JP6170071B2 - Ｃｎｓ損傷についてのバイオマーカーとしての自然免疫タンパク質 - Google Patents

Ｃｎｓ損傷についてのバイオマーカーとしての自然免疫タンパク質 Download PDF

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JP6170071B2
JP6170071B2 JP2014555851A JP2014555851A JP6170071B2 JP 6170071 B2 JP6170071 B2 JP 6170071B2 JP 2014555851 A JP2014555851 A JP 2014555851A JP 2014555851 A JP2014555851 A JP 2014555851A JP 6170071 B2 JP6170071 B2 JP 6170071B2
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protein
inflammasome
patient
injury
caspase
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JP2015508887A5 (enExample
JP2015508887A (ja
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ロバート ダブリュー． キーン，
ロバート ダブリュー． キーン，
ダブリュー． ダルトン ディートリッヒ，
ダブリュー． ダルトン ディートリッヒ，
フアン パブロ デ リベロ ヴァッカリ，
フアン パブロ デ リベロ ヴァッカリ，
ステファニー アダムチャック，
ステファニー アダムチャック，
エム． ロス ブロック，
エム． ロス ブロック，
アラン レビ，
アラン レビ，
マイケル ワイ． ワン，
マイケル ワイ． ワン，
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University of Miami
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University of Miami
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7095—Inflammation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
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  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2014555851A 2012-02-06 2013-02-06 Ｃｎｓ損傷についてのバイオマーカーとしての自然免疫タンパク質 Active JP6170071B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261595254P 2012-02-06 2012-02-06
US61/595,254 2012-02-06
PCT/US2013/024941 WO2013119673A1 (en) 2012-02-06 2013-02-06 Innate immune proteins as biomarkers for cns injury

Publications (3)

Publication Number Publication Date
JP2015508887A JP2015508887A (ja) 2015-03-23
JP2015508887A5 JP2015508887A5 (enExample) 2016-02-25
JP6170071B2 true JP6170071B2 (ja) 2017-07-26

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JP2014555851A Active JP6170071B2 (ja) 2012-02-06 2013-02-06 Ｃｎｓ損傷についてのバイオマーカーとしての自然免疫タンパク質

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US (4) US20150185232A1 (enExample)
EP (1) EP2812697B1 (enExample)
JP (1) JP6170071B2 (enExample)
CA (1) CA2863417C (enExample)
ES (1) ES2630905T3 (enExample)
WO (1) WO2013119673A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
GB2548942A (en) * 2014-04-08 2017-10-04 Univ Florida Protein biomarkers for acute, subacute and chronic traumatic injuries of the central nervous system
US11840565B2 (en) 2016-12-29 2023-12-12 University Of Miami Methods and compositions for treating virus-associated inflammation
MX2019007916A (es) 2016-12-29 2019-12-05 Univ Miami Metodo para modular la actividad de inflamasoma e inflamacion en el pulmon.
EP3685169A4 (en) * 2017-09-20 2021-09-08 University of Miami PROCESS FOR DETECTION OF INFLAMMASOME PROTEINS AS BIOMARKERS OF NEUROLOGICAL DISORDERS
WO2019199871A1 (en) * 2018-04-10 2019-10-17 Quanterix Corporation Quantification of neurofilament light chain in physiological samples
GB201815045D0 (en) 2018-09-14 2018-10-31 Univ Ulster Bispecific antibody targeting IL-1R1 and NLPR3
CN109406795A (zh) * 2018-11-20 2019-03-01 昆明医科大学 一种轻型脑外伤的血清分子诊断标记物及应用
EP3918336A1 (en) * 2019-01-31 2021-12-08 University of Geneva Prospective markers in traumatic brain injury (tbi)
WO2021071934A1 (en) * 2019-10-07 2021-04-15 United States Government As Represented By The Department Of Veterans Affairs Polymeric methylprednisolone conjugates and uses thereof
CA3176521A1 (en) * 2020-04-27 2021-11-04 University Of Miami Compositions and methods for treating inflammasome related diseases or conditions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004022156A2 (en) * 2002-09-04 2004-03-18 Washington University Methods for treating central nervous system damage
US8685400B2 (en) * 2007-07-30 2014-04-01 University Of Miami Modulating inflammasome activity and inflammation in the central nervous system
CA2715248A1 (en) * 2008-02-04 2009-08-13 Banyan Biomarkers, Inc. Process to diagnose or treat brain injury
CN102105054A (zh) * 2008-07-18 2011-06-22 氧生物治疗有限公司 治疗创伤性脑损伤的方法
US20120177632A1 (en) * 2011-01-10 2012-07-12 Shinohara Mari L Methods of optimizing disease treatment

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WO2013119673A1 (en) 2013-08-15
CA2863417A1 (en) 2013-08-15
EP2812697B1 (en) 2017-03-22
CA2863417C (en) 2020-07-28
US20170003303A1 (en) 2017-01-05
US20150185232A1 (en) 2015-07-02
US20200363432A1 (en) 2020-11-19
US20230349929A1 (en) 2023-11-02
EP2812697A4 (en) 2015-08-26
ES2630905T3 (es) 2017-08-25
JP2015508887A (ja) 2015-03-23
EP2812697A1 (en) 2014-12-17

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