IN2014MN00714A - - Google Patents

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Publication number
IN2014MN00714A
IN2014MN00714A IN714MUN2014A IN2014MN00714A IN 2014MN00714 A IN2014MN00714 A IN 2014MN00714A IN 714MUN2014 A IN714MUN2014 A IN 714MUN2014A IN 2014MN00714 A IN2014MN00714 A IN 2014MN00714A
Authority
IN
India
Prior art keywords
agonists
present
bitter taste
identifying compounds
provides methods
Prior art date
Application number
Inventor
Kambiz Shekdar
Purvi Manoj Shah
Joseph Gunnet
Jane V Leland
Peter H Brown
Louise Slade
Original Assignee
Chromocell Corp
Kraft Foods Group Brands Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chromocell Corp, Kraft Foods Group Brands Llc filed Critical Chromocell Corp
Publication of IN2014MN00714A publication Critical patent/IN2014MN00714A/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Seasonings (AREA)

Abstract

The present invention is based on applicants discovery disclosed herein of agonists for the TAS2R receptors TAS2R1 TAS2R4 TAS2R9 TAS2R13 TAS2R14 TAS2R16 TAS2R44 TAS2R46 and TAS2R60. The assignment of agonists to these receptors makes assays for identifying compounds that modulate bitter taste possible. For example the present invention provides methods of identifying compounds that inhibit the bitter taste due to these agonists. The present invention also provides methods of identifying compounds that selectively inhibit the bitter taste due to these agonists. The present invention further provides methods of identifying compounds that mimic the bitter taste due these agonists. The present invention also provides methods of identifying compounds that enhance the bitter taste due to these agonists.
IN714MUN2014 2011-10-20 2012-10-22 IN2014MN00714A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161549693P 2011-10-20 2011-10-20
PCT/US2012/061400 WO2013059836A1 (en) 2011-10-20 2012-10-22 Assays for identifying compounds that modulate bitter taste

Publications (1)

Publication Number Publication Date
IN2014MN00714A true IN2014MN00714A (en) 2015-07-03

Family

ID=48141484

Family Applications (1)

Application Number Title Priority Date Filing Date
IN714MUN2014 IN2014MN00714A (en) 2011-10-20 2012-10-22

Country Status (7)

Country Link
US (2) US9347934B2 (en)
EP (1) EP2769216B1 (en)
JP (1) JP6122858B2 (en)
CN (1) CN103998933B (en)
IN (1) IN2014MN00714A (en)
SG (1) SG11201401268RA (en)
WO (1) WO2013059836A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015026901A2 (en) * 2013-04-24 2017-11-14 Chromocell Corp Assays to identify compounds that modulate bitter taste
WO2017019890A1 (en) * 2015-07-28 2017-02-02 Mars, Incorporated Screening methods using canine t2r receptors and pet food products and compositions identified using the same
CN112442107B (en) * 2020-11-18 2023-05-09 渤海大学 Bitter suppressing peptide and application thereof

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL118460A (en) * 1996-05-28 1999-09-22 Dead Sea Works Ltd Edible salt mixture
WO2000038536A2 (en) * 1998-12-23 2000-07-06 Mount Sinai School Of Medicine Of New York University Inhibitors of the bitter taste response
US6692965B1 (en) 1999-11-23 2004-02-17 Chromocell Corporation Isolation of living cells and preparation of cell lines based on detection and quantification of preselected cellular ribonucleic acid sequences
CN1341632A (en) * 2000-09-05 2002-03-27 上海博德基因开发有限公司 A novel polypeptide-human gustatory receptor protein T2R6-17.05 and polynucleotide for coding polypeptide
US8030008B2 (en) * 2001-04-05 2011-10-04 Senomyx, Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
US7883856B2 (en) * 2001-04-05 2011-02-08 Senomyx Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
EP2270153A3 (en) 2002-09-25 2011-08-10 Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke Bitter taste receptors
JP2007522818A (en) 2004-02-18 2007-08-16 クロモセル コーポレイション Methods and materials using signaling probes
WO2006053771A2 (en) 2004-11-18 2006-05-26 Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke Stiftung Des Öffentlichen Rechts Agonists of bitter taste receptors and uses thereof
CA2612561A1 (en) 2005-06-22 2007-01-04 Senomyx, Inc. Identification of human t2r recepors that are activated by bitter molecules in coffee (chlorogenic lactones) and related assays for identifying human bitter taste modulators
US7923047B2 (en) * 2006-06-30 2011-04-12 Conagra Foods Rdm, Inc. Seasoning and method for seasoning a food product while reducing dietary sodium intake
US20080167286A1 (en) * 2006-12-12 2008-07-10 Abbott Laboratories Pharmaceutical compositions and their methods of use
BRPI0809856B1 (en) 2007-03-30 2016-08-23 Givaudan Sa bitter off-note blocking compound, flavor composition, consumable and consumable banknote locking method
CN101652342B (en) 2007-03-30 2014-01-29 奇华顿股份有限公司 Off-note blocking sensory organic compounds
EP2137322B1 (en) * 2007-03-30 2013-02-27 Givaudan SA Methods to identify tas2r modulators
EP1983342A1 (en) * 2007-04-18 2008-10-22 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand Antogonists of bitter taste receptors and uses thereof
US20100311786A1 (en) 2007-07-30 2010-12-09 Givaudan Sa Mono- or bicyclic carboxylic acids as off-note blockers
CZ2010180A3 (en) * 2007-08-21 2010-10-13 Senomyx, Inc Identification of human T2R receptors, which react to bitter compounds producing bitter taste in compositions, and their use in assays for the identification of compounds that inhibit (block) bitter taste of compositions as well as their use
US20110003711A1 (en) 2008-02-01 2011-01-06 Chromocell Corporation Cell lines expressing gaba receptor and methods using them
US8546085B2 (en) * 2008-06-13 2013-10-01 Givaudan Sa Methods of identifying modulators of the bitter taste receptor TAS2R44
WO2010015097A1 (en) * 2008-08-07 2010-02-11 Givaudan Sa Methods to identify modulators of the interaction between dextromethorphan and the bitter taste receptor tas2r46
EP2924112A1 (en) 2009-02-02 2015-09-30 Chromocell Corporation Novel cell lines and methods
EP2404172A1 (en) * 2009-03-06 2012-01-11 Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke Methods for isolating agonists and antagonists of taste receptors
WO2013022947A1 (en) 2011-08-08 2013-02-14 The Coca-Cola Company Cell lines comprising endogenous taste receptors and their uses

Also Published As

Publication number Publication date
WO2013059836A1 (en) 2013-04-25
CN103998933B (en) 2016-12-14
CN103998933A (en) 2014-08-20
EP2769216B1 (en) 2017-01-04
US20140248639A1 (en) 2014-09-04
US20160299127A1 (en) 2016-10-13
JP2014530628A (en) 2014-11-20
EP2769216A4 (en) 2015-05-13
EP2769216A1 (en) 2014-08-27
US9347934B2 (en) 2016-05-24
SG11201401268RA (en) 2014-05-29
JP6122858B2 (en) 2017-04-26

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