JP6091891B2 - ＳＩＲＰα−ＣＤ４７相互作用をターゲットとする、血液癌を治療するための組成物および方法 - Google Patents
ＳＩＲＰα−ＣＤ４７相互作用をターゲットとする、血液癌を治療するための組成物および方法 Download PDFInfo
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| PCT/CA2010/000743 WO2010130053A1 (en) | 2009-05-15 | 2010-05-14 | COMPOSITIONS AND METHODS FOR TREATING HEMATOLOGIC CANCERS TARGETING THE SIRPα - CD47 INTERACTION |
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| JP2020095230A Pending JP2020143146A (ja) | 2009-05-15 | 2020-06-01 | ＳＩＲＰα−ＣＤ４７相互作用をターゲットとする、血液癌を治療するための組成物および方法 |
| JP2022148798A Pending JP2022180495A (ja) | 2009-05-15 | 2022-09-20 | ＳＩＲＰα－ＣＤ４７相互作用をターゲットとする、血液癌を治療するための組成物および方法 |
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| JP2017218996A Active JP6410911B2 (ja) | 2009-05-15 | 2017-11-14 | ＳＩＲＰα−ＣＤ４７相互作用をターゲットとする、血液癌を治療するための組成物および方法 |
| JP2018178322A Pending JP2019011347A (ja) | 2009-05-15 | 2018-09-25 | ＳＩＲＰα−ＣＤ４７相互作用をターゲットとする、血液癌を治療するための組成物および方法 |
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| PT2429574E (pt) | 2009-05-15 | 2015-07-17 | Univ Health Network | Composições e métodos para o tratamento de cancros hematológicos tendo como alvo a interacção sirp-cd47 |
| ES2816647T3 (es) * | 2012-01-17 | 2021-04-05 | Univ Leland Stanford Junior | Reactivos SIRP-alfa de alta afinidad |
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| CN102643347A (zh) * | 2012-03-29 | 2012-08-22 | 中国人民解放军第四军医大学 | 一种白血病干细胞靶向可溶性蛋白TrxHis-hSIRPα |
| CN103804495A (zh) * | 2012-11-07 | 2014-05-21 | 深圳大学 | 抗肿瘤基因工程二价类抗体及其制备方法及抗肿瘤基因工程药物 |
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| WO2014121093A1 (en) | 2013-01-31 | 2014-08-07 | Thomas Jefferson University | Fusion proteins that facilitate cancer cell destruction |
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| CN103665165B (zh) * | 2013-08-28 | 2016-02-24 | 江苏匡亚生物医药科技有限公司 | 一种靶向人CD47-SIRPα信号通路的双特异性抗体及其制备方法和用途 |
| WO2015148416A1 (en) * | 2014-03-24 | 2015-10-01 | Deqiang Jing | Novel recombinant bi-functional fusion proteins, preparation and use thereof |
| CN113621075A (zh) * | 2014-08-08 | 2021-11-09 | Alx肿瘤生物技术公司 | SIRP-α变体构建体及其用途 |
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| CN106146670B (zh) * | 2015-04-24 | 2019-01-15 | 宜明昂科生物医药技术（上海）有限公司 | 一种新的重组双功能融合蛋白及其制备和应用 |
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| JP7078533B2 (ja) | 2015-10-21 | 2022-05-31 | オーエスイー イムノセラピューティクス | 炎症促進性細胞へのマクロファージ分極を改変して癌を治療するための抗ＳＩＲＰａ化合物 |
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| EP3487522A4 (en) | 2016-07-19 | 2020-04-01 | Teva Pharmaceuticals Australia Pty Ltd | ANTI-CD47 COMBINATION THERAPY |
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| US11702458B2 (en) | 2017-01-05 | 2023-07-18 | Kahr Medical Ltd. | PD1-41BBL fusion protein and methods of use thereof |
| PT3565828T (pt) | 2017-01-05 | 2022-02-08 | Kahr Medical Ltd | Proteína de fusão sirp1 alfa-41bbl e seus métodos de utilização |
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| SG11202000658PA (en) | 2017-07-26 | 2020-02-27 | Forty Seven Inc | Anti-sirp-alpha antibodies and related methods |
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| EP3694881A1 (en) | 2017-10-13 | 2020-08-19 | OSE Immunotherapeutics | Modified anti-sirpa antibodies and uses thereof |
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