CN103998933B - 鉴定调节苦味的化合物的测定 - Google Patents

鉴定调节苦味的化合物的测定 Download PDF

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Publication number
CN103998933B
CN103998933B CN201280062863.0A CN201280062863A CN103998933B CN 103998933 B CN103998933 B CN 103998933B CN 201280062863 A CN201280062863 A CN 201280062863A CN 103998933 B CN103998933 B CN 103998933B
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Prior art keywords
bitter taste
seq
tas2r44
tas2r14
tas2r9
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Expired - Fee Related
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CN201280062863.0A
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English (en)
Chinese (zh)
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CN103998933A (zh
Inventor
K·夏柯达
P·M·沙阿
J·古奈特
J·V·里兰
P·H·布朗
L·斯雷德
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Chromocell Corp
Intercontinental Great Brands LLC
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Chromocell Corp
Kraft Foods Global Brands LLC
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Seasonings (AREA)
CN201280062863.0A 2011-10-20 2012-10-22 鉴定调节苦味的化合物的测定 Expired - Fee Related CN103998933B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161549693P 2011-10-20 2011-10-20
US61/549,693 2011-10-20
PCT/US2012/061400 WO2013059836A1 (en) 2011-10-20 2012-10-22 Assays for identifying compounds that modulate bitter taste

Publications (2)

Publication Number Publication Date
CN103998933A CN103998933A (zh) 2014-08-20
CN103998933B true CN103998933B (zh) 2016-12-14

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US (2) US9347934B2 (enExample)
EP (1) EP2769216B1 (enExample)
JP (1) JP6122858B2 (enExample)
CN (1) CN103998933B (enExample)
IN (1) IN2014MN00714A (enExample)
SG (1) SG11201401268RA (enExample)
WO (1) WO2013059836A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9927424B2 (en) 2013-04-24 2018-03-27 Chromocell Corporation Assays for identifying compounds that modulate bitter taste
WO2017019890A1 (en) * 2015-07-28 2017-02-02 Mars, Incorporated Screening methods using canine t2r receptors and pet food products and compositions identified using the same
CN112442107B (zh) * 2020-11-18 2023-05-09 渤海大学 一种苦味抑制肽及其应用
EP4298209A1 (en) * 2021-05-07 2024-01-03 Firmenich Incorporated Cells expressing bitter taste receptors and uses thereof

Citations (5)

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US5853792A (en) * 1996-05-28 1998-12-29 Dead Sea Works Ltd Low sodium edible salt composition and process for its preparation
CN1341632A (zh) * 2000-09-05 2002-03-27 上海博德基因开发有限公司 一种新的多肽——人味觉感受器蛋白t2r6－17.05和编码这种多肽的多核苷酸
CN101583717A (zh) * 2006-11-01 2009-11-18 塞诺米克斯公司 特异性活化人t2r受体的苦味配体的鉴别和用于鉴别人苦味调节剂的相关测定
WO2010088633A2 (en) * 2009-02-02 2010-08-05 Chromocell Corporation Novel cell lines and methods
CN101828111A (zh) * 2007-08-21 2010-09-08 塞诺米克斯公司 人t2r苦味受体及其用途

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JP2002533693A (ja) 1998-12-23 2002-10-08 マウント シナイ スクール オブ メディシン オブ ニューヨーク ユニバーシティー 苦味応答のインヒビター
US6692965B1 (en) 1999-11-23 2004-02-17 Chromocell Corporation Isolation of living cells and preparation of cell lines based on detection and quantification of preselected cellular ribonucleic acid sequences
US7883856B2 (en) 2001-04-05 2011-02-08 Senomyx Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
EP2270155A3 (en) 2002-09-25 2011-08-10 Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke Bitter taste receptors
ATE540128T1 (de) 2004-02-18 2012-01-15 Chromocell Corp Verfahren und materialien unter anwendung von signalsonden
EP1815015B1 (en) 2004-11-18 2012-05-23 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke Stiftung des Öffentlichen Rechts Agonists of bitter taste receptors and uses thereof
CA2612561A1 (en) 2005-06-22 2007-01-04 Senomyx, Inc. Identification of human t2r recepors that are activated by bitter molecules in coffee (chlorogenic lactones) and related assays for identifying human bitter taste modulators
US7923047B2 (en) * 2006-06-30 2011-04-12 Conagra Foods Rdm, Inc. Seasoning and method for seasoning a food product while reducing dietary sodium intake
US20080167286A1 (en) * 2006-12-12 2008-07-10 Abbott Laboratories Pharmaceutical compositions and their methods of use
WO2008119196A1 (en) 2007-03-30 2008-10-09 Givaudan Sa Off-note blocking sensory organic compounds
CN101652342B (zh) 2007-03-30 2014-01-29 奇华顿股份有限公司 遮蔽不适感感觉的有机化合物
US8187822B2 (en) * 2007-03-30 2012-05-29 Givaudan S.A. Methods to identify modulators
EP1983342A1 (en) * 2007-04-18 2008-10-22 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand Antogonists of bitter taste receptors and uses thereof
US20100311786A1 (en) 2007-07-30 2010-12-09 Givaudan Sa Mono- or bicyclic carboxylic acids as off-note blockers
AU2009215106B2 (en) 2008-02-01 2015-07-23 Chromocell Corporation Cell lines and methods for making and using them
US8546085B2 (en) * 2008-06-13 2013-10-01 Givaudan Sa Methods of identifying modulators of the bitter taste receptor TAS2R44
WO2010015097A1 (en) * 2008-08-07 2010-02-11 Givaudan Sa Methods to identify modulators of the interaction between dextromethorphan and the bitter taste receptor tas2r46
WO2010099983A1 (en) * 2009-03-06 2010-09-10 Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke Methods for isolating agonists and antagonists of taste receptors
US20130040317A1 (en) 2011-08-08 2013-02-14 The University Of North Carolina At Chapel Hill Cell lines comprising endogenous taste receptors and their uses

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5853792A (en) * 1996-05-28 1998-12-29 Dead Sea Works Ltd Low sodium edible salt composition and process for its preparation
CN1341632A (zh) * 2000-09-05 2002-03-27 上海博德基因开发有限公司 一种新的多肽——人味觉感受器蛋白t2r6－17.05和编码这种多肽的多核苷酸
CN101583717A (zh) * 2006-11-01 2009-11-18 塞诺米克斯公司 特异性活化人t2r受体的苦味配体的鉴别和用于鉴别人苦味调节剂的相关测定
CN101828111A (zh) * 2007-08-21 2010-09-08 塞诺米克斯公司 人t2r苦味受体及其用途
WO2010088633A2 (en) * 2009-02-02 2010-08-05 Chromocell Corporation Novel cell lines and methods

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Modulation of Bitter Taste Perception by a Small Molecule hTAS2R Antagonist;Jay P. Slack 等;《Current Biology》;20100527;第20卷(第12期);第1104-1109页 *

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US20160299127A1 (en) 2016-10-13
US20140248639A1 (en) 2014-09-04
EP2769216A1 (en) 2014-08-27
EP2769216A4 (en) 2015-05-13
CN103998933A (zh) 2014-08-20
JP2014530628A (ja) 2014-11-20
WO2013059836A1 (en) 2013-04-25
IN2014MN00714A (enExample) 2015-07-03
JP6122858B2 (ja) 2017-04-26
SG11201401268RA (en) 2014-05-29
US9347934B2 (en) 2016-05-24
EP2769216B1 (en) 2017-01-04

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