JP6153470B2 - 糖鎖付加ポリペプチドおよび当該ポリペプチドを含む医薬組成物 - Google Patents

糖鎖付加ポリペプチドおよび当該ポリペプチドを含む医薬組成物 Download PDF

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Publication number
JP6153470B2
JP6153470B2 JP2013536471A JP2013536471A JP6153470B2 JP 6153470 B2 JP6153470 B2 JP 6153470B2 JP 2013536471 A JP2013536471 A JP 2013536471A JP 2013536471 A JP2013536471 A JP 2013536471A JP 6153470 B2 JP6153470 B2 JP 6153470B2
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JP
Japan
Prior art keywords
fmoc
group
glycosylated polypeptide
sugar chain
polypeptide
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Expired - Fee Related
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JP2013536471A
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English (en)
Japanese (ja)
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JPWO2013047846A1 (ja
Inventor
泉 坂本
泉 坂本
一博 深江
一博 深江
克成 手塚
克成 手塚
圭亮 田鶴
圭亮 田鶴
政敏 前田
政敏 前田
康宏 梶原
康宏 梶原
孝 辻
孝 辻
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Glytech Inc
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Glytech Inc
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2013536471A 2011-10-01 2012-09-28 糖鎖付加ポリペプチドおよび当該ポリペプチドを含む医薬組成物 Expired - Fee Related JP6153470B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011218793 2011-10-01
JP2011218793 2011-10-01
PCT/JP2012/075262 WO2013047846A1 (ja) 2011-10-01 2012-09-28 糖鎖付加ポリペプチドおよび当該ポリペプチドを含む医薬組成物

Publications (2)

Publication Number Publication Date
JPWO2013047846A1 JPWO2013047846A1 (ja) 2015-03-30
JP6153470B2 true JP6153470B2 (ja) 2017-06-28

Family

ID=47995870

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013536471A Expired - Fee Related JP6153470B2 (ja) 2011-10-01 2012-09-28 糖鎖付加ポリペプチドおよび当該ポリペプチドを含む医薬組成物

Country Status (16)

Country Link
US (1) US10358470B2 (https=)
EP (1) EP2762489B1 (https=)
JP (1) JP6153470B2 (https=)
KR (1) KR101979045B1 (https=)
CN (2) CN109134642A (https=)
AU (1) AU2012317325B2 (https=)
BR (1) BR112014007766B1 (https=)
CA (1) CA2850469C (https=)
DK (1) DK2762489T3 (https=)
IN (1) IN2014CN02982A (https=)
MY (1) MY168902A (https=)
PH (1) PH12014500694B1 (https=)
RU (1) RU2636456C2 (https=)
SG (2) SG11201401071YA (https=)
TW (1) TWI633115B (https=)
WO (1) WO2013047846A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2762489T3 (en) 2011-10-01 2018-07-02 Glytech Inc GLYCOSYLED POLYPEPTIDE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
SG11201507769SA (en) * 2013-03-29 2015-10-29 Glytech Inc Polypeptide having sialylated sugar chains attached thereto
CN114685645B (zh) * 2020-12-30 2025-03-21 深圳翰宇药业股份有限公司 一种索玛鲁肽的合成方法

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DE19717864C2 (de) 1997-04-23 2001-05-17 Fraunhofer Ges Forschung Humanes rekombinantes Interferon-beta, Verfahren zu seiner Herstellung und seine Verwendung
EE05214B1 (et) * 1998-04-28 2009-10-15 Applied Research Systems ARS Holding N.V. Polool-IFN- β konjugaat, selle valmistamismeetod ja farmatseutiline kompositsioon
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BR0208041A (pt) 2001-03-15 2004-02-25 Merck Patent Gmbh Interferon beta modificado com imunogenicidade reduzida
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Also Published As

Publication number Publication date
CA2850469A1 (en) 2013-04-04
DK2762489T3 (en) 2018-07-02
TW201321404A (zh) 2013-06-01
SG11201401071YA (en) 2014-08-28
CN104080803A (zh) 2014-10-01
TWI633115B (zh) 2018-08-21
AU2012317325B2 (en) 2016-10-06
AU2012317325A1 (en) 2014-04-17
BR112014007766A2 (pt) 2017-04-04
EP2762489B1 (en) 2018-03-28
IN2014CN02982A (https=) 2015-07-03
SG10201602076QA (en) 2016-04-28
CA2850469C (en) 2020-07-07
PH12014500694A1 (en) 2014-05-12
MY168902A (en) 2018-12-04
EP2762489A9 (en) 2015-02-11
KR101979045B1 (ko) 2019-05-15
PH12014500694B1 (en) 2020-01-31
RU2636456C2 (ru) 2017-11-23
EP2762489A1 (en) 2014-08-06
WO2013047846A1 (ja) 2013-04-04
CN104080803B (zh) 2020-08-04
US20140369964A1 (en) 2014-12-18
KR20140095051A (ko) 2014-07-31
JPWO2013047846A1 (ja) 2015-03-30
RU2014116550A (ru) 2015-10-27
US10358470B2 (en) 2019-07-23
EP2762489A4 (en) 2015-05-06
BR112014007766B1 (pt) 2022-05-10
CN109134642A (zh) 2019-01-04

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