Medtronic Inc | Implantable nerve stimulator and method of use |
| SE346468B (https=) | 1969-02-24 | 1972-07-10 | Lkb Medical Ab | |
| US3670737A (en) | 1970-07-02 | 1972-06-20 | Diapulse Corp Of America | Ultra-short wave athermapeutic apparatus |
| US3760812A (en) | 1971-03-19 | 1973-09-25 | Univ Minnesota | Implantable spiral wound stimulation electrodes |
| US3774620A (en) | 1971-06-14 | 1973-11-27 | Nemectron Gmbh | Electromedicinal apparatus for interference current therapy |
| US3895639A (en) | 1971-09-07 | 1975-07-22 | Rodler Ing Hans | Apparatus for producing an interference signal at a selected location |
| US3800802A (en) | 1972-01-07 | 1974-04-02 | Int Medical Electronics Ltd | Short-wave therapy apparatus |
| US3794022A (en) | 1972-06-30 | 1974-02-26 | E Nawracaj | Dual oscillator, variable pulse duration electrotherapeutic device |
| US3803463A (en) | 1972-07-10 | 1974-04-09 | J Cover | Weapon for immobilization and capture |
| US3897789A (en) | 1973-09-13 | 1975-08-05 | Stanley J Blanchard | Acupuncture apparatus |
| US3894532A (en) | 1974-01-17 | 1975-07-15 | Acupulse Inc | Instruments for transcutaneous and subcutaneous investigation and treatment |
| US3911930A (en) | 1974-03-01 | 1975-10-14 | Stimulation Tech | Method and structure of preventing and treating ileus, and reducing acute pain by electrical pulse stimulation |
| US4011861A (en) | 1974-04-03 | 1977-03-15 | Case Western Reserve University | Implantable electric terminal for organic tissue |
| US4055190A (en) | 1974-12-19 | 1977-10-25 | Michio Tany | Electrical therapeutic apparatus |
| US3952751A (en) | 1975-01-08 | 1976-04-27 | W. Denis Kendall | High-performance electrotherapeutic apparatus |
| US4026300A (en) | 1975-03-14 | 1977-05-31 | Liberty Mutual | Method and apparatus for interfacing to nerves |
| US3987790A (en) | 1975-10-01 | 1976-10-26 | Alza Corporation | Osmotically driven fluid dispenser |
| US4105017A (en) | 1976-11-17 | 1978-08-08 | Electro-Biology, Inc. | Modification of the growth repair and maintenance behavior of living tissue and cells by a specific and selective change in electrical environment |
| US4266532A (en) | 1976-11-17 | 1981-05-12 | Electro-Biology, Inc. | Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective change in electrical environment |
| US4315503A (en) | 1976-11-17 | 1982-02-16 | Electro-Biology, Inc. | Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective change in electrical environment |
| US4071033A (en) | 1976-12-20 | 1978-01-31 | Nawracaj Edward P | Electrotherapeutic device with modulated dual signals |
| US4141365A (en) | 1977-02-24 | 1979-02-27 | The Johns Hopkins University | Epidural lead electrode and insertion needle |
| US4360019A (en) | 1979-02-28 | 1982-11-23 | Andros Incorporated | Implantable infusion device |
| US4305115A (en) | 1979-03-14 | 1981-12-08 | Harry H. Leveen | Electrostatic shield |
| US4692147A (en) | 1980-04-02 | 1987-09-08 | Medtronic, Inc. | Drug administration device |
| US4405305A (en) | 1980-10-27 | 1983-09-20 | University Of Utah Research Foundation | Subcutaneous peritoneal injection catheter |
| US4379462A (en) | 1980-10-29 | 1983-04-12 | Neuromed, Inc. | Multi-electrode catheter assembly for spinal cord stimulation |
| CS226514B1 (en) | 1981-01-28 | 1984-04-16 | Petr Ing Csc Slovak | Apparatus for stimulating live tissues |
| US4454883A (en) | 1982-02-16 | 1984-06-19 | Therafield Holdings Limited | Electrotherapeutic apparatus |
| US4444203A (en) | 1982-03-26 | 1984-04-24 | Lab-A-Cath, Inc. | Intravenous catheter placing and specimen gathering device |
| US4530840A (en) | 1982-07-29 | 1985-07-23 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
| US4467808A (en) | 1982-09-17 | 1984-08-28 | Biolectron, Inc. | Method for preventing and treating osteoporosis in a living body by using electrical stimulation non-invasively |
| US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
| FR2541902B1 (fr) | 1983-03-04 | 1986-02-07 | Cofrem International Sa | Appareil therapeutique athermique |
| AU577549B2 (en) | 1983-09-14 | 1988-09-29 | Jacob Zabara | Neurocybernetic prothesis |
| JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
| US4816016A (en) | 1984-03-16 | 1989-03-28 | Pudenz-Schulte Medical Research Corp. | Subcutaneous infusion reservoir and pump system |
| US4618600A (en) | 1984-04-19 | 1986-10-21 | Biotechnology Research Associates, J.V. | Novel polypeptide diuretic/vasodilators |
| US4587975A (en) | 1984-07-02 | 1986-05-13 | Cardiac Pacemakers, Inc. | Dimension sensitive angioplasty catheter |
| US4674482A (en) | 1984-09-12 | 1987-06-23 | Irt, Inc. | Pulse electro-magnetic field therapy device with auto bias circuit |
| US4602624A (en) | 1984-10-11 | 1986-07-29 | Case Western Reserve University | Implantable cuff, method of manufacture, and method of installation |
| US4608985A (en) | 1984-10-11 | 1986-09-02 | Case Western Reserve University | Antidromic pulse generating wave form for collision blocking |
| US4649936A (en) | 1984-10-11 | 1987-03-17 | Case Western Reserve University | Asymmetric single electrode cuff for generation of unidirectionally propagating action potentials for collision blocking |
| US4865845A (en) | 1986-03-21 | 1989-09-12 | Alza Corporation | Release rate adjustment of osmotic or diffusional delivery devices |
| US4709698A (en) | 1986-05-14 | 1987-12-01 | Thomas J. Fogarty | Heatable dilation catheter |
| US5014699A (en) | 1986-05-23 | 1991-05-14 | Trustees Of The University Of Pennsylvania | Electromagnetic method and apparatus for healing living tissue |
| US4998532A (en) | 1986-05-23 | 1991-03-12 | Lti Biomedical, Inc. | Portable electro-therapy system |
| US4715852A (en) | 1986-07-21 | 1987-12-29 | Eaton Corporation | Implanted medication infusion device |
| US4774967A (en) | 1986-09-09 | 1988-10-04 | American Biointerface Corporation | Method and apparatus for mammalian nerve regeneration |
| US4791931A (en) | 1987-08-13 | 1988-12-20 | Pacesetter Infusion, Ltd. | Demand pacemaker using an artificial baroreceptor reflex |
| US4852573A (en) | 1987-12-04 | 1989-08-01 | Kennedy Philip R | Implantable neural electrode |
| EP0398960B1 (en) | 1988-01-21 | 1995-12-06 | Massachusetts Institute Of Technology | Transport of molecules across tissue using electroporation |
| US5389069A (en) | 1988-01-21 | 1995-02-14 | Massachusetts Institute Of Technology | Method and apparatus for in vivo electroporation of remote cells and tissue |
| US4890623A (en) | 1988-03-14 | 1990-01-02 | C. R. Bard, Inc. | Biopotential sensing device and method for making |
| CA1319174C (en) | 1988-04-21 | 1993-06-15 | Lawrence E. Bertolucci | Electrical nerve stimulation device for nausea control |
| US5208147A (en) * | 1988-07-21 | 1993-05-04 | Radiometer A/S | Means for measuring a characteristic in a sample fluid |
| US4955377A (en) | 1988-10-28 | 1990-09-11 | Lennox Charles D | Device and method for heating tissue in a patient's body |
| US5094242A (en) | 1988-11-07 | 1992-03-10 | Regents Of The University Of California | Implantable nerve stimulation device |
| US5057318A (en) | 1988-12-13 | 1991-10-15 | Alza Corporation | Delivery system for beneficial agent over a broad range of rates |
| US5059423A (en) | 1988-12-13 | 1991-10-22 | Alza Corporation | Delivery system comprising biocompatible beneficial agent formulation |
| US5458631A (en) | 1989-01-06 | 1995-10-17 | Xavier; Ravi | Implantable catheter with electrical pulse nerve stimulators and drug delivery system |
| WO1990007303A1 (en) | 1989-01-06 | 1990-07-12 | Angioplasty Systems, Inc. | Electrosurgical catheter for resolving atherosclerotic plaque |
| US5779698A (en) | 1989-01-18 | 1998-07-14 | Applied Medical Resources Corporation | Angioplasty catheter system and method for making same |
| US4976711A (en) | 1989-04-13 | 1990-12-11 | Everest Medical Corporation | Ablation catheter with selectively deployable electrodes |
| US5125928A (en) | 1989-04-13 | 1992-06-30 | Everest Medical Corporation | Ablation catheter with selectively deployable electrodes |
| US5006119A (en) | 1989-05-25 | 1991-04-09 | Engineering & Research Associates, Inc. | Hollow core coaxial catheter |
| US20030220521A1 (en) | 1989-07-27 | 2003-11-27 | G.D. Searle & Co. | Renal-selective prodrugs for control of renal sympathetic nerve activity in the treatment of hypertension |
| US5112614A (en) | 1989-09-14 | 1992-05-12 | Alza Corporation | Implantable delivery dispenser |
| RU1785710C (en) | 1989-10-06 | 1993-01-07 | Vremennyj Nauchnyj Kollektiv O | Microwave resonant therapeutic device |
| US4979511A (en) | 1989-11-03 | 1990-12-25 | Cyberonics, Inc. | Strain relief tether for implantable electrode |
| US5188837A (en) | 1989-11-13 | 1993-02-23 | Nova Pharmaceutical Corporation | Lipsopheres for controlled delivery of substances |
| US5851206A (en) | 1990-03-13 | 1998-12-22 | The Regents Of The University Of California | Method and apparatus for endovascular thermal thrombosis and thermal cancer treatment |
| US5193048A (en) | 1990-04-27 | 1993-03-09 | Kaufman Dennis R | Stun gun with low battery indicator and shutoff timer |
| US5184617A (en) | 1990-06-05 | 1993-02-09 | Staodyn, Inc. | Output pulse compensation for therapeutic-type electronic devices |
| US5095905A (en) | 1990-06-07 | 1992-03-17 | Medtronic, Inc. | Implantable neural electrode |
| US5498238A (en) | 1990-06-15 | 1996-03-12 | Cortrak Medical, Inc. | Simultaneous angioplasty and phoretic drug delivery |
| US5499971A (en) | 1990-06-15 | 1996-03-19 | Cortrak Medical, Inc. | Method for iontophoretically delivering drug adjacent to a heart |
| EP0533816B1 (en) | 1990-06-15 | 1995-06-14 | Cortrak Medical, Inc. | Drug delivery apparatus |
| US5234693A (en) | 1990-07-11 | 1993-08-10 | Alza Corporation | Delivery device with a protective sleeve |
| US5234692A (en) | 1990-07-11 | 1993-08-10 | Alza Corporation | Delivery device with a protective sleeve |
| US5058584A (en) | 1990-08-30 | 1991-10-22 | Medtronic, Inc. | Method and apparatus for epidural burst stimulation for angina pectoris |
| US5111815A (en) | 1990-10-15 | 1992-05-12 | Cardiac Pacemakers, Inc. | Method and apparatus for cardioverter/pacer utilizing neurosensing |
| EP0491979A1 (de) | 1990-12-22 | 1992-07-01 | Peter Dr. Ing. Osypka | Herzschrittmacher-Katheter mit zwei Polen |
| US5324255A (en) | 1991-01-11 | 1994-06-28 | Baxter International Inc. | Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasopasm |
| US5263480A (en) | 1991-02-01 | 1993-11-23 | Cyberonics, Inc. | Treatment of eating disorders by nerve stimulation |
| US5425364A (en) | 1991-02-15 | 1995-06-20 | Cardiac Pathways Corporation | Flexible strip assembly without feedthrough holes and device utilizing the same |
| US5269303A (en) | 1991-02-22 | 1993-12-14 | Cyberonics, Inc. | Treatment of dementia by nerve stimulation |
| US5199428A (en) | 1991-03-22 | 1993-04-06 | Medtronic, Inc. | Implantable electrical nerve stimulator/pacemaker with ischemia for decreasing cardiac workload |
| US5215086A (en) | 1991-05-03 | 1993-06-01 | Cyberonics, Inc. | Therapeutic treatment of migraine symptoms by stimulation |
| US5335657A (en) | 1991-05-03 | 1994-08-09 | Cyberonics, Inc. | Therapeutic treatment of sleep disorder by nerve stimulation |
| US5251634A (en) | 1991-05-03 | 1993-10-12 | Cyberonics, Inc. | Helical nerve electrode |
| US5299569A (en) | 1991-05-03 | 1994-04-05 | Cyberonics, Inc. | Treatment of neuropsychiatric disorders by nerve stimulation |
| US5458568A (en) | 1991-05-24 | 1995-10-17 | Cortrak Medical, Inc. | Porous balloon for selective dilatation and drug delivery |
| WO1992020291A1 (en) | 1991-05-24 | 1992-11-26 | Applied Medical Resources, Inc. | Articulating tissue cutter assembly |
| US5137727A (en) | 1991-06-12 | 1992-08-11 | Alza Corporation | Delivery device providing beneficial agent stability |
| US5766151A (en) * | 1991-07-16 | 1998-06-16 | Heartport, Inc. | Endovascular system for arresting the heart |
| US5213098A (en) | 1991-07-26 | 1993-05-25 | Medtronic, Inc. | Post-extrasystolic potentiation stimulation with physiologic sensor feedback |
| US5222494A (en) | 1991-07-31 | 1993-06-29 | Cyberonics, Inc. | Implantable tissue stimulator output stabilization system |
| US5231988A (en) | 1991-08-09 | 1993-08-03 | Cyberonics, Inc. | Treatment of endocrine disorders by nerve stimulation |
| WO1993006780A1 (en) | 1991-10-03 | 1993-04-15 | The General Hospital Corporation | Apparatus and method for vasodilation |
| US5215089A (en) | 1991-10-21 | 1993-06-01 | Cyberonics, Inc. | Electrode assembly for nerve stimulation |
| ES2201051T3 (es) | 1991-11-08 | 2004-03-16 | Boston Scientific Limited | Electrodo para ablacion que comprende detectores de temperatura aislados. |
| US5304206A (en) | 1991-11-18 | 1994-04-19 | Cyberonics, Inc. | Activation techniques for implantable medical device |
| US5358514A (en) | 1991-12-18 | 1994-10-25 | Alfred E. Mann Foundation For Scientific Research | Implantable microdevice with self-attaching electrodes |
| US5193539A (en) | 1991-12-18 | 1993-03-16 | Alfred E. Mann Foundation For Scientific Research | Implantable microstimulator |
| US5203326A (en) | 1991-12-18 | 1993-04-20 | Telectronics Pacing Systems, Inc. | Antiarrhythmia pacer using antiarrhythmia pacing and autonomic nerve stimulation therapy |
| US5193540A (en) | 1991-12-18 | 1993-03-16 | Alfred E. Mann Foundation For Scientific Research | Structure and method of manufacture of an implantable microstimulator |
| US5301683A (en) | 1991-12-23 | 1994-04-12 | Durkan John A | Diagnosing carpal tunnel syndrome |
| US5697882A (en) | 1992-01-07 | 1997-12-16 | Arthrocare Corporation | System and method for electrosurgical cutting and ablation |
| CA2131705C (en) | 1992-03-09 | 2008-10-21 | Aaron G. Filler | Image neurography and diffusion anisotropy imaging |
| US5300068A (en) | 1992-04-21 | 1994-04-05 | St. Jude Medical, Inc. | Electrosurgical apparatus |
| US5370680A (en) | 1992-05-27 | 1994-12-06 | Magnetic Resonance Therapeutics, Inc. | Athermapeutic apparatus employing electro-magnetic fields |
| JP3493196B2 (ja) | 1992-06-24 | 2004-02-03 | サイベロニクス,インク. | 神経刺激による神経精神障害の治療 |
| US5772590A (en) | 1992-06-30 | 1998-06-30 | Cordis Webster, Inc. | Cardiovascular catheter with laterally stable basket-shaped electrode array with puller wire |
| US5507724A (en) | 1992-07-01 | 1996-04-16 | Genetronics, Inc. | Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells |
| US5304120A (en) | 1992-07-01 | 1994-04-19 | Btx Inc. | Electroporation method and apparatus for insertion of drugs and genes into endothelial cells |
| US5484400A (en) | 1992-08-12 | 1996-01-16 | Vidamed, Inc. | Dual channel RF delivery system |
| US5542916A (en) | 1992-08-12 | 1996-08-06 | Vidamed, Inc. | Dual-channel RF power delivery system |
| DE4229693A1 (de) | 1992-09-05 | 1994-03-10 | Achim Dr Hansjuergens | Elektrotherapeutisches Gerät |
| DK0659073T3 (da) | 1992-09-10 | 2002-03-11 | Childrens Medical Center | Bionedbrydelige polymermatrixer med vedvarerende afgivelse af lokalanæstetika |
| US5922340A (en) | 1992-09-10 | 1999-07-13 | Children's Medical Center Corporation | High load formulations and methods for providing prolonged local anesthesia |
| US5700485A (en) | 1992-09-10 | 1997-12-23 | Children's Medical Center Corporation | Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid |
| US5478303A (en) | 1992-09-18 | 1995-12-26 | Foley-Nolan; Darragh | Electromagnetic apparatus for use in therapy |
| US5338662A (en) | 1992-09-21 | 1994-08-16 | Bio-Preserve Medical Corporation | Organ perfusion device |
| US5553611A (en) | 1994-01-06 | 1996-09-10 | Endocardial Solutions, Inc. | Endocardial measurement method |
| WO1994007446A1 (en) | 1992-10-05 | 1994-04-14 | Boston Scientific Corporation | Device and method for heating tissue |
| US5634899A (en) | 1993-08-20 | 1997-06-03 | Cortrak Medical, Inc. | Simultaneous cardiac pacing and local drug delivery method |
| US5807306A (en) | 1992-11-09 | 1998-09-15 | Cortrak Medical, Inc. | Polymer matrix drug delivery apparatus |
| US5334193A (en) | 1992-11-13 | 1994-08-02 | American Cardiac Ablation Co., Inc. | Fluid cooled ablation catheter |
| US5441483A (en) | 1992-11-16 | 1995-08-15 | Avitall; Boaz | Catheter deflection control |
| CA2109980A1 (en) | 1992-12-01 | 1994-06-02 | Mir A. Imran | Steerable catheter with adjustable bend location and/or radius and method |
| WO1994014128A2 (en) | 1992-12-11 | 1994-06-23 | Siemens Medical Systems, Inc. | Docking station for a patient monitoring system |
| US5256141A (en) | 1992-12-22 | 1993-10-26 | Nelson Gencheff | Biological material deployment method and apparatus |
| US5317155A (en) | 1992-12-29 | 1994-05-31 | The Electrogesic Corporation | Corona discharge apparatus |
| US5429634A (en) | 1993-09-09 | 1995-07-04 | Pdt Systems | Biogenic implant for drug delivery and method |
| US5792187A (en) | 1993-02-22 | 1998-08-11 | Angeion Corporation | Neuro-stimulation to control pain during cardioversion defibrillation |
| US5397338A (en) | 1993-03-29 | 1995-03-14 | Maven Labs, Inc. | Electrotherapy device |
| US5439440A (en) | 1993-04-01 | 1995-08-08 | Genetronics, Inc. | Electroporation system with voltage control feedback for clinical applications |
| DE69431295T2 (de) | 1993-04-21 | 2003-05-15 | Institut Pasteur, Paris | Biokompatibles implantat zur in vivo expression und sekretion von therapeutischer verbindung |
| FR2704151B1 (fr) | 1993-04-21 | 1995-07-13 | Klotz Antoine Olivier | Dispositif électronique destiné à la stimulation adrénergique du système sympathique relatif à la média veineuse. |
| US6517811B2 (en) | 1993-05-06 | 2003-02-11 | Research Corporation Technologies, Inc. | Compounds for cancer imaging and therapy |
| US5584863A (en) | 1993-06-24 | 1996-12-17 | Electropharmacology, Inc. | Pulsed radio frequency electrotherapeutic system |
| JP3898754B2 (ja) | 1993-07-01 | 2007-03-28 | ボストン サイエンティフィック リミテッド | 像形成、電位検出型及び切除カテーテル |
| US5860974A (en) | 1993-07-01 | 1999-01-19 | Boston Scientific Corporation | Heart ablation catheter with expandable electrode and method of coupling energy to an electrode on a catheter shaft |
| US5507791A (en) | 1993-08-31 | 1996-04-16 | Sit'ko; Sergei P. | Microwave resonance therapy |
| US5582609A (en) | 1993-10-14 | 1996-12-10 | Ep Technologies, Inc. | Systems and methods for forming large lesions in body tissue using curvilinear electrode elements |
| US5400784A (en) | 1993-10-15 | 1995-03-28 | Case Western Reserve University | Slowly penetrating inter-fascicular nerve cuff electrode and method of using |
| US5397308A (en) | 1993-10-22 | 1995-03-14 | Scimed Life Systems, Inc. | Balloon inflation measurement apparatus |
| US5470352A (en) | 1993-10-29 | 1995-11-28 | Northeastern University | Balloon angioplasty device |
| US5433739A (en) | 1993-11-02 | 1995-07-18 | Sluijter; Menno E. | Method and apparatus for heating an intervertebral disc for relief of back pain |
| US5571147A (en) | 1993-11-02 | 1996-11-05 | Sluijter; Menno E. | Thermal denervation of an intervertebral disc for relief of back pain |
| US5599345A (en) | 1993-11-08 | 1997-02-04 | Zomed International, Inc. | RF treatment apparatus |
| US5730127A (en) | 1993-12-03 | 1998-03-24 | Avitall; Boaz | Mapping and ablation catheter system |
| JPH07157424A (ja) | 1993-12-03 | 1995-06-20 | Lintec Corp | 局所麻酔用ゲル製剤 |
| US5458626A (en) | 1993-12-27 | 1995-10-17 | Krause; Horst E. | Method of electrical nerve stimulation for acceleration of tissue healing |
| US6099524A (en) | 1994-01-28 | 2000-08-08 | Cardiac Pacemakers, Inc. | Electrophysiological mapping and ablation catheter and method |
| US5697975A (en) | 1994-02-09 | 1997-12-16 | The University Of Iowa Research Foundation | Human cerebral cortex neural prosthetic for tinnitus |
| US6858024B1 (en) | 1994-02-14 | 2005-02-22 | Scimed Life Systems, Inc. | Guide catheter having selected flexural modulus segments |
| GB9407135D0 (en) | 1994-04-11 | 1994-06-01 | Aberdeen University And Plasma | Treatment of osteoporosis |
| US5505201A (en) | 1994-04-20 | 1996-04-09 | Case Western Reserve University | Implantable helical spiral cuff electrode |
| WO1995033514A1 (en) | 1994-06-09 | 1995-12-14 | Magnetic Resonance Therapeutics, Inc. | Electro-therapeutic method |
| US5505700A (en) | 1994-06-14 | 1996-04-09 | Cordis Corporation | Electro-osmotic infusion catheter |
| US6009877A (en) | 1994-06-24 | 2000-01-04 | Edwards; Stuart D. | Method for treating a sphincter |
| US6056744A (en) | 1994-06-24 | 2000-05-02 | Conway Stuart Medical, Inc. | Sphincter treatment apparatus |
| US6405732B1 (en) | 1994-06-24 | 2002-06-18 | Curon Medical, Inc. | Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors |
| WO1996000039A1 (en) | 1994-06-27 | 1996-01-04 | Ep Technologies, Inc. | Systems and methods for sensing temperature within the body |
| US5626862A (en) | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
| US5810802A (en) | 1994-08-08 | 1998-09-22 | E.P. Technologies, Inc. | Systems and methods for controlling tissue ablation using multiple temperature sensing elements |
| US5454782A (en) | 1994-08-11 | 1995-10-03 | Perkins; Rodney C. | Translumenal circumferential energy delivery device |
| WO1996004957A1 (en) | 1994-08-17 | 1996-02-22 | Electropharmacology, Inc. | Electrotherapeutic system |
| US5531778A (en) | 1994-09-20 | 1996-07-02 | Cyberonics, Inc. | Circumneural electrode assembly |
| US5540734A (en) | 1994-09-28 | 1996-07-30 | Zabara; Jacob | Cranial nerve stimulation treatments using neurocybernetic prosthesis |
| WO1996011723A1 (en) | 1994-10-17 | 1996-04-25 | Australasian Medical Technology Limited | Devices and methods for implementation of pulsed electromagnetic field therapy |
| US5722401A (en) | 1994-10-19 | 1998-03-03 | Cardiac Pathways Corporation | Endocardial mapping and/or ablation catheter probe |
| US5660848A (en) | 1994-11-02 | 1997-08-26 | The Population Council, Center For Biomedical Research | Subdermally implantable device |
| PT788351E (pt) | 1994-11-10 | 2003-06-30 | Univ Kentucky Res Foundation T | Dispositivo implantavel recarregavel de libertacaocontrolada para administrar medicamentos direc tamente numa porcao interna do corpo |
| US5571150A (en) | 1994-12-19 | 1996-11-05 | Cyberonics, Inc. | Treatment of patients in coma by nerve stimulation |
| US5569198A (en) | 1995-01-23 | 1996-10-29 | Cortrak Medical Inc. | Microporous catheter |
| US5608519A (en) | 1995-03-20 | 1997-03-04 | Gourley; Paul L. | Laser apparatus and method for microscopic and spectroscopic analysis and processing of biological cells |
| WO1996034571A1 (en) | 1995-05-04 | 1996-11-07 | Cosman Eric R | Cool-tip electrode thermosurgery system |
| US5540730A (en) | 1995-06-06 | 1996-07-30 | Cyberonics, Inc. | Treatment of motility disorders by nerve stimulation |
| WO1996039993A1 (en) | 1995-06-07 | 1996-12-19 | Gore Hybrid Technologies, Inc. | An implantable containment apparatus for a therapeutical device and method for loading and reloading the device therein |
| US6041252A (en) | 1995-06-07 | 2000-03-21 | Ichor Medical Systems Inc. | Drug delivery system and method |
| US6149620A (en) | 1995-11-22 | 2000-11-21 | Arthrocare Corporation | System and methods for electrosurgical tissue treatment in the presence of electrically conductive fluid |
| US6322558B1 (en) | 1995-06-09 | 2001-11-27 | Engineering & Research Associates, Inc. | Apparatus and method for predicting ablation depth |
| NZ311474A (en) | 1995-06-09 | 1997-09-22 | Euro Celtique Sa | Formulations for providing prolonged local anesthesia |
| US5983131A (en) | 1995-08-11 | 1999-11-09 | Massachusetts Institute Of Technology | Apparatus and method for electroporation of tissue |
| US5672174A (en) | 1995-08-15 | 1997-09-30 | Rita Medical Systems, Inc. | Multiple antenna ablation apparatus and method |
| US5711326A (en) | 1995-08-25 | 1998-01-27 | Whirlpool Corporation | Dishwasher accumulator soil removal grating for a filter system |
| US5707400A (en) | 1995-09-19 | 1998-01-13 | Cyberonics, Inc. | Treating refractory hypertension by nerve stimulation |
| US6615071B1 (en) | 1995-09-20 | 2003-09-02 | Board Of Regents, The University Of Texas System | Method and apparatus for detecting vulnerable atherosclerotic plaque |
| CA2231425A1 (en) | 1995-09-20 | 1997-03-27 | Texas Heart Institute | Detecting thermal discrepancies in vessel walls |
| US5700282A (en) | 1995-10-13 | 1997-12-23 | Zabara; Jacob | Heart rhythm stabilization using a neurocybernetic prosthesis |
| ATE275880T1 (de) | 1995-10-13 | 2004-10-15 | Transvascular Inc | Vorrichtung zur umgehung von arteriellen verengungen und/oder zur ausführung anderer transvaskularer eingriffe |
| US6283951B1 (en) | 1996-10-11 | 2001-09-04 | Transvascular, Inc. | Systems and methods for delivering drugs to selected locations within the body |
| US5755750A (en) | 1995-11-13 | 1998-05-26 | University Of Florida | Method and apparatus for selectively inhibiting activity in nerve fibers |
| US6073048A (en) | 1995-11-17 | 2000-06-06 | Medtronic, Inc. | Baroreflex modulation with carotid sinus nerve stimulation for the treatment of heart failure |
| US6010613A (en) | 1995-12-08 | 2000-01-04 | Cyto Pulse Sciences, Inc. | Method of treating materials with pulsed electrical fields |
| CN2291164Y (zh) | 1996-12-23 | 1998-09-16 | 祝强 | 降压仪 |
| CN1216930A (zh) | 1996-02-02 | 1999-05-19 | 血管转换公司 | 间质经血管介入的装置,系统和方法 |
| ES2233768T3 (es) | 1996-02-02 | 2005-06-16 | Alza Corporation | Liberacion prolongada de un agente activo utilizando un sistema implantable. |
| US5913876A (en) | 1996-02-20 | 1999-06-22 | Cardiothoracic Systems, Inc. | Method and apparatus for using vagus nerve stimulation in surgery |
| US6051017A (en) | 1996-02-20 | 2000-04-18 | Advanced Bionics Corporation | Implantable microstimulator and systems employing the same |
| US6036687A (en) | 1996-03-05 | 2000-03-14 | Vnus Medical Technologies, Inc. | Method and apparatus for treating venous insufficiency |
| US5747060A (en) | 1996-03-26 | 1998-05-05 | Euro-Celtique, S.A. | Prolonged local anesthesia with colchicine |
| US5690681A (en) | 1996-03-29 | 1997-11-25 | Purdue Research Foundation | Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation |
| US6735471B2 (en) | 1996-04-30 | 2004-05-11 | Medtronic, Inc. | Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure |
| US6006134A (en) | 1998-04-30 | 1999-12-21 | Medtronic, Inc. | Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers |
| US6449507B1 (en) | 1996-04-30 | 2002-09-10 | Medtronic, Inc. | Method and system for nerve stimulation prior to and during a medical procedure |
| US5690691A (en) | 1996-05-08 | 1997-11-25 | The Center For Innovative Technology | Gastro-intestinal pacemaker having phased multi-point stimulation |
| US5859762A (en) | 1996-05-13 | 1999-01-12 | International Business Machines Corporation | Docking station for portable computers |
| US5938690A (en) | 1996-06-07 | 1999-08-17 | Advanced Neuromodulation Systems, Inc. | Pain management system and method |
| US5861021A (en) | 1996-06-17 | 1999-01-19 | Urologix Inc | Microwave thermal therapy of cardiac tissue |
| US20020040204A1 (en) | 1996-06-24 | 2002-04-04 | Dev Nagendu B. | Electroporation-enhanced inhibition of vascular neointimal hyperplasia |
| US5944710A (en) | 1996-06-24 | 1999-08-31 | Genetronics, Inc. | Electroporation-mediated intravascular delivery |
| US6246912B1 (en) | 1996-06-27 | 2001-06-12 | Sherwood Services Ag | Modulated high frequency tissue modification |
| US5983141A (en) | 1996-06-27 | 1999-11-09 | Radionics, Inc. | Method and apparatus for altering neural tissue function |
| US5924997A (en) | 1996-07-29 | 1999-07-20 | Campbell; Thomas Henderson | Catheter and method for the thermal mapping of hot spots in vascular lesions of the human body |
| US6245026B1 (en) | 1996-07-29 | 2001-06-12 | Farallon Medsystems, Inc. | Thermography catheter |
| US6058328A (en) | 1996-08-06 | 2000-05-02 | Pacesetter, Inc. | Implantable stimulation device having means for operating in a preemptive pacing mode to prevent tachyarrhythmias and method thereof |
| US6135999A (en) | 1997-02-12 | 2000-10-24 | Oratec Internationals, Inc. | Concave probe for arthroscopic surgery |
| US5906636A (en) | 1996-09-20 | 1999-05-25 | Texas Heart Institute | Heat treatment of inflamed tissue |
| US5800464A (en) | 1996-10-03 | 1998-09-01 | Medtronic, Inc. | System for providing hyperpolarization of cardiac to enhance cardiac function |
| US5814079A (en) | 1996-10-04 | 1998-09-29 | Medtronic, Inc. | Cardiac arrhythmia management by application of adnodal stimulation for hyperpolarization of myocardial cells |
| US5704908A (en) | 1996-10-10 | 1998-01-06 | Genetronics, Inc. | Electroporation and iontophoresis catheter with porous balloon |
| US5893885A (en) | 1996-11-01 | 1999-04-13 | Cordis Webster, Inc. | Multi-electrode ablation catheter |
| US6091995A (en) | 1996-11-08 | 2000-07-18 | Surx, Inc. | Devices, methods, and systems for shrinking tissues |
| US6071251A (en) * | 1996-12-06 | 2000-06-06 | Abbott Laboratories | Method and apparatus for obtaining blood for diagnostic tests |
| US5954719A (en) | 1996-12-11 | 1999-09-21 | Irvine Biomedical, Inc. | System for operating a RF ablation generator |
| US5871449A (en) | 1996-12-27 | 1999-02-16 | Brown; David Lloyd | Device and method for locating inflamed plaque in an artery |
| AU5478298A (en) | 1997-01-13 | 1998-08-03 | Neurodan A/S | An implantable nerve stimulator electrode |
| US6026326A (en) | 1997-01-13 | 2000-02-15 | Medtronic, Inc. | Apparatus and method for treating chronic constipation |
| EP1011792B1 (en) | 1997-02-26 | 2005-12-07 | Alfred E. Mann Foundation for Scientific Research | Battery-powered patient implantable device |
| US6208894B1 (en) | 1997-02-26 | 2001-03-27 | Alfred E. Mann Foundation For Scientific Research And Advanced Bionics | System of implantable devices for monitoring and/or affecting body parameters |
| US5954761A (en) | 1997-03-25 | 1999-09-21 | Intermedics Inc. | Implantable endocardial lead assembly having a stent |
| DE69841076D1 (de) | 1997-03-27 | 2009-10-01 | Advanced Bionics Corp | System implantierbarer geräte zur beobachtung und beeinflussung von körperparametern |
| US6261281B1 (en) | 1997-04-03 | 2001-07-17 | Electrofect As | Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells |
| US7027869B2 (en) | 1998-01-07 | 2006-04-11 | Asthmatx, Inc. | Method for treating an asthma attack |
| US5948007A (en) | 1997-04-30 | 1999-09-07 | Medtronic, Inc. | Dual channel implantation neurostimulation techniques |
| US6024740A (en) | 1997-07-08 | 2000-02-15 | The Regents Of The University Of California | Circumferential ablation device assembly |
| WO1998051290A2 (en) | 1997-05-16 | 1998-11-19 | Children's Medical Center Corporation | Local anesthetic formulations comprising a site 1 sodium channel blocker combined with a second active agent |
| ATE419789T1 (de) | 1997-05-23 | 2009-01-15 | Prorhythm Inc | Wegwerfbarer fokussierender ultraschallapplikator hoher intensität |
| USRE40279E1 (en) | 1997-06-26 | 2008-04-29 | Sherwood Services Ag | Method and system for neural tissue modification |
| WO1999000060A1 (en) | 1997-06-26 | 1999-01-07 | Advanced Coronary Intervention | Electrosurgical catheter for resolving obstructions by radio frequency ablation |
| US6248345B1 (en) | 1997-07-02 | 2001-06-19 | Euro-Celtique, S.A. | Prolonged anesthesia in joints and body spaces |
| US6869431B2 (en) | 1997-07-08 | 2005-03-22 | Atrionix, Inc. | Medical device with sensor cooperating with expandable member |
| US6117101A (en) | 1997-07-08 | 2000-09-12 | The Regents Of The University Of California | Circumferential ablation device assembly |
| EP1779890B8 (en) | 1997-07-16 | 2009-07-08 | Metacure Limited | Smooth muscle controller |
| US6258084B1 (en) | 1997-09-11 | 2001-07-10 | Vnus Medical Technologies, Inc. | Method for applying energy to biological tissue including the use of tumescent tissue compression |
| US6917834B2 (en) | 1997-12-03 | 2005-07-12 | Boston Scientific Scimed, Inc. | Devices and methods for creating lesions in endocardial and surrounding tissue to isolate focal arrhythmia substrates |
| WO1999033407A1 (en) | 1997-12-31 | 1999-07-08 | Heartport, Inc. | Methods and apparatus for perfusion of isolated tissue structure |
| US6146380A (en) | 1998-01-09 | 2000-11-14 | Radionics, Inc. | Bent tip electrical surgical probe |
| CA2295134A1 (en) | 1998-01-15 | 1999-07-22 | Amethyst Technologies, Inc. | Improved pulsed electromagnetic energy treatment apparatus and method |
| US6251130B1 (en) | 1998-03-24 | 2001-06-26 | Innercool Therapies, Inc. | Device for applications of selective organ cooling |
| US6522932B1 (en) | 1998-02-10 | 2003-02-18 | Advanced Bionics Corporation | Implantable, expandable, multicontact electrodes and tools for use therewith |
| US6205361B1 (en) | 1998-02-10 | 2001-03-20 | Advanced Bionics Corporation | Implantable expandable multicontact electrodes |
| US6415187B1 (en) | 1998-02-10 | 2002-07-02 | Advanced Bionics Corporation | Implantable, expandable, multicontact electrodes and insertion needle for use therewith |
| US6258087B1 (en) | 1998-02-19 | 2001-07-10 | Curon Medical, Inc. | Expandable electrode assemblies for forming lesions to treat dysfunction in sphincters and adjoining tissue regions |
| US6273886B1 (en) | 1998-02-19 | 2001-08-14 | Curon Medical, Inc. | Integrated tissue heating and cooling apparatus |
| US6142993A (en) | 1998-02-27 | 2000-11-07 | Ep Technologies, Inc. | Collapsible spline structure using a balloon as an expanding actuator |
| US6086527A (en) | 1998-04-02 | 2000-07-11 | Scimed Life Systems, Inc. | System for treating congestive heart failure |
| US6314325B1 (en) | 1998-04-07 | 2001-11-06 | William R. Fitz | Nerve hyperpolarization method and apparatus for pain relief |
| NZ507185A (en) | 1998-04-14 | 2002-09-27 | Gmp Drug Delivery Inc | Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues |
| US6219577B1 (en) | 1998-04-14 | 2001-04-17 | Global Vascular Concepts, Inc. | Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues |
| US5916154A (en) | 1998-04-22 | 1999-06-29 | Nellcor Puritan Bennett | Method of enhancing performance in pulse oximetry via electrical stimulation |
| US6269269B1 (en) | 1998-04-23 | 2001-07-31 | Medtronic Inc. | Method and apparatus for synchronized treatment of obstructive sleep apnea |
| US6058331A (en) | 1998-04-27 | 2000-05-02 | Medtronic, Inc. | Apparatus and method for treating peripheral vascular disease and organ ischemia by electrical stimulation with closed loop feedback control |
| US5928272A (en) | 1998-05-02 | 1999-07-27 | Cyberonics, Inc. | Automatic activation of a neurostimulator device using a detection algorithm based on cardiac activity |
| US6192889B1 (en) | 1998-05-05 | 2001-02-27 | Woodside Biomedical, Inc. | Method of suppression and prevention of the gag reflex |
| AU3973599A (en) | 1998-05-08 | 1999-11-29 | Genetronics, Inc. | Electrically induced vessel vasodilation |
| US7198635B2 (en) | 2000-10-17 | 2007-04-03 | Asthmatx, Inc. | Modification of airways by application of energy |
| US6292695B1 (en) | 1998-06-19 | 2001-09-18 | Wilton W. Webster, Jr. | Method and apparatus for transvascular treatment of tachycardia and fibrillation |
| US6322559B1 (en) | 1998-07-06 | 2001-11-27 | Vnus Medical Technologies, Inc. | Electrode catheter having coil structure |
| EP1100579B1 (en) | 1998-07-13 | 2015-09-02 | Inovio Pharmaceuticals, Inc. | Skin and muscle-targeted gene therapy by pulsed electrical field |
| US6972013B1 (en) | 1998-07-13 | 2005-12-06 | Genetronics, Inc. | Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation |
| US7599736B2 (en) | 2001-07-23 | 2009-10-06 | Dilorenzo Biomedical, Llc | Method and apparatus for neuromodulation and physiologic modulation for the treatment of metabolic and neuropsychiatric disease |
| US6304787B1 (en) | 1998-08-26 | 2001-10-16 | Advanced Bionics Corporation | Cochlear electrode array having current-focusing and tissue-treating features |
| US6123702A (en) | 1998-09-10 | 2000-09-26 | Scimed Life Systems, Inc. | Systems and methods for controlling power in an electrosurgical probe |
| US6123718A (en) | 1998-11-02 | 2000-09-26 | Polymerex Medical Corp. | Balloon catheter |
| US7313444B2 (en) | 1998-11-20 | 2007-12-25 | Pacesetter, Inc. | Self-anchoring coronary sinus lead |
| US20070066972A1 (en) | 2001-11-29 | 2007-03-22 | Medwaves, Inc. | Ablation catheter apparatus with one or more electrodes |
| US6077227A (en) | 1998-12-28 | 2000-06-20 | Medtronic, Inc. | Method for manufacture and implant of an implantable blood vessel cuff |
| US7780628B1 (en) | 1999-01-11 | 2010-08-24 | Angiodynamics, Inc. | Apparatus and methods for treating congestive heart disease |
| US7122019B1 (en) | 2000-11-28 | 2006-10-17 | Flowmedica Inc. | Intra-aortic renal drug delivery catheter |
| US7329236B2 (en) | 1999-01-11 | 2008-02-12 | Flowmedica, Inc. | Intra-aortic renal drug delivery catheter |
| US7481803B2 (en) | 2000-11-28 | 2009-01-27 | Flowmedica, Inc. | Intra-aortic renal drug delivery catheter |
| US6749598B1 (en) | 1999-01-11 | 2004-06-15 | Flowmedica, Inc. | Apparatus and methods for treating congestive heart disease |
| AU2751200A (en) | 1999-02-02 | 2000-08-25 | Transurgical, Inc. | Intrabody hifu applicator |
| CA2364098C (en) | 1999-03-09 | 2010-11-16 | Thermage, Inc. | Apparatus and method for treatment of tissue |
| US6508774B1 (en) | 1999-03-09 | 2003-01-21 | Transurgical, Inc. | Hifu applications with feedback control |
| US6464687B1 (en) | 1999-03-09 | 2002-10-15 | Ball Semiconductor, Inc. | Implantable drug delivery system |
| US6678558B1 (en) | 1999-03-25 | 2004-01-13 | Genetronics, Inc. | Method and apparatus for reducing electroporation-mediated muscle reaction and pain response |
| US6325797B1 (en) | 1999-04-05 | 2001-12-04 | Medtronic, Inc. | Ablation catheter and method for isolating a pulmonary vein |
| US6738663B2 (en) | 1999-04-09 | 2004-05-18 | Oncostim, A Minnesota Corporation | Implantable device and method for the electrical treatment of cancer |
| US6366808B1 (en) | 2000-03-13 | 2002-04-02 | Edward A. Schroeppel | Implantable device and method for the electrical treatment of cancer |
| US6178349B1 (en) | 1999-04-15 | 2001-01-23 | Medtronic, Inc. | Drug delivery neural stimulation device for treatment of cardiovascular disorders |
| US6317615B1 (en) | 1999-04-19 | 2001-11-13 | Cardiac Pacemakers, Inc. | Method and system for reducing arterial restenosis in the presence of an intravascular stent |
| US6939346B2 (en) | 1999-04-21 | 2005-09-06 | Oratec Interventions, Inc. | Method and apparatus for controlling a temperature-controlled probe |
| US6933104B1 (en) * | 1999-04-23 | 2005-08-23 | Shiva Biomedical, Llc | Diagnosis and treatment of human kidney diseases |
| US6341236B1 (en) | 1999-04-30 | 2002-01-22 | Ivan Osorio | Vagal nerve stimulation techniques for treatment of epileptic seizures |
| US6923784B2 (en) | 1999-04-30 | 2005-08-02 | Medtronic, Inc. | Therapeutic treatment of disorders based on timing information |
| WO2000066017A1 (en) | 1999-05-04 | 2000-11-09 | Curon Medical, Inc. | Electrodes for creating lesions in tissue regions at or near a sphincter |
| US6178352B1 (en) | 1999-05-07 | 2001-01-23 | Woodside Biomedical, Inc. | Method of blood pressure moderation |
| US6304777B1 (en) | 1999-05-26 | 2001-10-16 | Impulse Dynamics N.V. | Induction of cardioplegia applied electrical signals |
| US6442424B1 (en) | 1999-05-26 | 2002-08-27 | Impulse Dynamics N.V. | Local cardiac motion control using applied electrical signals |
| US7171263B2 (en) | 1999-06-04 | 2007-01-30 | Impulse Dynamics Nv | Drug delivery device |
| US6838050B1 (en) | 1999-06-04 | 2005-01-04 | Oxibio, Inc. | Methods and devices for providing anti-infective activity to a medical device |
| CA2376903A1 (en) | 1999-06-25 | 2001-01-04 | Emory University | Devices and methods for vagus nerve stimulation |
| US6272383B1 (en) | 1999-06-28 | 2001-08-07 | Woodside Biomedical, Inc. | Electro-acupuncture method using an electrical stimulator |
| US6927049B2 (en) | 1999-07-21 | 2005-08-09 | The Regents Of The University Of California | Cell viability detection using electrical measurements |
| US7053063B2 (en) | 1999-07-21 | 2006-05-30 | The Regents Of The University Of California | Controlled electroporation and mass transfer across cell membranes in tissue |
| US6300108B1 (en) | 1999-07-21 | 2001-10-09 | The Regents Of The University Of California | Controlled electroporation and mass transfer across cell membranes |
| US6326177B1 (en) | 1999-08-04 | 2001-12-04 | Eastern Virginia Medical School Of The Medical College Of Hampton Roads | Method and apparatus for intracellular electro-manipulation |
| US6450942B1 (en) | 1999-08-20 | 2002-09-17 | Cardiorest International Ltd. | Method for reducing heart loads in mammals |
| US6599256B1 (en) | 1999-09-10 | 2003-07-29 | Transurgical, Inc. | Occlusion of tubular anatomical structures by energy application |
| US7510536B2 (en) | 1999-09-17 | 2009-03-31 | University Of Washington | Ultrasound guided high intensity focused ultrasound treatment of nerves |
| CA2384866C (en) | 1999-09-28 | 2012-07-10 | Stuart D. Edwards | Treatment of tissue by application of energy and drugs |
| US6272377B1 (en) | 1999-10-01 | 2001-08-07 | Cardiac Pacemakers, Inc. | Cardiac rhythm management system with arrhythmia prediction and prevention |
| US6473644B1 (en) | 1999-10-13 | 2002-10-29 | Cyberonics, Inc. | Method to enhance cardiac capillary growth in heart failure patients |
| US6287304B1 (en) | 1999-10-15 | 2001-09-11 | Neothermia Corporation | Interstitial cauterization of tissue volumes with electrosurgically deployed electrodes |
| US6669655B1 (en) | 1999-10-20 | 2003-12-30 | Transurgical, Inc. | Sonic element and catheter incorporating same |
| WO2001033172A1 (en) | 1999-10-29 | 2001-05-10 | Universität Zürich | Method of volumetric blood flow measurement |
| US6436091B1 (en) | 1999-11-16 | 2002-08-20 | Microsolutions, Inc. | Methods and implantable devices and systems for long term delivery of a pharmaceutical agent |
| US6711444B2 (en) | 1999-11-22 | 2004-03-23 | Scimed Life Systems, Inc. | Methods of deploying helical diagnostic and therapeutic element supporting structures within the body |
| US6542781B1 (en) | 1999-11-22 | 2003-04-01 | Scimed Life Systems, Inc. | Loop structures for supporting diagnostic and therapeutic elements in contact with body tissue |
| US6690971B2 (en) | 1999-11-30 | 2004-02-10 | Biotronik Mess - Und Therapiegeraete Gmbh & Co. Ingenieurbuero Berlin | Device for regulating heart rate and heart pumping force |
| US20020026228A1 (en) | 1999-11-30 | 2002-02-28 | Patrick Schauerte | Electrode for intravascular stimulation, cardioversion and/or defibrillation |
| US6592567B1 (en) | 1999-12-07 | 2003-07-15 | Chf Solutions, Inc. | Kidney perfusion catheter |
| US6415183B1 (en) | 1999-12-09 | 2002-07-02 | Cardiac Pacemakers, Inc. | Method and apparatus for diaphragmatic pacing |
| US20030150464A1 (en) | 1999-12-17 | 2003-08-14 | Casscells S. Ward | Inducing apoptosis of atrial myocytes to treat atrial fibrillation |
| US6328699B1 (en) | 2000-01-11 | 2001-12-11 | Cedars-Sinai Medical Center | Permanently implantable system and method for detecting, diagnosing and treating congestive heart failure |
| US6885888B2 (en) | 2000-01-20 | 2005-04-26 | The Cleveland Clinic Foundation | Electrical stimulation of the sympathetic nerve chain |
| US6356786B1 (en) | 2000-01-20 | 2002-03-12 | Electrocore Techniques, Llc | Method of treating palmar hyperhydrosis by electrical stimulation of the sympathetic nervous chain |
| US6356787B1 (en) | 2000-02-24 | 2002-03-12 | Electro Core Techniques, Llc | Method of treating facial blushing by electrical stimulation of the sympathetic nerve chain |
| US20060085046A1 (en) | 2000-01-20 | 2006-04-20 | Ali Rezai | Methods of treating medical conditions by transvascular neuromodulation of the autonomic nervous system |
| US6438423B1 (en) | 2000-01-20 | 2002-08-20 | Electrocore Technique, Llc | Method of treating complex regional pain syndromes by electrical stimulation of the sympathetic nerve chain |
| AU2001231196A1 (en) | 2000-01-27 | 2001-08-07 | The General Hospital Corporation | Delivery of therapeutic biological from implantable tissue matrices |
| US6514226B1 (en) | 2000-02-10 | 2003-02-04 | Chf Solutions, Inc. | Method and apparatus for treatment of congestive heart failure by improving perfusion of the kidney |
| US6868289B2 (en) | 2002-10-02 | 2005-03-15 | Standen Ltd. | Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor |
| US6706159B2 (en) * | 2000-03-02 | 2004-03-16 | Diabetes Diagnostics | Combined lancet and electrochemical analyte-testing apparatus |
| US6536949B1 (en) | 2000-03-07 | 2003-03-25 | Richard R. Heuser | Catheter for thermal evaluation of arteriosclerotic plaque |
| US6770070B1 (en) | 2000-03-17 | 2004-08-03 | Rita Medical Systems, Inc. | Lung treatment apparatus and method |
| US6605084B2 (en) | 2000-03-24 | 2003-08-12 | Transurgical, Inc. | Apparatus and methods for intrabody thermal treatment |
| US6287608B1 (en) | 2000-04-11 | 2001-09-11 | Intellicardia, Inc. | Method and apparatus for treatment of congestive heart failure by improving perfusion of the kidney by infusion of a vasodilator |
| US20010044596A1 (en) | 2000-05-10 | 2001-11-22 | Ali Jaafar | Apparatus and method for treatment of vascular restenosis by electroporation |
| US6936047B2 (en) | 2000-05-12 | 2005-08-30 | Agility Capital Llc | Multi-channel RF energy delivery with coagulum reduction |
| US6306423B1 (en) | 2000-06-02 | 2001-10-23 | Allergan Sales, Inc. | Neurotoxin implant |
| AU6682401A (en) | 2000-06-13 | 2001-12-24 | Atrionix Inc | Surgical ablation probe for forming a circumferential lesion |
| US6546270B1 (en) | 2000-07-07 | 2003-04-08 | Biosense, Inc. | Multi-electrode catheter, system and method |
| EP1299035B1 (en) | 2000-07-13 | 2013-02-13 | ReCor Medical, Inc. | Thermal treatment apparatus with focussed energy application |
| ES2467916T3 (es) | 2000-07-26 | 2014-06-13 | Boston Scientific Neuromodulation Corporation | Sistema estimulador recargable |
| US6795728B2 (en) | 2001-08-17 | 2004-09-21 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits by electroporation |
| US6697670B2 (en) | 2001-08-17 | 2004-02-24 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits by electroporation with improved comfort of patients |
| US6892099B2 (en) | 2001-02-08 | 2005-05-10 | Minnesota Medical Physics, Llc | Apparatus and method for reducing subcutaneous fat deposits, virtual face lift and body sculpturing by electroporation |
| US6862479B1 (en) | 2000-08-30 | 2005-03-01 | Advanced Bionics Corporation | Spinal cord stimulation as a therapy for sexual dysfunction |
| AU2434501A (en) | 2000-09-07 | 2002-03-22 | Sherwood Serv Ag | Apparatus for and treatment of the intervertebral disc |
| US6405079B1 (en) | 2000-09-22 | 2002-06-11 | Mehdi M. Ansarinia | Stimulation method for the dural venous sinuses and adjacent dura for treatment of medical conditions |
| US7623926B2 (en) | 2000-09-27 | 2009-11-24 | Cvrx, Inc. | Stimulus regimens for cardiovascular reflex control |
| US7840271B2 (en) | 2000-09-27 | 2010-11-23 | Cvrx, Inc. | Stimulus regimens for cardiovascular reflex control |
| US6850801B2 (en) | 2001-09-26 | 2005-02-01 | Cvrx, Inc. | Mapping methods for cardiovascular reflex control devices |
| US6985774B2 (en) | 2000-09-27 | 2006-01-10 | Cvrx, Inc. | Stimulus regimens for cardiovascular reflex control |
| US7499742B2 (en) | 2001-09-26 | 2009-03-03 | Cvrx, Inc. | Electrode structures and methods for their use in cardiovascular reflex control |
| US7616997B2 (en) | 2000-09-27 | 2009-11-10 | Kieval Robert S | Devices and methods for cardiovascular reflex control via coupled electrodes |
| US7158832B2 (en) | 2000-09-27 | 2007-01-02 | Cvrx, Inc. | Electrode designs and methods of use for cardiovascular reflex control devices |
| US6522926B1 (en) | 2000-09-27 | 2003-02-18 | Cvrx, Inc. | Devices and methods for cardiovascular reflex control |
| US6845267B2 (en) | 2000-09-28 | 2005-01-18 | Advanced Bionics Corporation | Systems and methods for modulation of circulatory perfusion by electrical and/or drug stimulation |
| US7306591B2 (en) | 2000-10-02 | 2007-12-11 | Novasys Medical, Inc. | Apparatus and methods for treating female urinary incontinence |
| US6640120B1 (en) | 2000-10-05 | 2003-10-28 | Scimed Life Systems, Inc. | Probe assembly for mapping and ablating pulmonary vein tissue and method of using same |
| US7104987B2 (en) | 2000-10-17 | 2006-09-12 | Asthmatx, Inc. | Control system and process for application of energy to airway walls and other mediums |
| CA2426944A1 (en) | 2000-10-26 | 2002-05-02 | Medtronic, Inc. | Method and apparatus to minimize the effects of a cardiac insult |
| JP4177102B2 (ja) | 2000-10-26 | 2008-11-05 | メドトロニック・インコーポレーテッド | 心機能及び心効率を改善するための装置 |
| US6616624B1 (en) | 2000-10-30 | 2003-09-09 | Cvrx, Inc. | Systems and method for controlling renovascular perfusion |
| US7081114B2 (en) | 2000-11-29 | 2006-07-25 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Electrophysiology/ablation catheter having lariat configuration of variable radius |
| US6681136B2 (en) | 2000-12-04 | 2004-01-20 | Science Medicus, Inc. | Device and method to modulate blood pressure by electrical waveforms |
| US6676657B2 (en) | 2000-12-07 | 2004-01-13 | The United States Of America As Represented By The Department Of Health And Human Services | Endoluminal radiofrequency cauterization system |
| US6666845B2 (en) | 2001-01-04 | 2003-12-23 | Advanced Neuromodulation Systems, Inc. | Implantable infusion pump |
| WO2002053207A2 (en) | 2001-01-04 | 2002-07-11 | Advanced Neuromodulation Systems, Inc. | Implantable infusion pump |
| JP4111829B2 (ja) | 2001-01-11 | 2008-07-02 | リタ メディカル システムズ インコーポレイテッド | 骨処置器具 |
| US6600954B2 (en) | 2001-01-25 | 2003-07-29 | Biocontrol Medical Bcm Ltd. | Method and apparatus for selective control of nerve fibers |
| US6672312B2 (en) | 2001-01-31 | 2004-01-06 | Transurgical, Inc. | Pulmonary vein ablation with myocardial tissue locating |
| US6564096B2 (en) | 2001-02-28 | 2003-05-13 | Robert A. Mest | Method and system for treatment of tachycardia and fibrillation |
| US6620151B2 (en) | 2001-03-01 | 2003-09-16 | Advanced Neuromodulation Systems, Inc. | Non-constant pressure infusion pump |
| WO2002070039A2 (en) | 2001-03-01 | 2002-09-12 | Three Arch Partners | Intravascular device for treatment of hypertension |
| US20020177846A1 (en) | 2001-03-06 | 2002-11-28 | Mulier Peter M.J. | Vaporous delivery of thermal energy to tissue sites |
| US6786904B2 (en) | 2002-01-10 | 2004-09-07 | Triton Biosystems, Inc. | Method and device to treat vulnerable plaque |
| CA2440387A1 (en) | 2001-03-23 | 2002-10-03 | Durect Corporation | Delivery of drugs from sustained release devices implanted in myocardial tissue or in the pericardial space |
| US7713705B2 (en) * | 2002-12-24 | 2010-05-11 | Biosite, Inc. | Markers for differential diagnosis and methods of use thereof |
| WO2002085448A2 (en) | 2001-04-20 | 2002-10-31 | The Board Of Regents Of The University Of Oklahoma | Cardiac neuromodulation and methods of using same |
| WO2002085192A2 (en) | 2001-04-23 | 2002-10-31 | Transurgical, Inc. | Improvements in ablation therapy |
| US6684105B2 (en) | 2001-08-31 | 2004-01-27 | Biocontrol Medical, Ltd. | Treatment of disorders by unidirectional nerve stimulation |
| US6972016B2 (en) | 2001-05-01 | 2005-12-06 | Cardima, Inc. | Helically shaped electrophysiology catheter |
| CA2445392C (en) | 2001-05-10 | 2011-04-26 | Rita Medical Systems, Inc. | Rf tissue ablation apparatus and method |
| JP2004533297A (ja) | 2001-05-29 | 2004-11-04 | メドトロニック・インコーポレーテッド | 心臓病の予防及び処置のための閉ループ神経調節システム |
| US7127284B2 (en) | 2001-06-11 | 2006-10-24 | Mercator Medsystems, Inc. | Electroporation microneedle and methods for its use |
| US20060167498A1 (en) | 2001-07-23 | 2006-07-27 | Dilorenzo Daniel J | Method, apparatus, and surgical technique for autonomic neuromodulation for the treatment of disease |
| ES2242048T3 (es) | 2001-07-27 | 2005-11-01 | Prof. Dr. Med. Patrick Schauerte | Unidad de neuroestimulacion para la inmovilizacion del corazon durante operaciones de cirugia cardiaca. |
| US6994706B2 (en) | 2001-08-13 | 2006-02-07 | Minnesota Medical Physics, Llc | Apparatus and method for treatment of benign prostatic hyperplasia |
| US6622041B2 (en) | 2001-08-21 | 2003-09-16 | Cyberonics, Inc. | Treatment of congestive heart failure and autonomic cardiovascular drive disorders |
| US6600956B2 (en) | 2001-08-21 | 2003-07-29 | Cyberonics, Inc. | Circumneural electrode assembly |
| US20030050635A1 (en) | 2001-08-22 | 2003-03-13 | Csaba Truckai | Embolization systems and techniques for treating tumors |
| JP4217618B2 (ja) | 2001-08-31 | 2009-02-04 | サイト パルス サイエンシズ、インコーポレイテッド | 細胞融合のためのノンリニアーな振幅の誘電泳動用波形 |
| US7778703B2 (en) | 2001-08-31 | 2010-08-17 | Bio Control Medical (B.C.M.) Ltd. | Selective nerve fiber stimulation for treating heart conditions |
| EP1434621A2 (en) | 2001-10-01 | 2004-07-07 | AM Discovery, Incorporated | Devices for treating atrial fibrilation |
| US8974446B2 (en) | 2001-10-11 | 2015-03-10 | St. Jude Medical, Inc. | Ultrasound ablation apparatus with discrete staggered ablation zones |
| US7488313B2 (en) | 2001-11-29 | 2009-02-10 | Boston Scientific Scimed, Inc. | Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment |
| US20030125790A1 (en) | 2001-12-27 | 2003-07-03 | Vitaly Fastovsky | Deployment device, system and method for medical implantation |
| US6893436B2 (en) | 2002-01-03 | 2005-05-17 | Afx, Inc. | Ablation instrument having a flexible distal portion |
| US20060189941A1 (en) | 2002-01-22 | 2006-08-24 | Mercator Medsystems, Inc. | Methods and kits for volumetric distribution of pharmaceutical agents via the vascular adventitia and microcirculation |
| US7155284B1 (en) | 2002-01-24 | 2006-12-26 | Advanced Bionics Corporation | Treatment of hypertension |
| WO2003066155A2 (en) | 2002-02-01 | 2003-08-14 | The Cleveland Clinic Foundation | Methods of affecting hypothalamic-related conditions |
| WO2003063692A2 (en) | 2002-02-01 | 2003-08-07 | The Cleveland Clinic Foundation | Delivery device for stimulating the sympathetic nerve chain |
| EP1476222A2 (en) | 2002-02-01 | 2004-11-17 | The Cleveland Clinic Foundation | Neural stimulation delivery device with independently moveable delivery structures |
| US7236821B2 (en) | 2002-02-19 | 2007-06-26 | Cardiac Pacemakers, Inc. | Chronically-implanted device for sensing and therapy |
| CN1652841A (zh) | 2002-03-14 | 2005-08-10 | 布雷恩斯盖特有限公司 | 血压调节技术 |
| US6736835B2 (en) | 2002-03-21 | 2004-05-18 | Depuy Acromed, Inc. | Early intervention spinal treatment methods and devices for use therein |
| JP4295627B2 (ja) | 2002-03-27 | 2009-07-15 | シーブイアールエックス, インコーポレイテッド | 電極構造体および循環系反射の制御におけるその使用方法 |
| US7620451B2 (en) | 2005-12-29 | 2009-11-17 | Ardian, Inc. | Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach |
| US8150519B2 (en) | 2002-04-08 | 2012-04-03 | Ardian, Inc. | Methods and apparatus for bilateral renal neuromodulation |
| US6978174B2 (en) | 2002-04-08 | 2005-12-20 | Ardian, Inc. | Methods and devices for renal nerve blocking |
| US20070135875A1 (en) * | 2002-04-08 | 2007-06-14 | Ardian, Inc. | Methods and apparatus for thermally-induced renal neuromodulation |
| US7617005B2 (en) | 2002-04-08 | 2009-11-10 | Ardian, Inc. | Methods and apparatus for thermally-induced renal neuromodulation |
| US7162303B2 (en) | 2002-04-08 | 2007-01-09 | Ardian, Inc. | Renal nerve stimulation method and apparatus for treatment of patients |
| US8131371B2 (en) | 2002-04-08 | 2012-03-06 | Ardian, Inc. | Methods and apparatus for monopolar renal neuromodulation |
| US20080213331A1 (en) | 2002-04-08 | 2008-09-04 | Ardian, Inc. | Methods and devices for renal nerve blocking |
| US8347891B2 (en) | 2002-04-08 | 2013-01-08 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen |
| US8551069B2 (en) | 2002-04-08 | 2013-10-08 | Medtronic Adrian Luxembourg S.a.r.l. | Methods and apparatus for treating contrast nephropathy |
| US7853333B2 (en) | 2002-04-08 | 2010-12-14 | Ardian, Inc. | Methods and apparatus for multi-vessel renal neuromodulation |
| US7653438B2 (en) | 2002-04-08 | 2010-01-26 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
| US8145317B2 (en) | 2002-04-08 | 2012-03-27 | Ardian, Inc. | Methods for renal neuromodulation |
| US8145316B2 (en) | 2002-04-08 | 2012-03-27 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
| US8774913B2 (en) | 2002-04-08 | 2014-07-08 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for intravasculary-induced neuromodulation |
| US7756583B2 (en) | 2002-04-08 | 2010-07-13 | Ardian, Inc. | Methods and apparatus for intravascularly-induced neuromodulation |
| US20070129761A1 (en) | 2002-04-08 | 2007-06-07 | Ardian, Inc. | Methods for treating heart arrhythmia |
| AU2003223583A1 (en) | 2002-04-11 | 2003-10-27 | Transvascular, Inc. | Devices and methods for transluminal or transthoracic interstitial electrode placement |
| DE60322523D1 (de) | 2002-04-16 | 2008-09-11 | Cyto Pulse Sciences Inc | Ien mit übersetzenden elektrischen feldern und elektroden-polaritäts-umkehr |
| US20030199747A1 (en) | 2002-04-19 | 2003-10-23 | Michlitsch Kenneth J. | Methods and apparatus for the identification and stabilization of vulnerable plaque |
| US20030236443A1 (en) | 2002-04-19 | 2003-12-25 | Cespedes Eduardo Ignacio | Methods and apparatus for the identification and stabilization of vulnerable plaque |
| US20030199768A1 (en) | 2002-04-19 | 2003-10-23 | Cespedes Eduardo Ignacio | Methods and apparatus for the identification and stabilization of vulnerable plaque |
| US20030199767A1 (en) | 2002-04-19 | 2003-10-23 | Cespedes Eduardo Ignacio | Methods and apparatus for the identification and stabilization of vulnerable plaque |
| US8328420B2 (en) | 2003-04-22 | 2012-12-11 | Marcio Marc Abreu | Apparatus and method for measuring biologic parameters |
| US20030204161A1 (en) | 2002-04-25 | 2003-10-30 | Bozidar Ferek-Petric | Implantable electroporation therapy device and method for using same |
| US6748953B2 (en) | 2002-06-11 | 2004-06-15 | Scimed Life Systems, Inc. | Method for thermal treatment of type II endoleaks in arterial aneurysms |
| US20040193228A1 (en) | 2003-03-31 | 2004-09-30 | Gerber Martin T. | Method, system and device for treating various disorders of the pelvic floor by electrical stimulation of the left and right pudendal nerves |
| US7993325B2 (en) | 2002-09-20 | 2011-08-09 | Angio Dynamics, Inc. | Renal infusion systems and methods |
| WO2004107965A2 (en) | 2002-09-20 | 2004-12-16 | Flowmedica, Inc. | Systems and methods for performing bi-lateral interventions or diagnosis in branched body lumens |
| WO2004030718A2 (en) | 2002-09-20 | 2004-04-15 | Flowmedica, Inc. | Method and apparatus for intra aortic substance delivery to a branch vessel |
| WO2004032791A2 (en) | 2002-09-20 | 2004-04-22 | Flowmedica, Inc. | Method and apparatus for selective material delivery via an intra-renal catheter |
| US7063679B2 (en) | 2002-09-20 | 2006-06-20 | Flowmedica, Inc. | Intra-aortic renal delivery catheter |
| AU2003300779A1 (en) | 2002-09-20 | 2004-05-04 | Flowmedica, Inc. | Catheter system for renal therapy |
| AU2003278858A1 (en) | 2002-09-20 | 2004-04-08 | Flowmedica, Inc. | Method and apparatus for selective drug infusion via an intraaortic flow diverter delivery catheter |
| US7150741B2 (en) | 2002-09-20 | 2006-12-19 | Advanced Neuromodulation Systems, Inc. | Programmable dose control module |
| US20050197624A1 (en) | 2004-03-04 | 2005-09-08 | Flowmedica, Inc. | Sheath for use in peripheral interventions |
| WO2004033034A1 (en) | 2002-10-04 | 2004-04-22 | Microchips, Inc. | Medical device for neural stimulation and controlled drug delivery |
| DE60331455D1 (de) | 2002-10-04 | 2010-04-08 | Microchips Inc | Medizinische vorrichtung zur gesteuerten arzneimittelverabreichung sowie herzüberwachung und/oder herzstimulation |
| US20040162590A1 (en) | 2002-12-19 | 2004-08-19 | Whitehurst Todd K. | Fully implantable miniature neurostimulator for intercostal nerve stimulation as a therapy for angina pectoris |
| US6978180B2 (en) | 2003-01-03 | 2005-12-20 | Advanced Neuromodulation Systems, Inc. | System and method for stimulation of a person's brain stem |
| US7444183B2 (en) | 2003-02-03 | 2008-10-28 | Enteromedics, Inc. | Intraluminal electrode apparatus and method |
| WO2004073505A2 (en) | 2003-02-20 | 2004-09-02 | Prorhythm, Inc. | Cardiac ablation devices |
| WO2004075776A2 (en) | 2003-02-24 | 2004-09-10 | Plc Systems Inc. | Method and system for prevention of radiocontrast nephropathy |
| US7004911B1 (en) | 2003-02-24 | 2006-02-28 | Hosheng Tu | Optical thermal mapping for detecting vulnerable plaque |
| US6923808B2 (en) | 2003-02-24 | 2005-08-02 | Boston Scientific Scimed, Inc. | Probes having helical and loop shaped inflatable therapeutic elements |
| WO2004078066A2 (en) | 2003-03-03 | 2004-09-16 | Sinus Rhythm Technologies, Inc. | Primary examiner |
| US20040176699A1 (en) | 2003-03-03 | 2004-09-09 | Volcano Therapeutics, Inc. | Thermography catheter with improved wall contact |
| US7517342B2 (en) | 2003-04-29 | 2009-04-14 | Boston Scientific Scimed, Inc. | Polymer coated device for electrically medicated drug delivery |
| US7221979B2 (en) | 2003-04-30 | 2007-05-22 | Medtronic, Inc. | Methods and apparatus for the regulation of hormone release |
| JP4212949B2 (ja) | 2003-05-06 | 2009-01-21 | 朝日インテック株式会社 | 薬液注入装置 |
| EP1635736A2 (en) | 2003-06-05 | 2006-03-22 | FlowMedica, Inc. | Systems and methods for performing bi-lateral interventions or diagnosis in branched body lumens |
| US7149574B2 (en) | 2003-06-09 | 2006-12-12 | Palo Alto Investors | Treatment of conditions through electrical modulation of the autonomic nervous system |
| US7738952B2 (en) | 2003-06-09 | 2010-06-15 | Palo Alto Investors | Treatment of conditions through modulation of the autonomic nervous system |
| US20060167437A1 (en) | 2003-06-17 | 2006-07-27 | Flowmedica, Inc. | Method and apparatus for intra aortic substance delivery to a branch vessel |
| JP4810425B2 (ja) | 2003-07-18 | 2011-11-09 | イースタン バージニア メディカル スクール | 電気パルスを発生するための装置および該装置を使用する方法 |
| EP1659970A4 (en) | 2003-08-05 | 2008-05-21 | Flowmedica Inc | SYSTEM AND METHOD FOR PREVENTING RADIO CONTRAST-INDUCED NEPHROPATHY |
| US7742809B2 (en) | 2003-08-25 | 2010-06-22 | Medtronic, Inc. | Electroporation catheter with sensing capabilities |
| CA2938411C (en) | 2003-09-12 | 2019-03-05 | Minnow Medical, Llc | Selectable eccentric remodeling and/or ablation of atherosclerotic material |
| US7502650B2 (en) | 2003-09-22 | 2009-03-10 | Cvrx, Inc. | Baroreceptor activation for epilepsy control |
| US7435248B2 (en) | 2003-09-26 | 2008-10-14 | Boston Scientific Scimed, Inc. | Medical probes for creating and diagnosing circumferential lesions within or around the ostium of a vessel |
| US20050153885A1 (en) | 2003-10-08 | 2005-07-14 | Yun Anthony J. | Treatment of conditions through modulation of the autonomic nervous system |
| US7186209B2 (en) | 2003-10-09 | 2007-03-06 | Jacobson Jerry I | Cardioelectromagnetic treatment |
| US7416549B2 (en) | 2003-10-10 | 2008-08-26 | Boston Scientific Scimed, Inc. | Multi-zone bipolar ablation probe assembly |
| US7480532B2 (en) | 2003-10-22 | 2009-01-20 | Cvrx, Inc. | Baroreflex activation for pain control, sedation and sleep |
| US7553625B2 (en) | 2003-12-22 | 2009-06-30 | John Wayne Cancer Institute | Method and apparatus for in vivo collection of circulating biological components |
| US7783353B2 (en) | 2003-12-24 | 2010-08-24 | Cardiac Pacemakers, Inc. | Automatic neural stimulation modulation based on activity and circadian rhythm |
| US8396560B2 (en) | 2004-11-18 | 2013-03-12 | Cardiac Pacemakers, Inc. | System and method for closed-loop neural stimulation |
| US20080015659A1 (en) | 2003-12-24 | 2008-01-17 | Yi Zhang | Neurostimulation systems and methods for cardiac conditions |
| ES2729378T3 (es) | 2003-12-24 | 2019-11-04 | Univ California | Ablación de tejido con electroporación irreversible |
| EP1742700A4 (en) | 2004-03-02 | 2008-05-28 | Cvrx Inc | EXTERNAL ACTIVATION OF BAROREFLEX |
| US20050209548A1 (en) | 2004-03-19 | 2005-09-22 | Dev Sukhendu B | Electroporation-mediated intravascular delivery |
| JP2005278739A (ja) * | 2004-03-29 | 2005-10-13 | Citizen Watch Co Ltd | 採血装置 |
| CA2563817C (en) | 2004-04-23 | 2018-07-10 | Yoram Palti | Treating a tumor or the like with electric fields at different frequencies |
| WO2006007048A2 (en) | 2004-05-04 | 2006-01-19 | The Cleveland Clinic Foundation | Methods of treating medical conditions by neuromodulation of the sympathetic nervous system |
| US8412348B2 (en) | 2004-05-06 | 2013-04-02 | Boston Scientific Neuromodulation Corporation | Intravascular self-anchoring integrated tubular electrode body |
| EP1750506A4 (en) | 2004-05-14 | 2010-03-17 | Flowmedica Inc | BILATERAL LOCAL RENAL DELIVERY FOR THE TREATMENT OF CONGESTIVE HEART FAILURE AND BNP THERAPY |
| US20050261672A1 (en) | 2004-05-18 | 2005-11-24 | Mark Deem | Systems and methods for selective denervation of heart dysrhythmias |
| US20050277868A1 (en) | 2004-06-11 | 2005-12-15 | University Of South Florida | Electroporation Device and Method for Delivery to Ocular Tissue |
| US20060067972A1 (en) | 2004-06-23 | 2006-03-30 | Flowmedica, Inc. | Devices for renal-based heart failure treatment |
| WO2006012050A2 (en) | 2004-06-30 | 2006-02-02 | Cvrx, Inc. | Connection structures for extra-vascular electrode lead body |
| US20060004417A1 (en) | 2004-06-30 | 2006-01-05 | Cvrx, Inc. | Baroreflex activation for arrhythmia treatment |
| FR2873385B1 (fr) | 2004-07-23 | 2006-10-27 | Centre Nat Rech Scient Cnrse | Surveillance et controle d'une electroporation |
| US7373204B2 (en) | 2004-08-19 | 2008-05-13 | Lifestim, Inc. | Implantable device and method for treatment of hypertension |
| EP1796568A1 (en) | 2004-09-09 | 2007-06-20 | Vnus Medical Technologies, Inc. | Methods and apparatus for treatment of hollow anatomical structures |
| US7532938B2 (en) | 2004-09-10 | 2009-05-12 | The Cleveland Clinic Foundation | Intraluminal electrode assembly |
| US20060069323A1 (en) | 2004-09-24 | 2006-03-30 | Flowmedica, Inc. | Systems and methods for bi-lateral guidewire cannulation of branched body lumens |
| US20060074453A1 (en) | 2004-10-04 | 2006-04-06 | Cvrx, Inc. | Baroreflex activation and cardiac resychronization for heart failure treatment |
| EP1809272A4 (en) | 2004-10-18 | 2008-01-02 | Maroon Biotech Corp | METHOD AND COMPOSITIONS FOR TREATING DAMAGES THROUGH FREE RADICALS |
| US7524318B2 (en) | 2004-10-28 | 2009-04-28 | Boston Scientific Scimed, Inc. | Ablation probe with flared electrodes |
| US20070083239A1 (en) | 2005-09-23 | 2007-04-12 | Denise Demarais | Methods and apparatus for inducing, monitoring and controlling renal neuromodulation |
| US7937143B2 (en) | 2004-11-02 | 2011-05-03 | Ardian, Inc. | Methods and apparatus for inducing controlled renal neuromodulation |
| US20060100618A1 (en) | 2004-11-08 | 2006-05-11 | Cardima, Inc. | System and method for performing ablation and other medical procedures using an electrode array with flex circuit |
| US8332047B2 (en) | 2004-11-18 | 2012-12-11 | Cardiac Pacemakers, Inc. | System and method for closed-loop neural stimulation |
| US20060116720A1 (en) | 2004-12-01 | 2006-06-01 | Penny Knoblich | Method and apparatus for improving renal function |
| WO2006069215A2 (en) | 2004-12-21 | 2006-06-29 | Ebr Systems, Inc. | Leadless cardiac system for pacing and arrhythmia treatment |
| EP3666328B1 (en) | 2004-12-27 | 2022-04-06 | Novocure GmbH | Treating a tumor or the like with electric fields at different orientations |
| US20090258002A1 (en) * | 2005-02-01 | 2009-10-15 | Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services | Biomarkers for Tissue Status |
| US9833618B2 (en) | 2005-02-04 | 2017-12-05 | Palo Alto Investors | Methods and compositions for treating a disease condition in a subject |
| US7860542B2 (en) * | 2005-02-14 | 2010-12-28 | Optiscan Biomedical Corporation | Analyte detection system with reduced sample volume |
| US7548780B2 (en) | 2005-02-22 | 2009-06-16 | Cardiac Pacemakers, Inc. | Cell therapy and neural stimulation for cardiac repair |
| CN102125430A (zh) | 2005-03-28 | 2011-07-20 | 明诺医学有限公司 | 选择性地治疗目标组织的内腔电组织表征和调谐射频能量 |
| US7499748B2 (en) | 2005-04-11 | 2009-03-03 | Cardiac Pacemakers, Inc. | Transvascular neural stimulation device |
| CA2614241C (en) | 2005-07-01 | 2013-11-12 | C.R. Bard, Inc. | Indwelling urinary drainage catheter |
| US7390894B2 (en) | 2005-07-07 | 2008-06-24 | Mayo Foundation For Medical Education And Research | Glutathione S-transferase sequence variants |
| AU2006268238A1 (en) | 2005-07-11 | 2007-01-18 | Medtronic Ablation Frontiers Llc | Low power tissue ablation system |
| AU2006279126A1 (en) | 2005-07-14 | 2007-02-15 | C.R. Bard, Inc. | Intra-abdominal pressure monitoring system |
| US20070021803A1 (en) | 2005-07-22 | 2007-01-25 | The Foundry Inc. | Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction |
| WO2007035843A2 (en) * | 2005-09-21 | 2007-03-29 | Dask Technologies, Llc | Methods and compositions for organ and tissue functionality |
| US8712522B1 (en) | 2005-10-18 | 2014-04-29 | Cvrx, Inc. | System for setting programmable parameters for an implantable hypertension treatment device |
| US20070156200A1 (en) | 2005-12-29 | 2007-07-05 | Lilian Kornet | System and method for regulating blood pressure and electrolyte balance |
| US7927290B2 (en) * | 2006-01-05 | 2011-04-19 | Panasonic Corporation | Blood test apparatus |
| US8571650B2 (en) | 2006-03-03 | 2013-10-29 | Palo Alto Investors | Methods and compositions for treating a renal associated condition in a subject |
| ITMO20060087A1 (it) * | 2006-03-17 | 2007-09-18 | Lorenz Biotech Spa | Apparato e metodo di elettrostimolazione |
| US20080004673A1 (en) | 2006-04-03 | 2008-01-03 | Cvrx, Inc. | Implantable extravascular electrostimulation system having a resilient cuff |
| US20070282376A1 (en) | 2006-06-06 | 2007-12-06 | Shuros Allan C | Method and apparatus for neural stimulation via the lymphatic system |
| EP2302395B1 (en) * | 2006-06-07 | 2015-04-15 | Health Diagnostic Laboratory, Inc. | Markers associated with arteriovascular events and methods of use thereof |
| US7647101B2 (en) | 2006-06-09 | 2010-01-12 | Cardiac Pacemakers, Inc. | Physical conditioning system, device and method |
| CN105056408B (zh) | 2006-06-28 | 2018-09-25 | 美敦力Af卢森堡公司 | 用于热诱导的肾神经调制的系统 |
| US20080039904A1 (en) | 2006-08-08 | 2008-02-14 | Cherik Bulkes | Intravascular implant system |
| US20080091255A1 (en) | 2006-10-11 | 2008-04-17 | Cardiac Pacemakers | Implantable neurostimulator for modulating cardiovascular function |
| JP5312337B2 (ja) | 2006-10-18 | 2013-10-09 | べシックス・バスキュラー・インコーポレイテッド | 標的組織の選択的な処置のための調節されたrfエネルギーおよび電気的な組織の特徴付け |
| US7744618B2 (en) * | 2006-12-07 | 2010-06-29 | Cardiac Pacemakers, Inc. | Device and method for modulating renal function |
| ES2430613T3 (es) * | 2007-01-29 | 2013-11-21 | Simon Fraser University | Aparato de neuroestimulación transvascular |
| WO2008128070A2 (en) * | 2007-04-11 | 2008-10-23 | The Cleveland Clinic Foundation | Method and apparatus for renal neuromodulation |
| US8630704B2 (en) | 2007-06-25 | 2014-01-14 | Cardiac Pacemakers, Inc. | Neural stimulation with respiratory rhythm management |
| US8690823B2 (en) * | 2007-07-13 | 2014-04-08 | Abbott Cardiovascular Systems Inc. | Drug coated balloon catheter |
| US20110160644A1 (en) * | 2007-08-17 | 2011-06-30 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems, devices, and methods including catheters configured to release ultraviolet energy absorbing agents |
| DE102008061418A1 (de) | 2007-12-12 | 2009-06-18 | Erbe Elektromedizin Gmbh | Vorrichtung zur kontaktlosen Kommunikation und Verwendung einer Speichereinrichtung |
| US7949398B1 (en) | 2007-12-27 | 2011-05-24 | Pacesetter, Inc. | Acquiring nerve activity from carotid body and/or sinus |
| US7848816B1 (en) | 2007-12-27 | 2010-12-07 | Pacesetter, Inc. | Acquiring nerve activity from carotid body and/or sinus |
| US9204927B2 (en) | 2009-05-13 | 2015-12-08 | St. Jude Medical, Atrial Fibrillation Division, Inc. | System and method for presenting information representative of lesion formation in tissue during an ablation procedure |
| JP2010021134A (ja) | 2008-06-11 | 2010-01-28 | Sumitomo Chemical Co Ltd | リチウム複合金属酸化物の製造方法 |
| US8617873B2 (en) | 2008-08-08 | 2013-12-31 | Neal Solomon | Intelligent medical device system for personalized medicine applications |
| US20100221752A2 (en) | 2008-10-06 | 2010-09-02 | Somalogic, Inc. | Ovarian Cancer Biomarkers and Uses Thereof |
| US20100087716A1 (en) | 2008-10-08 | 2010-04-08 | Nashed Ramses S | Portable microchip module for instantaneous analysis of bodily fluids |
| US20100114244A1 (en) * | 2008-10-31 | 2010-05-06 | Medtronic, Inc. | Electrical renal autonomic blockade |
| US20100166739A1 (en) | 2008-12-30 | 2010-07-01 | Lipella Paharmaceuticals Inc. | Methods and Compositions for Diagnosing Urological Disorders |
| US8808345B2 (en) | 2008-12-31 | 2014-08-19 | Medtronic Ardian Luxembourg S.A.R.L. | Handle assemblies for intravascular treatment devices and associated systems and methods |
| US8652129B2 (en) | 2008-12-31 | 2014-02-18 | Medtronic Ardian Luxembourg S.A.R.L. | Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation |
| US20100168739A1 (en) | 2008-12-31 | 2010-07-01 | Ardian, Inc. | Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation |
| JP2010162163A (ja) * | 2009-01-15 | 2010-07-29 | Sumitomo Bakelite Co Ltd | 体内留置用バルーンカテーテル |
| US20100331833A1 (en) * | 2009-06-26 | 2010-12-30 | Michael Maschke | In-vitro device monitoring during minimally invasive ablation therapy |
| US8568401B2 (en) | 2009-10-27 | 2013-10-29 | Covidien Lp | System for monitoring ablation size |
| US20110112400A1 (en) | 2009-11-06 | 2011-05-12 | Ardian, Inc. | High intensity focused ultrasound catheter apparatuses, systems, and methods for renal neuromodulation |
| US8591459B2 (en) * | 2009-12-21 | 2013-11-26 | Ethicon Endo-Surgery, Inc. | Use of biomarkers and therapeutic agents with surgical devices |
| EP2525715A4 (en) | 2010-01-19 | 2014-06-04 | Medtronic Ardian Luxembourg S R L | METHODS AND APPARATUS FOR RENAL NEUROMODULATION BY STEREOTACTIC RADIOTHERAPY |
| JP2011147758A (ja) * | 2010-01-22 | 2011-08-04 | Olympus Corp | 処置具 |
| CN102892454B (zh) | 2010-01-26 | 2016-01-20 | 迈克尔·A·埃文斯 | 用于去神经支配的方法、装置以及药剂 |
| US8870863B2 (en) | 2010-04-26 | 2014-10-28 | Medtronic Ardian Luxembourg S.A.R.L. | Catheter apparatuses, systems, and methods for renal neuromodulation |
| US10631912B2 (en) | 2010-04-30 | 2020-04-28 | Medtronic Xomed, Inc. | Interface module for use with nerve monitoring and electrosurgery |
| WO2011143199A1 (en) | 2010-05-10 | 2011-11-17 | Medtronic Inc. | System for selecting an ablation procedure based on comparing a biological response with a mathematical model |
| JP2013540995A (ja) | 2010-08-18 | 2013-11-07 | カリス ライフ サイエンシズ ルクセンブルク ホールディングス エス.アー.エール.エル. | 疾患に対する循環バイオマーカー |
| US20120065554A1 (en) * | 2010-09-09 | 2012-03-15 | Michael Pikus | Dual Balloon Ablation Catheter with Vessel Deformation Arrangement for Renal Nerve Ablation |
| US20120065506A1 (en) | 2010-09-10 | 2012-03-15 | Scott Smith | Mechanical, Electromechanical, and/or Elastographic Assessment for Renal Nerve Ablation |
| WO2012061161A1 (en) | 2010-10-25 | 2012-05-10 | Medtronic Ardian Luxembourg S.A.R.L. | Catheter apparatuses having multi-electrode arrays for renal neuromodulation and associated systems and methods |
| US20120265198A1 (en) | 2010-11-19 | 2012-10-18 | Crow Loren M | Renal nerve detection and ablation apparatus and method |
| US9023034B2 (en) | 2010-11-22 | 2015-05-05 | Boston Scientific Scimed, Inc. | Renal ablation electrode with force-activatable conduction apparatus |
| US10016233B2 (en) | 2010-12-06 | 2018-07-10 | Biosense Webster (Israel) Ltd. | Treatment of atrial fibrillation using high-frequency pacing and ablation of renal nerves |
| CN106264720A (zh) * | 2010-12-28 | 2017-01-04 | 西比姆公司 | 用于患者的交感再平衡的方法 |
| US20120191079A1 (en) | 2011-01-20 | 2012-07-26 | Hansen Medical, Inc. | System and method for endoluminal and translumenal therapy |
| EP2709517B1 (en) | 2011-05-18 | 2017-01-11 | St. Jude Medical, Inc. | Apparatus for assessing transvascular denervation |
| US8909316B2 (en) | 2011-05-18 | 2014-12-09 | St. Jude Medical, Cardiology Division, Inc. | Apparatus and method of assessing transvascular denervation |
| US20120296232A1 (en) | 2011-05-18 | 2012-11-22 | St. Jude Medical, Inc. | Method and apparatus of assessing transvascular denervation |
| WO2013013156A2 (en) | 2011-07-20 | 2013-01-24 | Boston Scientific Scimed, Inc. | Percutaneous devices and methods to visualize, target and ablate nerves |
| US8702619B2 (en) | 2011-08-26 | 2014-04-22 | Symap Holding Limited | Mapping sympathetic nerve distribution for renal ablation and catheters for same |
| US9820811B2 (en) | 2011-08-26 | 2017-11-21 | Symap Medical (Suzhou), Ltd | System and method for mapping the functional nerves innervating the wall of arteries, 3-D mapping and catheters for same |
| ES2972941T3 (es) | 2011-08-26 | 2024-06-17 | Symap Medical Suzhou Ltd | Sistema para localizar e identificar nervios funcionales que inervan la pared de las arterias |
| US9427579B2 (en) | 2011-09-29 | 2016-08-30 | Pacesetter, Inc. | System and method for performing renal denervation verification |
| WO2013074813A1 (en) | 2011-11-15 | 2013-05-23 | Boston Scientific Scimed, Inc. | Device and methods for renal nerve modulation monitoring |
| WO2013096461A1 (en) | 2011-12-20 | 2013-06-27 | Cardiac Pacemakers, Inc. | Apparatus for monitoring and ablating nerves |
| WO2013096548A1 (en) * | 2011-12-23 | 2013-06-27 | Volcano Corporation | Methods and apparatus for regulating blood pressure |
| EP2797533A1 (en) | 2011-12-28 | 2014-11-05 | Boston Scientific Scimed, Inc. | Balloon expandable multi-electrode rf ablation catheter |
| CN104135959A (zh) | 2011-12-29 | 2014-11-05 | 波士顿科学西美德公司 | 用于肾神经调变监测的装置和方法 |
| US9649064B2 (en) | 2012-01-26 | 2017-05-16 | Autonomix Medical, Inc. | Controlled sympathectomy and micro-ablation systems and methods |
| CA3151885C (en) | 2012-01-26 | 2024-10-22 | Autonomix Medical, Inc. | CONTROLLED SYMPATHECTOMY AND MICRO-ABLATION SYSTEMS AND METHODS |
| US20130218029A1 (en) | 2012-02-16 | 2013-08-22 | Pacesetter, Inc. | System and method for assessing renal artery nerve density |
| WO2013134121A2 (en) | 2012-03-07 | 2013-09-12 | Enteromedics Inc. | Devices for regulation of blood pressure and heart rate |
| CN104271062B (zh) | 2012-03-08 | 2017-07-07 | 美敦力Af卢森堡有限责任公司 | 采用神经调节装置的生物标志物取样和相关系统及方法 |
| US9439598B2 (en) | 2012-04-12 | 2016-09-13 | NeuroMedic, Inc. | Mapping and ablation of nerves within arteries and tissues |
| CN107374723B (zh) | 2012-05-11 | 2020-08-28 | 美敦力Af卢森堡有限责任公司 | 导管设备 |
| EP2852339B1 (en) | 2012-05-29 | 2020-12-23 | Autonomix Medical, Inc. | Endoscopic sympathectomy systems |
| US11357447B2 (en) | 2012-05-31 | 2022-06-14 | Sonivie Ltd. | Method and/or apparatus for measuring renal denervation effectiveness |
| US9295842B2 (en) | 2012-07-05 | 2016-03-29 | Mc10, Inc. | Catheter or guidewire device including flow sensing and use thereof |
| KR20150031324A (ko) | 2012-07-05 | 2015-03-23 | 엠씨10, 인크 | 유동 감지를 포함하는 카테터 장치 |
| CN102743225B (zh) | 2012-07-18 | 2014-04-02 | 深圳市惠泰医疗器械有限公司 | 肾动脉射频消融可控电极导管 |
| CN103284693B (zh) | 2012-08-24 | 2014-12-24 | 苏州信迈医疗器械有限公司 | 一种能够定位和识别血管壁内或外膜上神经的仪器及使用方法 |
| TWI498101B (zh) | 2012-08-30 | 2015-09-01 | 國立交通大學 | 神經纖維分佈之分析方法及標準化誘發復合動作電位之量測方法 |
| JP2014054430A (ja) | 2012-09-13 | 2014-03-27 | Nippon Koden Corp | カテーテル |
| WO2014059165A2 (en) | 2012-10-10 | 2014-04-17 | Boston Scientific Scimed, Inc. | Renal nerve modulation devices and methods |
| US9770593B2 (en) | 2012-11-05 | 2017-09-26 | Pythagoras Medical Ltd. | Patient selection using a transluminally-applied electric current |
| WO2014068577A2 (en) | 2012-11-05 | 2014-05-08 | Rainbow Medical Ltd. | Controlled tissue ablation |
| WO2014070999A2 (en) | 2012-11-05 | 2014-05-08 | Landy Toth | Systems, methods, and devices for monitoring and treatment of tissues within and/or through a lumen wall |
| US20140316496A1 (en) | 2012-11-21 | 2014-10-23 | NeuroTronik IP Holding (Jersey) Limited | Intravascular Electrode Arrays for Neuromodulation |
| WO2014091401A2 (en) | 2012-12-10 | 2014-06-19 | Perseus-Biomed Inc. | Dynamic denervation procedures and systems for the implementation thereof |
| CN104837434A (zh) | 2012-12-10 | 2015-08-12 | 皇家飞利浦有限公司 | 用于肾脏去神经的数字标尺和标线 |
| US10028764B2 (en) | 2013-02-21 | 2018-07-24 | Boston Scientific Scimed, Inc. | Ablation catheter with wireless temperature sensor |
| US10195467B2 (en) | 2013-02-21 | 2019-02-05 | Boston Scientific Scimed, Inc. | Ablation catheter system with wireless radio frequency temperature sensor |
| US20140249524A1 (en) | 2013-03-01 | 2014-09-04 | Boston Scientific Scimed, Inc. | System and method for performing renal nerve modulation |
| US20140246465A1 (en) | 2013-03-03 | 2014-09-04 | Joan Darnell Peterson | Fish n stow |
| AU2014249776B2 (en) | 2013-03-12 | 2017-04-20 | Boston Scientific Scimed, Inc. | Medical systems and methods for modulating nerves |
| US9510902B2 (en) | 2013-03-13 | 2016-12-06 | St. Jude Medical, Cardiology Division, Inc. | Ablation catheters and systems including rotational monitoring means |
| US9131982B2 (en) | 2013-03-14 | 2015-09-15 | St. Jude Medical, Cardiology Division, Inc. | Mediguide-enabled renal denervation system for ensuring wall contact and mapping lesion locations |
| US8876813B2 (en) | 2013-03-14 | 2014-11-04 | St. Jude Medical, Inc. | Methods, systems, and apparatus for neural signal detection |
| WO2014150441A2 (en) | 2013-03-15 | 2014-09-25 | St. Jude Medical, Cardiology Division, Inc. | Ablation system, methods, and controllers |
| US9974477B2 (en) | 2013-03-15 | 2018-05-22 | St. Jude Medical, Cardiology Division, Inc. | Quantification of renal denervation via alterations in renal blood flow pre/post ablation |
| US9775663B2 (en) | 2013-03-15 | 2017-10-03 | St. Jude Medical, Cardiology Division, Inc. | Ablation system, methods, and controllers |
| US9186212B2 (en) | 2013-03-15 | 2015-11-17 | St. Jude Medical, Cardiology Division, Inc. | Feedback systems and methods utilizing two or more sites along denervation catheter |
| US9179973B2 (en) | 2013-03-15 | 2015-11-10 | St. Jude Medical, Cardiology Division, Inc. | Feedback systems and methods for renal denervation utilizing balloon catheter |
| JP6139772B2 (ja) | 2013-03-15 | 2017-05-31 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | 電極パッドと共に使用するための制御ユニットおよび漏電を推定するための方法 |
| CA3205904A1 (en) | 2013-03-27 | 2014-10-02 | Autonomix Medical, Inc. | Systems and methods for neurological traffic and/or receptor functional evaluation and/or modification |
| WO2014162660A1 (ja) | 2013-04-01 | 2014-10-09 | テルモ株式会社 | モニタリングデバイス及びモニタリングデバイスキット |
| CN105392519A (zh) | 2013-05-02 | 2016-03-09 | 道格拉斯·C·哈灵顿 | 用于检测和治疗主动脉肾神经节的设备以及方法 |
| AU2014262639B2 (en) | 2013-05-08 | 2016-12-22 | Boston Scientific Scimed, Inc. | Systems and methods for temperature monitoring and control during an ablation procedure |
| CN105358084B (zh) | 2013-07-01 | 2018-11-09 | 波士顿科学国际有限公司 | 用于肾神经消融的医疗器械 |
| US20150025524A1 (en) | 2013-07-18 | 2015-01-22 | St. Jude Medical, Cardiology Division, Inc. | Renal denervation monitoring and feedback apparatus, system and method |
| US9931046B2 (en) | 2013-10-25 | 2018-04-03 | Ablative Solutions, Inc. | Intravascular catheter with peri-vascular nerve activity sensors |
| KR20160106582A (ko) | 2014-01-03 | 2016-09-12 | 엠씨10, 인크 | 유동 감지를 포함하는 카테터 또는 가이드 와이어 장치 및 그 용도 |
| US9848949B2 (en) | 2014-01-21 | 2017-12-26 | Oscor Inc. | Renal denervation system |
| EP2907464A1 (en) | 2014-02-12 | 2015-08-19 | Perseus-Biomed Inc. | Methods and systems for treating nerve structures |
| WO2015170281A1 (en) | 2014-05-07 | 2015-11-12 | Rainbow Medical Ltd | Controlled tissue ablation techniques |
| US11382515B2 (en) | 2014-08-07 | 2022-07-12 | Verve Medical, Inc. | Renal denervation using nerve fluorescing dye |
| US10231778B2 (en) | 2014-10-20 | 2019-03-19 | Biosense Webster (Israel) Ltd. | Methods for contemporaneous assessment of renal denervation |
| US10383685B2 (en) | 2015-05-07 | 2019-08-20 | Pythagoras Medical Ltd. | Techniques for use with nerve tissue |
-
2013
- 2013-03-08 CN CN201380024273.3A patent/CN104271062B/zh active Active
- 2013-03-08 EP EP13711530.9A patent/EP2822496B1/en active Active
- 2013-03-08 US US13/791,681 patent/US9510777B2/en active Active
- 2013-03-08 CN CN201710551040.9A patent/CN107260134B/zh active Active
- 2013-03-08 WO PCT/US2013/030041 patent/WO2013134733A2/en not_active Ceased
- 2013-03-08 RU RU2014140406A patent/RU2644933C2/ru active
- 2013-03-08 AU AU2013229776A patent/AU2013229776B2/en active Active
- 2013-03-08 JP JP2014561173A patent/JP6195856B2/ja active Active
- 2013-03-08 EP EP17208077.2A patent/EP3348220B1/en active Active
- 2013-03-08 US US13/791,751 patent/US9597018B2/en active Active
-
2016
- 2016-10-18 US US15/296,925 patent/US10368791B2/en active Active
-
2017
- 2017-02-03 US US15/424,575 patent/US10729365B2/en active Active
- 2017-08-03 US US15/667,901 patent/US11338140B2/en active Active
-
2020
- 2020-07-29 US US16/941,911 patent/US12121725B2/en active Active
-
2022
- 2022-04-11 US US17/717,958 patent/US12491364B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US12491364B2 (en) | 2025-12-09 |
| US20130237780A1 (en) | 2013-09-12 |
| US11338140B2 (en) | 2022-05-24 |
| US9510777B2 (en) | 2016-12-06 |
| US20170127987A1 (en) | 2017-05-11 |
| WO2013134733A3 (en) | 2013-11-21 |
| CN107260134A (zh) | 2017-10-20 |
| WO2013134733A2 (en) | 2013-09-12 |
| CN104271062A (zh) | 2015-01-07 |
| US10729365B2 (en) | 2020-08-04 |
| US20170202500A1 (en) | 2017-07-20 |
| JP2015513437A (ja) | 2015-05-14 |
| CN107260134B (zh) | 2021-06-08 |
| US12121725B2 (en) | 2024-10-22 |
| CN104271062B (zh) | 2017-07-07 |
| EP2822496B1 (en) | 2017-12-20 |
| RU2644933C2 (ru) | 2018-02-14 |
| US20200405207A1 (en) | 2020-12-31 |
| US9597018B2 (en) | 2017-03-21 |
| US20220296891A1 (en) | 2022-09-22 |
| EP2822496A2 (en) | 2015-01-14 |
| AU2013229776A1 (en) | 2014-09-18 |
| EP3348220B1 (en) | 2024-10-23 |
| US20130282001A1 (en) | 2013-10-24 |
| AU2013229776B2 (en) | 2016-12-15 |
| CA2865242A1 (en) | 2013-09-12 |
| EP3348220A1 (en) | 2018-07-18 |
| US10368791B2 (en) | 2019-08-06 |
| RU2014140406A (ru) | 2016-04-27 |
| US20180042535A1 (en) | 2018-02-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6195856B2 (ja) | 神経調節装置に関するバイオマーカーのサンプリングならびに関連システムおよび方法 | |
| US20260069355A1 (en) | Systems and methods for treating cancer and/or augmenting organ function | |
| US12257433B2 (en) | Methods for assessing efficacy of renal neuromodulation and associated systems and devices | |
| US10143419B2 (en) | Systems and methods for treating cancer and/or augmenting organ function | |
| US11779392B2 (en) | Methods and devices for localized disease treatment by ablation | |
| US9943354B2 (en) | Methods and devices for localized inhibition of inflammation by ablation | |
| EP4248897A2 (en) | Systems and methods for treating cancer and/or augmenting organ function | |
| CA2865242C (en) | Biomarker sampling in the context of neuromodulation devices and associated systems and methods |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160225 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20160225 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20170111 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20170118 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20170414 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170417 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20170718 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20170816 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6195856 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |