JP6122858B2 - 苦味を調整する化合物を同定するための検定 - Google Patents

苦味を調整する化合物を同定するための検定 Download PDF

Info

Publication number
JP6122858B2
JP6122858B2 JP2014537371A JP2014537371A JP6122858B2 JP 6122858 B2 JP6122858 B2 JP 6122858B2 JP 2014537371 A JP2014537371 A JP 2014537371A JP 2014537371 A JP2014537371 A JP 2014537371A JP 6122858 B2 JP6122858 B2 JP 6122858B2
Authority
JP
Japan
Prior art keywords
bitter taste
cell
bitter
tas2r9
tas2r13
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2014537371A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014530628A (ja
Inventor
シェクダー，カムビズ
シャー，パービ，マノジュ
ガネット，ジョセフ
リーランド，ジェーン，ブイ．
ブラウン，ピーター，エイチ．
スレイド，ルイーズ
Original Assignee
クロモセル コーポレーション
クロモセル コーポレーション
クラフト・フーズ・グループ・ブランズ・エルエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by クロモセル コーポレーション, クロモセル コーポレーション, クラフト・フーズ・グループ・ブランズ・エルエルシー filed Critical クロモセル コーポレーション
Publication of JP2014530628A publication Critical patent/JP2014530628A/ja
Application granted granted Critical
Publication of JP6122858B2 publication Critical patent/JP6122858B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Seasonings (AREA)
JP2014537371A 2011-10-20 2012-10-22 苦味を調整する化合物を同定するための検定 Active JP6122858B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161549693P 2011-10-20 2011-10-20
US61/549,693 2011-10-20
PCT/US2012/061400 WO2013059836A1 (en) 2011-10-20 2012-10-22 Assays for identifying compounds that modulate bitter taste

Publications (2)

Publication Number Publication Date
JP2014530628A JP2014530628A (ja) 2014-11-20
JP6122858B2 true JP6122858B2 (ja) 2017-04-26

Family

ID=48141484

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014537371A Active JP6122858B2 (ja) 2011-10-20 2012-10-22 苦味を調整する化合物を同定するための検定

Country Status (7)

Country Link
US (2) US9347934B2 (enExample)
EP (1) EP2769216B1 (enExample)
JP (1) JP6122858B2 (enExample)
CN (1) CN103998933B (enExample)
IN (1) IN2014MN00714A (enExample)
SG (1) SG11201401268RA (enExample)
WO (1) WO2013059836A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9927424B2 (en) 2013-04-24 2018-03-27 Chromocell Corporation Assays for identifying compounds that modulate bitter taste
WO2017019890A1 (en) * 2015-07-28 2017-02-02 Mars, Incorporated Screening methods using canine t2r receptors and pet food products and compositions identified using the same
CN112442107B (zh) * 2020-11-18 2023-05-09 渤海大学 一种苦味抑制肽及其应用
EP4298209A1 (en) * 2021-05-07 2024-01-03 Firmenich Incorporated Cells expressing bitter taste receptors and uses thereof

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL118460A (en) * 1996-05-28 1999-09-22 Dead Sea Works Ltd Edible salt mixture
JP2002533693A (ja) 1998-12-23 2002-10-08 マウント シナイ スクール オブ メディシン オブ ニューヨーク ユニバーシティー 苦味応答のインヒビター
US6692965B1 (en) 1999-11-23 2004-02-17 Chromocell Corporation Isolation of living cells and preparation of cell lines based on detection and quantification of preselected cellular ribonucleic acid sequences
CN1341632A (zh) * 2000-09-05 2002-03-27 上海博德基因开发有限公司 一种新的多肽——人味觉感受器蛋白t2r6－17.05和编码这种多肽的多核苷酸
US7883856B2 (en) 2001-04-05 2011-02-08 Senomyx Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
US8030008B2 (en) * 2001-04-05 2011-10-04 Senomyx, Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
EP2270155A3 (en) 2002-09-25 2011-08-10 Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke Bitter taste receptors
ATE540128T1 (de) 2004-02-18 2012-01-15 Chromocell Corp Verfahren und materialien unter anwendung von signalsonden
EP1815015B1 (en) 2004-11-18 2012-05-23 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke Stiftung des Öffentlichen Rechts Agonists of bitter taste receptors and uses thereof
CA2612561A1 (en) 2005-06-22 2007-01-04 Senomyx, Inc. Identification of human t2r recepors that are activated by bitter molecules in coffee (chlorogenic lactones) and related assays for identifying human bitter taste modulators
US7923047B2 (en) * 2006-06-30 2011-04-12 Conagra Foods Rdm, Inc. Seasoning and method for seasoning a food product while reducing dietary sodium intake
US20080167286A1 (en) * 2006-12-12 2008-07-10 Abbott Laboratories Pharmaceutical compositions and their methods of use
WO2008119196A1 (en) 2007-03-30 2008-10-09 Givaudan Sa Off-note blocking sensory organic compounds
CN101652342B (zh) 2007-03-30 2014-01-29 奇华顿股份有限公司 遮蔽不适感感觉的有机化合物
US8187822B2 (en) * 2007-03-30 2012-05-29 Givaudan S.A. Methods to identify modulators
EP1983342A1 (en) * 2007-04-18 2008-10-22 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand Antogonists of bitter taste receptors and uses thereof
US20100311786A1 (en) 2007-07-30 2010-12-09 Givaudan Sa Mono- or bicyclic carboxylic acids as off-note blockers
CN101828111B (zh) * 2007-08-21 2014-07-23 塞诺米克斯公司 人t2r苦味受体及其用途
AU2009215106B2 (en) 2008-02-01 2015-07-23 Chromocell Corporation Cell lines and methods for making and using them
US8546085B2 (en) * 2008-06-13 2013-10-01 Givaudan Sa Methods of identifying modulators of the bitter taste receptor TAS2R44
WO2010015097A1 (en) * 2008-08-07 2010-02-11 Givaudan Sa Methods to identify modulators of the interaction between dextromethorphan and the bitter taste receptor tas2r46
KR101751074B1 (ko) 2009-02-02 2017-06-26 크로모셀 코포레이션 신규한 세포주와 방법
WO2010099983A1 (en) * 2009-03-06 2010-09-10 Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke Methods for isolating agonists and antagonists of taste receptors
US20130040317A1 (en) 2011-08-08 2013-02-14 The University Of North Carolina At Chapel Hill Cell lines comprising endogenous taste receptors and their uses

Also Published As

Publication number Publication date
US20160299127A1 (en) 2016-10-13
US20140248639A1 (en) 2014-09-04
EP2769216A1 (en) 2014-08-27
CN103998933B (zh) 2016-12-14
EP2769216A4 (en) 2015-05-13
CN103998933A (zh) 2014-08-20
JP2014530628A (ja) 2014-11-20
WO2013059836A1 (en) 2013-04-25
IN2014MN00714A (enExample) 2015-07-03
SG11201401268RA (en) 2014-05-29
US9347934B2 (en) 2016-05-24
EP2769216B1 (en) 2017-01-04

Similar Documents

Publication Publication Date Title
Ahmad et al. G protein-coupled receptors in taste physiology and pharmacology
JP7018000B2 (ja) 甘味増強に関する方法
CN105358983B (zh) 用于鉴定调节苦味的化合物的测定
US8168403B2 (en) Agonists of bitter taste receptors and uses thereof
KR101440639B1 (ko) 핵산, 폴리펩타이드 및 이의 용도
JP5465656B2 (ja) 調節物質を同定するための方法
Yang et al. Current progress in understanding the structure and function of sweet taste receptor
US8709745B2 (en) Methods for isolating ligands of the human bitter taste receptor TAS2R49
JP2009533065A (ja) 味覚物質同定のための機能的方法
JP6122858B2 (ja) 苦味を調整する化合物を同定するための検定
WO2021150686A1 (en) High-sensitivity detection of gpcr activity and uses thereof
WO2008128730A2 (en) Antagonists of bitter taste receptors and uses thereof
JP2009544330A (ja) Ｒｇｓ２１活性の調節物質を同定するための方法、ｒｇｓ２１調節物質を含む組成物、および味覚を調節するためのその使用方法
JP2009534017A (ja) 核酸、ポリペプチドおよびその利用
KR101511394B1 (ko) 키메라 우마미 미각 수용체, 이를 코딩하는 핵산 및 이의 용도
Xia Probing the ligand binding pocket within the transmembrane domain of human T1R3

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140618

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140617

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20151020

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20160615

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160621

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20160920

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20161118

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20161220

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20170307

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20170403

R150 Certificate of patent or registration of utility model

Ref document number: 6122858

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150