JP6113653B2 - 改良型細胞培養培地 - Google Patents

改良型細胞培養培地 Download PDF

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JP6113653B2
JP6113653B2 JP2013506613A JP2013506613A JP6113653B2 JP 6113653 B2 JP6113653 B2 JP 6113653B2 JP 2013506613 A JP2013506613 A JP 2013506613A JP 2013506613 A JP2013506613 A JP 2013506613A JP 6113653 B2 JP6113653 B2 JP 6113653B2
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cell culture
medium
culture medium
production
polypeptide
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JP2013524826A (ja
JP2013524826A5 (enExample
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ブダッハ，ウォルフガング，アーンスト，グスタブ
チャシン，ヘレン，シー．
ドルシュ，ケアスティン
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ノバルティス アーゲー
ノバルティス アーゲー
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0031—Serum-free culture media
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/005—Protein-free medium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C12N2500/95—Protein-free medium and culture conditions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/99—Serum-free medium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2013506613A 2010-04-26 2011-04-25 改良型細胞培養培地 Active JP6113653B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32783710P 2010-04-26 2010-04-26
US61/327,837 2010-04-26
PCT/EP2011/056509 WO2011134921A1 (en) 2010-04-26 2011-04-25 Improved cell culture medium

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015204453A Division JP2016052310A (ja) 2010-04-26 2015-10-16 改良型細胞培養培地

Publications (3)

Publication Number Publication Date
JP2013524826A JP2013524826A (ja) 2013-06-20
JP2013524826A5 JP2013524826A5 (enExample) 2013-11-28
JP6113653B2 true JP6113653B2 (ja) 2017-04-12

Family

ID=44276356

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JP2013506613A Active JP6113653B2 (ja) 2010-04-26 2011-04-25 改良型細胞培養培地
JP2015204453A Pending JP2016052310A (ja) 2010-04-26 2015-10-16 改良型細胞培養培地

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JP2015204453A Pending JP2016052310A (ja) 2010-04-26 2015-10-16 改良型細胞培養培地

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US (2) US8986957B2 (enExample)
EP (2) EP3599276A1 (enExample)
JP (2) JP6113653B2 (enExample)
KR (1) KR101848945B1 (enExample)
CN (2) CN105331659B (enExample)
AU (1) AU2011246504B2 (enExample)
BR (1) BR112012027434B1 (enExample)
CA (1) CA2797140C (enExample)
ES (1) ES2755907T3 (enExample)
IL (1) IL222453B (enExample)
MX (1) MX2012012525A (enExample)
RU (1) RU2563353C2 (enExample)
SG (1) SG185037A1 (enExample)
WO (1) WO2011134921A1 (enExample)

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CN104822826B (zh) 2012-10-15 2019-04-30 百时美施贵宝公司 用于蛋白产生的哺乳动物细胞培养过程
CA2943667C (en) * 2014-01-29 2022-11-08 Lg Life Sciences Ltd. Method for modulating galactosylation of recombinant protein through optimization of culture medium
WO2015155975A1 (ja) * 2014-04-07 2015-10-15 東洋製罐グループホールディングス株式会社 動物細胞用培養液、及び培養容器
ES2733298T3 (es) 2014-07-18 2019-11-28 Sandoz Ag Cuantificación de TNFR2:Fc plegado erróneamente
SG11201705743YA (en) * 2015-04-01 2017-08-30 Boehringer Ingelheim Int Cell culture medium
EP3303555B1 (en) * 2015-05-29 2020-06-24 Merck Patent GmbH Deep eutectic solvents and/or ionic liquids in cell culture media
EP3303554B1 (en) * 2015-05-29 2020-06-24 Merck Patent GmbH Deep eutectic solvents and/or ionic liquids as feed media
WO2016207721A1 (en) 2015-06-25 2016-12-29 University Of Limerick Mechanical device for generating combinatorial library
JP2018536404A (ja) * 2015-11-09 2018-12-13 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｃｈｏ細胞において産生したポリペプチドの品質特性を操作する方法
KR20230124093A (ko) * 2016-05-10 2023-08-24 제넨테크, 인크. 폴리펩타이드의 재조합 생산 동안 트리설파이드 결합을감소시키기 위한 방법
KR102893388B1 (ko) * 2016-10-31 2025-11-28 삼성바이오에피스 주식회사 세포 배양 배지에서 원치 않는 배양 부산물을 감소시키는 공정
CN106676058B (zh) * 2016-12-09 2020-06-19 中农威特生物科技股份有限公司 一种bhk21悬浮细胞高密度流加培养方法及其在口蹄疫病毒增殖中的应用
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CA3167733A1 (en) * 2020-01-14 2021-07-22 Ajinomoto Co., Inc. High-density cell culture method

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Also Published As

Publication number Publication date
RU2012150281A (ru) 2014-06-10
US20130102032A1 (en) 2013-04-25
IL222453B (en) 2018-11-29
BR112012027434A2 (pt) 2015-09-22
KR20130098869A (ko) 2013-09-05
AU2011246504B2 (en) 2013-09-26
CN102858953B (zh) 2015-09-09
CN105331659B (zh) 2019-07-16
ES2755907T3 (es) 2020-04-24
EP3599276A1 (en) 2020-01-29
US9243224B2 (en) 2016-01-26
KR101848945B1 (ko) 2018-04-16
EP2563903B1 (en) 2019-08-21
CA2797140C (en) 2018-01-23
IL222453A0 (en) 2012-12-31
JP2016052310A (ja) 2016-04-14
CA2797140A1 (en) 2011-11-03
AU2011246504A1 (en) 2012-11-22
MX2012012525A (es) 2012-11-23
US20150218509A1 (en) 2015-08-06
JP2013524826A (ja) 2013-06-20
CN102858953A (zh) 2013-01-02
US8986957B2 (en) 2015-03-24
BR112012027434B1 (pt) 2020-09-29
CN105331659A (zh) 2016-02-17
WO2011134921A1 (en) 2011-11-03
RU2563353C2 (ru) 2015-09-20
EP2563903A1 (en) 2013-03-06
SG185037A1 (en) 2012-11-29

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