CN109134642A - 加成糖链的多肽及含有该多肽的医药组合物 - Google Patents

加成糖链的多肽及含有该多肽的医药组合物 Download PDF

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Publication number
CN109134642A
CN109134642A CN201811042210.1A CN201811042210A CN109134642A CN 109134642 A CN109134642 A CN 109134642A CN 201811042210 A CN201811042210 A CN 201811042210A CN 109134642 A CN109134642 A CN 109134642A
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Prior art keywords
sugar chain
polypeptide
addition
fmoc
amino acid
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CN201811042210.1A
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English (en)
Chinese (zh)
Inventor
坂本泉
深江博
深江一博
手塚克成
田鹤圭亮
前田政敏
梶原康宏
辻孝
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Sugar Lock Engineering Institute Co Ltd
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Sugar Lock Engineering Institute Co Ltd
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Publication of CN109134642A publication Critical patent/CN109134642A/zh
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
    • C07K14/565IFN-beta
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • A61K38/215IFN-beta
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201811042210.1A 2011-10-01 2012-09-28 加成糖链的多肽及含有该多肽的医药组合物 Pending CN109134642A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011-218793 2011-10-01
JP2011218793 2011-10-01
CN201280058952.8A CN104080803B (zh) 2011-10-01 2012-09-28 加成糖链的多肽及含有该多肽的医药组合物

Related Parent Applications (1)

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CN201280058952.8A Division CN104080803B (zh) 2011-10-01 2012-09-28 加成糖链的多肽及含有该多肽的医药组合物

Publications (1)

Publication Number Publication Date
CN109134642A true CN109134642A (zh) 2019-01-04

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CN201811042210.1A Pending CN109134642A (zh) 2011-10-01 2012-09-28 加成糖链的多肽及含有该多肽的医药组合物
CN201280058952.8A Expired - Fee Related CN104080803B (zh) 2011-10-01 2012-09-28 加成糖链的多肽及含有该多肽的医药组合物

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Country Status (16)

Country Link
US (1) US10358470B2 (https=)
EP (1) EP2762489B1 (https=)
JP (1) JP6153470B2 (https=)
KR (1) KR101979045B1 (https=)
CN (2) CN109134642A (https=)
AU (1) AU2012317325B2 (https=)
BR (1) BR112014007766B1 (https=)
CA (1) CA2850469C (https=)
DK (1) DK2762489T3 (https=)
IN (1) IN2014CN02982A (https=)
MY (1) MY168902A (https=)
PH (1) PH12014500694B1 (https=)
RU (1) RU2636456C2 (https=)
SG (2) SG11201401071YA (https=)
TW (1) TWI633115B (https=)
WO (1) WO2013047846A1 (https=)

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DK2762489T3 (en) 2011-10-01 2018-07-02 Glytech Inc GLYCOSYLED POLYPEPTIDE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
SG11201507769SA (en) * 2013-03-29 2015-10-29 Glytech Inc Polypeptide having sialylated sugar chains attached thereto
CN114685645B (zh) * 2020-12-30 2025-03-21 深圳翰宇药业股份有限公司 一种索玛鲁肽的合成方法

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Publication number Publication date
CA2850469A1 (en) 2013-04-04
DK2762489T3 (en) 2018-07-02
TW201321404A (zh) 2013-06-01
SG11201401071YA (en) 2014-08-28
CN104080803A (zh) 2014-10-01
TWI633115B (zh) 2018-08-21
AU2012317325B2 (en) 2016-10-06
AU2012317325A1 (en) 2014-04-17
BR112014007766A2 (pt) 2017-04-04
EP2762489B1 (en) 2018-03-28
IN2014CN02982A (https=) 2015-07-03
SG10201602076QA (en) 2016-04-28
CA2850469C (en) 2020-07-07
PH12014500694A1 (en) 2014-05-12
MY168902A (en) 2018-12-04
EP2762489A9 (en) 2015-02-11
KR101979045B1 (ko) 2019-05-15
PH12014500694B1 (en) 2020-01-31
RU2636456C2 (ru) 2017-11-23
EP2762489A1 (en) 2014-08-06
WO2013047846A1 (ja) 2013-04-04
CN104080803B (zh) 2020-08-04
US20140369964A1 (en) 2014-12-18
KR20140095051A (ko) 2014-07-31
JPWO2013047846A1 (ja) 2015-03-30
RU2014116550A (ru) 2015-10-27
US10358470B2 (en) 2019-07-23
JP6153470B2 (ja) 2017-06-28
EP2762489A4 (en) 2015-05-06
BR112014007766B1 (pt) 2022-05-10

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Application publication date: 20190104