JP6186277B2 - 抗her3抗体および組成物 - Google Patents

抗her3抗体および組成物 Download PDF

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Publication number
JP6186277B2
JP6186277B2 JP2013535578A JP2013535578A JP6186277B2 JP 6186277 B2 JP6186277 B2 JP 6186277B2 JP 2013535578 A JP2013535578 A JP 2013535578A JP 2013535578 A JP2013535578 A JP 2013535578A JP 6186277 B2 JP6186277 B2 JP 6186277B2
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antibody
her3
antibodies
light chain
composition
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Japanese (ja)
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JP2014503189A (ja
JP2014503189A5 (enExample
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ミッケル・ワンダール・ペダーセン
ヘレ・ヤコブセン
クラウス・ケーフェーズ
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Symphogen AS
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Symphogen AS
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2013535578A 2010-11-01 2011-10-31 抗her3抗体および組成物 Expired - Fee Related JP6186277B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US40878210P 2010-11-01 2010-11-01
DKPA201000988 2010-11-01
US61/408,782 2010-11-01
DKPA201000988 2010-11-02
DKPA201100672 2011-09-05
DKPA201100672 2011-09-05
US201161531407P 2011-09-06 2011-09-06
US61/531,407 2011-09-06
PCT/IB2011/054835 WO2012059858A1 (en) 2010-11-01 2011-10-31 Anti-her3 antibodies and compositions

Publications (3)

Publication Number Publication Date
JP2014503189A JP2014503189A (ja) 2014-02-13
JP2014503189A5 JP2014503189A5 (enExample) 2014-12-18
JP6186277B2 true JP6186277B2 (ja) 2017-08-23

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013535578A Expired - Fee Related JP6186277B2 (ja) 2010-11-01 2011-10-31 抗her3抗体および組成物
JP2013535577A Expired - Fee Related JP6033783B2 (ja) 2010-11-01 2011-10-31 Pan−her抗体組成物

Family Applications After (1)

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JP2013535577A Expired - Fee Related JP6033783B2 (ja) 2010-11-01 2011-10-31 Pan−her抗体組成物

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Country Link
US (1) US9217039B2 (enExample)
EP (3) EP2635605B1 (enExample)
JP (2) JP6186277B2 (enExample)
KR (2) KR101862832B1 (enExample)
AU (2) AU2011324871B2 (enExample)
CA (2) CA2816519C (enExample)
DK (1) DK2635604T3 (enExample)
ES (2) ES2692379T3 (enExample)
IL (2) IL225953A0 (enExample)
MX (2) MX347981B (enExample)
PL (1) PL2635604T3 (enExample)
TW (1) TW201231066A (enExample)
WO (2) WO2012059858A1 (enExample)

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Also Published As

Publication number Publication date
TW201231066A (en) 2012-08-01
MX2013004897A (es) 2013-07-15
JP2014503189A (ja) 2014-02-13
WO2012059857A3 (en) 2012-07-19
AU2011324871B2 (en) 2016-05-19
CA2816519C (en) 2019-01-15
EP2635605A1 (en) 2013-09-11
CA2816520C (en) 2017-11-21
AU2011324870B2 (en) 2015-01-29
IL225954B (en) 2018-05-31
KR101862832B1 (ko) 2018-05-30
AU2011324870A1 (en) 2013-01-31
EP2635604A2 (en) 2013-09-11
EP3156421B1 (en) 2018-06-06
IL225954A0 (en) 2013-07-31
WO2012059858A1 (en) 2012-05-10
KR20140026336A (ko) 2014-03-05
ES2616961T3 (es) 2017-06-14
EP2635605A4 (en) 2014-10-22
CA2816520A1 (en) 2012-05-10
AU2011324871A1 (en) 2013-05-09
MX2013004899A (es) 2013-07-15
US20130287684A1 (en) 2013-10-31
EP2635604B1 (en) 2016-11-30
JP6033783B2 (ja) 2016-11-30
IL225953A0 (en) 2013-07-31
KR101773120B1 (ko) 2017-08-30
DK2635604T3 (en) 2017-02-27
CA2816519A1 (en) 2012-05-10
MX348637B (es) 2017-06-22
WO2012059857A2 (en) 2012-05-10
EP3156421A1 (en) 2017-04-19
JP2014503188A (ja) 2014-02-13
EP2635605B1 (en) 2018-07-25
ES2692379T3 (es) 2018-12-03
US9217039B2 (en) 2015-12-22
KR20140026337A (ko) 2014-03-05
MX347981B (es) 2017-05-22
PL2635604T3 (pl) 2017-09-29

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