JP6122858B2 - 苦味を調整する化合物を同定するための検定 - Google Patents

苦味を調整する化合物を同定するための検定 Download PDF

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JP6122858B2
JP6122858B2 JP2014537371A JP2014537371A JP6122858B2 JP 6122858 B2 JP6122858 B2 JP 6122858B2 JP 2014537371 A JP2014537371 A JP 2014537371A JP 2014537371 A JP2014537371 A JP 2014537371A JP 6122858 B2 JP6122858 B2 JP 6122858B2
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bitter taste
cell
bitter
tas2r9
tas2r13
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JP2014530628A (ja
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シェクダー，カムビズ
シャー，パービ，マノジュ
ガネット，ジョセフ
リーランド，ジェーン，ブイ．
ブラウン，ピーター，エイチ．
スレイド，ルイーズ
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クロモセル コーポレーション
クロモセル コーポレーション
クラフト・フーズ・グループ・ブランズ・エルエルシー
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Seasonings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2014537371A 2011-10-20 2012-10-22 苦味を調整する化合物を同定するための検定 Active JP6122858B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161549693P 2011-10-20 2011-10-20
US61/549,693 2011-10-20
PCT/US2012/061400 WO2013059836A1 (en) 2011-10-20 2012-10-22 Assays for identifying compounds that modulate bitter taste

Publications (2)

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JP2014530628A JP2014530628A (ja) 2014-11-20
JP6122858B2 true JP6122858B2 (ja) 2017-04-26

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US (2) US9347934B2 (enExample)
EP (1) EP2769216B1 (enExample)
JP (1) JP6122858B2 (enExample)
CN (1) CN103998933B (enExample)
IN (1) IN2014MN00714A (enExample)
SG (1) SG11201401268RA (enExample)
WO (1) WO2013059836A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014257086A1 (en) 2013-04-24 2015-11-12 Chromocell Corporation Assays for identifying compounds that modulate bitter taste
WO2017019890A1 (en) * 2015-07-28 2017-02-02 Mars, Incorporated Screening methods using canine t2r receptors and pet food products and compositions identified using the same
CN112442107B (zh) * 2020-11-18 2023-05-09 渤海大学 一种苦味抑制肽及其应用
EP4298209A1 (en) * 2021-05-07 2024-01-03 Firmenich Incorporated Cells expressing bitter taste receptors and uses thereof

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL118460A (en) 1996-05-28 1999-09-22 Dead Sea Works Ltd Edible salt mixture
EP1139793B1 (en) * 1998-12-23 2009-10-14 Mount Sinai School of Medicine of New York University Inhibitors of the bitter taste response
US6692965B1 (en) 1999-11-23 2004-02-17 Chromocell Corporation Isolation of living cells and preparation of cell lines based on detection and quantification of preselected cellular ribonucleic acid sequences
CN1341632A (zh) 2000-09-05 2002-03-27 上海博德基因开发有限公司 一种新的多肽——人味觉感受器蛋白t2r6－17.05和编码这种多肽的多核苷酸
US7883856B2 (en) 2001-04-05 2011-02-08 Senomyx Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
US8030008B2 (en) 2001-04-05 2011-10-04 Senomyx, Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
EP2270156A3 (en) 2002-09-25 2011-08-10 Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke Bitter taste receptors
KR20100063144A (ko) 2004-02-18 2010-06-10 크로모셀 코포레이션 신호 프로브를 이용하는 방법 및 물질
WO2006053771A2 (en) 2004-11-18 2006-05-26 Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke Stiftung Des Öffentlichen Rechts Agonists of bitter taste receptors and uses thereof
AU2006262399A1 (en) 2005-06-22 2007-01-04 Senomyx, Inc. Identification of human T2R recepors that are activated by bitter molecules in coffee (chlorogenic lactones) and related assays for identifying human bitter taste modulators
US7923047B2 (en) * 2006-06-30 2011-04-12 Conagra Foods Rdm, Inc. Seasoning and method for seasoning a food product while reducing dietary sodium intake
US20080167286A1 (en) * 2006-12-12 2008-07-10 Abbott Laboratories Pharmaceutical compositions and their methods of use
BRPI0809856B1 (pt) 2007-03-30 2016-08-23 Givaudan Sa composto de bloqueio de nota desagradável (off-note) amarga, composição de sabor, produto consumível e método de bloqueio de notas desagradáveis em produtos consumíveis
JP5465656B2 (ja) * 2007-03-30 2014-04-09 ジボダン エス エー 調節物質を同定するための方法
CN101652342B (zh) 2007-03-30 2014-01-29 奇华顿股份有限公司 遮蔽不适感感觉的有机化合物
EP1983342A1 (en) 2007-04-18 2008-10-22 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand Antogonists of bitter taste receptors and uses thereof
US20100311786A1 (en) 2007-07-30 2010-12-09 Givaudan Sa Mono- or bicyclic carboxylic acids as off-note blockers
RU2522456C2 (ru) 2007-08-21 2014-07-10 Синомикс, Инк. Соединения, ингибирующие (блокирующие) горький вкус, способы их применения и получения
WO2009102569A2 (en) 2008-02-01 2009-08-20 Chromocell Corporation Novel cell lines and methods
US8546085B2 (en) * 2008-06-13 2013-10-01 Givaudan Sa Methods of identifying modulators of the bitter taste receptor TAS2R44
EP2329263A1 (en) * 2008-08-07 2011-06-08 Givaudan SA Methods to identify modulators of the interaction between dextromethorphan and the bitter taste receptor tas2r46
CN102369275A (zh) 2009-02-02 2012-03-07 卓莫赛尔公司 新型细胞系和方法
EP2404172A1 (en) 2009-03-06 2012-01-11 Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke Methods for isolating agonists and antagonists of taste receptors
WO2013022947A1 (en) 2011-08-08 2013-02-14 The Coca-Cola Company Cell lines comprising endogenous taste receptors and their uses

Also Published As

Publication number Publication date
SG11201401268RA (en) 2014-05-29
US9347934B2 (en) 2016-05-24
EP2769216A4 (en) 2015-05-13
WO2013059836A1 (en) 2013-04-25
JP2014530628A (ja) 2014-11-20
CN103998933A (zh) 2014-08-20
IN2014MN00714A (enExample) 2015-07-03
US20160299127A1 (en) 2016-10-13
EP2769216B1 (en) 2017-01-04
EP2769216A1 (en) 2014-08-27
CN103998933B (zh) 2016-12-14
US20140248639A1 (en) 2014-09-04

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