JP6169591B2 - 薬物送達デバイス用薬剤案内アセンブリ - Google Patents
薬物送達デバイス用薬剤案内アセンブリ Download PDFInfo
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- JP6169591B2 JP6169591B2 JP2014541667A JP2014541667A JP6169591B2 JP 6169591 B2 JP6169591 B2 JP 6169591B2 JP 2014541667 A JP2014541667 A JP 2014541667A JP 2014541667 A JP2014541667 A JP 2014541667A JP 6169591 B2 JP6169591 B2 JP 6169591B2
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- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
- B29C66/73—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset
- B29C66/739—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of the parts to be joined being a thermoplastic or a thermoset
- B29C66/7392—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of at least one of the parts being a thermoplastic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
- B29C66/73—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset
- B29C66/739—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of the parts to be joined being a thermoplastic or a thermoset
- B29C66/7392—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of at least one of the parts being a thermoplastic
- B29C66/73921—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of at least one of the parts being a thermoplastic characterised by the materials of both parts being thermoplastics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/80—General aspects of machine operations or constructions and parts thereof
- B29C66/83—General aspects of machine operations or constructions and parts thereof characterised by the movement of the joining or pressing tools
- B29C66/832—Reciprocating joining or pressing tools
- B29C66/8322—Joining or pressing tools reciprocating along one axis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
- B29K2995/0018—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds having particular optical properties, e.g. fluorescent or phosphorescent
- B29K2995/0026—Transparent
- B29K2995/0027—Transparent for light outside the visible spectrum
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
- B29K2995/0037—Other properties
- B29K2995/0056—Biocompatible, e.g. biopolymers or bioelastomers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2031/00—Other particular articles
- B29L2031/753—Medical equipment; Accessories therefor
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/4998—Combined manufacture including applying or shaping of fluent material
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- Mechanical Engineering (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Electromagnetism (AREA)
- Optics & Photonics (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Lining Or Joining Of Plastics Or The Like (AREA)
Description
ここで、一実施形態において、薬学的に活性な化合物は、最大1500Daまでの分子量を有し、および/または、ペプチド、タンパク質、多糖類、ワクチン、DNA、RNA、酵素、抗体もしくはそのフラグメント、ホルモンもしくはオリゴヌクレオチド、または上述の薬学的に活性な化合物の混合物であり、
ここで、さらなる実施形態において、薬学的に活性な化合物は、糖尿病、または糖尿病性網膜症などの糖尿病関連の合併症、深部静脈血栓塞栓症または肺血栓塞栓症などの血栓塞栓症、急性冠症候群(ACS)、狭心症、心筋梗塞、がん、黄斑変性症、炎症、枯草熱、アテローム性動脈硬化症および/または関節リウマチの処置および/または予防に有用であり、
ここで、さらなる実施形態において、薬学的に活性な化合物は、糖尿病または糖尿病性網膜症などの糖尿病に関連する合併症の処置および/または予防のための少なくとも1つのペプチドを含み、
ここで、さらなる実施形態において、薬学的に活性な化合物は、少なくとも1つのヒトインスリンもしくはヒトインスリン類似体もしくは誘導体、グルカゴン様ペプチド(GLP−1)もしくはその類似体もしくは誘導体、またはエキセンジン−3もしくはエキセンジン−4もしくはエキセンジン−3もしくはエキセンジン−4の類似体もしくは誘導体を含む。
H−(Lys)4−desPro36,desPro37エキセンジン−4(1−39)−NH2、
H−(Lys)5−desPro36,desPro37エキセンジン−4(1−39)−NH2、
desPro36エキセンジン−4(1−39)、
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)
、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);または
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
(ここで、基−Lys6−NH2が、エキセンジン−4誘導体のC−末端に結合していてもよい);
desPro36エキセンジン−4(1−39)−Lys6−NH2(AVE0010)、
H−(Lys)6−desPro36[Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desAsp28Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28Pro36,Pro37,Pro38[Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desMet(O)14,Asp28Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2;
desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Lys6−desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28,Pro36,Pro37,Pro38[Met(O)14,Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(S1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
または前述のいずれか1つのエキセンジン−4誘導体の薬学的に許容される塩もしくは溶媒和化合物
から選択される。
12 第1の部材
13 チャネル構造
14 くぼみ
15 インターフェース領域
16 凹部
18 凹部
20 第2の部材
22 表面部
24 表面部
26 接合部材
28 間隙
30 間隙
32 電磁放射
34 圧縮力
36 凹部
38 凹部
50 薬物送達デバイス
52 キャップ
54 ハウジング
56 投薬端
58 インターフェース
60 カートリッジ
62 表示要素
64 ボタン
66 近位端
68 遠位端
Claims (11)
- −少なくとも部分的に薬剤が充填された少なくとも1つのカートリッジ(60)を受けるためのハウジング(54)と、
−所定量の薬剤を投薬するための投薬端(56)と、
−カートリッジ(60)と該投薬端(56)との間に配置され、および少なくとも1つのチャンネル構造(13)を備える流体案内アセンブリであって、該流体案内アセンブリの少なくとも1つのチャネル構造(13)が、該少なくとも1つのカートリッジ(60)と該投薬端(56)との間の流体路に配置される流体案内アセンブリ(10)
とを備えた、出口を介して所定量の薬剤を投薬するように構成された薬物送達デバイスであって、前記流体案内アセンブリは、
−第1の表面部(22)に少なくとも1つの凹部(16、18)を有する第1の部材(12)と、
−該第1の部材(12)の第1の表面部(22)に面した第2の表面部を有して第1の部材と第2の部材(12、20)の間にインターフェース領域(15)を形成する、該第1の部材(12)に隣接して配置された第2の部材(20)と、
−第1および第2の部材(12、20)のインターフェース領域(15)に沿って延び、かつ該第1の部材(12)および/または該第2の部材(20)の少なくとも1つのくぼみ(14)によって形成された少なくとも1つのチャネル構造(13)とを備え、
ここで、少なくとも1つの凹部(16、18)に、該第1および/または第2の部材(12、20)の材料とは異なる材料を含む接合部材(26)が少なくとも部分的に充填され、
第2の部材(20)は、第1の部材(12)の第1の表面部(22)の少なくとも1つの凹部(16、18)に大きさおよび位置が対応する、第2の表面部(24)の凹部(36、38)を備え、
接合部材(26)は、電磁放射(32)の所定のスペクトル領域について、第1および/または第2の部材(12、20)の材料よりも大きい吸収係数を有する、
所定量の薬剤を出口を介して投薬するように構成された薬物送達デバイス。 - 第2の部材(20)は、少なくとも第1の部材(12)のくぼみ(14)にわたって延
びて、閉鎖した流体案内チャネル構造(14)を形成する、請求項1に記載の薬物送達デバイス。 - 第1の表面部(22)に少なくとも1つの凹部(16、18)を有する少なくとも第1の部材(12)と、
該凹部(16、18)を少なくとも部分的に充填し、該第1の部材(12)の該第1の表面部(22)から少なくとも部分的に突出し、該第1の部材(12)の材料とは異なる材料を含んで、該第1の部材(12)を第2の部材(20)に結合するための熱エネルギーを受ける接合部材(26)とを備え、
ここで、接合部材(26)が、第1の部材(12)の第1の表面部分(22)から少なくとも部分的に突出し、かつ接合部材(26)が、電磁放射(32)の所定のスペクトル領域について、第1および/または第2の部材(12、20)の材料よりも大きい吸収係数を有する、請求項1又は2に記載の薬物送達デバイスの流体案内アセンブリを形成するための流体案内プリアセンブリ。 - 薬物送達デバイスは、少なくとも1つのカートリッジ(60)を受けるためのハウジング(54)と、所定量の薬剤を投薬するための投薬端(56)と、流体案内アセンブリを備える請求項1または2に記載の薬物送達デバイスを製造する方法であって、
−第1の表面部(22)に少なくとも1つの凹部(16、18)を有する第1の部材(12)を設ける工程と、
−該第1の部材(12)の該第1の表面部(22)から少なくとも部分的に突出する接合部材(26)を、凹部(16、18)に少なくとも部分的に充填する工程と、
−該第1の部材(12)に隣接する第2の表面部(24)を有する第2の部材(20)を、第1および第2の表面部(22、24)が互いに対向して、該第1の部材と該第2の部材(12、20)の間にインターフェース領域(15)を形成するように配置する工程であって、
−接合部材が、第1および/または第2の部材(12、20)の材料とは異なる材料を含み、
−インターフェース領域(15)に沿って延びる少なくとも1つのチャネル構造(13)が、該第1の部材(12)および/または該第2の部材(20)の少なくとも1つのくぼみ(14)によって形成される工程と、
−流体案内アセンブリ(10)を形成するため熱エネルギーを接合部材(26)に供給して、第1および第2の部材(12、20)を接着する工程と、
−該少なくとも1つのカートリッジ(60)と該投薬端(56)との間の流体路に流体案内アセンブリの少なくとも1つのチャネル構造(13)を配置する工程と
を含む、請求項1または2に記載の薬物送達デバイスを製造する方法。 - 接合部材(26)が、第1の部材(12)の第1の表面部分(22)から少なくとも部分的に突出し、第2の部材(20)は、第1の部材(12)の第1の表面部(22)の少なくとも1つの凹部(16、18)に大きさおよび位置が対応する、第2の表面部(24)の凹部(36、38)を備え、接合部材(26)は、第1および/または第2の部材(12、20)の材料よりも大きい吸収係数を有し、接合部材(26)に電磁放射(32)の所定のスペクトル領域で電磁放射(32)を集中することにより熱エネルギーが電磁放射(32)によって接合部材(26)に供給される、請求項4に記載の方法。
- 第1および第2の部材(12、20)は、接合部材(26)への熱エネルギーの印加中に押し合わされる、請求項4または5に記載の方法。
- 第1および/または第2の表面部(22、24)に垂直な面に平行な方向への接合部材(26)の寸法は、第1および第2の部材(12、20)の互いに対応する凹部(16、
36、18、38)のそれぞれの深さの合計よりも大きい、請求項4〜6のいずれか1項に記載の方法。 - 第2の部材(20)の凹部(36、38)は、第1の部材(12)の凹部(16、18)よりも幅広である、請求項5〜7のいずれか1項に記載の方法。
- 第2の部材(20)の凹部(36、38)は、接合部材(26)の横方向伸長よりも幅広である、請求項5〜8のいずれか1項に記載の方法。
- 接合部材(26)が溶融する時に、接合部材(26)の過剰な材料が、接合部材と第2の部材(20)の凹部(36、38)との間の横方向間隙内へ延びて、間隙を充填する、請求項4〜9のいずれか1項に記載の方法。
- 第1および第2の部材(12、20)の第1および第2の表面(22、24)が直接機械的接触して互いに当接するまで、熱エネルギーが接合部材(26)に供給される、請求項4〜10のいずれか1項に記載の方法。
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EP11189280.8 | 2011-11-16 | ||
EP11189280 | 2011-11-16 | ||
PCT/EP2012/072788 WO2013072439A1 (en) | 2011-11-16 | 2012-11-15 | Medicament guiding assembly for a drug delivery device |
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JP2014533534A JP2014533534A (ja) | 2014-12-15 |
JP6169591B2 true JP6169591B2 (ja) | 2017-07-26 |
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US (1) | US10016562B2 (ja) |
EP (1) | EP2780064A1 (ja) |
JP (1) | JP6169591B2 (ja) |
CN (1) | CN103957965B (ja) |
WO (1) | WO2013072439A1 (ja) |
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US9787345B2 (en) * | 2014-03-31 | 2017-10-10 | Apple Inc. | Laser welding of transparent and opaque materials |
US10200516B2 (en) | 2014-08-28 | 2019-02-05 | Apple Inc. | Interlocking ceramic and optical members |
DE102016212690A1 (de) * | 2016-07-12 | 2018-01-18 | Robert Bosch Gmbh | Verfahren zum Ausbilden einer Laserschweißverbindung und Bauteileverbund |
EP3810234A1 (en) * | 2018-06-22 | 2021-04-28 | Sanofi | Drug delivery device, method for manufacturing a drug delivery device and use of a welded connection |
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IL50650A (en) | 1976-10-10 | 1979-05-31 | Drori Mordeki | Regulated flow-reducing device particularly useful for drip irrigation |
DE4402119C2 (de) * | 1994-01-25 | 1998-07-23 | Karlsruhe Forschzent | Verfahren zur Herstellung von Mikromembranpumpen |
IL121967A (en) | 1997-10-14 | 2001-06-14 | Hydro Plan Eng Ltd | Irrigation output unit |
JP3620316B2 (ja) * | 1998-11-16 | 2005-02-16 | 株式会社日立製作所 | マイクロポンプとその製造方法 |
DE19853773C2 (de) * | 1998-11-21 | 2001-02-22 | Daimler Chrysler Ag | Verfahren zum lösbaren Verbinden von Bauteilen |
JP4485361B2 (ja) * | 2002-08-07 | 2010-06-23 | ザ ペン ステイト リサーチ ファンデーション | ワークピースを製造用固定具に対して結合及び分離させる装置及び方法 |
AU2003901779A0 (en) * | 2003-04-15 | 2003-05-01 | Microtechnology Centre Management Limited | Microfluidic sealing |
US7284966B2 (en) * | 2003-10-01 | 2007-10-23 | Agency For Science, Technology & Research | Micro-pump |
DE102004011667B4 (de) | 2004-03-10 | 2006-03-23 | Technische Fachhochschule Berlin | Vorrichtung mit einem Halbleiterchip und einem mikrofluidischen System und Verfahren zur Herstellung |
US7220245B2 (en) | 2004-05-26 | 2007-05-22 | Kriesel Marshall S | Infusion apparatus |
US8029468B2 (en) * | 2005-02-15 | 2011-10-04 | Bioquiddity, Inc. | Fluid delivery and mixing apparatus with flow rate control |
JP2007276172A (ja) * | 2006-04-03 | 2007-10-25 | Seiko Epson Corp | 液体噴射ヘッド |
WO2009023547A2 (en) * | 2007-08-14 | 2009-02-19 | Arcxis Biotechnologies | Polymer microfluidic biochip fabrication |
SG175102A1 (en) * | 2009-04-30 | 2011-12-29 | Sanofi Aventis Deutschland | Axially adjustable connection of piston rod to piston for drive mechanism of a drug delivery device |
US20100318063A1 (en) | 2009-06-10 | 2010-12-16 | Cleo Cosmetic And Pharmaceuticals Co., Llc | Dual barrel syringe assembly |
JP5447331B2 (ja) * | 2009-12-21 | 2014-03-19 | 株式会社デンソー | 中空体の製造方法、中空体、流量測定装置の製造方法および流量測定装置 |
US20110243813A1 (en) * | 2010-03-30 | 2011-10-06 | Jackinsky Steve W | Diagnostic card with micro-fluidic channels and method of construction thereof |
EP2780062A1 (en) * | 2011-11-16 | 2014-09-24 | Sanofi-Aventis Deutschland GmbH | Medicament guiding assembly for a drug delivery device |
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2012
- 2012-11-15 JP JP2014541667A patent/JP6169591B2/ja not_active Expired - Fee Related
- 2012-11-15 US US14/356,878 patent/US10016562B2/en not_active Expired - Fee Related
- 2012-11-15 EP EP12787723.1A patent/EP2780064A1/en not_active Withdrawn
- 2012-11-15 WO PCT/EP2012/072788 patent/WO2013072439A1/en active Application Filing
- 2012-11-15 CN CN201280056398.XA patent/CN103957965B/zh not_active Expired - Fee Related
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JP2014533534A (ja) | 2014-12-15 |
CN103957965B (zh) | 2016-12-28 |
WO2013072439A1 (en) | 2013-05-23 |
CN103957965A (zh) | 2014-07-30 |
US10016562B2 (en) | 2018-07-10 |
US20140364811A1 (en) | 2014-12-11 |
EP2780064A1 (en) | 2014-09-24 |
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