ES2630905T3 - Proteínas inmunitarias innatas como biomarcadores para lesiones del SNC - Google Patents
Proteínas inmunitarias innatas como biomarcadores para lesiones del SNC Download PDFInfo
- Publication number
- ES2630905T3 ES2630905T3 ES13746979.7T ES13746979T ES2630905T3 ES 2630905 T3 ES2630905 T3 ES 2630905T3 ES 13746979 T ES13746979 T ES 13746979T ES 2630905 T3 ES2630905 T3 ES 2630905T3
- Authority
- ES
- Spain
- Prior art keywords
- patient
- protein
- injury
- inflamasome
- level
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 124
- 102000004169 proteins and genes Human genes 0.000 title claims abstract description 124
- 230000003902 lesion Effects 0.000 title claims abstract description 73
- 239000000090 biomarker Substances 0.000 title description 26
- 210000003169 central nervous system Anatomy 0.000 claims abstract description 96
- 208000014674 injury Diseases 0.000 claims abstract description 82
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 75
- 230000006378 damage Effects 0.000 claims abstract description 75
- 108090000426 Caspase-1 Proteins 0.000 claims abstract description 73
- 102100035904 Caspase-1 Human genes 0.000 claims abstract description 72
- 238000000034 method Methods 0.000 claims abstract description 65
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims abstract description 61
- 101001109463 Homo sapiens NACHT, LRR and PYD domains-containing protein 1 Proteins 0.000 claims abstract description 44
- 102100022698 NACHT, LRR and PYD domains-containing protein 1 Human genes 0.000 claims abstract description 43
- 108010034143 Inflammasomes Proteins 0.000 claims abstract description 41
- 239000012472 biological sample Substances 0.000 claims abstract description 37
- 210000002966 serum Anatomy 0.000 claims abstract description 13
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims abstract description 9
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims abstract description 9
- 210000002381 plasma Anatomy 0.000 claims abstract description 9
- 239000002773 nucleotide Substances 0.000 claims abstract description 8
- 125000003729 nucleotide group Chemical group 0.000 claims abstract description 8
- 230000006907 apoptotic process Effects 0.000 claims abstract description 7
- 210000004369 blood Anatomy 0.000 claims abstract description 6
- 239000008280 blood Substances 0.000 claims abstract description 6
- 102000021350 Caspase recruitment domains Human genes 0.000 claims abstract description 5
- 108091011189 Caspase recruitment domains Proteins 0.000 claims abstract description 5
- 239000013068 control sample Substances 0.000 claims abstract description 5
- 208000024891 symptom Diseases 0.000 claims abstract description 4
- 238000011282 treatment Methods 0.000 claims description 60
- 208000020431 spinal cord injury Diseases 0.000 claims description 49
- 208000030886 Traumatic Brain injury Diseases 0.000 claims description 46
- 230000009529 traumatic brain injury Effects 0.000 claims description 45
- 230000000324 neuroprotective effect Effects 0.000 claims description 29
- 238000003119 immunoblot Methods 0.000 claims description 16
- 238000004393 prognosis Methods 0.000 claims description 15
- 230000002631 hypothermal effect Effects 0.000 claims description 14
- 238000011156 evaluation Methods 0.000 claims description 13
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims description 10
- 230000002829 reductive effect Effects 0.000 claims description 8
- DYKFCLLONBREIL-KVUCHLLUSA-N minocycline Chemical compound C([C@H]1C2)C3=C(N(C)C)C=CC(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O DYKFCLLONBREIL-KVUCHLLUSA-N 0.000 claims description 7
- 229960004023 minocycline Drugs 0.000 claims description 7
- 229960003387 progesterone Drugs 0.000 claims description 5
- 239000000186 progesterone Substances 0.000 claims description 5
- VHRSUDSXCMQTMA-PJHHCJLFSA-N 6alpha-methylprednisolone Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)CO)CC[C@H]21 VHRSUDSXCMQTMA-PJHHCJLFSA-N 0.000 claims description 4
- 238000002965 ELISA Methods 0.000 claims description 4
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims description 4
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 claims description 4
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims description 4
- 229940089161 ginsenoside Drugs 0.000 claims description 4
- 229930182494 ginsenoside Natural products 0.000 claims description 4
- 229960004584 methylprednisolone Drugs 0.000 claims description 4
- 235000021283 resveratrol Nutrition 0.000 claims description 4
- 229940016667 resveratrol Drugs 0.000 claims description 4
- MEZLKOACVSPNER-GFCCVEGCSA-N selegiline Chemical compound C#CCN(C)[C@H](C)CC1=CC=CC=C1 MEZLKOACVSPNER-GFCCVEGCSA-N 0.000 claims description 4
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims description 4
- 229960002855 simvastatin Drugs 0.000 claims description 4
- VOXZDWNPVJITMN-SFFUCWETSA-N 17α-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-SFFUCWETSA-N 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims 4
- VOXZDWNPVJITMN-UHFFFAOYSA-N 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol Chemical compound OC1=CC=C2C3CCC(C)(C(CC4)O)C4C3CCC2=C1 VOXZDWNPVJITMN-UHFFFAOYSA-N 0.000 claims 3
- 206010073261 Ovarian theca cell tumour Diseases 0.000 claims 1
- 208000001644 thecoma Diseases 0.000 claims 1
- 102000005583 Pyrin Human genes 0.000 abstract description 2
- 108010059278 Pyrin Proteins 0.000 abstract description 2
- 235000018102 proteins Nutrition 0.000 description 108
- 239000003153 chemical reaction reagent Substances 0.000 description 21
- 210000000278 spinal cord Anatomy 0.000 description 19
- 239000012634 fragment Substances 0.000 description 14
- 208000034656 Contusions Diseases 0.000 description 13
- 206010021113 Hypothermia Diseases 0.000 description 13
- 230000009519 contusion Effects 0.000 description 12
- 239000003446 ligand Substances 0.000 description 10
- 210000002569 neuron Anatomy 0.000 description 10
- 230000004044 response Effects 0.000 description 10
- 230000004913 activation Effects 0.000 description 9
- 230000001154 acute effect Effects 0.000 description 9
- 230000000926 neurological effect Effects 0.000 description 9
- 210000004248 oligodendroglia Anatomy 0.000 description 9
- 238000011084 recovery Methods 0.000 description 9
- 210000001519 tissue Anatomy 0.000 description 9
- 208000029028 brain injury Diseases 0.000 description 8
- 230000034994 death Effects 0.000 description 8
- 231100000517 death Toxicity 0.000 description 8
- 239000000523 sample Substances 0.000 description 8
- 230000001225 therapeutic effect Effects 0.000 description 8
- 230000008733 trauma Effects 0.000 description 8
- 238000004458 analytical method Methods 0.000 description 7
- 210000004556 brain Anatomy 0.000 description 7
- 210000001652 frontal lobe Anatomy 0.000 description 7
- 230000007659 motor function Effects 0.000 description 7
- 206010048962 Brain oedema Diseases 0.000 description 6
- 208000032843 Hemorrhage Diseases 0.000 description 6
- 241000282412 Homo Species 0.000 description 6
- 125000003275 alpha amino acid group Chemical group 0.000 description 6
- 208000006752 brain edema Diseases 0.000 description 6
- 230000004927 fusion Effects 0.000 description 6
- 230000004054 inflammatory process Effects 0.000 description 6
- 230000007246 mechanism Effects 0.000 description 6
- 230000007170 pathology Effects 0.000 description 6
- -1 ASC Proteins 0.000 description 5
- 108091023037 Aptamer Proteins 0.000 description 5
- 206010010071 Coma Diseases 0.000 description 5
- 108010083674 Myelin Proteins Proteins 0.000 description 5
- 102000006386 Myelin Proteins Human genes 0.000 description 5
- 230000002349 favourable effect Effects 0.000 description 5
- 239000000499 gel Substances 0.000 description 5
- 230000002008 hemorrhagic effect Effects 0.000 description 5
- 230000028709 inflammatory response Effects 0.000 description 5
- 239000013610 patient sample Substances 0.000 description 5
- 230000002861 ventricular Effects 0.000 description 5
- 102100039289 Glial fibrillary acidic protein Human genes 0.000 description 4
- 101710193519 Glial fibrillary acidic protein Proteins 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 4
- SXEHKFHPFVVDIR-UHFFFAOYSA-N [4-(4-hydrazinylphenyl)phenyl]hydrazine Chemical compound C1=CC(NN)=CC=C1C1=CC=C(NN)C=C1 SXEHKFHPFVVDIR-UHFFFAOYSA-N 0.000 description 4
- 238000010171 animal model Methods 0.000 description 4
- 210000003050 axon Anatomy 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 230000002518 glial effect Effects 0.000 description 4
- 210000005046 glial fibrillary acidic protein Anatomy 0.000 description 4
- 238000012417 linear regression Methods 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 4
- 210000005012 myelin Anatomy 0.000 description 4
- 230000003472 neutralizing effect Effects 0.000 description 4
- 230000001936 parietal effect Effects 0.000 description 4
- 230000008506 pathogenesis Effects 0.000 description 4
- 230000004224 protection Effects 0.000 description 4
- 210000003296 saliva Anatomy 0.000 description 4
- 230000037152 sensory function Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 208000037816 tissue injury Diseases 0.000 description 4
- 210000002700 urine Anatomy 0.000 description 4
- 206010017076 Fracture Diseases 0.000 description 3
- 206010019196 Head injury Diseases 0.000 description 3
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 3
- 102100023057 Neurofilament light polypeptide Human genes 0.000 description 3
- 208000036110 Neuroinflammatory disease Diseases 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- 206010039203 Road traffic accident Diseases 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000002146 bilateral effect Effects 0.000 description 3
- 230000006835 compression Effects 0.000 description 3
- 238000007906 compression Methods 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000005484 gravity Effects 0.000 description 3
- 238000002991 immunohistochemical analysis Methods 0.000 description 3
- 230000002055 immunohistochemical effect Effects 0.000 description 3
- 238000002684 laminectomy Methods 0.000 description 3
- 238000004811 liquid chromatography Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000004949 mass spectrometry Methods 0.000 description 3
- 210000000274 microglia Anatomy 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 210000002161 motor neuron Anatomy 0.000 description 3
- 230000001537 neural effect Effects 0.000 description 3
- 108010090677 neurofilament protein L Proteins 0.000 description 3
- 230000003959 neuroinflammation Effects 0.000 description 3
- 210000003446 pia mater Anatomy 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 206010002941 Apallic syndrome Diseases 0.000 description 2
- 108010076667 Caspases Proteins 0.000 description 2
- 102000011727 Caspases Human genes 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 2
- 101000728679 Homo sapiens Apoptosis-associated speck-like protein containing a CARD Proteins 0.000 description 2
- 101000979333 Homo sapiens Neurofilament light polypeptide Proteins 0.000 description 2
- 101000661600 Homo sapiens Steryl-sulfatase Proteins 0.000 description 2
- 238000012313 Kruskal-Wallis test Methods 0.000 description 2
- 238000000585 Mann–Whitney U test Methods 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 102000012064 NLR Proteins Human genes 0.000 description 2
- 208000001738 Nervous System Trauma Diseases 0.000 description 2
- 102000012288 Phosphopyruvate Hydratase Human genes 0.000 description 2
- 108010022181 Phosphopyruvate Hydratase Proteins 0.000 description 2
- 101000661598 Rattus norvegicus Steryl-sulfatase Proteins 0.000 description 2
- 208000006011 Stroke Diseases 0.000 description 2
- 102000002689 Toll-like receptor Human genes 0.000 description 2
- 108020000411 Toll-like receptor Proteins 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- 230000003044 adaptive effect Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000003376 axonal effect Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 210000005013 brain tissue Anatomy 0.000 description 2
- 230000002490 cerebral effect Effects 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 238000010217 densitometric analysis Methods 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000002405 diagnostic procedure Methods 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229960005309 estradiol Drugs 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000004817 gas chromatography Methods 0.000 description 2
- 102000050702 human PYCARD Human genes 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000015788 innate immune response Effects 0.000 description 2
- 238000007917 intracranial administration Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 210000002540 macrophage Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000002105 nanoparticle Substances 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 208000028412 nervous system injury Diseases 0.000 description 2
- 230000037000 normothermia Effects 0.000 description 2
- 238000000399 optical microscopy Methods 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 210000001152 parietal lobe Anatomy 0.000 description 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 2
- 208000005026 persistent vegetative state Diseases 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 230000007115 recruitment Effects 0.000 description 2
- 230000011664 signaling Effects 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 230000002123 temporal effect Effects 0.000 description 2
- 210000003478 temporal lobe Anatomy 0.000 description 2
- 230000000472 traumatic effect Effects 0.000 description 2
- 210000004885 white matter Anatomy 0.000 description 2
- 102100032814 ATP-dependent zinc metalloprotease YME1L1 Human genes 0.000 description 1
- 108091005508 Acid proteases Proteins 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 206010002329 Aneurysm Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 102000010565 Apoptosis Regulatory Proteins Human genes 0.000 description 1
- 108010063104 Apoptosis Regulatory Proteins Proteins 0.000 description 1
- 208000025978 Athletic injury Diseases 0.000 description 1
- 208000010392 Bone Fractures Diseases 0.000 description 1
- 201000006474 Brain Ischemia Diseases 0.000 description 1
- 206010052346 Brain contusion Diseases 0.000 description 1
- 102000000584 Calmodulin Human genes 0.000 description 1
- 108010041952 Calmodulin Proteins 0.000 description 1
- 102000003952 Caspase 3 Human genes 0.000 description 1
- 108090000397 Caspase 3 Proteins 0.000 description 1
- 208000014912 Central Nervous System Infections Diseases 0.000 description 1
- 206010008120 Cerebral ischaemia Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 description 1
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 description 1
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- 206010011732 Cyst Diseases 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 206010012289 Dementia Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 108090000204 Dipeptidase 1 Proteins 0.000 description 1
- 102000047174 Disks Large Homolog 4 Human genes 0.000 description 1
- 108700019745 Disks Large Homolog 4 Proteins 0.000 description 1
- 102100024117 Disks large homolog 2 Human genes 0.000 description 1
- 101710185758 Disks large homolog 2 Proteins 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000007356 Fracture Dislocation Diseases 0.000 description 1
- 108010015133 Galactose oxidase Proteins 0.000 description 1
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 1
- 206010018852 Haematoma Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010061998 Hepatic lesion Diseases 0.000 description 1
- 206010019909 Hernia Diseases 0.000 description 1
- 101000738757 Homo sapiens Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 Proteins 0.000 description 1
- 208000023105 Huntington disease Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 206010022840 Intraventricular haemorrhage Diseases 0.000 description 1
- 208000034693 Laceration Diseases 0.000 description 1
- 102100038609 Lactoperoxidase Human genes 0.000 description 1
- 108010023244 Lactoperoxidase Proteins 0.000 description 1
- 108060001084 Luciferase Proteins 0.000 description 1
- 239000005089 Luciferase Substances 0.000 description 1
- 201000009906 Meningitis Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 108010020004 Microtubule-Associated Proteins Proteins 0.000 description 1
- 102000009664 Microtubule-Associated Proteins Human genes 0.000 description 1
- 102000008109 Mixed Function Oxygenases Human genes 0.000 description 1
- 108010074633 Mixed Function Oxygenases Proteins 0.000 description 1
- 206010027951 Mood swings Diseases 0.000 description 1
- 101000933115 Mus musculus Caspase-4 Proteins 0.000 description 1
- 102000003896 Myeloperoxidases Human genes 0.000 description 1
- 108090000235 Myeloperoxidases Proteins 0.000 description 1
- 229940127523 NMDA Receptor Antagonists Drugs 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 102100023233 Neurensin-1 Human genes 0.000 description 1
- 108050002720 Neurensin-1 Proteins 0.000 description 1
- 108010088373 Neurofilament Proteins Proteins 0.000 description 1
- 102000008763 Neurofilament Proteins Human genes 0.000 description 1
- 206010060860 Neurological symptom Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 102100037408 Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 Human genes 0.000 description 1
- 108091000080 Phosphotransferase Proteins 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 208000008348 Post-Concussion Syndrome Diseases 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 101800000795 Proadrenomedullin N-20 terminal peptide Proteins 0.000 description 1
- 108010029485 Protein Isoforms Proteins 0.000 description 1
- 102000001708 Protein Isoforms Human genes 0.000 description 1
- 102000000033 Purinergic Receptors Human genes 0.000 description 1
- 108010080192 Purinergic Receptors Proteins 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 206010040026 Sensory disturbance Diseases 0.000 description 1
- 206010040030 Sensory loss Diseases 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 206010041738 Sports injury Diseases 0.000 description 1
- 208000032851 Subarachnoid Hemorrhage Diseases 0.000 description 1
- 208000002667 Subdural Hematoma Diseases 0.000 description 1
- 102100021994 Synapsin-2 Human genes 0.000 description 1
- 101710197509 Synapsin-2 Proteins 0.000 description 1
- 102000004874 Synaptophysin Human genes 0.000 description 1
- 108090001076 Synaptophysin Proteins 0.000 description 1
- 108090000848 Ubiquitin Proteins 0.000 description 1
- 102000044159 Ubiquitin Human genes 0.000 description 1
- 208000003443 Unconsciousness Diseases 0.000 description 1
- 102100035071 Vimentin Human genes 0.000 description 1
- 108010065472 Vimentin Proteins 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000033289 adaptive immune response Effects 0.000 description 1
- 230000004721 adaptive immunity Effects 0.000 description 1
- 108091005764 adaptor proteins Proteins 0.000 description 1
- 102000035181 adaptor proteins Human genes 0.000 description 1
- 230000016571 aggressive behavior Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 210000002565 arteriole Anatomy 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 210000001130 astrocyte Anatomy 0.000 description 1
- 210000004227 basal ganglia Anatomy 0.000 description 1
- 108010005774 beta-Galactosidase Proteins 0.000 description 1
- 102000005936 beta-Galactosidase Human genes 0.000 description 1
- 102000006635 beta-lactamase Human genes 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 229910052793 cadmium Inorganic materials 0.000 description 1
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 1
- 210000005056 cell body Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 208000010353 central nervous system vasculitis Diseases 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000006720 chronic neuroinflammation Effects 0.000 description 1
- 230000001149 cognitive effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011961 computed axial tomography Methods 0.000 description 1
- 230000009514 concussion Effects 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 210000000877 corpus callosum Anatomy 0.000 description 1
- 210000003618 cortical neuron Anatomy 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000000104 diagnostic biomarker Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 101150069842 dlg4 gene Proteins 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 238000001378 electrochemiluminescence detection Methods 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 239000006274 endogenous ligand Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000003492 excitotoxic effect Effects 0.000 description 1
- 231100000063 excitotoxicity Toxicity 0.000 description 1
- 239000006277 exogenous ligand Substances 0.000 description 1
- 210000001808 exosome Anatomy 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 238000002866 fluorescence resonance energy transfer Methods 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 239000012213 gelatinous substance Substances 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000003825 glutamate receptor antagonist Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 102000048187 human NLRP1 Human genes 0.000 description 1
- 208000003906 hydrocephalus Diseases 0.000 description 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000010166 immunofluorescence Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 108091005434 innate immune receptors Proteins 0.000 description 1
- 210000005007 innate immune system Anatomy 0.000 description 1
- 230000004068 intracellular signaling Effects 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 229940057428 lactoperoxidase Drugs 0.000 description 1
- 208000018883 loss of balance Diseases 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000001906 matrix-assisted laser desorption--ionisation mass spectrometry Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 239000002082 metal nanoparticle Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 230000009525 mild injury Effects 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 201000006938 muscular dystrophy Diseases 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 210000000944 nerve tissue Anatomy 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 230000007171 neuropathology Effects 0.000 description 1
- 230000004112 neuroprotection Effects 0.000 description 1
- 239000004090 neuroprotective agent Substances 0.000 description 1
- 231100000189 neurotoxic Toxicity 0.000 description 1
- 230000002887 neurotoxic effect Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 210000000869 occipital lobe Anatomy 0.000 description 1
- 238000006384 oligomerization reaction Methods 0.000 description 1
- 210000004789 organ system Anatomy 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- PIRWNASAJNPKHT-SHZATDIYSA-N pamp Chemical compound C([C@@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)N)C(C)C)C1=CC=CC=C1 PIRWNASAJNPKHT-SHZATDIYSA-N 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000009518 penetrating injury Effects 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 238000010837 poor prognosis Methods 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000007112 pro inflammatory response Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000000092 prognostic biomarker Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 208000019116 sleep disease Diseases 0.000 description 1
- 208000022925 sleep disturbance Diseases 0.000 description 1
- 206010041569 spinal fracture Diseases 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 102000000580 synaptojanin Human genes 0.000 description 1
- 108010016910 synaptojanin Proteins 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 210000001138 tear Anatomy 0.000 description 1
- MPLHNVLQVRSVEE-UHFFFAOYSA-N texas red Chemical compound [O-]S(=O)(=O)C1=CC(S(Cl)(=O)=O)=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MPLHNVLQVRSVEE-UHFFFAOYSA-N 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 238000002627 tracheal intubation Methods 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 239000010981 turquoise Substances 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 210000005048 vimentin Anatomy 0.000 description 1
- 244000052613 viral pathogen Species 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 230000001755 vocal effect Effects 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7095—Inflammation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261595254P | 2012-02-06 | 2012-02-06 | |
| US201261595254P | 2012-02-06 | ||
| PCT/US2013/024941 WO2013119673A1 (en) | 2012-02-06 | 2013-02-06 | Innate immune proteins as biomarkers for cns injury |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2630905T3 true ES2630905T3 (es) | 2017-08-25 |
Family
ID=48947960
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13746979.7T Active ES2630905T3 (es) | 2012-02-06 | 2013-02-06 | Proteínas inmunitarias innatas como biomarcadores para lesiones del SNC |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US20150185232A1 (enExample) |
| EP (1) | EP2812697B1 (enExample) |
| JP (1) | JP6170071B2 (enExample) |
| CA (1) | CA2863417C (enExample) |
| ES (1) | ES2630905T3 (enExample) |
| WO (1) | WO2013119673A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140302532A1 (en) | 2011-04-12 | 2014-10-09 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury |
| GB2548942A (en) * | 2014-04-08 | 2017-10-04 | Univ Florida | Protein biomarkers for acute, subacute and chronic traumatic injuries of the central nervous system |
| US11840565B2 (en) | 2016-12-29 | 2023-12-12 | University Of Miami | Methods and compositions for treating virus-associated inflammation |
| MX2019007916A (es) | 2016-12-29 | 2019-12-05 | Univ Miami | Metodo para modular la actividad de inflamasoma e inflamacion en el pulmon. |
| EP3685169A4 (en) * | 2017-09-20 | 2021-09-08 | University of Miami | PROCESS FOR DETECTION OF INFLAMMASOME PROTEINS AS BIOMARKERS OF NEUROLOGICAL DISORDERS |
| WO2019199871A1 (en) * | 2018-04-10 | 2019-10-17 | Quanterix Corporation | Quantification of neurofilament light chain in physiological samples |
| GB201815045D0 (en) | 2018-09-14 | 2018-10-31 | Univ Ulster | Bispecific antibody targeting IL-1R1 and NLPR3 |
| CN109406795A (zh) * | 2018-11-20 | 2019-03-01 | 昆明医科大学 | 一种轻型脑外伤的血清分子诊断标记物及应用 |
| EP3918336A1 (en) * | 2019-01-31 | 2021-12-08 | University of Geneva | Prospective markers in traumatic brain injury (tbi) |
| WO2021071934A1 (en) * | 2019-10-07 | 2021-04-15 | United States Government As Represented By The Department Of Veterans Affairs | Polymeric methylprednisolone conjugates and uses thereof |
| CA3176521A1 (en) * | 2020-04-27 | 2021-11-04 | University Of Miami | Compositions and methods for treating inflammasome related diseases or conditions |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004022156A2 (en) * | 2002-09-04 | 2004-03-18 | Washington University | Methods for treating central nervous system damage |
| US8685400B2 (en) * | 2007-07-30 | 2014-04-01 | University Of Miami | Modulating inflammasome activity and inflammation in the central nervous system |
| CA2715248A1 (en) * | 2008-02-04 | 2009-08-13 | Banyan Biomarkers, Inc. | Process to diagnose or treat brain injury |
| CN102105054A (zh) * | 2008-07-18 | 2011-06-22 | 氧生物治疗有限公司 | 治疗创伤性脑损伤的方法 |
| US20120177632A1 (en) * | 2011-01-10 | 2012-07-12 | Shinohara Mari L | Methods of optimizing disease treatment |
-
2013
- 2013-02-06 EP EP13746979.7A patent/EP2812697B1/en active Active
- 2013-02-06 US US14/376,383 patent/US20150185232A1/en not_active Abandoned
- 2013-02-06 CA CA2863417A patent/CA2863417C/en active Active
- 2013-02-06 JP JP2014555851A patent/JP6170071B2/ja active Active
- 2013-02-06 WO PCT/US2013/024941 patent/WO2013119673A1/en not_active Ceased
- 2013-02-06 ES ES13746979.7T patent/ES2630905T3/es active Active
-
2016
- 2016-07-20 US US15/214,868 patent/US20170003303A1/en not_active Abandoned
-
2020
- 2020-08-06 US US16/986,904 patent/US20200363432A1/en not_active Abandoned
-
2023
- 2023-07-05 US US18/347,108 patent/US20230349929A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013119673A1 (en) | 2013-08-15 |
| JP6170071B2 (ja) | 2017-07-26 |
| CA2863417A1 (en) | 2013-08-15 |
| EP2812697B1 (en) | 2017-03-22 |
| CA2863417C (en) | 2020-07-28 |
| US20170003303A1 (en) | 2017-01-05 |
| US20150185232A1 (en) | 2015-07-02 |
| US20200363432A1 (en) | 2020-11-19 |
| US20230349929A1 (en) | 2023-11-02 |
| EP2812697A4 (en) | 2015-08-26 |
| JP2015508887A (ja) | 2015-03-23 |
| EP2812697A1 (en) | 2014-12-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2630905T3 (es) | Proteínas inmunitarias innatas como biomarcadores para lesiones del SNC | |
| Hulme et al. | The developing landscape of diagnostic and prognostic biomarkers for spinal cord injury in cerebrospinal fluid and blood | |
| Hong et al. | DJ-1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson’s disease | |
| Wunsch et al. | The enteric nervous system is a potential autoimmune target in multiple sclerosis | |
| WO2011160096A2 (en) | Glial fibrillary acidic protein, autoantigens and autoantibodies thereto as biomarkers of neural injury or neurological disorder or condition | |
| Pradhan et al. | Blood circulatory level of seven sirtuins in Alzheimer’s disease: potent biomarker based on translational research | |
| KR20230125105A (ko) | 신경학적 장애의 바이오마커로서 인플라마솜 단백질의검출 방법 | |
| ES2689753T3 (es) | Fármaco de diagnóstico y método de diagnóstico para la enfermedad de Alzheimer | |
| Wu et al. | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration | |
| Banks et al. | Assessing blood granulocyte colony-stimulating factor as a potential biomarker of acute traumatic brain injury in mice and humans | |
| Stejskal et al. | DETERMINATION OF SERUM VISININ LIKE PROTEIN-1 AND ITS POTENTIAL FOR THE DIAGNOSIS OF BRAIN INJURY DUE TO THE STROKE-A PILOT STUDY. | |
| US20240060995A1 (en) | Innate immune proteins as biomarkers for traumatic brain injury in adult and pediatric patients | |
| Shaker et al. | Serum levels of S100b, interleukin-6 and anti-transglutaminase Ii IgA as immune markers in a sample of Egyptian children with autistic spectrum disorders | |
| Li et al. | CORRELATION BETWEEN NLRP6 INFLAMMASOME AND THE LEVELS OF INFLAMMATORY CYTOKINES IL-1b AND IL-18 IN SERUM OF PATIENTS WITH MENIERE’S DISEASE | |
| WO2023212583A9 (en) | Innate immune proteins as biomarkers for traumatic brain injury in adult and pediatric patients | |
| Ji et al. | Baseline S100B protein as a potential predicator for postoperative cognitive dysfunction in elderly patients after hip joint replacement surgery | |
| Casemore | Biomarkers of Dry Eye Disease | |
| Ozturk et al. | The relationship between serum prolidase activity and histone H3 protein levels and fibromyalgia. | |
| Choi et al. | Enhanced apoptotic activity in allergic diseases and its relationship with eosinophil cationic protein, systemic inflammation, and severity of atopic sensitisation | |
| Ulfa et al. | Serum High Mobility Group Box 1 (HMGB1) Protein Levels and Cognitive Function in Epilepsy Patients: A Cross-Sectional Study | |
| US20200057078A1 (en) | Melanotransferrin for use in the diagnosis of parkinson`s disease | |
| TWI521204B (zh) | 阿茲海默症之分子指標 | |
| Anczykowski et al. | The reference level of serum S-100B protein for poor prognosis in patients with intracranial extracerebral hematoma | |
| WO2022214717A1 (es) | Biomarcador en líquido cefalorraquídeo para enfermedad de alzheimer | |
| Haque | Salivary Huntingtin in Huntington's Disease |